• 2020 Citations
19982019
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Research Output 1998 2019

2019

CALIMA: the semi-automated open-source calcium imaging analyzer

Radstake, F. D. W., Raaijmakers, E. A. L., Luttge, R., Zinger, S. & Frimat, J-P., 1 Oct 2019, In : Computer Methods and Programs in Biomedicine. 179, 10 p., 104991

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Calcium
Imaging techniques
Neurons
Cellular radio systems
Software

Nano- and microengineered neuronal cell networks for brain-on-chip technology

Bastiaens, A. J., 23 Jan 2019, Eindhoven: Technische Universiteit Eindhoven. 131 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
Technology
Brain

The need for physiological micro-nanofluidic systems of the brain

Frimat, J-P. & Luttge, R., 7 May 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 11 p., 100

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
2018

Advancing a MEMS-Based 3D cell culture system for in vitro neuro-electrophysiological recordings

Bastiaens, A. J., Frimat, J. M. S., van Nunen, A. G. A., Schurink, B., Homburg, F. G. A. & Luttge, R., 13 Dec 2018, In : Frontiers in Mechanical Engineering. 4, p. 1-10 10 p., 21

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Micro-Electrical-Mechanical Systems
Cell Culture Techniques
Microelectrodes
Neurons
Fungi

A novel microfluidic platform to study cancer cell invasion : self-standing matrices integrated in microfluidic chips

Eslami Amirabadi, H., 11 Jun 2018, Eindhoven: Technische Universiteit Eindhoven. 116 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File

Hybrid business models for ‘Organ-on-a-Chip’ technology: the best of both worlds

van de Burgwal, L. H. M., van Dorst, P., Viëtor, H., Luttge, R. & Claassen, E., 1 Jun 2018, In : PharmaNutrition. 6, 2, p. 55-63 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Technology
translation (genetics)
laboratory equipment
human physiology
Equipment and Supplies
1 Citation (Scopus)
Open Access
File
Polydimethylsiloxane
Lithography
Substrates
Cell culture
Atomic force microscopy
3 Citations (Scopus)

Nanoscale membrane actuator for in vitro mechano-stimuli responsive studies of neuronal cell networks on chip

Xie, S., Gardeniers, J. G. E. & Luttge, R., 9 May 2018, In : Journal of Micromechanics and Microengineering. 28, 8, 12 p., 085011

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Actuators
Membranes
Brain
Microfluidics
Brain models
2 Citations (Scopus)

Single cell trapping by capillary pumping using NOA81 replica moulded stencils

Moonen, E., Luttge, R. & Frimat, J. P., 5 Oct 2018, In : Microelectronic Engineering. 197, p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Syringes
Micromachining
replicas
Molding
Adhesives
2 Citations (Scopus)

Validation and optimization of an image-based screening method applied to the study of neuronal processes on nanogrooves

Bastiaens, A. J., Xie, S., Mustafa, D. A. M., Frimat, J-P., den Toonder, J. M. J. & Luttge, R., 6 Nov 2018, In : Frontiers in Cellular Neuroscience. 12, 14 p., 415

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Neurites
Software
Cues
Cultured Cells
Neurons
2017
9 Citations (Scopus)

A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing"

Eslami Amirabadi, H., Sahebali, S., Frimat, J. M. S., Luttge, R. & den Toonder, J. M. J., 17 Oct 2017, In : Biomedical Microdevices. 19, 4, 11 p., 19:92

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)

Fabrication and characterization of microsieve electrode array (μSEA) enabling cell positioning on 3D electrodes

Schurink, B., Tiggelaar, R. M., Gardeniers, J. G. E. & Luttge, R., 1 Jan 2017, In : Journal of Micromechanics and Microengineering. 27, 1, p. 1-16 015017

Research output: Contribution to journalArticleAcademicpeer-review

Fabrication
Electrodes
Silicon
Boron
Microelectrodes
1 Citation (Scopus)

In Vitro and In Vivo evaluation of a hydrogel-based microneedle device for transdermal electro-modulated analgesia

Indermun, S., Choonara, Y. E., Kumar, P., du Toit, L. C., Modi, G., Luttge, R., Govender, M. & Pillay, V., 2017, In : European Journal of Pharmaceutical Sciences. 106, 4, p. 1111–1116 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Analgesia
Chronic Pain
Equipment and Supplies
Pharmacokinetics

Passive pumping for the parallel trapping of single neurons onto a microsieve electrode array

