• 2048 Citations
19982019
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Research Output 1998 2019

1998
3 Citations (Scopus)

Manufacturing pinhole arrays for X-ray source diagnostics using LIGA

Gerner, M., Holldack, K., Luttge, R. & Schmidt, M., 1998, In : Microsystem Technologies. 4, 4, p. 184-186

Research output: Contribution to journalArticleAcademicpeer-review

pinholes
Magnets
manufacturing
X rays
Storage rings
1999
7 Citations (Scopus)

40 keV Shaped electron beam lithography for LIGA intermediate mask fabrication

Luttge, R., Adam, D., Burkhardt, F., Hoke, F., Schacke, H., Schmidt, M., Wolf, H. & Schmidt, A., 1999, Proceedings of the 1998 International Conference on Micro- and Nanofabrication (MNE98), 22-24 September 1998, Leuven, Belgium. p. 247-250 (Microelectronic Engineering; vol. 46, no. 1-4)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

masks
lithography
electron beams
fabrication
photographic developers
2001
10 Citations (Scopus)

High precision mask fabrication for deep X-ray lithography using 40-kV shaped electron beam lithography

Schmidt, A., Himmelsbach, G., Luttge, R., Adam, D., Hoke, F., Schacke, H., Belic, N., Hartmann, H., Burkhard, F. & Wolf, H., 2001, Micro-and Nano- Engineering 2000 (MNE 2000), 18-21 September 2000, Jena, Germany. p. 761-767 (Microelectronic Engineering; vol. 57-58)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

masks
lithography
electron beams
fabrication
x rays
2003
33 Citations (Scopus)

Comparison of capillary zone electrophoresis performance of powder-blasted and hydrogen fluoride-etched microchannels in glass

Pu, Q-S., Luttge, R., Gardeniers, J. G. E. & Berg, van den, A., 2003, In : Electrophoresis. 24, 1-2, p. 162-171 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrofluoric Acid
Capillary Electrophoresis
Microchannels
Electrophoresis
Powders
262 Citations (Scopus)

Silicon micromachined hollow microneedles for transdermal liquid transport

Gardeniers, J. G. E., Luttge, R., Berenschot, J. W., Boer, de, M. J., Yeshurun, S. Y., Hefetz, M., Oever, van't, R. & Berg, van den, A., 2003, In : Journal of Microelectromechanical Systems. 12, 6, p. 855-862

Research output: Contribution to journalArticleAcademicpeer-review

Needles
Silicon
Liquids
Skin
Fabrication
2004
1 Citation (Scopus)

Apoptosis induced kinetic changes in autofluorescence of HL60 cells : application for single cell analysis on chip

Wolbers, F., Valero, A., Andersson, H., Luttge, R., Berg, van den, A. & Vermes, I., 2004, In : Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde. 29, 5, p. 296-297 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Direct measurement of lithium in whole blood using a capillary electrophoresis microchip

Vrouwe, E. X., Kölling, P., Luttge, R. & Berg, van den, A., 2004, In : Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde. 29, 5, p. 295-296 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)

Direct measurement of lithium in whole blood using microchip capillary electrophoresis with integrated conductivity detection

Vrouwe, E. X., Luttge, R. & Berg, van den, A., 2004, In : Electrophoresis. 25, 10-11, p. 1660-1667 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microchip Electrophoresis
Capillary electrophoresis
Capillary Electrophoresis
Lithium
Blood
2005
23 Citations (Scopus)

A new pulsed electric field microreactor : comparison between the laboratory and microtechnology scale

Fox, M. B., Esveld, D. C., Luttge, R. & Boom, R. M., 2005, In : Lab on a Chip. 5, 9, p. 943-948

Research output: Contribution to journalArticleAcademicpeer-review

Microtechnology
Membrane Potentials
Pasteurization
Electroporation
Electric fields
89 Citations (Scopus)

Apoptotic cell death dynamics of HL60 cells studied using a microfluidic cell trap device

