• 48 Citations
20162019
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Personal profile

Research profile

Rens de Vries started as a doctoral candidate at the Eindhoven University of Technology in September 2016 under the supervision of prof. Luc Brunsveld. In his research, he is exploring how small molecules influence the behavior of nuclear receptors, especially their effects on dimerization and cofactor recruitment. Nuclear receptors regulate the expression of specific genes, thereby controlling our development, homeostasis and metabolism. In multiple diseases, such as neurodegenerative diseases and cancer, the nuclear receptor function is altered. Selectively targeting these nuclear receptors and restoring their behavior, is very interesting in drug discovery. In the human body, processes such as dimerization and cofactor recruitment of these receptors are tightly and selectively mediated. How nature accomplished such a high degree of control is still poorly understood. Making use of protein crystallography, assay development and computational approaches, Rens tries to make his contribution to understand this interesting phenomenon and to potentially exploit it.

Academic background

Rens de Vries (1993) received his Bachelor and Master degree in Biomedical Engineering at Eindhoven University of Technology (TU/e) in 2014 and 2016 respectively. During his master, he performed research in the group of prof. dr. ir. Luc Brunsveld, under the direct supervision of dr. Christian Ottmann. In this research, the interaction between two proteins, important in Parkinson’s disease, was analyzed and quantified. This research was continued during his internship at the Lead Discovery Center GmbH in Dortmund where High-Throughput Screening and Assay Development were used to find drug candidates for this interaction. In 2016, he started as a PhD candidate under the supervision of prof. dr. ir. Luc Brunsveld in the field of Chemical Biology. In his research, he analyses how ligand design can fundamentally change the behavior of nuclear receptors.

Quote

If we desire the same level of precision as nature in drug development, we should not be interested in whether a drug works, we should strive to understand why it works.

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Research Output 2016 2019

  • 48 Citations
  • 4 Article

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 1 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
5 Citations (Scopus)

Ligand dependent switch from RXR homo- to RXR-NURR1 heterodimerization

Scheepstra, M., Andrei, S. A., de Vries, R. M. J. M., Meijer, F. A., Ma, J-N., Burstein, E. S., Olsson, R., Ottmann, C., Milroy, L-G. & Brunsveld, L., 1 Sep 2017, In : ACS Chemical Neuroscience. 8, 9, p. 2065-2077 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Switches
Ligands
Proteins
10 Citations (Scopus)

Structural interface between LRRK2 and 14-3-3 protein

Stevers, L. M., de Vries, R. M. J. M., Doveston, R. G., Milroy, L. G., Brunsveld, L. & Ottmann, C., 23 Mar 2017, In : Biochemical Journal. 474, 7, p. 1273-1287

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
14-3-3 Proteins
Protein Kinases
Parkinson Disease
Phosphorylation
Ubiquitination
33 Citations (Scopus)

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR

Stevers, L. M., Lam, C. V., Leysen, S. F. R., Meijer, F. A., van Scheppingen, D. S., de Vries, R. M. J. M., Carlile, G. W., Milroy, L. G., Thomas, D. Y., Brunsveld, L. & Ottmann, C., 1 Mar 2016, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 113, 9, p. E1152-E1161 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cystic Fibrosis Transmembrane Conductance Regulator
14-3-3 Proteins
Binding Sites
Cystic Fibrosis
Cell Membrane