• 2048 Citations
19982019
If you made any changes in Pure these will be visible here soon.

Research Output 1998 2019

7 Citations (Scopus)

40 keV Shaped electron beam lithography for LIGA intermediate mask fabrication

Luttge, R., Adam, D., Burkhardt, F., Hoke, F., Schacke, H., Schmidt, M., Wolf, H. & Schmidt, A., 1999, Proceedings of the 1998 International Conference on Micro- and Nanofabrication (MNE98), 22-24 September 1998, Leuven, Belgium. p. 247-250 (Microelectronic Engineering; vol. 46, no. 1-4)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

masks
lithography
electron beams
fabrication
photographic developers
12 Citations (Scopus)

Advances in 3D neuronal cell culture

Frimat, J. M. S., Xie, S., Bastiaens, A. J., Schurink, B., Wolbers, F., den Toonder, J. M. J. & Luttge, R., 2015, In : Journal of Vacuum Science and Technology, B. 33, p. 1-6 06F902

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Advancing a MEMS-Based 3D cell culture system for in vitro neuro-electrophysiological recordings

Bastiaens, A. J., Frimat, J. M. S., van Nunen, A. G. A., Schurink, B., Homburg, F. G. A. & Luttge, R., 13 Dec 2018, In : Frontiers in Mechanical Engineering. 4, p. 1-10 10 p., 21

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Micro-Electrical-Mechanical Systems
Cell Culture Techniques
Microelectrodes
Neurons
Fungi
1 Citation (Scopus)

An actuator chip for in vitro mechano-stimuli responsive studies of primary cortical cell networks

Xie, S., Gardeniers, J. G. E. & Luttge, R., 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 495-496 2 p. M045b

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Polydimethylsiloxane
Microfluidics
Pneumatics
Lithography
Rats
23 Citations (Scopus)

A new pulsed electric field microreactor : comparison between the laboratory and microtechnology scale

Fox, M. B., Esveld, D. C., Luttge, R. & Boom, R. M., 2005, In : Lab on a Chip. 5, 9, p. 943-948

Research output: Contribution to journalArticleAcademicpeer-review

Microtechnology
Membrane Potentials
Pasteurization
Electroporation
Electric fields
28 Citations (Scopus)

An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug delivery

Indermun, S., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G., Luttge, R. & Pillay, V., 2014, In : International Journal of Pharmaceutics. 462, 1-2, p. 52-65 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Hydrogels
Pharmaceutical Preparations
carbopol 940
Drug Delivery Systems
9 Citations (Scopus)

A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing"

Eslami Amirabadi, H., Sahebali, S., Frimat, J. M. S., Luttge, R. & den Toonder, J. M. J., 17 Oct 2017, In : Biomedical Microdevices. 19, 4, 11 p., 19:92

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

A novel microfluidic platform to study cancer cell invasion : self-standing matrices integrated in microfluidic chips

Eslami Amirabadi, H., 11 Jun 2018, Eindhoven: Technische Universiteit Eindhoven. 116 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
1 Citation (Scopus)

Apoptosis induced kinetic changes in autofluorescence of HL60 cells : application for single cell analysis on chip

Wolbers, F., Valero, A., Andersson, H., Luttge, R., Berg, van den, A. & Vermes, I., 2004, In : Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde. 29, 5, p. 296-297 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

89 Citations (Scopus)

Apoptotic cell death dynamics of HL60 cells studied using a microfluidic cell trap device

Valero, A., Merino, F., Wolbers, F., Luttge, R., Vermes, I., Andersson, H. & Berg, van den, A., 2005, In : Lab on a Chip. 5, 1, p. 49-55 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microfluidics
HL-60 Cells
Cell death
Cell Death
Apoptosis
24 Citations (Scopus)

Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

Verhoeven, M., Bystrova, S. N., Winnubst, L., Qureshi, H., Gruijl, de, T. D., Scheper, R. J. & Luttge, R., 2012, In : Microelectronic Engineering. 98, p. 659-662 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

eggs
delivery
Skin
Porosity
ceramics
129 Citations (Scopus)

Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin

Verbaan, F. J., Bal, S. M., Berg, van den, D. J., Groenink, W. H. H., Verpoorten, H., Luttge, R. & Bouwstra, J. A., 2007, In : Journal of Controlled Release. 117, 2, p. 238-245 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Weight
Skin
Trypan Blue
Fluorescein-5-isothiocyanate
Needles

Brain on a chip

Wolbers, F., Schurink, B., Xie, S., Toonder, den, J. M. J. & Luttge, R., 2013

Research output: Contribution to conferencePosterAcademic

CALIMA: the semi-automated open-source calcium imaging analyzer

Radstake, F. D. W., Raaijmakers, E. A. L., Luttge, R., Zinger, S. & Frimat, J-P., 1 Oct 2019, In : Computer Methods and Programs in Biomedicine. 179, 10 p., 104991

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Calcium
Imaging techniques
Neurons
Cellular radio systems
Software

Cancer intravasation-on-a-chip : a LEGO house for tumors!

