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Research Output 2000 2020

2020

Metabolic Health Index (MHI): assessment of comorbidity in bariatric patients based on biomarkers

van Loon, S. L. M., Deneer, R., Nienhuijs, S. W., Wilbik, A., Kaymak, U., van Riel, N., Scharnhorst, V. & Boer, A-K., 1 Feb 2020, In : Obesity Surgery. 30, 2, p. 714-724 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bariatrics
Comorbidity
Biomarkers
Health
Ambulatory Surgical Procedures
2019
9 Downloads (Pure)

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A. & Arts, I. C. W., Oct 2019, In : PLoS Computational Biology. 15, 10, 23 p., e1007400.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lipid Metabolism
Radioactive tracers
isotope labeling
Isotopes
lipid metabolism
1 Citation (Scopus)
11 Downloads (Pure)

Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples

Félix Garza, Z. C., Lenz, M., Liebmann, J., Ertaylan, G., Born, M., Arts, I. C. W., Hilbers, P. A. J. & Van Riel, N. A. W., 17 Aug 2019, In : BMC Medical Genomics. 12, 1, 14 p., 121.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biopsy
Skin
Atopic Dermatitis
Psoriasis
Skin Diseases
31 Downloads (Pure)

Computational modelling of energy balance in individuals with Metabolic Syndrome

Rozendaal, Y., Wang, Y., Hilbers, P. & van Riel, N., 26 Feb 2019, In : BMC Systems Biology. 13, 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Computational Modeling
Energy Balance
Energy balance
Energy Metabolism
Energy

Deep learning methods to translate gene expression changes induced in vitro in rat hepatocytes to human in vivo

de Kok, T. M., O'Donnovan, S., Lenz, M., Wimmenauer, F., Lukas, A., Neeven, J., Stumm, T., Krishna, A., Lopatta, D., Smirnov, E., Ertaylan, G., van Riel, N., Jennen, D., Cavill, R., Driessens, K. & Peeters, R., 15 Oct 2019, In : Toxicology Letters. 314, p. S170-S170 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

Deep learning with convolutional neural networks for histopathology image analysis

Bosnacki, D., van Riel, N. A. W. & Veta, M., 2019, Automated reasoning for systems biology and medicine. Lio, P. & Zuliani, P. (eds.). Springer, p. 453-469 (Computational Biology Series; vol. 30).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Dynamics in human muscle bioenergetics: in silico and in vivo studies of metabolism during exercise

Hendriks, A., Nabben, M. W., Schmitz, J. P. J., Hilbers, P. A. J., Prompers, J. J. & van Riel, N. A. W., 2019, (In preparation) Eindhoven: Technische Universiteit Eindhoven.

Research output: Working paperAcademic

1 Citation (Scopus)
19 Downloads (Pure)

Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator

O’Donovan, S. D., Lenz, M., Goossens, G. H., van der Kallen, C. J. H., Eussen, S. J. M. P., Stehouwer, C. D. A., van Greevenbroek, M. M., Schram, M. T., Sep, S. J., Peeters, R. L. M., Blaak, E. E., van Riel, N. A. W., de Kok, T. M. C. M. & Arts, I. C. W., 1 Dec 2019, In : Scientific Reports. 9, 1, 10 p., 9388.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Glucose Tolerance Test
Insulin Resistance
Muscles
Appointments and Schedules
Glucose Clamp Technique
2 Downloads (Pure)

Integrated machine learning and mechanistic modelling of Metabolic Syndrome development and dynamics

Van Riel, N., Apr 2019, In : European Journal of Clinical Investigation. 49, S1, p. 40-41 S5-L5.

Research output: Contribution to journalMeeting AbstractAcademic

Open Access
2018

A distance measure for heterogeneity using genome scale metabolic networks

Cabbia, A., Hilbers, P. A. J. & van Riel, N. A. W., 14 Oct 2018.

Research output: Contribution to conferencePosterAcademic

Metabolic Networks and Pathways
Genome
Neoplasms
Organized Financing
European Union
61 Downloads (Pure)

Applications of Canonical Correlation Analysis to microbial and metabolite data of metabolic syndrome patients

van der Stam, J. A., Prodan, A., van Baar, A., Hilbers, P. A. J., Groen, B., Nieuwdorp, M., Levin, E. & van Riel, N. A. W., 15 May 2018.

Research output: Contribution to conferencePosterAcademic

Open Access
File
61 Downloads (Pure)

Computational modelling of postprandial glucose and insulin dynamics: the role of amino acids

van Sloun, B., Lenz, M., van Riel, N. A. W. & Arts, I., 15 May 2018. 1 p.

