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Research Output 2000 2019

2019

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A. & Arts, I. C. W., 3 Oct 2019, In : PLoS Computational Biology. 15, 10, 23 p., e1007400

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipid Metabolism
Radioactive tracers
isotope labeling
Isotopes
lipid metabolism

Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples

Félix Garza, Z. C., Lenz, M., Liebmann, J., Ertaylan, G., Born, M., Arts, I. C. W., Hilbers, P. A. J. & Van Riel, N. A. W., 17 Aug 2019, In : BMC Medical Genomics. 12, 1, 14 p., 121

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biopsy
Skin
Atopic Dermatitis
Psoriasis
Skin Diseases

Computational modelling of bile acid and lipid metabolism

Sips, F. L. P., 3 Jul 2019, Eindhoven: Technische Universiteit Eindhoven. 226 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Bile Acids and Salts
Lipid Metabolism

Computational modelling of energy balance in individuals with Metabolic Syndrome

Rozendaal, Y., Wang, Y., Hilbers, P. & van Riel, N., 26 Feb 2019, In : BMC Systems Biology. 13, 24, 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Computational Modeling
Energy Balance
Energy balance
Energy Metabolism
Energy

Deep learning methods to translate gene expression changes induced in vitro in rat hepatocytes to human in vivo

de Kok, T. M., O'Donnovan, S., Lenz, M., Wimmenauer, F., Lukas, A., Neeven, J., Stumm, T., Krishna, A., Lopatta, D., Smirnov, E., Ertaylan, G., van Riel, N., Jennen, D., Cavill, R., Driessens, K. & Peeters, R., 15 Oct 2019, In : Toxicology Letters. 314, p. S170-S170 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

Dynamics in human muscle bioenergetics: in silico and in vivo studies of metabolism during exercise

Hendriks, A., Nabben, M. W., Schmitz, J. P. J., Hilbers, P. A. J., Prompers, J. J. & van Riel, N. A. W., 2019, (In preparation) Eindhoven: Technische Universiteit Eindhoven

Research output: Working paperAcademic

Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator

O’Donovan, S. D., Lenz, M., Goossens, G. H., van der Kallen, C. J. H., Eussen, S. J. M. P., Stehouwer, C. D. A., van Greevenbroek, M. M., Schram, M. T., Sep, S. J., Peeters, R. L. M., Blaak, E. E., van Riel, N. A. W., de Kok, T. M. C. M. & Arts, I. C. W., 28 Jun 2019, In : Scientific Reports. 9, 1, 10 p., 9388

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Glucose Tolerance Test
Insulin Resistance
Muscles
Appointments and Schedules
Glucose Clamp Technique

Integrated machine learning and mechanistic modelling of Metabolic Syndrome development and dynamics

Van Riel, N., Apr 2019, In : European Journal of Clinical Investigation. 49, S1, p. 40-41 S5-L5

Research output: Contribution to journalMeeting AbstractAcademic

Open Access

Metabolic Health Index (MHI): Assessment of Comorbidity in Bariatric Patients Based on Biomarkers

van Loon, S. L. M., Deneer, R., Nienhuijs, S. W., Wilbik, A., Kaymak, U., van Riel, N., Scharnhorst, V. & Boer, A-K., 14 Nov 2019, In : Obesity Surgery.

Research output: Contribution to journalArticleAcademicpeer-review

2018

A distance measure for heterogeneity using genome scale metabolic networks

Cabbia, A., Hilbers, P. A. J. & van Riel, N. A. W., 14 Oct 2018

Research output: Contribution to conferencePosterAcademic

Metabolic Networks and Pathways
Genome
Neoplasms
Organized Financing
European Union

Applications of Canonical Correlation Analysis to microbial and metabolite data of metabolic syndrome patients

van der Stam, J. A., Prodan, A., van Baar, A., Hilbers, P. A. J., Groen, B., Nieuwdorp, M., Levin, E. & van Riel, N. A. W., 15 May 2018

Research output: Contribution to conferencePosterAcademic

Open Access
File

Computational modelling of postprandial glucose and insulin dynamics: the role of amino acids

van Sloun, B., Lenz, M., van Riel, N. A. W. & Arts, I., 15 May 2018 1 p.

