• 2052 Citations
19982019
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Personal profile

Quote

“Temporal and spatial control of the cellular microenvironment is key to developing physiological and clinically relevant platform technologies for the prevention, relief and cure of human diseases. Hence, the understanding of critical design rules for bio-hybrid systems is important.”

Research profile

Regina Luttge is an Associate Professor in the Microsystems section and Chair of Neuro-Nanoscale Engineering at Eindhoven University of Technology (TU/e). Her research line investigates and develops microsystems for medicine and biology with integrated bio-inspired functionality mediated by shrinking structural dimensions and controlling material properties at the nanoscale applying emerging and established micro-nanofabrication methods.

The specific goal is to combine microfluidics with tissue engineering to create a realistic in vitro model of the brain, which can provide insights into both normal and disease-state function. In her previous research (ERC-StG, 2011-2016), she mainly used a soft-lithography approach for the rational design of miniaturized 3D culture experiments and the generation of artificial micro-environments of physiological relevance working with primary neurons. With the results of her ERC-research, Luttge and her team aim to forward-engineer a living brain-on-chip from neuronal stem cells.

Academic background

Regina Luttge studied Applied Sciences in Germany and worked as an engineering researcher at Institut für Mikrotechnik in Mainz for nearly five years prior to starting her PhD studies in Microsystems Technologies at Imperial College, London, in 1999. In 2003 she received her PhD from the University of London on the development of fabrication technology for micro-optical scanners. Switching her research interest to microfluidics applications, Luttge went on to work at the University of Twente MESA+ Institute for Nanotechnology. Initially as a senior scientist and later as an Assistant Professor. She was appointed Associate Professor in the TU/e Microsystems Group in 2013.

Besides education and research, Regina is actively involved in scientific entrepreneurship. Since 2012, she has been Chief Scientific Officer at MyLife Technologies BV. She is passionate about spinning off new businesses based on her research at TU/e, particularly on topics in which unique opportunities arise for students at all levels of their educational program to take part in business development.

Affiliated with

Partners in (semi-)industry

  • MyLife Technologies B.V.

Fingerprint Dive into the research topics where Regina Luttge is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Silicon Chemical Compounds
Lithography Engineering & Materials Science
lithography Physics & Astronomy
Fabrication Engineering & Materials Science
Polydimethylsiloxane Engineering & Materials Science
Capillary electrophoresis Chemical Compounds
Brain Engineering & Materials Science
Microfluidics Engineering & Materials Science

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Research Output 1998 2019

10 Citations (Scopus)

A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing"

Eslami Amirabadi, H., Sahebali, S., Frimat, J. M. S., Luttge, R. & den Toonder, J. M. J., 17 Oct 2017, In : Biomedical Microdevices. 19, 4, 11 p., 19:92

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Passive pumping for the parallel trapping of single neurons onto a microsieve electrode array

Frimat, J. P., Schurink, B. & Luttge, R., 1 Nov 2017, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 35, 6, 6 p., 06GA01

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
neurons
Neurons
pumping
trapping
chips
1 Citation (Scopus)

In Vitro and In Vivo evaluation of a hydrogel-based microneedle device for transdermal electro-modulated analgesia

Indermun, S., Choonara, Y. E., Kumar, P., du Toit, L. C., Modi, G., Luttge, R., Govender, M. & Pillay, V., 2017, In : European Journal of Pharmaceutical Sciences. 106, 4, p. 1111–1116 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Analgesia
Chronic Pain
Equipment and Supplies
Pharmacokinetics
4 Citations (Scopus)

Displacement Talbot lithography nanopatterned microsieve array for directional neuronal network formation in brain-on-chip

Xie, S., Schurink, B., Berenschot, E. J. W., Tiggelaar, R. M., Gardeniers, J. G. E. & Luttge, R., 1 Nov 2016, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 34, 6, p. 1-7 06KI02

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microelectrodes
Lithography
brain
Brain
lithography
16 Citations (Scopus)

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays

Boks, M. A., Unger, W. W. J., Engels, S., Ambrosini, M., Van Kooyk, Y. & Luttge, R., 14 Jul 2015, In : International Journal of Pharmaceutics. 491, 1-2, p. 375-383 9 p., 14977

Research output: Contribution to journalArticleAcademicpeer-review

Ceramics
Vaccines
T-Lymphocytes
Vaccination
Syringes

Prizes

Nanotechnology
Microfluidics
Tissue Engineering
Nanostructures
Coculture Techniques

Sieving neuronal network communication

Regina Luttge (Recipient), 2015

Recognition: ERCStartingScientific

Bioreactors
Telecommunication networks
Brain
Microelectrodes
Functional analysis

Courses

Honors project

1/09/18 → …

Course

Microfabrication methods

1/09/15 → …

Course

Student theses

A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

Author: Labeur, T., 29 Aug 2019

Supervisor: Bouten, C. (Supervisor 1), Luttge, R. (Supervisor 2), Kurniawan, N. (Supervisor 2) & Bastiaens, A. (Supervisor 2)

Student thesis: Master

Mechanical characterization of freestanding buckled ultrathin membranes

Author: Shafqat, S., 31 Jan 2014

Supervisor: Geers, M. (Supervisor 1), Luttge, R. (Supervisor 2), Klootwijk, J. (External person) (External coach), Hoefnagels, J. (Supervisor 2) & van der Sluis, O. (Supervisor 2)

Student thesis: Master

Microfluidic device to characterize the effect of chemical agents on mechanical properties of cells

Author: Henderikx, R., 19 Jul 2016

Supervisor: den Toonder, J. (Supervisor 1), Dekker, R. (External person) (External coach), Luttge, R. (Supervisor 2), van Donkelaar, C. (Supervisor 2), Sahebali, S. (Supervisor 2) & Stoute, R. (External person) (External coach)

Student thesis: Master

Soft nanofibrous scaffolds for breast tumour models: fabrication and characterization

Author: Miggiels, A., 30 Nov 2015

Supervisor: Eslami Amirabadi, H. (Supervisor 1), den Toonder, J. (Supervisor 2), Luttge, R. (Supervisor 2) & van Breemen, L. (Supervisor 2)

Student thesis: Master