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Personal profile

Research profile

Natal van Riel is Professor of Biomedical Systems Biology at the department of Biomedical Engineering (research group Computational Biology) at Eindhoven University of Technology, where he leads the Systems Biology and Metabolic Diseases research program. He is also part-time Professor of Computational Modelling at Amsterdam University Medical Centers (location AMC, University of Amsterdam's Faculty of Medicine). His research focuses on modelling of metabolic networks and physiology, learning algorithms to develop personalized models (metabolic ‘digital twins’), methods for analysis of dynamic models, and applications in Metabolic Syndrome and associated diseases such as Type 2 Diabetes.
The role of bile acids in the complex interaction between gut microbiome and metabolic health is currently an important research focus in his group (e.g. in the RESOLVE project in collaboration with Amsterdam UMC). Within the NWO program ‘Complexity in Health and Nutrition’, Natal van Riel also focuses on modelling the digestion and metabolism of nutrients in the project ‘Metabolic adaptation, transitions and resilience in overweight individuals’.

Academic background

Natal van Riel studied Electrical Engineering at Eindhoven University of Technology (TU/e, The Netherlands) where he was trained in system identification and control engineering. After receiving his MSc degree in 1995, he started PhD research in the Biotechnology group of Unilever Research Vlaardingen (The Netherlands) under supervision of Prof. Theo Verrips, on integrating computational modelling and experiments to study cell metabolism. In 2000, he obtained his PhD from Utrecht University (The Netherlands). From 2000 to 2003, he worked in the department of Electrical Engineering of TU/e, investigating the application of system and control theory to understand biological processes. In 2003, he was appointed as Assistant Professor in the department of Biomedical Engineering at TU/e where he initiated Systems Biology research. This was expanded when he joined the group of Prof. Peter Hilbers in 2006, to lead the Computational Systems Biology research program, investigating complex, multi-factorial diseases. In 2014, Natal van Riel was appointed Associate Professor of Systems Biology and Metabolic Diseases. In that same year he was a visiting scholar of the department of Bioengineering at the University of California San Diego (UCSD) in the group of Prof. Bernhard Palsson. In 2015, he was appointed part-time Professor of Computational Modelling at the Academic Medical Center AMC (University of Amsterdam). In 2019, he was appointed full Professor of Biomedical Systems Biology at TU/e. He also serves as a board member of the TU/e's Data Science Center.

Quote

In the past decade Systems Biology has become an established methodology for integrative and quantitative life science research. It is our goal to translate Systems Biology to biomedical and medical research and education to understand, cure and prevent diseases.

External positions

Professor Computational Modelling, Academic Medical Centre Amsterdam

Nov 2015 → …

Associate member of the Maastricht Centre for Systems Biology (MaCSBio), Maastricht University

2015 → …

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2000 2019

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A. & Arts, I. C. W., 3 Oct 2019, In : PLoS Computational Biology. 15, 10, 23 p., e1007400

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipid Metabolism
Radioactive tracers
isotope labeling
Isotopes
lipid metabolism

Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples

Félix Garza, Z. C., Lenz, M., Liebmann, J., Ertaylan, G., Born, M., Arts, I. C. W., Hilbers, P. A. J. & Van Riel, N. A. W., 17 Aug 2019, In : BMC Medical Genomics. 12, 1, 14 p., 121

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Biopsy
Skin
Atopic Dermatitis
Psoriasis
Skin Diseases

Computational modelling of bile acid and lipid metabolism

Sips, F. L. P., 3 Jul 2019, Eindhoven: Technische Universiteit Eindhoven. 226 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Bile Acids and Salts
Lipid Metabolism

Computational modelling of energy balance in individuals with Metabolic Syndrome

Rozendaal, Y., Wang, Y., Hilbers, P. & van Riel, N., 26 Feb 2019, In : BMC Systems Biology. 13, 24, 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Computational Modeling
Energy Balance
Energy balance
Energy Metabolism
Energy