Valero, A., Merino, F., Wolbers, F., Luttge, R., Vermes, I., Andersson, H. & Berg, van den, A., 2005, In : Lab on a Chip. 5, 1, p. 49-55 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microfluidics
HL-60 Cells
Cell death
Cell Death
Apoptosis

Evaluation of the viability of hl60 cells in contact with commonly used microchip materials

Wolbers, F., Braak, ter, P. M., Gac, Le, S., Luttge, R., Andersson, H., Vermes, I. & Berg, van den, A., 2005, Proceedings of the 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2005), 9-13 October 2005, Boston, Massachussetts. San Diego: Transducer Research Foundation, Vol. 1, p. 1288-1290

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Cells
Borosilicate glass
Silicon oxides
Transducers
Experiments
1 Citation (Scopus)

Flow-through microfluidic chip for cell transfection by electropermeabilization

Valero, A., Luttge, R., Nieuwkasteele, Van, J. W., Andersson, H. & Berg, van den, A., 2005, Proceedings of the 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2005), 9-13 October 2005, Boston, Massachussetts. San Diego: Transducer Research Foundation, Vol. 1, p. 1395-1397

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Propidium
Silicon
Microfluidics
Transducers
Assays
31 Citations (Scopus)

Microchip analysis of lithium in blood using moving boundary electrophoresis and zone electrophoresis

Vrouwe, E. X., Luttge, R., Olthuis, W. & Berg, van den, A., 2005, In : Electrophoresis. 26, 15, p. 3032-3042 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microchip Analytical Procedures
Electrophoresis
Lithium
Blood
Capillary Electrophoresis
2006
176 Citations (Scopus)

Electroporation of cells in microfluidic devices: A review

Fox, M. B., Esveld, D. C., Valero, A., Luttge, R., Mastwijk, H. C., Bartels, P. V., Berg, van den, A. & Boom, R. M., 2006, In : Analytical and Bioanalytical Chemistry. 385, 3, p. 474-485

Research output: Contribution to journalArticleAcademicpeer-review

Lab-On-A-Chip Devices
Electroporation
Microfluidics
Electric fields
Pasteurization
25 Citations (Scopus)

Rapid inorganic ion analysis using quantitative microchip capillary electrophoresis

Vrouwe, E. X., Luttge, R., Olthuis, W. & van den Berg, A., 2006, In : Journal of Chromatography, A. 1102, 1-2, p. 287-293 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microchip Electrophoresis
Electroosmosis
Capillary electrophoresis
Capillary Electrophoresis
Electrolytes
34 Citations (Scopus)

Viability study of HL60 cells in contact with commonly used microchip materials

Wolbers, F., Braak, ter, P., Gac, Le, S., Luttge, R., Andersson, H., Vermes, I. & Berg, van den, A., 2006, In : Electrophoresis. 27, 24, p. 5073-5080 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

HL-60 Cells
Apoptosis
Propidium
Silicon
Cell Cycle
2007
129 Citations (Scopus)

Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin

Verbaan, F. J., Bal, S. M., Berg, van den, D. J., Groenink, W. H. H., Verpoorten, H., Luttge, R. & Bouwstra, J. A., 2007, In : Journal of Controlled Release. 117, 2, p. 238-245 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Weight
Skin
Trypan Blue
Fluorescein-5-isothiocyanate
Needles
8 Citations (Scopus)

Field emission to control tip-sample distance in magnetic probe recording

Fèbre, Le, A. J., Luttge, R., Abelmann, L. & Lodder, J. C., 2007, In : Journal of Physics: Conference Series. 61, 1, p. 673-677

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
magnetic probes
field emission
recording
probes
chromium
40 Citations (Scopus)

Integrated lithographic molding for microneedle-based devices

Luttge, R., Berenschot, J. W., Boer, de, M. J., Altpeter, D. M., Vrouwe, E. X., Berg, van den, A. & Elwenspoek, M., 2007, In : Journal of Microelectromechanical Systems. 16, 4, p. 872-884