Research output: Contribution to conferencePosterAcademic

Open Access
File
16 Citations (Scopus)
39 Downloads (Pure)

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects

Bouter, K., Bakker, G. J., Levin, E., Hartstra, A. V., Kootte, R. S., Udayappan, S. D., Katiraei, S., Bahler, L., Gilijamse, P. W., Tremaroli, V., Stahlman, M., Holleman, F., van Riel, N. A. W., Verberne, H. J., Romijn, J. A., Dallinga-Thie, G. M., Serlie, M. J., Ackermans, M. T., Kemper, E. M., Willems van Dijk, K. & 3 others, Backhed, F., Groen, A. K. & Nieuwdorp, M., 25 May 2018, In : Clinical and Translational Gastroenterology. 9, 5, 155.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Butyrates
Volatile Fatty Acids
Brown Adipose Tissue
Glucose
Butyric Acid
1 Citation (Scopus)
72 Downloads (Pure)

Domain intelligible models

Imangaliyev, S., Prodan, A., Nieuwdorp, M., Groen, A. K., van Riel, N. A. W. & Levin, E., 1 Oct 2018, In : Methods : a companion to methods in enzymology. 149, p. 69-73

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Metagenome
Biological Phenomena
Microorganisms
Cost functions
Insulin Resistance
15 Citations (Scopus)
64 Downloads (Pure)

Find drugs that delay many diseases of old age

Bellantuono, I., DeCabo, R., Ehninger, D., Fernandes, A., Howlett, S. E., Müller, R., Potter, P., Tchkonia, T., Trendelenburg, A-U., Trejo, J. L., Vandenbroucke, R., van Os, R. & van Riel, N. A. W., 15 Feb 2018, In : Nature. 554, 7692, p. 293-295 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access
File
30 Downloads (Pure)

Genome-scale metabolic models for personalized nutrition and healthy aging

Cabbia, A., Hilbers, P. A. J. & van Riel, N. A. W., 25 Sep 2018.

Research output: Contribution to conferencePosterAcademic

Open Access
File
2 Citations (Scopus)
38 Downloads (Pure)

In silico analysis identifies intestinal transit as a key determinant of systemic bile acid metabolism

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, A. K. & van Riel, N. A. W., 8 Jun 2018, In : Frontiers in Physiology. 9, 631.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bile Acids and Salts
Computer Simulation
Bariatric Surgery
Lipid Metabolism
Type 2 Diabetes Mellitus
8 Downloads (Pure)

In silico clinical studies on the efficacy of blue light for treating psoriasis

Felix Garza, Z. C., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 2018. 1 p.

Research output: Contribution to conferencePosterAcademic

Open Access
File
Psoriasis
Computer Simulation
Light
Population
Therapeutics
4 Citations (Scopus)
33 Downloads (Pure)

In vivo and in silico dynamics of the development of Metabolic Syndrome

Rozendaal, Y. J. W., Wang, Y., Paalvast, Y., Tambyrajah, L. L., Li, Z., Willems van Dijk, K., Rensen, P. C. N., Kuivenhoven, J. A., Groen, A. K., Hilbers, P. A. J. & van Riel, N. A. W., 1 Jun 2018, In : PLoS Computational Biology. 14, 6, e1006145.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
metabolic syndrome
Cholesterol
Computer Simulation
Lipids
Glucose
9 Citations (Scopus)
69 Downloads (Pure)

Model-based analysis of postprandial glycemic response dynamics for different types of food

Rozendaal, Y. J., Maas, A. H., van Pul, C., Cottaar, E. J. E., Haak, H. R., Hilbers, P. A. J. & van Riel, N. A., Jun 2018, In : Clinical Nutrition Experimental. 19, p. 32-45

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Insulin
Glucose
Food
Meals
Glycemic Index
5 Citations (Scopus)
34 Downloads (Pure)

Physical activity and nutrition influences in ageing (PANINI): consortium mission statement

Whittaker, A. C., Delledonne, M., Finni, T., Garagnani, P., Greig, C., Kallen, V., Kokko, K., Lord, J., Maier, A. B., Meskers, C. G. M., Santos, N. C., Sipila, S., Thompson, J. L. & van Riel, N. A. W., Jun 2018, In : Aging Clinical and Experimental Research. 30, 6, p. 685-692

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
25 Downloads (Pure)

The role of dopamine receptors in obesity: an in silico exploration

van Beers, H. H. M. H. & van Riel, N. A. W., 15 May 2018. 1 p.

Research output: Contribution to conferencePosterAcademic

Open Access
File
7 Citations (Scopus)
1 Downloads (Pure)

Visible light therapy: molecular mechanisms and therapeutic opportunities

Felix Garza, Z. C., Born, M., Hilbers, P. A. J., van Riel, N. A. W. & Liebmann, J., 2018, In : Current Medicinal Chemistry. 25, 40, p. 5564-5577

Research output: Contribution to journalArticleAcademicpeer-review

Phototherapy
Light
Skin
Therapeutics
Cells
2017
177 Downloads (Pure)

A dynamic model for prediction of psoriasis management by blue light irradiation

Felix Garza, Z. C., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 26 Jan 2017, In : Frontiers in Physiology. 8, p. 1-17 28.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
17 Downloads (Pure)

Aging and lifestyle: impact on skeletal muscle function

Cabbia, A. & van Riel, N. A. W., 1 Sep 2017.

