• 2082 Citations
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Personal profile


“Temporal and spatial control of the cellular microenvironment is key to developing physiological and clinically relevant platform technologies for the prevention, relief and cure of human diseases. Hence, the understanding of critical design rules for bio-hybrid systems is important.”

Research profile

Regina Luttge is an Associate Professor in the Microsystems section and Chair of Neuro-Nanoscale Engineering at Eindhoven University of Technology (TU/e). Her research line investigates and develops microsystems for medicine and biology with integrated bio-inspired functionality mediated by shrinking structural dimensions and controlling material properties at the nanoscale applying emerging and established micro-nanofabrication methods.

The specific goal is to combine microfluidics with tissue engineering to create a realistic in vitro model of the brain, which can provide insights into both normal and disease-state function. In her previous research (ERC-StG, 2011-2016), she mainly used a soft-lithography approach for the rational design of miniaturized 3D culture experiments and the generation of artificial micro-environments of physiological relevance working with primary neurons. With the results of her ERC-research, Luttge and her team aim to forward-engineer a living brain-on-chip from neuronal stem cells.

Academic background

Regina Luttge studied Applied Sciences in Germany and worked as an engineering researcher at Institut für Mikrotechnik in Mainz for nearly five years prior to starting her PhD studies in Microsystems Technologies at Imperial College, London, in 1999. In 2003 she received her PhD from the University of London on the development of fabrication technology for micro-optical scanners. Switching her research interest to microfluidics applications, Luttge went on to work at the University of Twente MESA+ Institute for Nanotechnology. Initially as a senior scientist and later as an Assistant Professor. She was appointed Associate Professor in the TU/e Microsystems Group in 2013.

Besides education and research, Regina is actively involved in scientific entrepreneurship. Since 2012, she has been Chief Scientific Officer at MyLife Technologies BV. She is passionate about spinning off new businesses based on her research at TU/e, particularly on topics in which unique opportunities arise for students at all levels of their educational program to take part in business development.

Affiliated with

Partners in (semi-)industry

  • MyLife Technologies B.V.

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  • 2 Similar Profiles
Lithography Engineering & Materials Science
Cell culture Engineering & Materials Science
Brain Engineering & Materials Science
Polydimethylsiloxane Engineering & Materials Science
Silicon Chemical Compounds
Osteoblasts Engineering & Materials Science
Substrates Engineering & Materials Science
Ceramics Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1998 2019

12 Citations (Scopus)
107 Downloads (Pure)

A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing"

Eslami Amirabadi, H., Sahebali, S., Frimat, J. M. S., Luttge, R. & den Toonder, J. M. J., 17 Oct 2017, In : Biomedical Microdevices. 19, 4, 11 p., 19:92.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
78 Downloads (Pure)

Passive pumping for the parallel trapping of single neurons onto a microsieve electrode array

Frimat, J. P., Schurink, B. & Luttge, R., 1 Nov 2017, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 35, 6, 6 p., 06GA01.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)
1 Downloads (Pure)

In Vitro and In Vivo evaluation of a hydrogel-based microneedle device for transdermal electro-modulated analgesia

Indermun, S., Choonara, Y. E., Kumar, P., du Toit, L. C., Modi, G., Luttge, R., Govender, M. & Pillay, V., 2017, In : European Journal of Pharmaceutical Sciences. 106, 4, p. 1111–1116 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chronic Pain
Equipment and Supplies
4 Citations (Scopus)
72 Downloads (Pure)

Displacement Talbot lithography nanopatterned microsieve array for directional neuronal network formation in brain-on-chip

Xie, S., Schurink, B., Berenschot, E. J. W., Tiggelaar, R. M., Gardeniers, J. G. E. & Luttge, R., 1 Nov 2016, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 34, 6, p. 1-7 06KI02.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
16 Citations (Scopus)

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays

Boks, M. A., Unger, W. W. J., Engels, S., Ambrosini, M., Van Kooyk, Y. & Luttge, R., 14 Jul 2015, In : International Journal of Pharmaceutics. 491, 1-2, p. 375-383 9 p., 14977.

Research output: Contribution to journalArticleAcademicpeer-review



Tissue Engineering
Coculture Techniques

Sieving neuronal network communication

R. Luttge (Recipient), 2015

Prize: ERCStartingScientific

Telecommunication networks
Functional analysis


Honors project

1/09/18 → …


Microfabrication methods

1/09/15 → …


Student theses

A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

Author: Labeur, T., 29 Aug 2019

Supervisor: Bouten, C. (Supervisor 1), Luttge, R. (Supervisor 2), Kurniawan, N. (Supervisor 2) & Bastiaens, A. (Supervisor 2)

Student thesis: Master

Mechanical characterization of freestanding buckled ultrathin membranes

Author: Shafqat, S., 31 Jan 2014

Supervisor: Geers, M. (Supervisor 1), Luttge, R. (Supervisor 2), Klootwijk, J. (External person) (External coach), Hoefnagels, J. (Supervisor 2) & van der Sluis, O. (Supervisor 2)

Student thesis: Master

Microfluidic device to characterize the effect of chemical agents on mechanical properties of cells

Author: Henderikx, R., 19 Jul 2016

Supervisor: den Toonder, J. (Supervisor 1), Dekker, R. (External person) (External coach), Luttge, R. (Supervisor 2), van Donkelaar, C. (Supervisor 2), Sahebali, S. (Supervisor 2) & Stoute, R. (External person) (External coach)

Student thesis: Master

Soft nanofibrous scaffolds for breast tumour models: fabrication and characterization

Author: Miggiels, A., 30 Nov 2015

Supervisor: Eslami Amirabadi, H. (Supervisor 1), den Toonder, J. (Supervisor 2), Luttge, R. (Supervisor 2) & van Breemen, L. (Supervisor 2)

Student thesis: Master