Research Output per year
Research Output per year
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Research output per year
Rens de Vries started as a doctoral candidate at the Eindhoven University of Technology in September 2016 under the supervision of prof. Luc Brunsveld. In his research, he is exploring how small molecules influence the behavior of nuclear receptors, especially their effects on dimerization and cofactor recruitment. Nuclear receptors regulate the expression of specific genes, thereby controlling our development, homeostasis and metabolism. In multiple diseases, such as neurodegenerative diseases and cancer, the nuclear receptor function is altered. Selectively targeting these nuclear receptors and restoring their behavior, is very interesting in drug discovery. In the human body, processes such as dimerization and cofactor recruitment of these receptors are tightly and selectively mediated. How nature accomplished such a high degree of control is still poorly understood. Making use of protein crystallography, assay development and computational approaches, Rens tries to make his contribution to understand this interesting phenomenon and to potentially exploit it.
Rens de Vries (1993) received his Bachelor and Master degree in Biomedical Engineering at Eindhoven University of Technology (TU/e) in 2014 and 2016 respectively. During his master, he performed research in the group of prof. dr. ir. Luc Brunsveld, under the direct supervision of dr. Christian Ottmann. In this research, the interaction between two proteins, important in Parkinson’s disease, was analyzed and quantified. This research was continued during his internship at the Lead Discovery Center GmbH in Dortmund where High-Throughput Screening and Assay Development were used to find drug candidates for this interaction. In 2016, he started as a PhD candidate under the supervision of prof. dr. ir. Luc Brunsveld in the field of Chemical Biology. In his research, he analyses how ligand design can fundamentally change the behavior of nuclear receptors.
If we desire the same level of precision as nature in drug development, we should not be interested in whether a drug works, we should strive to understand why it works.
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Thesis › Phd Thesis 1 (Research TU/e / Graduation TU/e)
Research output: Contribution to journal › Review article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
de Vries, Rens M.J.M. (Recipient), 7 Feb 2020
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
Luc Brunsveld, Rens M.J.M. de Vries, Christian Ottmann, Femke A. Meijer & L.M. Stevers
19/02/16
1 item of Media coverage
Press/Media: Expert Comment
Luc Brunsveld, Rens M.J.M. de Vries, Christian Ottmann, Femke A. Meijer & L.M. Stevers
18/02/16 → 19/02/16
5 items of Media coverage
Press/Media: Expert Comment
Luc Brunsveld, Rens M.J.M. de Vries, Christian Ottmann, Femke A. Meijer & L.M. Stevers
18/02/16
1 item of Media coverage
Press/Media: Expert Comment