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Personal profile

Research profile

 

Pim de Vink received his Bachelor degree in Chemistry at the University of Amsterdam in 2014 under the supervision of Professor J.N.H Reek where he worked on supramolecular ligands for rhodium-catalyzed asymmetric hydrogenation and hydroformylation. He then continued to obtain his Master’s degree in Biomedical Engineering at the Eindhoven University of Technology in 2016. During his graduation he explored the supramolecular biology of cucurbit[8]uril and 14-3-3. He completed his degree with a 4-month internship the Max Planck Institute for Molecular Physiology on gold-catalyzed ligand directed divergent scaffold synthesis in the group of Professor H. Waldmann.  

 

Currently, he is a PhD candidate under supervision of dr. L.-G. Milroy and prof. L. Brunsveld and works on the interface between supramolecular chemistry and chemical biology. In particular his research focuses on control over multi-component proteins complexes using host/guest chemistry and there role in artificial signaling networks.

 

Fingerprint Dive into the research topics where Pim J. de Vink is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
14-3-3 Proteins Chemical Compounds
Proteins Engineering & Materials Science
Stabilization Chemical Compounds
Molecules Chemical Compounds
Biological Products Chemical Compounds
Thermodynamics Medicine & Life Sciences
Molecular dynamics Chemical Compounds
Screening Chemical Compounds

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Research Output 2013 2019

  • 47 Citations
  • 5 Article
  • 1 Chapter
  • 1 Conference contribution
1 Citation (Scopus)
40 Downloads (Pure)

Cooperativity basis for small-molecule stabilization of protein-protein interactions

de Vink, P. J., Andrei, S. A., Higuchi, Y., Ottmann, C., Milroy, L-G. & Brunsveld, L., 14 Mar 2019, In : Chemical Science. 10, 10, p. 2869-2874 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Stabilization
Molecules
Proteins
14-3-3 Proteins
Fluorescence
1 Downloads (Pure)

Molecular recognition of proteins by cucurbiturils

de Vink, P. J. & Brunsveld, L., 5 Nov 2019, Cucurbiturils and Related Macrocycles. Kim, K. (ed.). London: Royal Society of Chemistry, Vol. 28. p. 464-482 (Monographs in Supramolecular Chemistry; vol. 28).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

5 Citations (Scopus)
8 Downloads (Pure)

Site-directed fragment-based screening for the discovery of protein-protein interaction stabilizers

Sijbesma, E., Hallenbeck, K. K., Leysen, S., de Vink, P. J., Skóra, L., Jahnke, W., Brunsveld, L., Arkin, M. R. & Ottmann, C., 27 Feb 2019, In : Journal of the American Chemical Society. 141, 8, p. 3524–3531 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Screening
Proteins
Estrogen Receptors
Stabilization
14-3-3 Proteins
6 Citations (Scopus)
37 Downloads (Pure)

A thermodynamic model for multivalency in 14-3-3 protein-protein interactions

Stevers, L. M., de Vink, P. J., Ottmann, C., Huskens, J. & Brunsveld, L., Oct 2018, In : Journal of the American Chemical Society. 140, 43, p. 14498–14510 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
14-3-3 Proteins
Thermodynamics
Proteins
Binding sites
Binding Sites
7 Citations (Scopus)
1 Downloads (Pure)

Rationally designed semisynthetic natural product analogues for stabilization of 14-3-3 protein–protein interactions

Andrei, S. A., de Vink, P., Sijbesma, E., Han, L., Brunsveld, L., Kato, N., Ottmann, C. & Higuchi, Y., 8 Oct 2018, In : Angewandte Chemie - International Edition. 57, 41, p. 13470-13474

Research output: Contribution to journalArticleAcademicpeer-review

Biological Products
Molecular dynamics
Stabilization
14-3-3 Proteins
X ray crystallography

Student theses

Supramolecular biology of 14-3-3 and Cucurbit[8]uril

Author: de Vink, P., 25 Aug 2016

Supervisor: Brunsveld, L. (Supervisor 1)

Student thesis: Master