• 2040 Citations
19982019
If you made any changes in Pure these will be visible here soon.

Research Output 1998 2019

Filter
Article
2019

CALIMA: the semi-automated open-source calcium imaging analyzer

Radstake, F. D. W., Raaijmakers, E. A. L., Luttge, R., Zinger, S. & Frimat, J-P., 1 Oct 2019, In : Computer Methods and Programs in Biomedicine. 179, 10 p., 104991

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Calcium
Imaging techniques
Neurons
Cellular radio systems
Software
Open Access
File
Brain models
Cell culture
brain
Anisotropy
anisotropy

Nanogroove-enhanced hydrogel scaffolds for 3D neuronal cell culture: an easy access brain-on-chip model

Bastiaens, A., Xie, S. & Luttge, R., 1 Oct 2019, In : Micromachines. 10, 10, 17 p., 638

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Scaffolds (biology)
Cell culture
Hydrogels
Brain
Brain models
2018

Advancing a MEMS-Based 3D cell culture system for in vitro neuro-electrophysiological recordings

Bastiaens, A. J., Frimat, J. M. S., van Nunen, A. G. A., Schurink, B., Homburg, F. G. A. & Luttge, R., 13 Dec 2018, In : Frontiers in Mechanical Engineering. 4, p. 1-10 10 p., 21

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Micro-Electrical-Mechanical Systems
Cell Culture Techniques
Microelectrodes
Neurons
Fungi

Hybrid business models for ‘Organ-on-a-Chip’ technology: the best of both worlds

van de Burgwal, L. H. M., van Dorst, P., Viëtor, H., Luttge, R. & Claassen, E., 1 Jun 2018, In : PharmaNutrition. 6, 2, p. 55-63 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Technology
translation (genetics)
laboratory equipment
human physiology
Equipment and Supplies
2 Citations (Scopus)
Open Access
File
Polydimethylsiloxane
Lithography
Substrates
Cell culture
Atomic force microscopy
3 Citations (Scopus)

Nanoscale membrane actuator for in vitro mechano-stimuli responsive studies of neuronal cell networks on chip

Xie, S., Gardeniers, J. G. E. & Luttge, R., 9 May 2018, In : Journal of Micromechanics and Microengineering. 28, 8, 12 p., 085011

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Actuators
Membranes
Brain
Microfluidics
Brain models
2 Citations (Scopus)

Single cell trapping by capillary pumping using NOA81 replica moulded stencils

Moonen, E., Luttge, R. & Frimat, J. P., 5 Oct 2018, In : Microelectronic Engineering. 197, p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Syringes
Micromachining
replicas
Molding
Adhesives
3 Citations (Scopus)

Validation and optimization of an image-based screening method applied to the study of neuronal processes on nanogrooves

Bastiaens, A. J., Xie, S., Mustafa, D. A. M., Frimat, J-P., den Toonder, J. M. J. & Luttge, R., 6 Nov 2018, In : Frontiers in Cellular Neuroscience. 12, 14 p., 415

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Neurites
Software
Cues
Cultured Cells
Neurons
2017
9 Citations (Scopus)

A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing"

Eslami Amirabadi, H., Sahebali, S., Frimat, J. M. S., Luttge, R. & den Toonder, J. M. J., 17 Oct 2017, In : Biomedical Microdevices. 19, 4, 11 p., 19:92

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)

Fabrication and characterization of microsieve electrode array (μSEA) enabling cell positioning on 3D electrodes

Schurink, B., Tiggelaar, R. M., Gardeniers, J. G. E. & Luttge, R., 1 Jan 2017, In : Journal of Micromechanics and Microengineering. 27, 1, p. 1-16 015017

Research output: Contribution to journalArticleAcademicpeer-review

Fabrication
Electrodes
Silicon
Boron
Microelectrodes
1 Citation (Scopus)

