• 1556 Citations
20002022

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Personal profile

Research profile

Natal van Riel is Professor of Biomedical Systems Biology at the department of Biomedical Engineering (research group Computational Biology) at Eindhoven University of Technology, where he leads the Systems Biology and Metabolic Diseases research program. He is also part-time Professor of Computational Modelling at Amsterdam University Medical Centers (location AMC, University of Amsterdam's Faculty of Medicine). His research focuses on modelling of metabolic networks and physiology, learning algorithms to develop personalized models (metabolic ‘digital twins’), methods for analysis of dynamic models, and applications in Metabolic Syndrome and associated diseases such as Type 2 Diabetes.
The role of bile acids in the complex interaction between gut microbiome and metabolic health is currently an important research focus in his group (e.g. in the RESOLVE project in collaboration with Amsterdam UMC). Within the NWO program ‘Complexity in Health and Nutrition’, Natal van Riel also focuses on modelling the digestion and metabolism of nutrients in the project ‘Metabolic adaptation, transitions and resilience in overweight individuals’. In cooperation with the Catharina hospital in Eindhoven he has developed the Metabolic Health Index (MHI) to quantify the benefit of bariatric surgery to resolve metabolic diseases (type 2 diabetes, dyslipidemia), which is a second important outcome of the surgical treatment in addition to weight reduction.

Academic background

Natal van Riel studied Electrical Engineering at Eindhoven University of Technology (TU/e, The Netherlands) where he was trained in system identification and control engineering. After receiving his MSc degree in 1995, he started PhD research in the Biotechnology group of Unilever Research Vlaardingen (The Netherlands) under supervision of Prof. Theo Verrips, on integrating computational modelling and experiments to study cell metabolism. In 2000, he obtained his PhD from Utrecht University (The Netherlands). From 2000 to 2003, he worked in the department of Electrical Engineering of TU/e, investigating the application of system and control theory to understand biological processes. In 2003, he was appointed as Assistant Professor in the department of Biomedical Engineering at TU/e where he initiated Systems Biology research. This was expanded when he joined the group of Prof. Peter Hilbers in 2006, to lead the Computational Systems Biology research program, investigating complex, multi-factorial diseases. In 2014, Natal van Riel was appointed Associate Professor of Systems Biology and Metabolic Diseases. In that same year he was a visiting scholar of the department of Bioengineering at the University of California San Diego (UCSD) in the group of Prof. Bernhard Palsson. In 2015, he was appointed part-time Professor of Computational Modelling at the Academic Medical Center AMC (University of Amsterdam). In 2019, he was appointed full Professor of Biomedical Systems Biology at TU/e. He also serves as a board member of the TU/e's Data Science Center.

Quote

In the past decade Systems Biology has become an established methodology for integrative and quantitative life science research. It is our goal to translate Systems Biology to biomedical and medical research and education to understand, cure and prevent diseases.

External positions

Professor Computational Modelling, Academic Medical Centre Amsterdam

Nov 2015 → …

Associate member of the Maastricht Centre for Systems Biology (MaCSBio), Maastricht University

2015 → …

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Projects

NWO/Complexity/MATRyOSka

van Riel, N. A. W., Aktas, G., O'Donovan, S. D., Arts, I. C. W. & Afman, L.

1/10/1731/12/22

Project: Research direct

Research Output

Metabolic Health Index (MHI): assessment of comorbidity in bariatric patients based on biomarkers

van Loon, S. L. M., Deneer, R., Nienhuijs, S. W., Wilbik, A., Kaymak, U., van Riel, N., Scharnhorst, V. & Boer, A-K., 1 Feb 2020, In : Obesity Surgery. 30, 2, p. 714-724 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine

    Meessen, E. C. E., Sips, F. L. P., Eggink, H. M., Koehorst, M., Romijn, J. A., Groen, A. K., van Riel, N. A. W. & Soeters, M. R., 1 Mar 2020, In : Physiological Reports. 8, 5, 14 p., e14358.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 7 Downloads (Pure)

