• 1289 Citations
20002019
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Personal profile

Research profile

Natal van Riel is Associate Professor of Systems Biology and Metabolic Diseases at the department of Biomedical Engineering (research group Computational Biology). He is also part-time Professor of Computational Modelling at the University of Amsterdam's Faculty of Medicine (Academic Medical Center, AMC). His research focuses on modelling of metabolic networks and physiology, learning algorithms to develop personalized models, methods for analysis of dynamic models, and applications in Metabolic Syndrome and associated diseases such as Type 2 Diabetes.

Modelling the digestion and metabolism of nutrients is an important research focus in his group (e.g. in the RESOLVE project in collaboration with Amsterdam Medical Centre). Within the NWO program ‘Complexity in Health and Nutrition’, Natal van Riel also focuses on the role of bile acids in the complex interaction between nutrition and health. This research is performed together with Maastricht Center for Systems Biology (MaCSBio) in the project ‘Metabolic adaptation, transitions and resilience in overweight individuals’.

Academic background

Natal van Riel studied Electrical Engineering at Eindhoven University of Technology (TU/e, The Netherlands) where he was trained in system identification and control engineering. After receiving his MSc degree in 1995, he started PhD research in the Biotechnology group of Unilever Research Vlaardingen (The Netherlands) under supervision of Prof. Theo Verrips, on integrating computational modelling and experiments to study cell metabolism. In 2000, he obtained his PhD from Utrecht University (The Netherlands). From 2000 to 2003, he worked in the department of Electrical Engineering of TU/e, investigating the application of system and control theory to understand biological processes. In 2003, he was appointed as Assistant Professor in the department of Biomedical Engineering at TU/e where he initiated Systems Biology research. This was expanded when he joined the group of Prof. Peter Hilbers in 2006, to lead the Computational Systems Biology research program, investigating complex, multi-factorial diseases. In 2014, Natal van Riel was appointed Associate Professor of Systems Biology and Metabolic Diseases. In that same year he was a visiting scholar of the department of Bioengineering at the University of California San Diego (UCSD) in the group of Prof. Bernhard Palsson. In 2015, he was appointed part-time Professor of Computational Modelling at the Academic Medical Center AMC (University of Amsterdam). He also serves as a board member of the TU/e's Data Science Center.

Quote

In the past decade Systems Biology has become an established methodology for integrative and quantitative life science research. It is our goal to translate Systems Biology to biomedical and medical research and education to understand, cure and prevent diseases.

External positions

Professor Computational Modelling, Academic Medical Centre Amsterdam

Nov 2015 → …

Associate member of the Maastricht Centre for Systems Biology (MaCSBio), Maastricht University

2015 → …

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2000 2019

Dynamics in human muscle bioenergetics: in silico and in vivo studies of metabolism during exercise

Hendriks, A., Nabben, M. W., Schmitz, J. P. J., Hilbers, P. A. J., Prompers, J. J. & van Riel, N. A. W., 2019, (In preparation) Eindhoven: Technische Universiteit Eindhoven

Research output: Working paperAcademic

A distance measure for heterogeneity using genome scale metabolic networks

Cabbia, A., Hilbers, P. A. J. & van Riel, N. A. W., 14 Oct 2018

Research output: Contribution to conferencePosterAcademic

Metabolic Networks and Pathways
Genome
Neoplasms
Organized Financing
European Union

Applications of Canonical Correlation Analysis to microbial and metabolite data of metabolic syndrome patients

van der Stam, J. A., Prodan, A., van Baar, A., Hilbers, P. A. J., Groen, B., Nieuwdorp, M., Levin, E. & van Riel, N. A. W., 15 May 2018

Research output: Contribution to conferencePosterAcademic

Open Access
File

Computational modelling of postprandial glucose and insulin dynamics: the role of amino acids

van Sloun, B., Lenz, M., van Riel, N. A. W. & Arts, I., 15 May 2018 1 p.