Research output: Contribution to journalArticleAcademicpeer-review

Molding
Needles
Fabrication
Capillary electrophoresis
Silicon
17 Citations (Scopus)

Laser interferometric nanolithography using a new positive chemical amplified resist

Luttge, R., Wolferen, Van, H. A. G. M. & Abelmann, L., 2007, In : Journal of Vacuum Science and Technology, B. 25, 6, p. 2476-2480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanolithography
Lasers
lasers
Fabrication
fabrication
46 Citations (Scopus)

Microchip capillary electrophoresis for point-of-care analysis of lithium

Vrouwe, E. X., Luttge, R., Vermes, I. & Berg, van den, A., 2007, In : Clinical Chemistry. 53, 1, p. 117-123 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microchip Electrophoresis
Point-of-Care Systems
Capillary electrophoresis
Capillary Electrophoresis
Lithium
15 Citations (Scopus)

Study of crack formation in high-aspect ratio SU-8 structures on silicon

Bystrova, S. N., Luttge, R. & Berg, van den, A., 2007, In : Microelectronic Engineering. 84, 5-8, p. 1113-1116

Research output: Contribution to journalArticleAcademicpeer-review

crack initiation
Silicon
high aspect ratio
Crack initiation
Aspect ratio
2008
130 Citations (Scopus)

Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method

Verbaan, F. J., Bal, S. M., Berg, van den, D. J., Dijksman, J. A., Hecke, van, M., Verpoorten, H., Berg, van den, A., Luttge, R. & Bouwstra, J. A., 2008, In : Journal of Controlled Release. 128, 1, p. 80-88 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Skin
Silicon
Metals
Trypan Blue
8 Citations (Scopus)

Microneedle array electrode for human EEG recording

Luttge, R., Bystrova, S. N. & Putten, Van, M. J. A. M., 2008, Proceedings of the 4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008, 23-27 November 2008, 23-27 November 2008, Antwerp, Belgium. Vander Sloten, J., Verdonck, J. P., Nyssen, M. & Haueisen, J. (eds.). Berlin: Springer, p. 1246-1249 (IFMBE Proceedings; vol. 22)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Electroencephalography
Electrodes
Skin
Gels
Mountings
2009
29 Citations (Scopus)

Massively parallel fabrication of repetitive nanostructures : nanolithography for nanoarrays

Luttge, R., 2009, In : Journal of Physics D: Applied Physics. 42, 12, 18 p., 123001

Research output: Contribution to journalArticleAcademicpeer-review

Nanolithography
Nanostructures
Fabrication
fabrication
interference
2010
1 Citation (Scopus)

Nanolithography for oxide nanoarrays and their application in medical devices

Luttge, R., 2010, Oxide-based Materials and Devices, 23 January 2010, San Francisco, California. Teherani, F. H., Look, D. C., Litton, C. W. & Rogers, D. J. (eds.). Bellingham: SPIE, p. 76031J- (Proceedings of SPIE; vol. 7603)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Nanolithography
Oxides
Metamaterials
Medical applications
Photonic crystals
1 Citation (Scopus)

Novel approach to produce nanopatterned titanium implants by combining nanoimprint lithography and reactive ion etching

Domanski, M., Luttge, R., Lamers, E., Winnubst, A. J. A., Walboomers, X. F., Jansen, J. A. & Gardeniers, J. G. E., 2010, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010), 3-7 October 2010, Groningen, The Netherlands. San Diego: Chemical and Biological Microsystems Society, Vol. 1, p. 518-520

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

grooves
lithography
titanium
etching
nanofabrication
159 Citations (Scopus)

The influence of nanoscale grooved substrates on osteoblast behavior and extracellular matrix deposition

Lamers, E., Walboomers, X. F., Domanski, M., Riet, te, J., van Delft, F. C. M. J. M., Luttge, R., Winnubst, A. J. A., Gardeniers, J. G. E. & Jansen, J. A., 2010, In : Biomaterials. 31, 12, p. 3307-3316 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Osteoblasts
Extracellular Matrix
Bone
Bone and Bones
Substrates
97 Citations (Scopus)