In Vitro and In Vivo evaluation of a hydrogel-based microneedle device for transdermal electro-modulated analgesia

Indermun, S., Choonara, Y. E., Kumar, P., du Toit, L. C., Modi, G., Luttge, R., Govender, M. & Pillay, V., 2017, In : European Journal of Pharmaceutical Sciences. 106, 4, p. 1111–1116 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Analgesia
Chronic Pain
Equipment and Supplies
Pharmacokinetics

Passive pumping for the parallel trapping of single neurons onto a microsieve electrode array

Frimat, J. P., Schurink, B. & Luttge, R., 1 Nov 2017, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 35, 6, 6 p., 06GA01

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
neurons
Neurons
pumping
trapping
chips
2016
4 Citations (Scopus)

Displacement Talbot lithography nanopatterned microsieve array for directional neuronal network formation in brain-on-chip

Xie, S., Schurink, B., Berenschot, E. J. W., Tiggelaar, R. M., Gardeniers, J. G. E. & Luttge, R., 1 Nov 2016, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 34, 6, p. 1-7 06KI02

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microelectrodes
Lithography
brain
Brain
lithography
2015
11 Citations (Scopus)

Advances in 3D neuronal cell culture

Frimat, J. M. S., Xie, S., Bastiaens, A. J., Schurink, B., Wolbers, F., den Toonder, J. M. J. & Luttge, R., 2015, In : Journal of Vacuum Science and Technology, B. 33, p. 1-6 06F902

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
16 Citations (Scopus)

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays

Boks, M. A., Unger, W. W. J., Engels, S., Ambrosini, M., Van Kooyk, Y. & Luttge, R., 14 Jul 2015, In : International Journal of Pharmaceutics. 491, 1-2, p. 375-383 9 p., 14977

Research output: Contribution to journalArticleAcademicpeer-review

Ceramics
Vaccines
T-Lymphocytes
Vaccination
Syringes
1 Citation (Scopus)

Ex vivo evaluation of a microneedle array device for transdermal application

Indermun, S., Choonara, Y. E., Kumar, P., Du Toit, L. C., Modi, G., Van Vuuren, S., Luttge, R. & Pillay, V., 30 Dec 2015, In : International Journal of Pharmaceutics. 496, 2, p. 351-359 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Equipment and Supplies
Skin
Hydrogel
Swine
Pharmaceutical Preparations
10 Citations (Scopus)

Highly uniform sieving structure by corner lithography and silicon wet etching

Schurink, B., Berenschot, E. J. W., Tiggelaar, R. M. & Luttge, R., 16 Aug 2015, In : Microelectronic Engineering. 144, p. 12-18 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

sieves
Sieves
Wet etching
Silicon
Lithography
8 Citations (Scopus)

Insertion process of ceramic nanoporous microneedles by means of a novel mechanical applicator design

Hartmann, X. H. M., van der Linde, P., Homburg, F. G. A., van Breemen, L. C. A., de Jong, A. M. & Luttge, R., 18 Nov 2015, In : Pharmaceutics. 7, 4, p. 503-522 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ceramics
Thumb
Adhesives
Skin
Artificial Skin
31 Citations (Scopus)

Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays

van der Maaden, K., Luttge, R., Vos, P. J. W., Bouwstra, J., Kersten, G. & Ploemen, I. H. J., Aug 2015, In : Drug Delivery and Translational Research. 5, 4, p. 397-406

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2014
28 Citations (Scopus)

An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug delivery

Indermun, S., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G., Luttge, R. & Pillay, V., 2014, In : International Journal of Pharmaceutics. 462, 1-2, p. 52-65 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Hydrogels
Pharmaceutical Preparations
carbopol 940
Drug Delivery Systems
128 Citations (Scopus)

Current advances in the fabrication of microneedles for transdermal delivery

Indermun, S., Luttge, R., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G. & Pillay, V., 2014, In : Journal of Controlled Release. 185, p. 130-138