Research output: Contribution to conferencePosterAcademic

File
4 Citations (Scopus)
56 Downloads (Pure)

An in vivo magnetic resonance spectroscopy study of the effects of caloric and non-caloric sweeteners on liver lipid metabolism in rats

Janssens, S., Ciapaite, J., Wolters, J. C., van Riel, N. A., Nicolay, K. & Prompers, J. J., 10 May 2017, In : Nutrients. 9, 5, 19 p., 476.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Sweetening Agents
sweeteners
Lipid Metabolism
lipid metabolism
spectroscopy
3 Citations (Scopus)

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy

Nabben, M., Schmitz, J. P. J., Ciapaite, J., le Clercq, C. M. P., van Riel, N. A., Haak, H. R., Nicolay, K., de Coo, I. F. M., Smeets, H., Praet, S. F., van Loon, L. J. & Prompers, J. J., 1 May 2017, In : American Journal of Physiology : Regulatory Integrative and Comparative Physiology. 312, 5, p. R689-R701 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mitochondrial Myopathies
Nitrates
Exercise
Oxygen
Costs and Cost Analysis

Dissecting the cell heterogeneity of skin in inflammatory dermatological conditions through deconvolution of tissue expression profiles

Felix Garza, Z. C., Lenz, M., Liebmann, J., Born, M., Arts, I., Hilbers, P. A. J. & van Riel, N. A. W., 2017.

Research output: Contribution to conferenceAbstractAcademic

Skin
Atopic Dermatitis
Psoriasis
Gene Expression
Dermatology
104 Downloads (Pure)

Gene expression-based cellular profiling of skin in health and inflammatory dermatological conditions

Felix Garza, Z. C., Lenz, M., Liebmann, J., Born, M., Arts, I. C. W., Hilbers, P. A. J. & van Riel, N. A. W., 2017. 1 p.

Research output: Contribution to conferenceAbstractAcademic

File
Gene Expression
Skin
Health
Atopic Dermatitis
Psoriasis
1 Citation (Scopus)
50 Downloads (Pure)

Identifying user preferences for a digital educational solution for young seniors with diabetes

van der Molen, P., Maas, A. H., Chen, W., van Pul, C., Cottaar, E. J. E., van Riel, N. A. W., Hilbers, P. A. J. & Haak, H. R., 1 Aug 2017, In : Diabetes Spectrum. 30, 3, p. 182-187 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Education
Interviews
Equipment and Supplies
Video Games
Research
21 Downloads (Pure)

Lessons learned from computer models on blue light therapy for psoriasis vulgaris

Felix Garza, Z. C., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 2017, p. 101-102.

Research output: Contribution to conferenceAbstractAcademic

Open Access
File
Phototherapy
Psoriasis
Computer Simulation
Keratinocytes
Therapeutics
10 Citations (Scopus)
104 Downloads (Pure)

Methodologies for quantitative systems pharmacology (QSP) models: Design and Estimation

Ribba, B., Grimm, H., Agoram, B., Davies, M. R., Gadkar, K., Niederer, S., van Riel, N., Timmis, J. & van der Graaf, P., 1 Aug 2017, In : CPT: Pharmacometrics & Systems Pharmacology. 6, 8, p. 496-498 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pharmacology
Methodology
Research
Medicine
Granularity
49 Downloads (Pure)

Presentation : Development of an age-specific genome-scale model of skeletal muscle metabolism

Cabbia, A. & van Riel, N. A. W., 1 Sep 2017.

Research output: Contribution to conferenceOtherAcademic

File
Sarcopenia
Life Style
Skeletal Muscle
Genome
Exercise

The effect of Bariatric surgery on VLDL metabolism

Yildirim, V. & van Riel, N. A. W., 2017, (Unpublished).