The influence of nanoscale topographical cues on initial osteoblast morphology and migration

Lamers, E., Horssen, van, R., Riet, te, J., van Delft, F. C. M. J. M., Luttge, R., Walboomers, X. F. & Jansen, J. A., 2010, In : European Cells and Materials. 20, p. 329-343 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Osteoblasts
Topography
Cues
Adhesion
Focal Adhesions
59 Citations (Scopus)

The interaction between nanoscale surface features and mechanical loading and its effect on osteoblast-like cells behavior

Prodanov, L., Riet, te, J., Lamers, E., Domanski, M., Luttge, R., Van Loon, J. J., Jansen, J. A. & Walboomers, X. F., 2010, In : Biomaterials. 31, 30, p. 7758-7765 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Osteoblasts
Textures
Biomimetic materials
Biocompatible Materials
Surface topography
2011
12 Citations (Scopus)

Cryo dualbeam focused ion beam-scanning electron microscopy to evaluate the interface between cells and nanopatterned scaffolds

Lamers, E., Walboomers, X. F., Domanski, M., McKerr, G., O'Hagan, B. M., Barnes, C. A., Peto, L., Luttge, R., Winnubst, A. J. A., Gardeniers, J. G. E. & Jansen, J. A., 2011, In : Tissue Engineering. Part C: Methods. 17, 1, p. 1-7

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Micromolding for ceramic microneedle arrays

Bystrova, S. N. & Luttge, R., 2011, In : Microelectronic Engineering. 88, 8, p. 1681-1684

Research output: Contribution to journalArticleAcademicpeer-review

Silicones
ceramics
Fabrication
Silicone Elastomers
microhardness

Nanotechnology

Luttge, R., 2011, Microfabrication for Industrial Applications. Luttge, R. (ed.). Boston: William Andrew Publishing, p. 91-146 312 p. (Micro and Nano Technologies)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

nanotechnology
2012
24 Citations (Scopus)

Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

Verhoeven, M., Bystrova, S. N., Winnubst, L., Qureshi, H., Gruijl, de, T. D., Scheper, R. J. & Luttge, R., 2012, In : Microelectronic Engineering. 98, p. 659-662 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

eggs
delivery
Skin
Porosity
ceramics
38 Citations (Scopus)

Dynamic cell adhesion and migration on nanoscale grooved substrates

Lamers, E., Riet, te, J., Domanski, M., Luttge, R., Figdor, C. G., Gardeniers, J. G. E., Walboomers, X. F. & Jansen, J. A., 2012, In : European Cells and Materials. 23, p. 182-194

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cell adhesion
Cell Adhesion
Cell Movement
Adhesion
Substrates
35 Citations (Scopus)

Influence of partner diversity on collaborative public R&D project outcomes : a study of application and commercialization of nanotechnologies in the Netherlands

Raesfeld, A. V., Geurts, P., Jansen, M., Boshuizen, J. & Luttge, R., 2012, In : Technovation. 32, 3-4, p. 227-233 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nanotechnology
The Netherlands
Commercialization
Value chain
Complementarity
31 Citations (Scopus)

In vitro and in vivo evaluation of the inflammatory response to nanoscale grooved substrates

Lamers, E., Walboomers, X. F., Domanski, M., Prodanov, L., Melis, J., Luttge, R., Winnubst, A. J. A., Anderson, J. M., Gardeniers, J. G. E. & Jansen, J. A., 2012, In : Nanomedicine. 8, 3, p. 308-317

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
Interleukins
Biocompatible Materials
Cytokines
Biomaterials
9 Citations (Scopus)

Production and characterization of miro- and nano-features in biomedical alumina and zirconia ceramics using a tape casting route