Research output: Contribution to conferencePosterAcademic

Open Access
File
3 Citations

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects

Bouter, K., Bakker, G. J., Levin, E., Hartstra, A. V., Kootte, R. S., Udayappan, S. D., Katiraei, S., Bahler, L., Gilijamse, P. W., Tremaroli, V., Stahlman, M., Holleman, F., van Riel, N. A. W., Verberne, H. J., Romijn, J. A., Dallinga-Thie, G. M., Serlie, M. J., Ackermans, M. T., Kemper, E. M., Willems van Dijk, K. & 3 othersBackhed, F., Groen, A. K. & Nieuwdorp, M., 25 May 2018, In : Clinical and Translational Gastroenterology. 9, 5, 155

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Butyrates
Volatile Fatty Acids
Brown Adipose Tissue
Glucose
Butyric Acid

Prizes

AMC Principal Investigator

Natal van Riel (Recipient), 1 May 2016

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Heart Neoplasms
Practice Guidelines
Chronic Disease
Stroke
Myocardial Infarction

Koninklijke Onderscheiding; Lid in de Orde van Oranje-Nassau/ Recipient of Dutch Royal Order of Chivalry, Order of Orange-Nassau

Natal van Riel (Recipient), 27 Mar 2014

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

Activities 2001 2018

4th Dutch Bioinformatics & Systems Biology Conference

Natal van Riel (Organiser)
15 May 201816 May 2018

Activity: Participating in or organising an event typesConferenceScientific

Systems Medicine of Metabolic Syndrome; metabolic benefits of bariatric surgery

Natal van Riel (Speaker)
2 Mar 2018

Activity: Talk or presentation typesInvited talkScientific

Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery

Natal van Riel (Speaker)
6 Jul 2018

Activity: Talk or presentation typesInvited talkScientific

A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass

L.C.P. Thijssen (Speaker), Natal van Riel (Member)
15 May 2018

Activity: Talk or presentation typesContributed talkScientific

Modeling of postprandial metabolic dynamics in human individuals

Natal van Riel (Organiser)
22 Jan 2018

Activity: Participating in or organising an event typesWorkshop, seminar, course or exhibitionScientific

Press / Media

RESOLVE Metabolic Syndrome

Natal van Riel

11/10/17

1 media contribution

Press/Media: Research

PANINI Public Engagement Event

Andrea Cabbia & Natal van Riel

29/01/17

1 media contribution

Press/Media: Public Engagement Activities

Syndromen modelleren

Natal van Riel

22/04/16

1 media contribution

Press/Media: Public Engagement Activities

The consistency of metabolism

Natal van Riel

14/12/15

1 media contribution

Press/Media: Public Engagement Activities

Student theses

A computational model for the drug treatment effects for the EGF pathway

Author: van Tienhoven, S., 31 Jan 2013

Supervisor: van Riel, N. (Supervisor 1) & Hilbers, P. (Supervisor 2)

Student thesis: Master

Added value of independent component analysis to identify epileptic networks

Author: Klooster, D., 31 Oct 2014

Supervisor: Hilbers, P. (Supervisor 1), van Riel, N. (Supervisor 2), Ossenblok, P. (External coach) & ten Eikelder, H. (External coach)

Student thesis: Master

A hybrid systems approach to identification of nonlinear biochemical processes

Author: Lindenaar, D., 28 Feb 2006

Supervisor: Musters, M. (Supervisor 1), van Riel, N. (Supervisor 2) & van den Bosch, P. (Supervisor 2)

Student thesis: Master

File

Algorithms for estimation of model errors and uncertainties arising in black box system identification

Author: van Riel, N., 31 Oct 1995

Supervisor: van den Bosch, P. (Supervisor 1)

Student thesis: Master

File

A mathematical model for platelet adhesion and activation: application to cerebral arteries

Author: Lourens, M., 31 Aug 2007

Supervisor: van de Vosse, F. (Supervisor 1), Nicolaij, K. (Supervisor 2), Bovendeerd, P. (Supervisor 2), Huyghe, J. (Supervisor 2) & van Riel, N. (Supervisor 2)

Student thesis: Master