Research output: Contribution to journalArticleAcademicpeer-review

Needles
Needlestick Injuries
Macromolecular Substances
Phobic Disorders
Drug Delivery Systems
14 Citations (Scopus)

Imprint lithography provides topographical nanocues to guide cell growth in primary cortical cell culture

Xie, S. & Luttge, R., 2014, In : Microelectronic Engineering. 124, p. 30-36 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Polyethyleneimine
Cell growth
Cell culture
Lithography
Brain
7 Citations (Scopus)

Nanoscaffold's stiffness affects primary cortical cell network formation

Xie, S., Schurink, B., Wolbers, F., Luttge, R. & Hassink, G., 1 Nov 2014, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 32, 6, 5 p., 06FD03

Research output: Contribution to journalArticleAcademicpeer-review

stiffness
Stiffness
Silicon
Polydimethylsiloxane
brain
2013
8 Citations (Scopus)

Hydrogel/poly-dimethylsiloxane hybrid bioreactor facilitating 3D cell culturing

Schurink, B. & Luttge, R., 2013, In : Journal of Vacuum Science and Technology, B. 31, 6, 5 p., 06F903

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
cell culturing
bioreactors
Polydimethylsiloxane
Bioreactors
Hydrogels
38 Citations (Scopus)

The effect of nanometric surface texture on bone contact to titanium implants in rabbit tibia

Prodanov, L., Lamers, E., Domanski, M., Luttge, R., Jansen, J. A. & Walboomers, X. F., 2013, In : Biomaterials. 34, 12, p. 2920-2927 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Titanium
Tibia
Bone
Textures
Rabbits
2012
24 Citations (Scopus)

Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

Verhoeven, M., Bystrova, S. N., Winnubst, L., Qureshi, H., Gruijl, de, T. D., Scheper, R. J. & Luttge, R., 2012, In : Microelectronic Engineering. 98, p. 659-662 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

eggs
delivery
Skin
Porosity
ceramics
38 Citations (Scopus)

Dynamic cell adhesion and migration on nanoscale grooved substrates

Lamers, E., Riet, te, J., Domanski, M., Luttge, R., Figdor, C. G., Gardeniers, J. G. E., Walboomers, X. F. & Jansen, J. A., 2012, In : European Cells and Materials. 23, p. 182-194

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cell adhesion
Cell Adhesion
Cell Movement
Adhesion
Substrates
35 Citations (Scopus)

Influence of partner diversity on collaborative public R&D project outcomes : a study of application and commercialization of nanotechnologies in the Netherlands

Raesfeld, A. V., Geurts, P., Jansen, M., Boshuizen, J. & Luttge, R., 2012, In : Technovation. 32, 3-4, p. 227-233 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nanotechnology
The Netherlands
Commercialization
Value chain
Complementarity
31 Citations (Scopus)

In vitro and in vivo evaluation of the inflammatory response to nanoscale grooved substrates

Lamers, E., Walboomers, X. F., Domanski, M., Prodanov, L., Melis, J., Luttge, R., Winnubst, A. J. A., Anderson, J. M., Gardeniers, J. G. E. & Jansen, J. A., 2012, In : Nanomedicine. 8, 3, p. 308-317

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
Interleukins
Biocompatible Materials
Cytokines
Biomaterials
9 Citations (Scopus)

Production and characterization of miro- and nano-features in biomedical alumina and zirconia ceramics using a tape casting route

Domanski, M., Winnubst, A. J. A., Luttge, R., Lamers, E., Walboomers, X. F., Jansen, J. A. & Gardeniers, J. G. E., 2012, In : Journal of Materials Science: Materials in Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Aluminum Oxide
Ceramics
Silicon
Zirconia
Tapes
15 Citations (Scopus)

Submicron-patterning of bulk titanium by nanoimprint lithography and reactive ion etching