Eslami Amirabadi, H., Sahebali, S., Miggiels, A. L. W., Frimat, J. P., Luttge, R. & den Toonder, J., Nov 2015

Research output: Contribution to conferencePosterAcademic

Open Access
File
Neoplasms
Microfluidics
Extracellular Matrix
Ethics
Blood Vessels

Cancer intravasation-on-a-chip (CIChip) : towards tumor tissue engineering

Eslami Amirabadi, H., Frimat, J. M. S., Luttge, R. & Toonder, den, J. M. J., 2014

Research output: Contribution to conferencePosterAcademic

Open Access
File

Cancer metastasis-on-a-chip

Eslami Amirabadi, H., Luttge, R. & Toonder, den, J. M. J., 2013

Research output: Contribution to conferencePosterAcademic

Open Access
File
33 Citations (Scopus)

Comparison of capillary zone electrophoresis performance of powder-blasted and hydrogen fluoride-etched microchannels in glass

Pu, Q-S., Luttge, R., Gardeniers, J. G. E. & Berg, van den, A., 2003, In : Electrophoresis. 24, 1-2, p. 162-171 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrofluoric Acid
Capillary Electrophoresis
Microchannels
Electrophoresis
Powders
16 Citations (Scopus)

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays

Boks, M. A., Unger, W. W. J., Engels, S., Ambrosini, M., Van Kooyk, Y. & Luttge, R., 14 Jul 2015, In : International Journal of Pharmaceutics. 491, 1-2, p. 375-383 9 p., 14977

Research output: Contribution to journalArticleAcademicpeer-review

Ceramics
Vaccines
T-Lymphocytes
Vaccination
Syringes
12 Citations (Scopus)

Cryo dualbeam focused ion beam-scanning electron microscopy to evaluate the interface between cells and nanopatterned scaffolds

Lamers, E., Walboomers, X. F., Domanski, M., McKerr, G., O'Hagan, B. M., Barnes, C. A., Peto, L., Luttge, R., Winnubst, A. J. A., Gardeniers, J. G. E. & Jansen, J. A., 2011, In : Tissue Engineering. Part C: Methods. 17, 1, p. 1-7

Research output: Contribution to journalArticleAcademicpeer-review

131 Citations (Scopus)

Current advances in the fabrication of microneedles for transdermal delivery

Indermun, S., Luttge, R., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G. & Pillay, V., 2014, In : Journal of Controlled Release. 185, p. 130-138

Research output: Contribution to journalArticleAcademicpeer-review

Needles
Needlestick Injuries
Macromolecular Substances
Phobic Disorders
Drug Delivery Systems
3 Citations (Scopus)

Direct measurement of lithium in whole blood using a capillary electrophoresis microchip

Vrouwe, E. X., Kölling, P., Luttge, R. & Berg, van den, A., 2004, In : Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde. 29, 5, p. 295-296 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)

Direct measurement of lithium in whole blood using microchip capillary electrophoresis with integrated conductivity detection

Vrouwe, E. X., Luttge, R. & Berg, van den, A., 2004, In : Electrophoresis. 25, 10-11, p. 1660-1667 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microchip Electrophoresis
Capillary electrophoresis
Capillary Electrophoresis
Lithium
Blood
4 Citations (Scopus)

Displacement Talbot lithography nanopatterned microsieve array for directional neuronal network formation in brain-on-chip

Xie, S., Schurink, B., Berenschot, E. J. W., Tiggelaar, R. M., Gardeniers, J. G. E. & Luttge, R., 1 Nov 2016, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 34, 6, p. 1-7 06KI02

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microelectrodes
Lithography
brain
Brain
lithography
1 Citation (Scopus)

Drug delivery through microneedles

Luttge, R., 1 Jan 2016, Microsystems for Pharmatechnology : Manipulation of Fluids, Particles, Droplets, and Cells. Dietzel, A. (ed.). Dordrecht: Springer, p. 275-298 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Drug delivery
Technology
Pharmaceutical Preparations
Vaccines
Drug products
38 Citations (Scopus)

Dynamic cell adhesion and migration on nanoscale grooved substrates

Lamers, E., Riet, te, J., Domanski, M., Luttge, R., Figdor, C. G., Gardeniers, J. G. E., Walboomers, X. F. & Jansen, J. A., 2012, In : European Cells and Materials. 23, p. 182-194