Research output: Contribution to conferencePosterAcademic

Open Access
File
13 Citations (Scopus)

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects

Bouter, K., Bakker, G. J., Levin, E., Hartstra, A. V., Kootte, R. S., Udayappan, S. D., Katiraei, S., Bahler, L., Gilijamse, P. W., Tremaroli, V., Stahlman, M., Holleman, F., van Riel, N. A. W., Verberne, H. J., Romijn, J. A., Dallinga-Thie, G. M., Serlie, M. J., Ackermans, M. T., Kemper, E. M., Willems van Dijk, K. & 3 othersBackhed, F., Groen, A. K. & Nieuwdorp, M., 25 May 2018, In : Clinical and Translational Gastroenterology. 9, 5, 155

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Butyrates
Volatile Fatty Acids
Brown Adipose Tissue
Glucose
Butyric Acid
1 Citation (Scopus)

Domain intelligible models

Imangaliyev, S., Prodan, A., Nieuwdorp, M., Groen, A. K., van Riel, N. A. W. & Levin, E., 1 Oct 2018, In : Methods : a companion to methods in enzymology. 149, p. 69-73

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Metagenome
Biological Phenomena
Microorganisms
Cost functions
Insulin Resistance
13 Citations (Scopus)

Find drugs that delay many diseases of old age

Bellantuono, I., DeCabo, R., Ehninger, D., Fernandes, A., Howlett, S. E., Müller, R., Potter, P., Tchkonia, T., Trendelenburg, A-U., Trejo, J. L., Vandenbroucke, R., van Os, R. & van Riel, N. A. W., 15 Feb 2018, In : Nature. 554, 7692, p. 293-295 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access
File

Genome-scale metabolic models for personalized nutrition and healthy aging

Cabbia, A., Hilbers, P. A. J. & van Riel, N. A. W., 25 Sep 2018

Research output: Contribution to conferencePosterAcademic

Open Access
File
2 Citations (Scopus)

In silico analysis identifies intestinal transit as a key determinant of systemic bile acid metabolism

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, A. K. & van Riel, N. A. W., 8 Jun 2018, In : Frontiers in Physiology. 9, 631

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bile Acids and Salts
Computer Simulation
Bariatric Surgery
Lipid Metabolism
Type 2 Diabetes Mellitus

In silico clinical studies on the efficacy of blue light for treating psoriasis

Felix Garza, Z. C., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 2018 1 p.

Research output: Contribution to conferencePosterAcademic

Open Access
File
Psoriasis
Computer Simulation
Light
Population
Therapeutics
4 Citations (Scopus)

In vivo and in silico dynamics of the development of Metabolic Syndrome

Rozendaal, Y. J. W., Wang, Y., Paalvast, Y., Tambyrajah, L. L., Li, Z., Willems van Dijk, K., Rensen, P. C. N., Kuivenhoven, J. A., Groen, A. K., Hilbers, P. A. J. & van Riel, N. A. W., 1 Jun 2018, In : PLoS Computational Biology. 14, 6, e1006145

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
metabolic syndrome
Cholesterol
Computer Simulation
Lipids
Glucose
6 Citations (Scopus)

Model-based analysis of postprandial glycemic response dynamics for different types of food

Rozendaal, Y. J., Maas, A. H., van Pul, C., Cottaar, E. J. E., Haak, H. R., Hilbers, P. A. J. & van Riel, N. A., Jun 2018, In : Clinical Nutrition Experimental. 19, p. 32-45

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Insulin
Glucose
Food
Meals
Glycemic Index

Modeling the effect of blue light irradiation on inflammatory skin diseases

Felix Garza, Z. C., 6 Nov 2018, Eindhoven: Technische Universiteit Eindhoven. 145 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
Phototherapy
Skin Diseases
Light
4 Citations (Scopus)

Physical activity and nutrition influences in ageing (PANINI): consortium mission statement

Whittaker, A. C., Delledonne, M., Finni, T., Garagnani, P., Greig, C., Kallen, V., Kokko, K., Lord, J., Maier, A. B., Meskers, C. G. M., Santos, N. C., Sipila, S., Thompson, J. L. & van Riel, N. A. W., Jun 2018, In : Aging Clinical and Experimental Research. 30, 6, p. 685-692

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Systems biology of Metabolic Syndrome development and treatment

Rozendaal, Y. J. W., 21 Dec 2018, Eindhoven: Technische Universiteit Eindhoven. 138 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
Systems Biology
Therapeutics

The role of dopamine receptors in obesity: an in silico exploration

van Beers, H. H. M. H. & van Riel, N. A. W., 15 May 2018 1 p.

