• 9 Citations
20182019
If you made any changes in Pure these will be visible here soon.

Personal profile

Quote

"Creating an enhanced vaccine formulation designed to eliminate bacterial infections"

Academic background

Pascal Welzen (Stein, 1990) received his MSc in Molecular Chemistry from Radboud University in 2016. During his Master traineeship he worked on the chemical synthesis of the MS2 viral capsid protein by solid phase peptide synthesis and native chemical ligation at the group of Jan van Hest (Radboud University). Before starting his Master education Pascal did his Bachelor internship at the TNO Eindhoven conducting research on self-healing thermos reversible bio based coatings. At the moment he is working as a PhD student on polymer assemblies for antigen display at the Bio-organic Chemistry department (Jan van Hest) based at the Eindhoven University of Technology (TU/e).

Research profile

Polymer assemblies for antigen display

Polymersomes are an interesting group of polymeric vesicles. Due to their ability to encapsulate cargo, e.g. antigen/peptides, it is possible to use polymersomes for drug delivery systems. By altering the composition of the block copolymer it is possible to control the polymersome size and membrane thickness and, consequently, the drug release profile. A cocktail of different sized polymersomes with various membrane thicknesses creates a multi stage drug release profile enhancing immune response. Furthermore, by functionalizing the outer membrane with bioactive compounds targeted delivery of these vesicles is enhanced. 

The main focus of this project is to create a system able to encapsulate, carry, target and release streptococcal antigens and peptides, focused on creating an enhanced vaccine formulation designed to eliminate bacterial infections.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2018 2019

  • 9 Citations
  • 2 Article
Open Access
File
Terpolymers
Cell membranes
Encapsulation
Cell culture
Self assembly
9 Citations (Scopus)

Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts

van Oppen, L. M. P. E., Abdelmohsen, L. K. E. A., van Emst-de Vries, S. E., Welzen, P. L. W., Wilson, D. A., Smeitink, J. A. M., Koopman, W. J. H., Brock, R., Willems, P. H. G. M., Williams, D. S. & van Hest, J. C. M., 25 Jul 2018, In : ACS Central Science. 4, 7, p. 917-928 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Fibroblasts
Shielding
Polyethylene glycols
Carbonates

Activities 2015 2015

Dutch Peptide Symposium - 2015

Pascal Welzen (Organiser)
27 May 2015

Activity: Participating in or organising an event typesConferenceScientific