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cell adhesion
Cell Adhesion
Cell Movement
Adhesion
Substrates
176 Citations (Scopus)

Electroporation of cells in microfluidic devices: A review

Fox, M. B., Esveld, D. C., Valero, A., Luttge, R., Mastwijk, H. C., Bartels, P. V., Berg, van den, A. & Boom, R. M., 2006, In : Analytical and Bioanalytical Chemistry. 385, 3, p. 474-485

Research output: Contribution to journalArticleAcademicpeer-review

Lab-On-A-Chip Devices
Electroporation
Microfluidics
Electric fields
Pasteurization

Evaluation of the viability of hl60 cells in contact with commonly used microchip materials

Wolbers, F., Braak, ter, P. M., Gac, Le, S., Luttge, R., Andersson, H., Vermes, I. & Berg, van den, A., 2005, Proceedings of the 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2005), 9-13 October 2005, Boston, Massachussetts. San Diego: Transducer Research Foundation, Vol. 1, p. 1288-1290

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Cells
Borosilicate glass
Silicon oxides
Transducers
Experiments
Open Access
File
Brain models
Cell culture
brain
Anisotropy
anisotropy
1 Citation (Scopus)

Ex vivo evaluation of a microneedle array device for transdermal application

Indermun, S., Choonara, Y. E., Kumar, P., Du Toit, L. C., Modi, G., Van Vuuren, S., Luttge, R. & Pillay, V., 30 Dec 2015, In : International Journal of Pharmaceutics. 496, 2, p. 351-359 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Equipment and Supplies
Skin
Hydrogel
Swine
Pharmaceutical Preparations
2 Citations (Scopus)

Fabrication and characterization of microsieve electrode array (μSEA) enabling cell positioning on 3D electrodes

Schurink, B., Tiggelaar, R. M., Gardeniers, J. G. E. & Luttge, R., 1 Jan 2017, In : Journal of Micromechanics and Microengineering. 27, 1, p. 1-16 015017

Research output: Contribution to journalArticleAcademicpeer-review

Fabrication
Electrodes
Silicon
Boron
Microelectrodes
8 Citations (Scopus)

Field emission to control tip-sample distance in magnetic probe recording

Fèbre, Le, A. J., Luttge, R., Abelmann, L. & Lodder, J. C., 2007, In : Journal of Physics: Conference Series. 61, 1, p. 673-677

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
magnetic probes
field emission
recording
probes
chromium
1 Citation (Scopus)

Flow-through microfluidic chip for cell transfection by electropermeabilization

Valero, A., Luttge, R., Nieuwkasteele, Van, J. W., Andersson, H. & Berg, van den, A., 2005, Proceedings of the 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2005), 9-13 October 2005, Boston, Massachussetts. San Diego: Transducer Research Foundation, Vol. 1, p. 1395-1397

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Propidium
Silicon
Microfluidics
Transducers
Assays
10 Citations (Scopus)

Highly uniform sieving structure by corner lithography and silicon wet etching

Schurink, B., Berenschot, E. J. W., Tiggelaar, R. M. & Luttge, R., 16 Aug 2015, In : Microelectronic Engineering. 144, p. 12-18 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

sieves
Sieves
Wet etching
Silicon
Lithography
10 Citations (Scopus)

High precision mask fabrication for deep X-ray lithography using 40-kV shaped electron beam lithography

Schmidt, A., Himmelsbach, G., Luttge, R., Adam, D., Hoke, F., Schacke, H., Belic, N., Hartmann, H., Burkhard, F. & Wolf, H., 2001, Micro-and Nano- Engineering 2000 (MNE 2000), 18-21 September 2000, Jena, Germany. p. 761-767 (Microelectronic Engineering; vol. 57-58)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

masks
lithography
electron beams
fabrication
x rays

Hybrid business models for ‘Organ-on-a-Chip’ technology: the best of both worlds

van de Burgwal, L. H. M., van Dorst, P., Viëtor, H., Luttge, R. & Claassen, E., 1 Jun 2018, In : PharmaNutrition. 6, 2, p. 55-63 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Technology
translation (genetics)
laboratory equipment
human physiology
Equipment and Supplies
8 Citations (Scopus)

Hydrogel/poly-dimethylsiloxane hybrid bioreactor facilitating 3D cell culturing

Schurink, B. & Luttge, R., 2013, In : Journal of Vacuum Science and Technology, B. 31, 6, 5 p., 06F903

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
cell culturing
bioreactors
Polydimethylsiloxane
Bioreactors
Hydrogels
14 Citations (Scopus)

Imprint lithography provides topographical nanocues to guide cell growth in primary cortical cell culture

