Nico H.J. Pijls


  • 19483 Citations
1992 …2019
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Personal profile


The most important prognostic parameter in coronary artery diseaseis the presence and extent of inducible ischemia, which can be best assessed by Fractional Flow Reserve.

Research profile

Nico Pijls is part-time professor of Pathophysiology of the Circulation at the TU/e department of Biomedical Engineering, research group Cardiovascular Biomechanics. His main affiliation is with Catharina Hospital Eindhoven, where he is a cardiologist specialized in diseases of the coronary arteries.Pijls and co-workers developed a new and innovative method to improve coronary intervention techniques by means of Fractional Flow Reserve (FFR) measurement.

Academic background

Nico Pijls studied at Radboud University Nijmegen (The Netherlands) where he obtained both a MSc degree in Mathematics and Physics and his medical degree. In 1991, he obtained his PhD at the same university with a thesis on maximal myocardial perfusion as a measure of the functional significance of coronary artery disease. Since 1992, Nico Pijls is a cardiologist at Catharina Hospital Eindhoven (The Netherlands).In 1999, he was appointed part-time professor of Pathophysiology of Circulation at Eindhoven University of Technology, department of Biomedical Engineering.

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Research Output 1992 2019

Myocardial Infarction
Myocardial Reperfusion

A protocol update of the fractional flow reserve versus angiography for multivessel evaluation (FAME) 3 trial: a comparison of fractional flow reserve–guided percutaneous coronary intervention and coronary artery bypass graft surgery in patients with multivessel coronary artery disease

Zimmermann, F. M., de Bruyne, B., Pijls, N. H. J., Desai, M., Oldroyd, K. G., Reardon, M. J., Wendler, O., Woo, J., Yeung, A. C. & Fearon, W. F., 1 Aug 2019, In : American Heart Journal. 214, p. 156-157 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Association of improvement in fractional flow reserve with outcomes, including symptomatic relief, after percutaneous coronary intervention

Fournier, S., Ciccarelli, G., Toth, G. G., Milkas, A., Xaplanteris, P., Tonino, P. A. L., Fearon, W. F., Pijls, N. H. J., Barbato, E. & de Bruyne, B., 1 Apr 2019, In : JAMA Cardiology. 4, 4, p. 370-374 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Percutaneous Coronary Intervention
Coronary Artery Disease
Randomized Controlled Trials
North America
2 Citations (Scopus)

Continuous thermodilution to assess absolute flow and microvascular resistance: validation in humans using [15O]H2O positron emission tomography

Everaars, H., de Waard, G. A., Schumacher, S. P., Zimmermann, F. M., Bom, M. J., van de Ven, P. M., Raijmakers, P. G., Lammertsma, A. A., Götte, M. J., van Rossum, A. C., Kurata, A., Marques, K. M. J., Pijls, N. H. J., van Royen, N. & Knaapen, P., 1 Jan 2019, In : European Heart Journal. 40, 28, p. 2350-2359 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Positron-Emission Tomography

Feasibility and safety of jailed-pressure wire technique using durable optical fiber pressure wire for intervention of coronary bifurcation lesions

Omori, H., Kawase, Y., Hara, M., Tanigaki, T., Okamoto, S., Hirata, T., Kikuchi, J., Ota, H., Sobue, Y., Miyake, T., Kawamura, I., Okubo, M., Kamiya, H., Tsuchiya, K., Suzuki, T., Pijls, N. H. J. & Matsuo, H., 4 Aug 2019, In : Catheterization and Cardiovascular Interventions. 94, 2, p. E61-E66

Research output: Contribution to journalArticleAcademicpeer-review

Optical Fibers
Stable Angina


Student theses

A physiologically representative in vitro model of the coronary circulation

Author: Bohté, V., 31 Aug 2002

Supervisor: Baaijens, F. (Supervisor 1), Pijls, N. (Supervisor 2), Rutten, M. (Supervisor 2), van de Vosse, F. (Supervisor 2) & de Bruyne, B. (External person) (External coach)

Student thesis: Master

Computational modeling of hemodynamics in coronary artery bypass surgery

Author: Keijsers, J., 31 Aug 2012

Supervisor: Huberts, W. (Supervisor 1), Pijls, N. (Supervisor 2), de Mol, B. (Supervisor 2), Hose, R. (External person) (External coach) & van de Vosse, F. (Supervisor 2)

Student thesis: Master

Effect of percutaneous transluminal balloon angioplasty on cell proliferation in in vitro cultured porcine coronary arteries

Author: van Leeuwen, M., 2004

Supervisor: Pijls, N. (Supervisor 1), van de Vosse, F. (Supervisor 2), Post, M. (Supervisor 2), Buth, J. (External person) (External coach), Rutten, M. (Supervisor 2) & van den Heuvel, L. (Supervisor 2)

Student thesis: Master

Intracoronary cooling in acute myocardial infarction

Author: Rosalina, T., 31 Aug 2015

Supervisor: Rutten, M. (Supervisor 1), van de Vosse, F. (Supervisor 2), Otterspoor, L. C. (External person) (External coach), Pijls, N. (Supervisor 2) & van Rietbergen, B. (Supervisor 2)

Student thesis: Master

Intramyocardial pressure and its influence on the coronary circulation

Author: van den Berg, P., 31 Oct 2003

Supervisor: Bovendeerd, P. (Supervisor 1), van de Vosse, F. (Supervisor 2), Rutten, M. (Supervisor 2), Pijls, N. (Supervisor 2), Arts, M. (Supervisor 2) & Westerhof, N. (External person) (Supervisor 2)

Student thesis: Master