Deep learning methods to translate gene expression changes induced in vitro in rat hepatocytes to human in vivo

de Kok, T. M., O'Donnovan, S., Lenz, M., Wimmenauer, F., Lukas, A., Neeven, J., Stumm, T., Krishna, A., Lopatta, D., Smirnov, E., Ertaylan, G., van Riel, N., Jennen, D., Cavill, R., Driessens, K. & Peeters, R., 15 Oct 2019, In : Toxicology Letters. 314, p. S170-S170 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

Prizes

AMC Principal Investigator

Natal van Riel (Recipient), 1 May 2016

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Heart Neoplasms
Practice Guidelines
Chronic Disease
Stroke
Myocardial Infarction

Koninklijke Onderscheiding; Lid in de Orde van Oranje-Nassau/ Recipient of Dutch Royal Order of Chivalry, Order of Orange-Nassau

Natal van Riel (Recipient), 27 Mar 2014

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Activities 2001 2018

Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery

Natal van Riel (Speaker)
6 Jul 2018

Activity: Talk or presentation typesInvited talkScientific

4th Dutch Bioinformatics & Systems Biology Conference

Natal van Riel (Organiser)
15 May 201816 May 2018

Activity: Participating in or organising an event typesConferenceScientific

A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass

L.C.P. Thijssen (Speaker), Natal van Riel (Member)
15 May 2018

Activity: Talk or presentation typesContributed talkScientific

Systems Medicine of Metabolic Syndrome; metabolic benefits of bariatric surgery

Natal van Riel (Speaker)
2 Mar 2018

Activity: Talk or presentation typesInvited talkScientific

Modeling of postprandial metabolic dynamics in human individuals

Natal van Riel (Organiser)
22 Jan 2018

Activity: Participating in or organising an event typesWorkshop, seminar, course or exhibitionScientific

Courses

DBL Computational biology

1/09/12 → …

Course

Endocrinology and metabolism

1/09/13 → …

Course

Project Computational biology

1/09/14 → …

Course

Synthetic and systems biology

1/09/13 → …

Course

Press / Media

New computational tool predicts progression of metabolic syndrome in mice

Natal van Riel & Y.J.W. Rozendaal

7/06/18

1 media contribution

Press/Media: Research

RESOLVE Metabolic Syndrome

Natal van Riel

11/10/17

1 media contribution

Press/Media: Research

PANINI Public Engagement Event

Andrea Cabbia & Natal van Riel

29/01/17

1 media contribution

Press/Media: Public Engagement Activities

Syndromen modelleren

Natal van Riel

22/04/16

1 media contribution

Press/Media: Public Engagement Activities

The consistency of metabolism

Natal van Riel

14/12/15

1 media contribution

Press/Media: Public Engagement Activities

Student theses

A computational model for the drug treatment effects for the EGF pathway

Author: van Tienhoven, S., 31 Jan 2013

Supervisor: van Riel, N. (Supervisor 1) & Hilbers, P. (Supervisor 2)

Student thesis: Master

Added value of independent component analysis to identify epileptic networks

Author: Klooster, D., 31 Oct 2014

Supervisor: Hilbers, P. (Supervisor 1), van Riel, N. (Supervisor 2), Ossenblok, P. (External coach) & ten Eikelder, H. (External coach)

Student thesis: Master

A hybrid systems approach to identification of nonlinear biochemical processes

Author: Lindenaar, D., 28 Feb 2006

Supervisor: Musters, M. (Supervisor 1), van Riel, N. (Supervisor 2) & van den Bosch, P. (Supervisor 2)

Student thesis: Master

File

Algorithms for estimation of model errors and uncertainties arising in black box system identification

Author: van Riel, N., 31 Oct 1995

Supervisor: van den Bosch, P. (Supervisor 1)

Student thesis: Master

File

A mathematical model for platelet adhesion and activation: application to cerebral arteries

Author: Lourens, M., 31 Aug 2007

Supervisor: van de Vosse, F. (Supervisor 1), Nicolaij, K. (Supervisor 2), Bovendeerd, P. (Supervisor 2), Huyghe, J. (Supervisor 2) & van Riel, N. (Supervisor 2)

Student thesis: Master