• 75 Citations
20162020

Research output per year

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Research Output

  • 75 Citations
  • 5 Article
  • 1 Review article
2020

Elucidation of an allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

de Vries, R. M. J. M., Doveston, R. G., Meijer, F. A. & Brunsveld, L., 3 Apr 2020, In : ChemMedChem : chemistry enabling drug discovery. 15, 7, p. 561-565 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
7 Downloads (Pure)

Ligand-based design of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists

Meijer, F. A., Doveston, R. G., de Vries, R. M. J. M., Vos, G. M., Vos, A. A. A., Leysen, S., Scheepstra, M., Ottmann, C., Milroy, L-G. & Brunsveld, L., 9 Jan 2020, In : Journal of Medicinal Chemistry. 63, 1, p. 241-259 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
22 Downloads (Pure)
2019

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 5 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
7 Citations (Scopus)
188 Downloads (Pure)
2017

Ligand dependent switch from RXR homo- to RXR-NURR1 heterodimerization

Scheepstra, M., Andrei, S. A., de Vries, R. M. J. M., Meijer, F. A., Ma, J-N., Burstein, E. S., Olsson, R., Ottmann, C., Milroy, L-G. & Brunsveld, L., 1 Sep 2017, In : ACS Chemical Neuroscience. 8, 9, p. 2065-2077 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
8 Citations (Scopus)
99 Downloads (Pure)

Structural interface between LRRK2 and 14-3-3 protein

Stevers, L. M., de Vries, R. M. J. M., Doveston, R. G., Milroy, L. G., Brunsveld, L. & Ottmann, C., 1 Apr 2017, In : Biochemical Journal. 474, 7, p. 1273-1287 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
13 Citations (Scopus)
216 Downloads (Pure)
2016

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR

Stevers, L. M., Lam, C. V., Leysen, S. F. R., Meijer, F. A., van Scheppingen, D. S., de Vries, R. M. J. M., Carlile, G. W., Milroy, L. G., Thomas, D. Y., Brunsveld, L. & Ottmann, C., 1 Mar 2016, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 113, 9, p. E1152-E1161 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
46 Citations (Scopus)
13 Downloads (Pure)