Domanski, M., Winnubst, A. J. A., Luttge, R., Lamers, E., Walboomers, X. F., Jansen, J. A. & Gardeniers, J. G. E., 2012, In : Journal of Materials Science: Materials in Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Aluminum Oxide
Ceramics
Silicon
Zirconia
Tapes
15 Citations (Scopus)

Submicron-patterning of bulk titanium by nanoimprint lithography and reactive ion etching

Domanski, M., Luttge, R., Lamers, E., Walboomers, X. F., Winnubst, A. J. A., Jansen, J. A. & Gardeniers, J. G. E., 2012, In : Nanotechnology. 23, 6, 065306

Research output: Contribution to journalArticleAcademicpeer-review

Nanoimprint lithography
Reactive ion etching
Titanium
Silicon
Masks
2013

Brain on a chip

Wolbers, F., Schurink, B., Xie, S., Toonder, den, J. M. J. & Luttge, R., 2013

Research output: Contribution to conferencePosterAcademic

Cancer metastasis-on-a-chip

Eslami Amirabadi, H., Luttge, R. & Toonder, den, J. M. J., 2013

Research output: Contribution to conferencePosterAcademic

Open Access
File
8 Citations (Scopus)

Hydrogel/poly-dimethylsiloxane hybrid bioreactor facilitating 3D cell culturing

Schurink, B. & Luttge, R., 2013, In : Journal of Vacuum Science and Technology, B. 31, 6, 5 p., 06F903

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
cell culturing
bioreactors
Polydimethylsiloxane
Bioreactors
Hydrogels
38 Citations (Scopus)

The effect of nanometric surface texture on bone contact to titanium implants in rabbit tibia

Prodanov, L., Lamers, E., Domanski, M., Luttge, R., Jansen, J. A. & Walboomers, X. F., 2013, In : Biomaterials. 34, 12, p. 2920-2927 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Titanium
Tibia
Bone
Textures
Rabbits
2014
28 Citations (Scopus)

An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug delivery

Indermun, S., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G., Luttge, R. & Pillay, V., 2014, In : International Journal of Pharmaceutics. 462, 1-2, p. 52-65 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Hydrogels
Pharmaceutical Preparations
carbopol 940
Drug Delivery Systems

Cancer intravasation-on-a-chip (CIChip) : towards tumor tissue engineering

Eslami Amirabadi, H., Frimat, J. M. S., Luttge, R. & Toonder, den, J. M. J., 2014

Research output: Contribution to conferencePosterAcademic

Open Access
File
131 Citations (Scopus)

Current advances in the fabrication of microneedles for transdermal delivery

Indermun, S., Luttge, R., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G. & Pillay, V., 2014, In : Journal of Controlled Release. 185, p. 130-138

Research output: Contribution to journalArticleAcademicpeer-review

Needles
Needlestick Injuries
Macromolecular Substances
Phobic Disorders
Drug Delivery Systems
14 Citations (Scopus)

Imprint lithography provides topographical nanocues to guide cell growth in primary cortical cell culture

Xie, S. & Luttge, R., 2014, In : Microelectronic Engineering. 124, p. 30-36 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Polyethyleneimine
Cell growth
Cell culture
Lithography
Brain
7 Citations (Scopus)

Nanoscaffold's stiffness affects primary cortical cell network formation

Xie, S., Schurink, B., Wolbers, F., Luttge, R. & Hassink, G., 1 Nov 2014, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 32, 6, 5 p., 06FD03

Research output: Contribution to journalArticleAcademicpeer-review

stiffness
Stiffness
Silicon
Polydimethylsiloxane
brain
6 Citations (Scopus)

Patient-controlled analgesia: therapeutic interventions using transdermal electro-activated and electro-modulated drug delivery

Indermun, S., Choonara, Y. E., Kumar, P., Du Toit, L. C., Modi, G., Luttge, R. & Pillay, V., 2014, In : European Journal of Pharmaceutical Sciences. 103, 2, p. 353-366 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Patient-Controlled Analgesia
Chronic Pain
Iontophoresis
Pharmaceutical Preparations
Drug Delivery Systems