Domanski, M., Luttge, R., Lamers, E., Walboomers, X. F., Winnubst, A. J. A., Jansen, J. A. & Gardeniers, J. G. E., 2012, In : Nanotechnology. 23, 6, 065306

Research output: Contribution to journalArticleAcademicpeer-review

Nanoimprint lithography
Reactive ion etching
Titanium
Silicon
Masks
2011
12 Citations (Scopus)

Cryo dualbeam focused ion beam-scanning electron microscopy to evaluate the interface between cells and nanopatterned scaffolds

Lamers, E., Walboomers, X. F., Domanski, M., McKerr, G., O'Hagan, B. M., Barnes, C. A., Peto, L., Luttge, R., Winnubst, A. J. A., Gardeniers, J. G. E. & Jansen, J. A., 2011, In : Tissue Engineering. Part C: Methods. 17, 1, p. 1-7

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Micromolding for ceramic microneedle arrays

Bystrova, S. N. & Luttge, R., 2011, In : Microelectronic Engineering. 88, 8, p. 1681-1684

Research output: Contribution to journalArticleAcademicpeer-review

Silicones
ceramics
Fabrication
Silicone Elastomers
microhardness
2010
158 Citations (Scopus)

The influence of nanoscale grooved substrates on osteoblast behavior and extracellular matrix deposition

Lamers, E., Walboomers, X. F., Domanski, M., Riet, te, J., van Delft, F. C. M. J. M., Luttge, R., Winnubst, A. J. A., Gardeniers, J. G. E. & Jansen, J. A., 2010, In : Biomaterials. 31, 12, p. 3307-3316 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Osteoblasts
Extracellular Matrix
Bone
Bone and Bones
Substrates
97 Citations (Scopus)

The influence of nanoscale topographical cues on initial osteoblast morphology and migration

Lamers, E., Horssen, van, R., Riet, te, J., van Delft, F. C. M. J. M., Luttge, R., Walboomers, X. F. & Jansen, J. A., 2010, In : European Cells and Materials. 20, p. 329-343 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Osteoblasts
Topography
Cues
Adhesion
Focal Adhesions
58 Citations (Scopus)

The interaction between nanoscale surface features and mechanical loading and its effect on osteoblast-like cells behavior

Prodanov, L., Riet, te, J., Lamers, E., Domanski, M., Luttge, R., Van Loon, J. J., Jansen, J. A. & Walboomers, X. F., 2010, In : Biomaterials. 31, 30, p. 7758-7765 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Osteoblasts
Textures
Biomimetic materials
Biocompatible Materials
Surface topography
2009
29 Citations (Scopus)

Massively parallel fabrication of repetitive nanostructures : nanolithography for nanoarrays

Luttge, R., 2009, In : Journal of Physics D: Applied Physics. 42, 12, 18 p., 123001

Research output: Contribution to journalArticleAcademicpeer-review

Nanolithography
Nanostructures
Fabrication
fabrication
interference
2008
130 Citations (Scopus)

Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method

Verbaan, F. J., Bal, S. M., Berg, van den, D. J., Dijksman, J. A., Hecke, van, M., Verpoorten, H., Berg, van den, A., Luttge, R. & Bouwstra, J. A., 2008, In : Journal of Controlled Release. 128, 1, p. 80-88 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Skin
Silicon
Metals
Trypan Blue
2007
129 Citations (Scopus)

Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin

Verbaan, F. J., Bal, S. M., Berg, van den, D. J., Groenink, W. H. H., Verpoorten, H., Luttge, R. & Bouwstra, J. A., 2007, In : Journal of Controlled Release. 117, 2, p. 238-245 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Weight
Skin
Trypan Blue
Fluorescein-5-isothiocyanate
Needles
8 Citations (Scopus)

Field emission to control tip-sample distance in magnetic probe recording

Fèbre, Le, A. J., Luttge, R., Abelmann, L. & Lodder, J. C., 2007, In : Journal of Physics: Conference Series. 61, 1, p. 673-677