Research output: Contribution to conferencePosterAcademic

Open Access
File
5 Citations (Scopus)

Visible light therapy: molecular mechanisms and therapeutic opportunities

Felix Garza, Z. C., Born, M., Hilbers, P. A. J., van Riel, N. A. W. & Liebmann, J., 2018, In : Current Medicinal Chemistry. 25, 40, p. 5564-5577

Research output: Contribution to journalArticleAcademicpeer-review

Phototherapy
Light
Skin
Therapeutics
Flavins
2017

A dynamic model for prediction of psoriasis management by blue light irradiation

Felix Garza, Z. C., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 26 Jan 2017, In : Frontiers in Physiology. 8, p. 1-17 28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Aging and lifestyle: impact on skeletal muscle function

Cabbia, A. & van Riel, N. A. W., 1 Sep 2017

Research output: Contribution to conferencePosterAcademic

File
4 Citations (Scopus)

An in vivo magnetic resonance spectroscopy study of the effects of caloric and non-caloric sweeteners on liver lipid metabolism in rats

Janssens, S., Ciapaite, J., Wolters, J. C., van Riel, N. A., Nicolay, K. & Prompers, J. J., 10 May 2017, In : Nutrients. 9, 5, 19 p., 476

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Sweetening Agents
sweeteners
Lipid Metabolism
lipid metabolism
spectroscopy
3 Citations (Scopus)

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy

Nabben, M., Schmitz, J. P. J., Ciapaite, J., le Clercq, C. M. P., van Riel, N. A., Haak, H. R., Nicolay, K., de Coo, I. F. M., Smeets, H., Praet, S. F., van Loon, L. J. & Prompers, J. J., 1 May 2017, In : American Journal of Physiology : Regulatory Integrative and Comparative Physiology. 312, 5, p. R689-R701 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mitochondrial Myopathies
Nitrates
Exercise
Oxygen
Costs and Cost Analysis

Dissecting the cell heterogeneity of skin in inflammatory dermatological conditions through deconvolution of tissue expression profiles

Felix Garza, Z. C., Lenz, M., Liebmann, J., Born, M., Arts, I., Hilbers, P. A. J. & van Riel, N. A. W., 2017

Research output: Contribution to conferenceAbstractAcademic

Skin
Atopic Dermatitis
Psoriasis
Gene Expression
Dermatology

Gene expression-based cellular profiling of skin in health and inflammatory dermatological conditions

Felix Garza, Z. C., Lenz, M., Liebmann, J., Born, M., Arts, I. C. W., Hilbers, P. A. J. & van Riel, N. A. W., 2017 1 p.

Research output: Contribution to conferenceAbstractAcademic

File
Gene Expression
Skin
Health
Atopic Dermatitis
Psoriasis
1 Citation (Scopus)

Identifying user preferences for a digital educational solution for young seniors with diabetes

van der Molen, P., Maas, A. H., Chen, W., van Pul, C., Cottaar, E. J. E., van Riel, N. A. W., Hilbers, P. A. J. & Haak, H. R., 1 Aug 2017, In : Diabetes Spectrum. 30, 3, p. 182-187 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Education
Interviews
Equipment and Supplies
Video Games
Research

Lessons learned from computer models on blue light therapy for psoriasis vulgaris

Felix Garza, Z. C., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 2017, p. 101-102

Research output: Contribution to conferenceAbstractAcademic

Open Access
File
Phototherapy
Psoriasis
Computer Simulation
Keratinocytes
Therapeutics
10 Citations (Scopus)

Methodologies for quantitative systems pharmacology (QSP) models: Design and Estimation

Ribba, B., Grimm, H., Agoram, B., Davies, M. R., Gadkar, K., Niederer, S., van Riel, N., Timmis, J. & van der Graaf, P., 1 Aug 2017, In : CPT: Pharmacometrics & Systems Pharmacology. 6, 8, p. 496-498 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pharmacology
Methodology
Research
Medicine
Granularity