Xie, S. & Luttge, R., 2014, In : Microelectronic Engineering. 124, p. 30-36 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Polyethyleneimine
Cell growth
Cell culture
Lithography
Brain
130 Citations (Scopus)

Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method

Verbaan, F. J., Bal, S. M., Berg, van den, D. J., Dijksman, J. A., Hecke, van, M., Verpoorten, H., Berg, van den, A., Luttge, R. & Bouwstra, J. A., 2008, In : Journal of Controlled Release. 128, 1, p. 80-88 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Skin
Silicon
Metals
Trypan Blue
35 Citations (Scopus)

Influence of partner diversity on collaborative public R&D project outcomes : a study of application and commercialization of nanotechnologies in the Netherlands

Raesfeld, A. V., Geurts, P., Jansen, M., Boshuizen, J. & Luttge, R., 2012, In : Technovation. 32, 3-4, p. 227-233 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nanotechnology
The Netherlands
Commercialization
Value chain
Complementarity
8 Citations (Scopus)

Insertion process of ceramic nanoporous microneedles by means of a novel mechanical applicator design

Hartmann, X. H. M., van der Linde, P., Homburg, F. G. A., van Breemen, L. C. A., de Jong, A. M. & Luttge, R., 18 Nov 2015, In : Pharmaceutics. 7, 4, p. 503-522 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ceramics
Thumb
Adhesives
Skin
Artificial Skin
40 Citations (Scopus)

Integrated lithographic molding for microneedle-based devices

Luttge, R., Berenschot, J. W., Boer, de, M. J., Altpeter, D. M., Vrouwe, E. X., Berg, van den, A. & Elwenspoek, M., 2007, In : Journal of Microelectromechanical Systems. 16, 4, p. 872-884

Research output: Contribution to journalArticleAcademicpeer-review

Molding
Needles
Fabrication
Capillary electrophoresis
Silicon

Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip

Eslami Amirabadi, H., Sahebali, S., Miggiels, A. L. W., Frimat, J-P., Luttge, R. & den Toonder, J., Nov 2015

Research output: Contribution to conferencePosterAcademic

Open Access
File
Microfluidics
Scaffolds
Assays
Microfabrication
Controllability
2 Citations (Scopus)
Open Access
File
Polydimethylsiloxane
Lithography
Substrates
Cell culture
Atomic force microscopy
1 Citation (Scopus)

In Vitro and In Vivo evaluation of a hydrogel-based microneedle device for transdermal electro-modulated analgesia

Indermun, S., Choonara, Y. E., Kumar, P., du Toit, L. C., Modi, G., Luttge, R., Govender, M. & Pillay, V., 2017, In : European Journal of Pharmaceutical Sciences. 106, 4, p. 1111–1116 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Analgesia
Chronic Pain
Equipment and Supplies
Pharmacokinetics
31 Citations (Scopus)

In vitro and in vivo evaluation of the inflammatory response to nanoscale grooved substrates

Lamers, E., Walboomers, X. F., Domanski, M., Prodanov, L., Melis, J., Luttge, R., Winnubst, A. J. A., Anderson, J. M., Gardeniers, J. G. E. & Jansen, J. A., 2012, In : Nanomedicine. 8, 3, p. 308-317

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
Interleukins
Biocompatible Materials
Cytokines
Biomaterials
17 Citations (Scopus)

Laser interferometric nanolithography using a new positive chemical amplified resist

Luttge, R., Wolferen, Van, H. A. G. M. & Abelmann, L., 2007, In : Journal of Vacuum Science and Technology, B. 25, 6, p. 2476-2480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanolithography
Lasers
lasers
Fabrication
fabrication
3 Citations (Scopus)

Manufacturing pinhole arrays for X-ray source diagnostics using LIGA

Gerner, M., Holldack, K., Luttge, R. & Schmidt, M., 1998, In : Microsystem Technologies. 4, 4, p. 184-186

Research output: Contribution to journalArticleAcademicpeer-review

pinholes
Magnets
manufacturing
X rays
Storage rings
29 Citations (Scopus)

Massively parallel fabrication of repetitive nanostructures : nanolithography for nanoarrays

Luttge, R., 2009, In : Journal of Physics D: Applied Physics. 42, 12, 18 p., 123001

Research output: Contribution to journalArticleAcademicpeer-review

Nanolithography
Nanostructures
Fabrication
fabrication
interference
31 Citations (Scopus)

Microchip analysis of lithium in blood using moving boundary electrophoresis and zone electrophoresis

Vrouwe, E. X., Luttge, R., Olthuis, W. & Berg, van den, A., 2005, In : Electrophoresis. 26, 15, p. 3032-3042 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microchip Analytical Procedures
Electrophoresis
Lithium
Blood
Capillary Electrophoresis