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Research Output 2000 2019

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Conference contribution
2009

A multi scale computational model of human skeletal muscle to quantify metabolite dynamics in individual fiber types from 31P MRS measurements

Schmitz, J. P. J., Riel, van, N. A. W., Jeneson, J. A. L., Nicolay, K. & Hilbers, P. A. J., 2009, Proceedings of the 3rd FEBS Advanced Lecture Course on Systems Biology: From Molecular Biology to Biological Function (FEBS-SysBio2009), 7-13 March 2009, Alpbach, Austria.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Dynamic modeling of the hypoxia induced HIF-1 response: a quantitative data-driven approach

Tiemann, C. A., Riel, van, N. A. W., Rouschop, K. M., Starmans, M. H. W., Lambin, P. & Hilbers, P. A. J., 2009, Proceedings of the 2nd Dutch BME Conference 2009 (BME 2009), 22-23 January 2009, Egmond aan Zee, The Netherlands. p. pp.-72

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Oxygen
Tumors
Sensitivity analysis
Fisher information matrix
Network components

Hypoxia Induced HIF-1 Response: identifying a mechanism for its exponential behavior

Tiemann, C. A., Hilbers, P. A. J. & Riel, van, N. A. W., 2009, 10th International Conference on Systems Biology (ICSB 2009), august 30 - september 4, 2009, Stanford, CA, USA.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Measurement of calcium and force dynamics in mouse EDL fibers at 15-35C

Groenendaal, W., Riel, van, N. A. W., Jeneson, J. A. L., Nicolay, K., Hilbers, P. A. J. & Wiseman, R. W., 2009, Proceedings of the 2nd Dutch BME Conference 2009 (BME 2009), 22-23 January 2009, Egmond aan Zee, The Netherlands. p. 130-

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

calcium
mice
skeletal muscle
temperature
fluorescent dyes

Multi scale computational modeling of skeletal muscle metabolism

Schmitz, J. P. J., Riel, van, N. A. W., Nicolay, K., Hilbers, P. A. J. & Jeneson, J. A. L., 2009, Proceedings of the The Cardiac Physiome : Multi-scale and Multi-physics Mathematical Modelling Applied to the Heart, 20-24 July, 2009, Cambridge, United Kingdom.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Prediction of Twitch and High Frequency Local Calcium Dynamics in Mouse EDL Fibers at 15-35C

Groenendaal, W., Riel, van, N. A. W., Jeneson, J. A. L., Eikelder, ten, H. M. M., Nicolaij, K., Hilbers, P. A. J. & Wiseman, R. W., 2009, Biophysical Society Meeting Abstracts, Boston. p. 233a- (Biophysical journal; vol. 96, no. 3, supplement 1)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
mice
calcium
fibers
predictions

Regulation of excitation-contraction coupling in fast twitch muscles

Groenendaal, W., Riel, van, N. A. W., Jeneson, J. A. L., Nicolay, K. & Hilbers, P. A. J., 2009, Proceedings of the 14th International Conference Biochemistry of Exercise: Muscles as Molecular and Metabolic Machines, 2-4 June 2009, Guelph, Ontario, Canada. Canada, Guelph

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2008

A multi-scale model of human skeletal muscle

Schmitz, J. P. J., Jeneson, J. A. L., Nicolay, K., Hilbers, P. A. J. & Riel, van, N. A. W., 2008, Proceedings of the BMES 2008 Annual Fall Meeting, Oct 2-4, 2008, St. Louis, Missouri. United States, St. Louis

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

A multi-scale model of human skeletal muscle: extracting metabolite dynamics at cellular scale from measurements at whole organ

Schmitz, J. P. J., Jeneson, J. A. L., Nicolay, K., Hilbers, P. A. J. & Riel, van, N. A. W., 2008, Ninth International Conference on Systems Biology (ICSB 2008), 22-28 August 2008, Sweden, Gothenburg. Sweden, Gothenburg, p. DS-1-1-48-

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Skeletal Muscle
Muscles
Adenosine Triphosphate
Magnetic Resonance Spectroscopy
Neurophysiological Recruitment
9 Citations (Scopus)