Frimat, J. P., Schurink, B. & Luttge, R., 1 Nov 2017, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 35, 6, 6 p., 06GA01

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
neurons
Neurons
pumping
trapping
chips
2016
1 Citation (Scopus)

An actuator chip for in vitro mechano-stimuli responsive studies of primary cortical cell networks

Xie, S., Gardeniers, J. G. E. & Luttge, R., 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 495-496 2 p. M045b

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Polydimethylsiloxane
Microfluidics
Pneumatics
Lithography
Rats
4 Citations (Scopus)

Displacement Talbot lithography nanopatterned microsieve array for directional neuronal network formation in brain-on-chip

Xie, S., Schurink, B., Berenschot, E. J. W., Tiggelaar, R. M., Gardeniers, J. G. E. & Luttge, R., 1 Nov 2016, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 34, 6, p. 1-7 06KI02

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microelectrodes
Lithography
brain
Brain
lithography
1 Citation (Scopus)

Drug delivery through microneedles

Luttge, R., 1 Jan 2016, Microsystems for Pharmatechnology : Manipulation of Fluids, Particles, Droplets, and Cells. Dietzel, A. (ed.). Dordrecht: Springer, p. 275-298 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Drug delivery
Technology
Pharmaceutical Preparations
Vaccines
Drug products
3 Citations (Scopus)

Nano- and microfabrication for industrial and biomedical applications

Luttge, R., 15 Jun 2016, 2nd ed. Elsevier. 278 p. (Micro and nano technologies)

Research output: Book/ReportBookAcademic

Microfabrication
Nanotechnology
Microsystems
Lithography
Nanolithography
2015
10 Citations (Scopus)

Advances in 3D neuronal cell culture

Frimat, J. M. S., Xie, S., Bastiaens, A. J., Schurink, B., Wolbers, F., den Toonder, J. M. J. & Luttge, R., 2015, In : Journal of Vacuum Science and Technology, B. 33, p. 1-6 06F902

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Cancer intravasation-on-a-chip : a LEGO house for tumors!

Eslami Amirabadi, H., Sahebali, S., Miggiels, A. L. W., Frimat, J. P., Luttge, R. & den Toonder, J., Nov 2015

Research output: Contribution to conferencePosterAcademic

Open Access
File
Neoplasms
Microfluidics
Extracellular Matrix
Ethics
Blood Vessels
15 Citations (Scopus)

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays

Boks, M. A., Unger, W. W. J., Engels, S., Ambrosini, M., Van Kooyk, Y. & Luttge, R., 14 Jul 2015, In : International Journal of Pharmaceutics. 491, 1-2, p. 375-383 9 p., 14977

Research output: Contribution to journalArticleAcademicpeer-review

Ceramics
Vaccines
T-Lymphocytes
Vaccination
Syringes
1 Citation (Scopus)

Ex vivo evaluation of a microneedle array device for transdermal application

Indermun, S., Choonara, Y. E., Kumar, P., Du Toit, L. C., Modi, G., Van Vuuren, S., Luttge, R. & Pillay, V., 30 Dec 2015, In : International Journal of Pharmaceutics. 496, 2, p. 351-359 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Equipment and Supplies
Skin
Hydrogel
Swine
Pharmaceutical Preparations
10 Citations (Scopus)

Highly uniform sieving structure by corner lithography and silicon wet etching

Schurink, B., Berenschot, E. J. W., Tiggelaar, R. M. & Luttge, R., 16 Aug 2015, In : Microelectronic Engineering. 144, p. 12-18 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

sieves
Sieves
Wet etching
Silicon
Lithography
8 Citations (Scopus)

Insertion process of ceramic nanoporous microneedles by means of a novel mechanical applicator design

Hartmann, X. H. M., van der Linde, P., Homburg, F. G. A., van Breemen, L. C. A., de Jong, A. M. & Luttge, R., 18 Nov 2015, In : Pharmaceutics. 7, 4, p. 503-522 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ceramics
Thumb
Adhesives
Skin
Artificial Skin

Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip

Eslami Amirabadi, H., Sahebali, S., Miggiels, A. L. W., Frimat, J-P., Luttge, R. & den Toonder, J., Nov 2015

Research output: Contribution to conferencePosterAcademic

Open Access
File
Microfluidics
Scaffolds
Assays
Microfabrication
Controllability
31 Citations (Scopus)

Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays

van der Maaden, K., Luttge, R., Vos, P. J. W., Bouwstra, J., Kersten, G. & Ploemen, I. H. J., Aug 2015, In : Drug Delivery and Translational Research. 5, 4, p. 397-406

