• 14 Citations
20182019
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Personal profile

Quote

"A person who never made a mistake never tried anything new" - Albert Einstein

Research profile

Nikita Subedi is Doctoral Candidate in the group of immunoengineering under the supervision of Dr. Jurjen Tel. Her research focuses on understanding cellular interaction in immune cells.  She works on developing a Microfluidic droplet based single cell analysis platform to study different effector functions that are generated as a result of interaction of immune cells with their partner cells or molecules. 

Academic background

Nikita Subedi (1990) is from Kathmandu, Nepal. She did her bachelors in Biotechnology, from Kathmandu University, Nepal in 2012. She completed her masters as MSc in Molecular Mechanisms of Diseases from Radboud UMC in 2016. As a part of her master’s training, she worked in two different laboratories, one in RIMLS, Radboud UMC, Nijmegen and the other in DFCI, Harvard Medical School, Boston both of them working in immunology. In Nijmegen she studied plasmacytoid dendritic cells with the group of Dr. Jurjen Tel in understanding the functional heterogeinity within these immune subsets. Her project in DFCI was about developing nanoparticle targeting check point inhibitors like PD1 molecules in T cells thus boosting the T cell mediated cytotoxicity. She joined the group of immunoengineering in 2017 to continue as as PhD candidate in the feild.

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Research Output 2018 2019

  • 14 Citations
  • 2 Article
  • 1 Review article

A pipette-tip based method for seeding cells to droplet microfluidic platforms

Sinha, N., Subedi, N., Wimmers, F., Soennichsen, M. & Tel, J., 11 Feb 2019, In : Journal of Visualized Experiments (JoVE). 144, 10 p., e57848

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cloud seeding
Microfluidics
Encapsulation
Poisson distribution
Poisson Distribution
1 Citation (Scopus)

Integrating immunology and microfluidics for single immune cell analysis

Sinha, N., Subedi, N. & Tel, J., 16 Oct 2018, In : Frontiers in Immunology. 9, 16 p., 2373

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Single-Cell Analysis
Microfluidics
Allergy and Immunology
Immune System
Point-of-Care Systems
13 Citations (Scopus)

Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

Wimmers, F., Subedi, N., van Buuringen, N., Heister, D., Vivié, J., Beeren-Reinieren, I., Woestenenk, R., Dolstra, H., Piruska, A., Jacobs, J. F. M., van Oudenaarden, A., Figdor, C. G., Huck, W. T. S., de Vries, I. J. M. & Tel, J., 1 Dec 2018, In : Nature Communications. 9, 1, 12 p., 3317

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Paracrine Communication
interferon
Single-Cell Analysis
Interferon Type I
Interferon-alpha

Student theses