Computational modeling indicates anaerobic glycogenolytic ATP synthesis contributes little to quadriceps energy balance during exhaustive bicycling exercise

Jeneson, J. A. L., Schmitz, J. P. J., Riel, van, N. A. W., Groenendaal, W., Nicolaij, K. & Hilbers, P. A. J., 2008, Experimental biology 2008, San Diego California. San Diego: FASEB, p. 756.1- (FASEB Journal : The Journal of the Federation of American Societies for Experimental Biology; vol. 22)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
Bicycling
Adenosine Triphosphate
Glycogenolysis
Hexoses
Phosphocreatine

Computational modelling identifies impact of subtle anatomical variation on skeletal muscle local calcium dynamics

Groenendaal, W., Riel, van, N. A. W., Jeneson, J. A. L., Eikelder, ten, H. M. M., Nicolay, K. & Hilbers, P. A. J., 2008, Experimental biology 2008, San Diego California. San Diego: FASEB, p. 756.11- (FASEB Journal : The Journal of the Federation of American Societies for Experimental Biology; vol. 22)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
Skeletal Muscle
Calcium
Troponin C
Sarcomeres
Mitochondria

Dynamic modeling of time-course microarray data by estimating hidden transcriptional activity profiles

Tiemann, C. A., Moon, S., Stark, J., Starmans, M. H. W., Lambin, P., Hilbers, P. A. J. & Riel, van, N. A. W., 2008, International Conference on Systems Biology, Sweden, Goteborg. p. pp.-102

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

gene
modeling
hypoxia
cancer
method
1 Citation (Scopus)

In vitro and in silico experiments to identify the influence of temperature on skeletal muscle calcium and force dynamics

Groenendaal, W., Jeneson, J. A. L., Riel, van, N. A. W., Eikelder, ten, H. M. M., Nicolay, K. & Hilbers, P. A. J., 2008, Experimental biology San Diego, United States, April 5-9 2008. FASEB, p. 756.5- (FASEB Journal : The Journal of the Federation of American Societies for Experimental Biology; vol. 22)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

skeletal muscle
calcium
stimulation
muscles
temperature

Kinetic modeling and analysis of nonlinear biochemical networks with no quantitative information

Musters, M. W. J. M., Jong, de, H., Bosch, van den, P. P. J. & Riel, van, N. A. W., 2008, Ninth International Conference on Systems Biology (ICSB 2008), 22-28 August 2008, Sweden, Gothenburg. Sweden Gothenborg, p. 28-28

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Kinetics
Metabolic engineering
Design of experiments
Parameter estimation
Numerical analysis

Modeling the glycolytic pathway in human skeletal muscle tissue; understanding the regulation of its hundredfold dynamic range

Schmitz, J. P. J., Jeneson, J. A. L., Nicolay, K., Hilbers, P. A. J. & Riel, van, N. A. W., 2008, Ninth International Conference on Systems Biology (ICSB 2008), 22-28 August 2008, Sweden, Gothenburg. p. DS-1-1-06-

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Skeletal Muscle
Muscles
Glycolysis
Glucose
Magnets

Systems biology of the mammalian Unfolded Protein Response

Riel, van, N. A. W., Tiemann, C. A., Jeneson, J. A. L. & Hilbers, P. A. J., 2008, Experimental biology 2008, San Diego California. FASEB, p. 1021.1- (FASEB Journal : The Journal of the Federation of American Societies for Experimental Biology; vol. 22)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Unfolded Protein Response
Systems Biology
Endoplasmic Reticulum Stress
Dithiothreitol
Protein Folding

The role of temporal resolution in determining pharmacokinetic parameters from DCE-MR data

Heisen, M., Fan, X., Twellmann, T., Buurman, J., Riel, van, N. A. W., Karczmar, G. S. & Haar Romenij, ter, B. M., 2008, Proceedings of the 16th Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), 3-9 May 2008, Toronto, Canada. p. 3836-