    A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

    O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A. & Arts, I. C. W., Oct 2019, In : PLoS Computational Biology. 15, 10, 23 p., e1007400.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 18 Downloads (Pure)

    Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples

    Félix Garza, Z. C., Lenz, M., Liebmann, J., Ertaylan, G., Born, M., Arts, I. C. W., Hilbers, P. A. J. & Van Riel, N. A. W., 17 Aug 2019, In : BMC Medical Genomics. 12, 1, 14 p., 121.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 2 Citations (Scopus)
    22 Downloads (Pure)

    Computational modelling of energy balance in individuals with Metabolic Syndrome

    Rozendaal, Y., Wang, Y., Hilbers, P. & van Riel, N., 26 Feb 2019, In : BMC Systems Biology. 13, 14 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 1 Citation (Scopus)
    39 Downloads (Pure)

    Prizes

    AMC Principal Investigator

    Natal van Riel (Recipient), 1 May 2016

    Prize: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

  • Koninklijke Onderscheiding; Lid in de Orde van Oranje-Nassau/ Recipient of Dutch Royal Order of Chivalry, Order of Orange-Nassau

    Natal van Riel (Recipient), 27 Mar 2014

    Prize: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

    Activities

    Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery

    Natal van Riel (Speaker)
    6 Jul 2018

    Activity: Talk or presentation typesInvited talkScientific

    A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass

    L.C.P. Thijssen (Speaker), Natal van Riel (Member)
    15 May 2018

    Activity: Talk or presentation typesContributed talkScientific

    4th Dutch Bioinformatics & Systems Biology Conference

    Natal van Riel (Organiser)
    15 May 201816 May 2018

    Activity: Participating in or organising an event typesConferenceScientific

    Systems Medicine of Metabolic Syndrome; metabolic benefits of bariatric surgery

    Natal van Riel (Speaker)
    2 Mar 2018

    Activity: Talk or presentation typesInvited talkScientific

    Modeling of postprandial metabolic dynamics in human individuals

    Natal van Riel (Organiser)
    22 Jan 2018

    Activity: Participating in or organising an event typesWorkshop, seminar, course or exhibitionScientific

    Courses

    DBL Computational biology

    1/09/12 → …

    Course

    Endocrinology and metabolism

    1/09/13 → …

    Course

    Project Computational biology

    1/09/1431/08/20

    Course

    Synthetic and systems biology

    1/09/13 → …

    Course

    Student theses

    A computational model for the drug treatment effects for the EGF pathway

    Author: van Tienhoven, S., 31 Jan 2013

    Supervisor: van Riel, N. (Supervisor 1) & Hilbers, P. (Supervisor 2)

    Student thesis: Master

    Added value of independent component analysis to identify epileptic networks

    Author: Klooster, D., 31 Oct 2014

    Supervisor: Hilbers, P. (Supervisor 1), van Riel, N. (Supervisor 2), Ossenblok, P. (External coach) & ten Eikelder, H. (External coach)

    Student thesis: Master

    A hybrid systems approach to identification of nonlinear biochemical processes

    Author: Lindenaar, D., 28 Feb 2006

    Supervisor: Musters, M. (Supervisor 1), van Riel, N. (Supervisor 2) & van den Bosch, P. (Supervisor 2)

    Student thesis: Master

    File

    Algorithms for estimation of model errors and uncertainties arising in black box system identification

    Author: van Riel, N., 31 Oct 1995

    Supervisor: van den Bosch, P. (Supervisor 1)

    Student thesis: Master

    File

    A mathematical model for platelet adhesion and activation: application to cerebral arteries

    Author: Lourens, M., 31 Aug 2007

    Supervisor: van de Vosse, F. (Supervisor 1), Nicolaij, K. (Supervisor 2), Bovendeerd, P. (Supervisor 2), Huyghe, J. (Supervisor 2) & van Riel, N. (Supervisor 2)

    Student thesis: Master