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
magnetic probes
field emission
recording
probes
chromium
40 Citations (Scopus)

Integrated lithographic molding for microneedle-based devices

Luttge, R., Berenschot, J. W., Boer, de, M. J., Altpeter, D. M., Vrouwe, E. X., Berg, van den, A. & Elwenspoek, M., 2007, In : Journal of Microelectromechanical Systems. 16, 4, p. 872-884

Research output: Contribution to journalArticleAcademicpeer-review

Molding
Needles
Fabrication
Capillary electrophoresis
Silicon
17 Citations (Scopus)

Laser interferometric nanolithography using a new positive chemical amplified resist

Luttge, R., Wolferen, Van, H. A. G. M. & Abelmann, L., 2007, In : Journal of Vacuum Science and Technology, B. 25, 6, p. 2476-2480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanolithography
Lasers
lasers
Fabrication
fabrication
45 Citations (Scopus)

Microchip capillary electrophoresis for point-of-care analysis of lithium

Vrouwe, E. X., Luttge, R., Vermes, I. & Berg, van den, A., 2007, In : Clinical Chemistry. 53, 1, p. 117-123 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microchip Electrophoresis
Point-of-Care Systems
Capillary electrophoresis
Capillary Electrophoresis
Lithium
15 Citations (Scopus)

Study of crack formation in high-aspect ratio SU-8 structures on silicon

Bystrova, S. N., Luttge, R. & Berg, van den, A., 2007, In : Microelectronic Engineering. 84, 5-8, p. 1113-1116

Research output: Contribution to journalArticleAcademicpeer-review

crack initiation
Silicon
high aspect ratio
Crack initiation
Aspect ratio
2006
176 Citations (Scopus)

Electroporation of cells in microfluidic devices: A review

Fox, M. B., Esveld, D. C., Valero, A., Luttge, R., Mastwijk, H. C., Bartels, P. V., Berg, van den, A. & Boom, R. M., 2006, In : Analytical and Bioanalytical Chemistry. 385, 3, p. 474-485

Research output: Contribution to journalArticleAcademicpeer-review

Lab-On-A-Chip Devices
Electroporation
Microfluidics
Electric fields
Pasteurization
25 Citations (Scopus)

Rapid inorganic ion analysis using quantitative microchip capillary electrophoresis

Vrouwe, E. X., Luttge, R., Olthuis, W. & van den Berg, A., 2006, In : Journal of Chromatography, A. 1102, 1-2, p. 287-293 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microchip Electrophoresis
Electroosmosis
Capillary electrophoresis
Capillary Electrophoresis
Electrolytes
34 Citations (Scopus)

Viability study of HL60 cells in contact with commonly used microchip materials

Wolbers, F., Braak, ter, P., Gac, Le, S., Luttge, R., Andersson, H., Vermes, I. & Berg, van den, A., 2006, In : Electrophoresis. 27, 24, p. 5073-5080 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

HL-60 Cells
Apoptosis
Propidium
Silicon
Cell Cycle
2005
23 Citations (Scopus)

A new pulsed electric field microreactor : comparison between the laboratory and microtechnology scale

Fox, M. B., Esveld, D. C., Luttge, R. & Boom, R. M., 2005, In : Lab on a Chip. 5, 9, p. 943-948

Research output: Contribution to journalArticleAcademicpeer-review

Microtechnology
Membrane Potentials
Pasteurization
Electroporation
Electric fields
89 Citations (Scopus)

Apoptotic cell death dynamics of HL60 cells studied using a microfluidic cell trap device

Valero, A., Merino, F., Wolbers, F., Luttge, R., Vermes, I., Andersson, H. & Berg, van den, A., 2005, In : Lab on a Chip. 5, 1, p. 49-55 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microfluidics
HL-60 Cells
Cell death
Cell Death
Apoptosis