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

image resolution
tumor
parameter
pharmacokinetics
modeling
2007

Analysis of nonlinear biochemical networks: the hybrid approach

Musters, M. W. J. M. & Riel, van, N. A. W., 2007, Proceedings of the 26th Benelux meeting on Systems and Control, 13-15 March 2007, Lommel, Belgium. Lommel, Belgium, p. 73-73

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Calcium dynamics in time and space

Groenendaal, W., Riel, van, N. A. W., Jeneson, J. A. L., Eikelder, ten, H. M. M., Nicolaij, K. & Hilbers, P. A. J., 2007, Proceedings IEEE Benulux EMBS Symposium. Netherlands, Heeze

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Mitochondrial dysfunction in type 2 diabetes

Groenendaal, W., Stiphout, van, R. G. P. M., Verhoog, P. J., Jeneson, J. A. L., Riel, van, N. A. W. & Hilbers, P. A. J., 2007, Proceedings of the 2nd FEBS Advanced Lecture Course on Systems Biology - from Molecules to Life (FEBS-SysBio2007), 10-16 March 2007, Gosau, Austria. Austria, Gosau

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Type 2 Diabetes Mellitus
Mitochondria
Reticulum
Systems Biology
Skeletal Muscle

Modeling skeletal muscle energetics in time and space

Groenendaal, W., Verhoog, P. J., Riel, van, N. A. W., Jeneson, J. A. L. & Hilbers, P. A. J., 2007, Omics : assembling systems biology. Switzerland, Centro Stefano Franscini

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Multistep Feed-Forward Activation by Calcium in the Energy Buffered Skeletal Muscle Cell

Stiphout, van, R. G. P. M., Verhoog, P. J., Riel, van, N. A. W., Eikelder, ten, H. M. M., Nicolay, K., Hilbers, P. A. J. & Jeneson, J. A. L., 2007, Proceedings of the First Dutch Conference on Bio-Medical Engineering (BME 2007) 18-19 January 2007, Egmond aan zee, The Netherlands.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Adenosinetriphosphate
Muscle
Calcium
Chemical activation
Cells
2 Citations (Scopus)

Qualitative analysis of nonlinear biochemical networks

Musters, M. W. J. M., Jong, de, H., Bosch, van den, P. P. J. & Riel, van, N. A. W., 2007, ICSB 2007. United States, Long Beach

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)

Qualitative analysis of nonlinear biochemical networks with piecewise-affine functions

Musters, M. W. J. M., Jong, de, H., Bosch, van den, P. P. J. & Riel, van, N. A. W., 2007, Proceedings of the 10th International Conference on Hybrid Systems: Computation and Control (HSCC 2007) 3-5 April 2007, Pisa, Italy. Bemporad, A., Bicchi, A. & Buttazzo, G. (eds.). Berlin, Germany: Sringer, p. 727-730 (Lecture Notes in Computer Science; vol. 4416)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
Systems analysis

Realistic Cellular Oxygen Model Reveals High Potential Gains with Dose Painting and Offers a General Solution for Incorporating Cellular Distributions that Underlie Imaging Data

Petit, S. F., Lambin, P., Seigneuric, R., Murrer, L. H. P., Riel, van, N. A. W., Dekker, A. L. A. J. & Wouters, B. G., 2007, 49th ASTRO Annual Meeting. United States, Los Angeles

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Real-time multi object tracking from different datastreams at different frequencies

Caby, B., Riel, van, N. A. W., Hilbers, P. A. J. & Macq, B., 2007, Dutch Conference on BioMedical Engineering. Netherlands, Egmond aan Zee

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Patient rehabilitation
Probability density function

The influence of the muscle architecture on the energy balance of skeletal muscle cells

Verhoog, P. J., Jeneson, J. A. L., Riel, van, N. A. W., Stiphout, van, R. G. P. M., Eikelder, ten, H. M. M., Bosnacki, D. & Hilbers, P. A. J., 2007, Proceedings of the First Dutch Conference on Bio-Medical Engineering (BME 2007) 18-19 January 2007, Egmond aan zee, The Netherlands. Netherlands, Egmond aan Zee

