• 1109 Citations

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Personal profile

Research profile

Richard Lopata is an Associate Professor at the TU/e research group Cardiovascular Biomechanics (department of Biomedical Engineering) where he leads the PULS/e lab, Photoacoustics & Ultrasound Laboratory Eindhoven.  The PULS/e lab facilitates research on technology development, such as ultrasound functional imaging, photoacoustics and image-based modeling; and more applied science, in particular ultrasound-based biomechanical modeling for improved clinical decision making.

In his research, Richard Lopata aims amongst others at the ultrasonic characterization of vulnerable arteries, such as aneurysms and plaques. A patient-specific biomechanical model of these arteries may help to better assess rupture risk, and ultrasound has the ability to provide highly detailed information on plaque geometry and distensibility. A second research line concerns the development and testing of 2-D and 3-D ultrasound imaging techniques for the assessment of cardiac function. The focus here is on acquisition, algorithms and methods that process the (raw) ultrasound data to produce measurements, needed in the clinic, and on methods to validate these measurements. These functional imaging techniques include motion/strain imaging, flow imaging and multi-perspective ultrasound imaging. Recent efforts are aimed at the assessment of cardiac function during exercise, together with USONO (spin-off company).

Photoacoustic imaging techniques, aimed at skin disease and plaque vulnerability assessment, are developed and validated in a preclinical setting.

Close collaborations with both clinical and technical partners were established over the years, paramount for a successful translation of these techniques from bench (lab) to bedside (clinic).

Academic background

Richard Lopata studied BioMedical Engineering at Eindhoven University of Technology (TU/e, The Netherlands) and received his MSc in 2004 on pharmacokinetic parameter estimation in dynamic contrast-enhanced MRI. From 2004-2009, Richard performed PhD research at the Clinical Physics Laboratory of Radboudumc (Nijmegen, The Netherlands), resulting in his PhD thesis on '2D and 3D Ultrasound Strain Imaging: Methods & In Vivo Applications'.

The following two years,he was a postdoctoral researcher at Maastricht University Medical Center (The Netherlands) and TU/e. In this period he was awarded a NWO-TTW VENI grant (2011).

In 2012, he became an assistant professor at TU/e. He works at the TU/e research group for Cardiovascular Biomechanics (department of Biomedical Engineering). Lopata founded the Photoacoustics and Ultrasound Laboratory Eindhoven, PULS/e. in 2014. In this period, Lopata was granted several EU-funded grants (FP7, H2020) and national grants.

In January 2017, he was appointed associate professor, receiving an ERC starting grant later that year. He has graduated over 35 MSc students and 1 PhD student, and is currently supervising 9 PhD students, two post-docs and 10 MSc students.

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Research Output

Open Access
  • Automated 3D geometry segmentation of the healthy and diseased carotid artery in free-hand, probe tracked ultrasound images

    de Ruijter, J., van Sambeek, M., van de Vosse, F. & Lopata, R., 1 Mar 2020, In : Medical Physics. 47, 3, p. 1034-1047 14 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 15 Downloads (Pure)
  • Reproducibility assessment of ultrasound-based aortic stiffness quantification and verification using Bi-axial tensile testing

    van Disseldorp, E. M. J., van den Hoven, M. H. M. H., van de Vosse, F. N., van Sambeek, M. R. H. M. & Lopata, R. G. P., Mar 2020, In : Journal of the Mechanical Behavior of Biomedical Materials. 103, 10 p., 103571.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Ultrasound-based estimation of remaining cardiac function in LVAD-supported ex vivo hearts

    Fixsen, L. S., Petterson, N. J., Houthuizen, P., Rutten, M. C. M., van de Vosse, F. N. & Lopata, R. G. P., 1 Jan 2020, (Accepted/In press) In : Artificial Organs.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Prizes

    Multi-perspective Ultrasound Strain Imaging & Elastography

    R.G.P. Lopata (Recipient), 2017

    Prize: ERCStartingScientific

  • NWO Veni Award : Monitoring an aneurysm with an ultrasonogram

    R.G.P. Lopata (Recipient), 2011

    Prize: NWOVeniScientific

  • The stiffening of arteries viewed from multiple angles

    Richard Lopata (Recipient), 2019

    Prize: NWOVidiScientific

  • Student theses

    A constitutive material model to describe the mechanical behavior of human skin in shear, tensile and indentation tests

    Author: Rooijakkers, T., 31 Aug 2017

    Supervisor: Oomens, C. (Supervisor 1), Loerakker, S. (Supervisor 2), Lopata, R. (Supervisor 2) & Soetens, J. (Supervisor 2)

    Student thesis: Master

    An in-silico imaging system based on k-Wave for multi-perspective ultrasound imaging of abdominal aortic aneurysms

    Author: Nooijens, S., 31 Jan 2019

    Supervisor: van de Vosse, F. (Supervisor 1), Lopata, R. (Supervisor 2), Oomens, C. (Supervisor 2), Petterson, N. (Supervisor 2) & Bouwman, R. (Supervisor 2)

    Student thesis: Master

    Assessing strain and damage in cartilage explants with ultrasound

    Author: Stavenuiter, I., 31 Jan 2019

    Supervisor: Ito, K. (Supervisor 1), van Donkelaar, R. (Supervisor 2), Lopata, R. (Supervisor 2) & van de Vosse, F. (Supervisor 2)

    Student thesis: Master

    Correlation-based discrimination between myocardial tissue and blood in 3D echocardiographic images

    Author: Saris, A., 30 Apr 2012

    Supervisor: Nillesen, M. M. (External person) (External coach), Lopata, R. (Supervisor 1), de Korte, C. (External coach) & van de Vosse, F. (Supervisor 2)

    Student thesis: Master