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2014
28 Citations (Scopus)

An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug delivery

Indermun, S., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G., Luttge, R. & Pillay, V., 2014, In : International Journal of Pharmaceutics. 462, 1-2, p. 52-65 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Hydrogels
Pharmaceutical Preparations
carbopol 940
Drug Delivery Systems

Cancer intravasation-on-a-chip (CIChip) : towards tumor tissue engineering

Eslami Amirabadi, H., Frimat, J. M. S., Luttge, R. & Toonder, den, J. M. J., 2014

Research output: Contribution to conferencePosterAcademic

Open Access
File
126 Citations (Scopus)

Current advances in the fabrication of microneedles for transdermal delivery

Indermun, S., Luttge, R., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G. & Pillay, V., 2014, In : Journal of Controlled Release. 185, p. 130-138

Research output: Contribution to journalArticleAcademicpeer-review

Needles
Needlestick Injuries
Macromolecular Substances
Phobic Disorders
Drug Delivery Systems
13 Citations (Scopus)

Imprint lithography provides topographical nanocues to guide cell growth in primary cortical cell culture

Xie, S. & Luttge, R., 2014, In : Microelectronic Engineering. 124, p. 30-36 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Polyethyleneimine
Cell growth
Cell culture
Lithography
Brain
6 Citations (Scopus)

Nanoscaffold's stiffness affects primary cortical cell network formation

Xie, S., Schurink, B., Wolbers, F., Luttge, R. & Hassink, G., 1 Nov 2014, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 32, 6, 5 p., 06FD03

Research output: Contribution to journalArticleAcademicpeer-review

stiffness
Stiffness
Silicon
Polydimethylsiloxane
brain
6 Citations (Scopus)

Patient-controlled analgesia: therapeutic interventions using transdermal electro-activated and electro-modulated drug delivery

Indermun, S., Choonara, Y. E., Kumar, P., Du Toit, L. C., Modi, G., Luttge, R. & Pillay, V., 2014, In : European Journal of Pharmaceutical Sciences. 103, 2, p. 353-366 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Patient-Controlled Analgesia
Chronic Pain
Iontophoresis
Pharmaceutical Preparations
Drug Delivery Systems
2013

Brain on a chip

Wolbers, F., Schurink, B., Xie, S., Toonder, den, J. M. J. & Luttge, R., 2013

Research output: Contribution to conferencePosterAcademic

Cancer metastasis-on-a-chip

Eslami Amirabadi, H., Luttge, R. & Toonder, den, J. M. J., 2013

Research output: Contribution to conferencePosterAcademic

Open Access
File
7 Citations (Scopus)

Hydrogel/poly-dimethylsiloxane hybrid bioreactor facilitating 3D cell culturing

Schurink, B. & Luttge, R., 2013, In : Journal of Vacuum Science and Technology, B. 31, 6, 5 p., 06F903

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
cell culturing
bioreactors
Polydimethylsiloxane
Bioreactors
Hydrogels
37 Citations (Scopus)

The effect of nanometric surface texture on bone contact to titanium implants in rabbit tibia

Prodanov, L., Lamers, E., Domanski, M., Luttge, R., Jansen, J. A. & Walboomers, X. F., 2013, In : Biomaterials. 34, 12, p. 2920-2927 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Titanium
Tibia
Bone
Textures
Rabbits
2012
24 Citations (Scopus)

Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

Verhoeven, M., Bystrova, S. N., Winnubst, L., Qureshi, H., Gruijl, de, T. D., Scheper, R. J. & Luttge, R., 2012, In : Microelectronic Engineering. 98, p. 659-662 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

eggs
delivery
Skin
Porosity
ceramics
38 Citations (Scopus)

Dynamic cell adhesion and migration on nanoscale grooved substrates

Lamers, E., Riet, te, J., Domanski, M., Luttge, R., Figdor, C. G., Gardeniers, J. G. E., Walboomers, X. F. & Jansen, J. A., 2012, In : European Cells and Materials. 23, p. 182-194

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cell adhesion
Cell Adhesion
Cell Movement
Adhesion
Substrates
35 Citations (Scopus)

Influence of partner diversity on collaborative public R&D project outcomes : a study of application and commercialization of nanotechnologies in the Netherlands

Raesfeld, A. V., Geurts, P., Jansen, M., Boshuizen, J. & Luttge, R., 2012, In : Technovation. 32, 3-4, p. 227-233 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nanotechnology
The Netherlands
Commercialization
Value chain
Complementarity
31 Citations (Scopus)