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Muscle Cells
Skeletal Muscle
Calcium
Muscles
Anura
2006

Calcium handling in the diabetic heart

Ligeti, L., Miklós, Z., Riel, van, N. A. W., Vusse, van der, G. J. & Ivanics, T., 2006, Acta Physiologica Congress : Joint Meeting of The German Society of Physiology and The Federation of European Physiological Societies 2006. p. 1312 (Acta Physiologica; vol. 186, no. S1)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Diabetes Mellitus
Calcium
Ryanodine Receptor Calcium Release Channel
Adrenergic Agents
Cardiomyopathies

Computational analysis of disturbed calcium handling in the diabetic heart

Riel, van, N. A. W., Stiphout, van, R. G. P. M., Jeneson, J. A. L., Hilbers, P. A. J., Ligeti, L., Ivanics, T. & Vusse, van der, G., 2006, Acta Physiologica Congress : Joint Meeting of The German Society of Physiology and The Federation of European Physiological Societies 2006. p. S651:13011- (Acta Physiologica; vol. 188)

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Calcium
Adenosine Triphosphate
Sarcoplasmic Reticulum
Homeostasis
Diabetic Cardiomyopathies

Effect of parenteral alanyl-glutamine on glutamine production rates

Rooyackers, O., Prohn, M., Riel, van, N. A. W. & Wernerman, J., 2006, 18th European Society of Intensive Care Medicine (ESICM) Annual Congress, Amsterdam.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Experiment design for estimation in models combining signal transduction and metabolic pathways: control of nitrogen uptake in yeast

Riel, van, N. A. W., 2006, Seventh International Conference on Systems Biology (ICSB 2006), Yokohama, Japan, 9-13 october 2006. Kitano, X. (ed.). ICSB

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Experiment design for parameter estimation in models combining signal transduction and metabolic pathways: control of nitrogen uptake in yeast

Riel, van, N. A. W., 2006, Seventh International Conference on Systems Biology. Japan, Yokohama, p. CD-rom

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Signal transduction
Yeast
Parameter estimation
Nitrogen
Experiments

Hybrid identification of nonlinear biochemical processes

Musters, M. W. J. M., Lindenaar, D. J. W., Juloski, A. L. & Riel, van, N. A. W., 2006, 14th IFAC Symposium on System Identification SYSID 2006. Newcastle, Australia: IFAC

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Mathematical modeling of transcapillary insulin transport

Zijlstra, E. D., Sjöstrand, M., Groenendaal, W., Riel, van, N. A. W., Lönroth, P. & Wagenmakers, A. J. M., 2006, 11th annual Congress of the European College of Sport Science (ECSS). Switzerland, Lausanne

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Temporal gene expression profiling applied to the hypoxic response

Seigneuric, R., Starmans, F. J. M., Magagnin, M. G., Riel, van, N. A. W., Wouters, B. G. & Lambin, P., 2006, Seventh International Conference on Systems Biology. Japan, Yokohama, p. CD-rom

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Gene Expression Profiling
Prostatic Neoplasms
Breast Neoplasms
Biological Phenomena
Cell Line

Temporal gene expression profiling applied to the hypoxis response

Seigneuric, R., Starmans, M. H. W., Magagnin, M. G., Riel, van, N. A. W., Wouters, B. G. & Lambin, P., 2006, Seventh International Conference on Systems Biology, Yokohama, Japan. Kitano, X. (ed.).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

The potential therapeutic gain of redistributing dose to hypoxic regions using dose-painting: a modeling study

Petit, S. F., Riel, van, N. A. W., Murrer, L. H. P., Seigneuric, R., Lambin, P. & Wouters, B. G., 2006, 8th Biennial ESTRO Meeting on Physics and Radiation Technology for Clinical Radiotherapy. Portugal, Lisboa

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2005

Improved graphical analysis for reducing the parameter search space of a model of the extracellular matrix

Musters, M. W. J. M., Bosch, van den, P. P. J. & Riel, van, N. A. W., 2005, Proc. 6th Int. Conference on Systems Biology. Boston, USA