Playing with numbers: the development of an educational diabetes game

Maas, A. H., 6 Sep 2017, Eindhoven: Technische Universiteit Eindhoven. 273 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
File
Sarcopenia
Life Style
Skeletal Muscle
Genome
Exercise

The effect of Bariatric surgery on VLDL metabolism

Yildirim, V. & van Riel, N. A. W., 2017, (Unpublished)

Research output: Contribution to conferenceAbstractAcademic

Bariatric Surgery
VLDL Lipoproteins
Dyslipidemias
Gastric Bypass
Insulin
AMP-Activated Protein Kinases
Oxidative Phosphorylation
Energy Metabolism
Neoplasms
Glycolysis
2016
22 Citations (Scopus)

A genome-scale metabolic network reconstruction of tomato (Solanum lycopersicum L.) and its application to photorespiratory metabolism

Yuan, H., Cheung, C. Y. M., Poolman, M. G., Hilbers, P. A. J. & van Riel, N. A. W., 1 Jan 2016, In : Plant Journal. 85, 2, p. 289-304 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
11 Citations (Scopus)

Altered energetics of exercise explain risk of rhabdomyolysis in very long-chain acyl-coa dehydrogenase deficiency

Diekman, E. F., Visser, G., Schmitz, J. P. J., Nievelstein, R. A. J., De Sain-van Der Velden, M., Wardrop, M., Van Der Pol, W. L., Houten, S. M., van Riel, N. A. W., Takken, T. & Jeneson, J. A. L., 16 Feb 2016, In : PLoS ONE. 11, 2, 18 p., e0147818

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Long-Chain Acyl-CoA Dehydrogenase
acyl-CoA dehydrogenase
rhabdomyolysis
Rhabdomyolysis
Oxidoreductases

A mathematical model for investigation of intestinal changes on the postprandial bile acid profile

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, B. & van Riel, N. A. W., 2016, Book of abstracts of BioSB 2016. p. 32 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File

A mathematical model of the intestinal transit and enterohepatic circulation of bile acids

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, A. K. & van Riel, N. A. W., 2016, Abstracts of the XXIV International Bile Acid Meeting: Bile Acids in Health and Disease. Freiburg: Falk Foundation , p. 135 1 p. 69

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File

Analysis of gastrointestinal surgery with a computational model of bile acid metabolism

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, A. K. & van Riel, N. A. W., 2016

Research output: Contribution to conferencePosterAcademic

3 Citations (Scopus)

Concept development of the Eindhoven Diabetes Education Simulator project

Maas, A. H., van der Molen, P., van de Vijver, R., Chen, W., van Pul, C., Cottaar, E. J. E., van Riel, N. A. W., Hilbers, P. A. J. & Haak, H., 30 Mar 2016, In : Games for Health Journal. 5, 2, p. 120-127 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical problems
chronic illness
Simulators
Education
education

Defining the threshold and boundaries of the keratinocytes response to blue light exposure

Felix Garza, Z. C., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 2016

Research output: Contribution to conferencePosterAcademic

thresholds
irradiation
Redox cells
apoptosis
nitric oxide
10 Citations (Scopus)

Flux balance analysis of plant metabolism: the effect of biomass composition and model structure on model predictions

Yuan, H., Cheung, C. Y. M., Hilbers, P. A. J. & van Riel, N. A. W., 26 Apr 2016, In : Frontiers in Plant Science. 7, 13 p., 537

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Genome-scale metabolic modelling of Arabidopsis and tomato

Yuan, H., 14 Dec 2016, Eindhoven: Technische Universiteit Eindhoven. 141 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File

In silico BAT activation in a glucose-lipid model of the metabolic syndrome

Rozendaal, Y. J. W., Paalvast, Y., Wang, Y., Hilbers, P. A. J. & van Riel, N. A. W., 26 Oct 2016

Research output: Contribution to conferencePosterAcademic

Modelling blue light treatment of inflammatory skin conditions to optimize the therapeutic approach.

Felix Garza, Z. C., van den Biggelaar, E. P. F., Liebmann, J., Born, M., Hilbers, P. A. J., van Riel, N. A. W. & Hoekstra, A. G. (ed.), 2016

Research output: Contribution to conferenceAbstractAcademic