In vitro and in vivo evaluation of the inflammatory response to nanoscale grooved substrates

Lamers, E., Walboomers, X. F., Domanski, M., Prodanov, L., Melis, J., Luttge, R., Winnubst, A. J. A., Anderson, J. M., Gardeniers, J. G. E. & Jansen, J. A., 2012, In : Nanomedicine. 8, 3, p. 308-317

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
Interleukins
Biocompatible Materials
Cytokines
Biomaterials
8 Citations (Scopus)

Production and characterization of miro- and nano-features in biomedical alumina and zirconia ceramics using a tape casting route

Domanski, M., Winnubst, A. J. A., Luttge, R., Lamers, E., Walboomers, X. F., Jansen, J. A. & Gardeniers, J. G. E., 2012, In : Journal of Materials Science: Materials in Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Aluminum Oxide
Ceramics
Silicon
Zirconia
Tapes
15 Citations (Scopus)

Submicron-patterning of bulk titanium by nanoimprint lithography and reactive ion etching

Domanski, M., Luttge, R., Lamers, E., Walboomers, X. F., Winnubst, A. J. A., Jansen, J. A. & Gardeniers, J. G. E., 2012, In : Nanotechnology. 23, 6, 065306

Research output: Contribution to journalArticleAcademicpeer-review

Nanoimprint lithography
Reactive ion etching
Titanium
Silicon
Masks
2011
12 Citations (Scopus)

Cryo dualbeam focused ion beam-scanning electron microscopy to evaluate the interface between cells and nanopatterned scaffolds

Lamers, E., Walboomers, X. F., Domanski, M., McKerr, G., O'Hagan, B. M., Barnes, C. A., Peto, L., Luttge, R., Winnubst, A. J. A., Gardeniers, J. G. E. & Jansen, J. A., 2011, In : Tissue Engineering. Part C: Methods. 17, 1, p. 1-7

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Micromolding for ceramic microneedle arrays

Bystrova, S. N. & Luttge, R., 2011, In : Microelectronic Engineering. 88, 8, p. 1681-1684

Research output: Contribution to journalArticleAcademicpeer-review

Silicones
ceramics
Fabrication
Silicone Elastomers
microhardness

Nanotechnology

Luttge, R., 2011, Microfabrication for Industrial Applications. Luttge, R. (ed.). Boston: William Andrew Publishing, p. 91-146 312 p. (Micro and Nano Technologies)

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

nanotechnology
2010
1 Citation (Scopus)

Nanolithography for oxide nanoarrays and their application in medical devices

Luttge, R., 2010, Oxide-based Materials and Devices, 23 January 2010, San Francisco, California. Teherani, F. H., Look, D. C., Litton, C. W. & Rogers, D. J. (eds.). Bellingham: SPIE, p. 76031J- (Proceedings of SPIE; vol. 7603)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Nanolithography
Oxides
Metamaterials
Medical applications
Photonic crystals
1 Citation (Scopus)

Novel approach to produce nanopatterned titanium implants by combining nanoimprint lithography and reactive ion etching

Domanski, M., Luttge, R., Lamers, E., Winnubst, A. J. A., Walboomers, X. F., Jansen, J. A. & Gardeniers, J. G. E., 2010, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010), 3-7 October 2010, Groningen, The Netherlands. San Diego: Chemical and Biological Microsystems Society, Vol. 1, p. 518-520

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

grooves
lithography
titanium
etching
nanofabrication
158 Citations (Scopus)

The influence of nanoscale grooved substrates on osteoblast behavior and extracellular matrix deposition

Lamers, E., Walboomers, X. F., Domanski, M., Riet, te, J., van Delft, F. C. M. J. M., Luttge, R., Winnubst, A. J. A., Gardeniers, J. G. E. & Jansen, J. A., 2010, In : Biomaterials. 31, 12, p. 3307-3316 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Osteoblasts
Extracellular Matrix
Bone
Bone and Bones
Substrates
97 Citations (Scopus)

The influence of nanoscale topographical cues on initial osteoblast morphology and migration

Lamers, E., Horssen, van, R., Riet, te, J., van Delft, F. C. M. J. M., Luttge, R., Walboomers, X. F. & Jansen, J. A., 2010, In : European Cells and Materials. 20, p. 329-343 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Osteoblasts
Topography
Cues
Adhesion
Focal Adhesions