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Research profile

Nicholas Kurniawan is an Assistant Professor in the Soft Tissue Engineering and Mechanobiology group. His research focuses on understanding why and how cells behave the way they do in different physical environments. To answer this question, he creates biomimetic cellular environments at multiple scales—from 2D micropatterns to 3D extracellular matrices and bioreactors—where every physical and mechanical cues to the cells can be precisely controlled. These in vitro platforms enable him to systematically break down the origins of basic cellular behavior, such as orientation, migration, and differentiation. The overarching goal is to use the obtained insights to direct cell response in vivo, for example to promote tissue regeneration or to slow down disease progression. Nicholas’s research is highly interdisciplinary, encompassing biophysics, cell biology, protein polymers, biomechanics, and soft matter.

Academic background

Nicholas Kurniawan received his PhD in 2012 from the National University of Singapore (Singapore), studying the role of matrix viscoelasticity in cancer metastasis. He then carried out postdoctoral research as a Marie Curie Fellow at AMOLF (Amsterdam, the Netherlands), investigating the hierarchical structure-property relation in the cytoskeleton and extracellular matrices. In 2015, he joined Eindhoven University of Technology (TU/e) in Eindhoven, the Netherlands, as an Assistant Professor in the research group Soft Tissue Engineering and Mechanobiology (department of Biomedical Engineering). He is also a member of the Institute for Complex Molecular Systems (ICMS).

Quote

The cell is a physical entity that interacts with its surrounding objects. By smartly designing the cellular environment, we essentially can have a remote control for steering cell behavior.

Fingerprint Dive into the research topics where Nicholas A. Kurniawan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Tissue Chemical Compounds
fibrin Physics & Astronomy
Fibrin Chemical Compounds
Mechanics Chemical Compounds
Fibers Chemical Compounds
fibers Physics & Astronomy
stiffening Physics & Astronomy
Collagen Engineering & Materials Science

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2010 2019

A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 1 Jan 2019, In : Soft Matter. 15, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

stirring
Magnetic scales
Colloids
Research laboratories
cells

Entropic forces drive cellular contact guidance

Buskermolen, A. B. C., Suresh, H., Shishvan, S. S., Vigliotti, A., DeSimone, A., Kurniawan, N. A., Bouten, C. V. C. & Deshpande, V. S., 21 May 2019, In : Biophysical Journal. 116, 10, p. 1994-2008 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Stress Fibers
Entropy
Cell Size
Cell Nucleus Shape
Cell Nucleus Size

Image-based analysis of uniaxial ring test for mechanical characterization of soft materials and biological tissues

van Haaften, E. E., van Turnhout, M. C. & Kurniawan, N. A., 25 Mar 2019, In : Soft Matter. 15, 16, p. 3353-3361 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Systematic errors
Biological materials
Stretching
Tissue
Elastomers

Substrate curvature as aregulator of cellular orientation and migration

Werner, M., 19 Sep 2019, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Courses

Heart and blood

1/09/15 → …

Course

Thermodynamics

1/09/15 → …

Course

Student theses

Cell directed nanoparticle drug delivery for tissue engineering

Author: Vogel, M., 30 Sep 2015

Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Ottmann, C. (Supervisor 2) & Kurniawan, N. (External coach)

Student thesis: Master

Design of a DNA-based tension probe for the quantification of cellular traction forces at a molecular level

Author: van der Putten, C., 25 Jan 2018

Supervisor: Kurniawan, N. (Supervisor 1), de Greef, T. (Supervisor 2) & Bouten, C. (Supervisor 2)

Student thesis: Master

Endothelium outgrowth under flow: a study of the outgrowth of endothelial monolayers under high shear rates

Author: Vlemmings, D., 28 Feb 2019

Supervisor: Kurniawan, N. (Supervisor 1) & van Haaften, E. (Supervisor 2)

Student thesis: Master

Evaluation of the potential of cell-laden chondroitin sulfate methacrylate hydrogels for cartilage regeneration

Author: Nijhuis, M., 25 Oct 2018

Supervisor: Ito, K. (Supervisor 1), van Donkelaar, C. (Supervisor 2), van Hooijdonk - Mouser, V. (Supervisor 2), Vermonden, T. (External person) (External coach) & Kurniawan, N. (Supervisor 2)

Student thesis: Master

The effect of testosterone and alendronate on bone formation in a 3D in vitro system

Author: van den Broek, E., 30 Aug 2018

Supervisor: Ito, K. (Supervisor 1), Hofmann, S. (Supervisor 2), Melke, J. (Supervisor 2) & Kurniawan, N. (Supervisor 2)

Student thesis: Master