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

In silico biology for physiological understanding of heart metabolism

Riel, van, N. A. W., 2005, Proc. Int. Conference on Computational and Mathematical Methods in Science and Engineering (CMMSE). Int. Conf. on Computational and Mathematical Methods

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Lack of unique parameter values in databased modeling of calcium-contraction coupling: consequences for the analysis of contractile performance of the diabetic heart

Riel, van, N. A. W., Op den Buijs, J., Ligeti, L., Ivanics, T. & Vusse, van der, G., 2005, Proc. FASEB Experimental Biology. San Diego, USA: FASEB

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Numerical method for databased modeling of switching characteristics of calcium handling in the intact heart

Riel, van, N. A. W., Op den Buijs, J., Ligeti, L., Ivanics, T. & Vusse, van der, G., 2005, Proc. 49th Biophysical Society Annual Meeting. Long Beach, CA, USA: Biophysical Society

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)

One-Step Ahead Prediction for Parameter Estimation in Physiological Hybrid Models

Riel, van, N. A. W., Juloski, A. L. & Op den Buijs, J., 2005, Proc. IFAC World Congress. Prague, Cz: IFAC World Congress

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Qualitative Piecewise-affine approach for modeling biological networks

Musters, M. W. J. M., Weiland, S. & Riel, van, N. A. W., 2005, Proceedings of the 24th Benelux meeting on Systems and Control, 22-24 March 2005, Houffalize, Belgium. Houffalize, Belgium, p. 114-114

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

The potential therapeutic gain of redisributing dose to hypoxic regions using dose-painting: a modeling study

Petit, S. F., Riel, van, N. A. W., Murrer, L. H. P., Seigneuric, R., Lambin, P. & Wouters, B. G., 2005, Proc. 8th Biennial ESTRO Meeting on Physics and Radiation Technology for Clinical Radiotherapy. Lisbon, Portugal

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Transmembrane diffiusion of unbound fatty acids is insufficient for cardiac energy requirements

Musters, M. W. J. M., Bassingthwaighte, J. B., Vusse, van der, G. J. & Riel, van, N. A. W., 2005, Proc. 49th Annual Meeting, Biophysical Society. Long Beach, California, USA

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2004

A biomolecular pathway of vascular wall integrity as a hybrid piecewise constant system

Musters, M. W. J. M., Op den Buijs, J. & Riel, van, N. A. W., 2004, Proc. 23rd Benelux Meeting on Systems and Control. Helvoirt, Netherlands, p. 48-48

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Analysis of the transforming growth factor-beta1 pathway and extracellular matrix formation as a hybrid system

Musters, M. W. J. M. & Riel, van, N. A. W., 2004, Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society. San Francisco, p. 2901-2904

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Transforming Growth Factor beta1
Transforming Growth Factor beta
Extracellular Matrix
Blood Vessels
Cytokines
3 Citations (Scopus)

Identifiability analysis of the standard pharmacokinetic models in DCE MR imaging of tumours

Lopata, R. G. P. & Riel, van, N. A. W., 2004, Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society. p. 1040-1043

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

tumor
mathematical analysis
sampling
simulation
pharmacokinetics
2 Citations (Scopus)

Identification of a switching model of calcium cycling in isolated rat hearts

Op den Buijs, J., Juloski, A. L., Ivanics, T., Ligeti, L., Vusse, van der, G. J. & Riel, van, N. A. W., 2004, EMBC : Engineering in medicine and biology : annual international conference : proceedings, 26th, September 1-5, 2004. Piscataway, NJ, USA: Institute of Electrical and Electronics Engineers, p. 841-844

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Calcium
Statistical Models
Isoproterenol
Cardiac Myocytes
Theoretical Models

Qualitative simulation of transforming growth factor beta 1 and extracellular matrix balance

Musters, M. W. J. M. & Riel, van, N. A. W., 2004, Proc. 5th Int. Conference on Systems Biology. Heidelberg, Germany, p. 231-231

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review