Research output: Contribution to conferenceAbstractAcademic

Bariatric Surgery
VLDL Lipoproteins
Dyslipidemias
Gastric Bypass
Insulin
AMP-Activated Protein Kinases
Oxidative Phosphorylation
Energy Metabolism
Neoplasms
Glycolysis
2016
24 Citations (Scopus)
135 Downloads (Pure)

A genome-scale metabolic network reconstruction of tomato (Solanum lycopersicum L.) and its application to photorespiratory metabolism

Yuan, H., Cheung, C. Y. M., Poolman, M. G., Hilbers, P. A. J. & van Riel, N. A. W., 1 Jan 2016, In : Plant Journal. 85, 2, p. 289-304 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
13 Citations (Scopus)
92 Downloads (Pure)

Altered energetics of exercise explain risk of rhabdomyolysis in very long-chain acyl-coa dehydrogenase deficiency

Diekman, E. F., Visser, G., Schmitz, J. P. J., Nievelstein, R. A. J., De Sain-van Der Velden, M., Wardrop, M., Van Der Pol, W. L., Houten, S. M., van Riel, N. A. W., Takken, T. & Jeneson, J. A. L., 16 Feb 2016, In : PLoS ONE. 11, 2, 18 p., e0147818.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Long-Chain Acyl-CoA Dehydrogenase
acyl-CoA dehydrogenase
rhabdomyolysis
Rhabdomyolysis
Oxidoreductases
34 Downloads (Pure)

A mathematical model for investigation of intestinal changes on the postprandial bile acid profile

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, B. & van Riel, N. A. W., 2016, Book of abstracts of BioSB 2016. p. 32 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
94 Downloads (Pure)

A mathematical model of the intestinal transit and enterohepatic circulation of bile acids

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, A. K. & van Riel, N. A. W., 2016, Abstracts of the XXIV International Bile Acid Meeting: Bile Acids in Health and Disease. Freiburg: Falk Foundation , p. 135 1 p. 69

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File

Analysis of gastrointestinal surgery with a computational model of bile acid metabolism

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, A. K. & van Riel, N. A. W., 2016.

Research output: Contribution to conferencePosterAcademic

3 Citations (Scopus)
2 Downloads (Pure)

Concept development of the Eindhoven Diabetes Education Simulator project

Maas, A. H., van der Molen, P., van de Vijver, R., Chen, W., van Pul, C., Cottaar, E. J. E., van Riel, N. A. W., Hilbers, P. A. J. & Haak, H., 30 Mar 2016, In : Games for Health Journal. 5, 2, p. 120-127 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical problems
chronic illness
Simulators
Education
education

Defining the threshold and boundaries of the keratinocytes response to blue light exposure

Felix Garza, Z. C., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 2016.

Research output: Contribution to conferencePosterAcademic

thresholds
irradiation
Redox cells
apoptosis
nitric oxide
11 Citations (Scopus)
112 Downloads (Pure)

Flux balance analysis of plant metabolism: the effect of biomass composition and model structure on model predictions

Yuan, H., Cheung, C. Y. M., Hilbers, P. A. J. & van Riel, N. A. W., 26 Apr 2016, In : Frontiers in Plant Science. 7, 13 p., 537.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

In silico BAT activation in a glucose-lipid model of the metabolic syndrome

Rozendaal, Y. J. W., Paalvast, Y., Wang, Y., Hilbers, P. A. J. & van Riel, N. A. W., 26 Oct 2016.

Research output: Contribution to conferencePosterAcademic

Modelling blue light treatment of inflammatory skin conditions to optimize the therapeutic approach.

Felix Garza, Z. C., van den Biggelaar, E. P. F., Liebmann, J., Born, M., Hilbers, P. A. J., van Riel, N. A. W. & Hoekstra, A. G. (ed.), 2016.

Research output: Contribution to conferenceAbstractAcademic

Modelling the glucose and lipid system during health and disease

Rozendaal, Y. J. W., Wang, Y., Paalvast, Y., Groen, B., Hilbers, P. A. J. & van Riel, N. A. W., 8 Apr 2016.

Research output: Contribution to conferencePosterAcademic

Modelling the glucose and lipid system during health and disease reveals differences in the underlying pathways

Rozendaal, Y. J. W., Wang, Y., Paalvast, Y., Groen, B., Hilbers, P. A. J. & van Riel, N. A. W., 19 Apr 2016.

Research output: Contribution to conferencePosterAcademic

43 Downloads (Pure)

Predicting the response of keratinocytes to damage of the epidermal barrier in atopic dermatitis

Felix Garza, Z. C., van den Biggelaar, E. P. F., Liebmann, J., Born, M., Hilbers, P. A. J. & van Riel, N. A. W., 28 Feb 2016.

Research output: Contribution to conferenceAbstractAcademic

Open Access
File
Atopic Dermatitis
Keratinocytes
Epidermis
Cell Count
Skin Diseases
8 Citations (Scopus)
1 Downloads (Pure)

Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes

Nyman, E., Rozendaal, Y. J. W., Helmlinger, G., Hamrén, B., Kjellsson, M. C., Strålfors, P., van Riel, N. A. W., Gennemark, P. & Cedersund, G., 6 Apr 2016, In : Interface Focus. 6, 2, 14 p., 20150075.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medical problems
Type 2 Diabetes Mellitus
Pharmacology
Pharmaceutical Preparations
Meals