• 986 Citations
20042019
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Personal profile

Research profile

Richard Lopata is an Associate Professor at the TU/e research group Cardiovascular Biomechanics (department of Biomedical Engineering) where he leads the PULS/e lab, Photoacoustics & Ultrasound Laboratory Eindhoven.  The PULS/e lab facilitates research on technology development, such as ultrasound functional imaging, photoacoustics and image-based modeling; and more applied science, in particular ultrasound-based biomechanical modeling for improved clinical decision making.

In his research, Richard Lopata aims amongst others at the ultrasonic characterization of vulnerable arteries, such as aneurysms and plaques. A patient-specific biomechanical model of these arteries may help to better assess rupture risk, and ultrasound has the ability to provide highly detailed information on plaque geometry and distensibility. A second research line concerns the development and testing of 2-D and 3-D ultrasound imaging techniques for the assessment of cardiac function. The focus here is on acquisition, algorithms and methods that process the (raw) ultrasound data to produce measurements, needed in the clinic, and on methods to validate these measurements. These functional imaging techniques include motion/strain imaging, flow imaging and multi-perspective ultrasound imaging. Recent efforts are aimed at the assessment of cardiac function during exercise, together with USONO (spin-off company).

Photoacoustic imaging techniques, aimed at skin disease and plaque vulnerability assessment, are developed and validated in a preclinical setting.

Close collaborations with both clinical and technical partners were established over the years, paramount for a successful translation of these techniques from bench (lab) to bedside (clinic).

Academic background

Richard Lopata studied BioMedical Engineering at Eindhoven University of Technology (TU/e, The Netherlands) and received his MSc in 2004 on pharmacokinetic parameter estimation in dynamic contrast-enhanced MRI. From 2004-2009, Richard performed PhD research at the Clinical Physics Laboratory of Radboudumc (Nijmegen, The Netherlands), resulting in his PhD thesis on '2D and 3D Ultrasound Strain Imaging: Methods & In Vivo Applications'.

The following two years,he was a postdoctoral researcher at Maastricht University Medical Center (The Netherlands) and TU/e. In this period he was awarded a NWO-TTW VENI grant (2011).

In 2012, he became an assistant professor at TU/e. He works at the TU/e research group for Cardiovascular Biomechanics (department of Biomedical Engineering). Lopata founded the Photoacoustics and Ultrasound Laboratory Eindhoven, PULS/e. in 2014. In this period, Lopata was granted several EU-funded grants (FP7, H2020) and national grants.

In January 2017, he was appointed associate professor, receiving an ERC starting grant later that year. He has graduated over 35 MSc students and 1 PhD student, and is currently supervising 9 PhD students, two post-docs and 10 MSc students.

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Research Output 2004 2019

Atherosclerotic carotid bifurcation phantoms with stenotic soft inclusions for ultrasound flow and vessel wall elastography imaging

Chayer, B., van den Hoven, M., Roy Cardinal, M. H., Li, H., Swillens, A., Lopata, R. & Cloutier, G., 2 May 2019, In : Physics in Medicine and Biology. 64, 9, 12 p., 095025

Research output: Contribution to journalArticleAcademicpeer-review

Elasticity Imaging Techniques
Blood Vessels
Elastic Modulus
Internal Carotid Artery
Atherosclerotic Plaques

Echocardiographic assessment of left bundle branch–related strain dyssynchrony: a comparison with tagged MRI

Fixsen, L. S., de Lepper, A. G. W., Strik, M., van Middendorp, L. B., Prinzen, F. W., van de Vosse, F. N., Houthuizen, P. & Lopata, R. G. P., 1 Aug 2019, In : Ultrasound in Medicine and Biology. 45, 8, p. 2063-2074

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
echocardiography
bundles
Echocardiography
Software
computer programs

Including surrounding tissue improves ultrasound-based 3D mechanical characterization of abdominal aortic aneurysms

Petterson, N. J., van Disseldorp, E. M. J., van Sambeek, M. R. H. M., van de Vosse, F. N. & Lopata, R. G. P., 6 Mar 2019, In : Journal of Biomechanics. 85, p. 126-133

Research output: Contribution to journalArticleAcademicpeer-review

Abdominal Aortic Aneurysm
Spine
Ultrasonics
Tissue
Aorta

Mechanical analysis of aortic aneurysms using 3D ultrasound : towards patient-specific risk assessment

van Disseldorp, E. M. J., 10 Jan 2019, Eindhoven: Technische Universiteit Eindhoven. 178 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
Risk assessment
Ultrasonics
3 Citations (Scopus)
Vascular Stiffness
Abdominal Aortic Aneurysm
Healthy Volunteers
Volunteers
Aortic Rupture

Prizes

Multi-perspective Ultrasound Strain Imaging & Elastography

Richard Lopata (Recipient), 2017

Recognition: ERCStartingScientific

Elasticity Imaging Techniques
Aortic Valve Stenosis
Abdominal Aortic Aneurysm
Ultrasonography
Three-Dimensional Imaging

NWO Veni Award : Monitoring an aneurysm with an ultrasonogram

Richard Lopata (Recipient), 2011

Recognition: NWOVeniScientific

Ultrasonography
Monitoring

The stiffening of arteries viewed from multiple angles

Richard Lopata (Recipient), 2019

Recognition: NWOVidiScientific

Aneurysm
Arteries
Rupture
Blood Vessels
Aorta

Student theses

A constitutive material model to describe the mechanical behavior of human skin in shear, tensile and indentation tests

Author: Rooijakkers, T., 31 Aug 2017

Supervisor: Oomens, C. (Supervisor 1), Loerakker, S. (Supervisor 2), Lopata, R. (Supervisor 2) & Soetens, J. (Supervisor 2)

Student thesis: Master

An in-silico imaging system based on k-Wave for multi-perspective ultrasound imaging of abdominal aortic aneurysms

Author: Nooijens, S., 31 Jan 2019

Supervisor: van de Vosse, F. (Supervisor 1), Lopata, R. (Supervisor 2), Oomens, C. (Supervisor 2), Petterson, N. (Supervisor 2) & Bouwman, R. (Supervisor 2)

Student thesis: Master

Assessing strain and damage in cartilage explants with ultrasound

Author: Stavenuiter, I., 31 Jan 2019

Supervisor: Ito, K. (Supervisor 1), van Donkelaar, R. (Supervisor 2), Lopata, R. (Supervisor 2) & van de Vosse, F. (Supervisor 2)

Student thesis: Master

Correlation-based discrimination between myocardial tissue and blood in 3D echocardiographic images

Author: Saris, A., 30 Apr 2012

Supervisor: Nillesen, M. M. (External person) (External coach), Lopata, R. (Supervisor 1), de Korte, C. (External coach) & van de Vosse, F. (Supervisor 2)

Student thesis: Master