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Research profile
Natal van Riel is Professor of Biomedical Systems Biology at the department of Biomedical Engineering (research group Computational Biology) at Eindhoven University of Technology, where he leads the Systems Biology and Metabolic Diseases research program. He is also part-time Professor of Computational Modelling at Amsterdam University Medical Centers (location AMC, University of Amsterdam's Faculty of Medicine). His research focuses on modelling of metabolic networks and physiology, machine learning for parameter estimation, methods for analysis of dynamic models, and applications in Metabolic Syndrome and associated diseases such as Type 2 Diabetes.
The role of bile acids in the complex interaction between gut microbiome and metabolic health is currently an important research focus in his group (e.g. in the RESOLVE project in collaboration with Amsterdam UMC). Within the NWO program ‘Complexity in Health and Nutrition’, Natal van Riel also focuses on modelling the digestion and metabolism of nutrients in the project ‘Metabolic adaptation, transitions and resilience in overweight individuals’. In cooperation with the Catharina hospital in Eindhoven he has developed the Metabolic Health Index (MHI) to quantify the benefit of bariatric surgery to resolve metabolic diseases (type 2 diabetes, dyslipidemia), which is a second important outcome of the surgical treatment in addition to weight reduction. He develops metabolic 'digital twins' of human individuals to enable predictive, preventive, personalized, and participatory medicine. In the DiaGame project digital twins are developed to empower patients with diabetes in self-management of their disease.
Academic background
Natal van Riel studied Electrical Engineering at Eindhoven University of Technology (TU/e, The Netherlands) where he was trained in system identification and control engineering. After receiving his MSc degree in 1995, he started PhD research in the Biotechnology group of Unilever Research Vlaardingen (The Netherlands) under supervision of Prof. Theo Verrips, on integrating computational modelling and experiments to study cell metabolism. In 2000, he obtained his PhD from Utrecht University (The Netherlands). From 2000 to 2003, he worked in the department of Electrical Engineering of TU/e, investigating the application of system and control theory to understand biological processes. In 2003, he was appointed as Assistant Professor in the department of Biomedical Engineering at TU/e where he initiated Systems Biology research. This was expanded when he joined the group of Prof. Peter Hilbers in 2006, to lead the Computational Systems Biology research program, investigating complex, multi-factorial diseases. In 2014, Natal van Riel was appointed Associate Professor of Systems Biology and Metabolic Diseases. In that same year he was a visiting scholar of the department of Bioengineering at the University of California San Diego (UCSD) in the group of Prof. Bernhard Palsson. In 2015, he was appointed part-time Professor of Computational Modelling at the Academic Medical Center AMC (University of Amsterdam). In 2019, he was appointed full Professor of Biomedical Systems Biology at TU/e.
Quote
In the past decade Systems Biology has become an established methodology for integrative and quantitative life science research. It is our goal to translate Systems Biology to biomedical and medical research and education to understand, cure and prevent diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Professor Computational Modelling, Academic Medical Centre Amsterdam
Nov 2015 → …
Associate member of the Maastricht Centre for Systems Biology (MaCSBio), Maastricht University
2015 → …
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Projects
- 1 Active
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NWO/Complexity/MATRyOSka
van Riel, N. A. W., O'Donovan, S., Arts, I. C. W. & Afman, L.
1/10/17 → 31/12/22
Project: Research direct
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Accuracy of vital parameters measured by a wearable patch following major abdominal cancer surgery
van der Stam, J. A., Mestrom, E. H. J., Scheerhoorn, J., Jacobs, F., de Hingh, I. H. J. T., van Riel, N. A. W., Boer, A-K., Scharnhorst, V., Nienhuijs, S. W. & Bouwman, R. A., Apr 2022, In: European Journal of Surgical Oncology. 48, 4, p. 917-923 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
A Markov model for inferring event types on diabetes patients data
Ferreira de Carvalho, D., Kaymak, U., Van Gorp, P. & van Riel, N., 1 Nov 2022, In: Healthcare Analytics. 2, 10 p., 100024.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
Fecal microbiota transplantation as tool to study the interrelation between microbiota composition and miRNA expression
Wortelboer, K., Bakker, G. J., Winkelmeijer, M., van Riel, N., Levin, E., Nieuwdorp, M., Herrema, H. & Davids, M., 1 Apr 2022, In: Microbiological Research. 257, 7 p., 126972.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Downloads (Pure) -
Kinetic Modeling of Saccharomyces cerevisiae Central Carbon Metabolism: Achievements, Limitations, and Opportunities
Lao-Martil, D., Verhagen, K. J. A., Schmitz, J. P. J., Teusink, B., Wahl, S. A. & van Riel, N. A. W., 13 Jan 2022, In: Metabolites. 12, 1, 23 p., 74.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile1 Citation (Scopus)8 Downloads (Pure) -
Left atrial reservoir strain as a predictor of cardiac outcome in patients with heart failure: the HaFaC cohort study
Bouwmeester, S., van der Stam, J. A., van Loon, S. L. M., van Riel, N. A. W., Boer, A-K., Dekker, L. R., Scharnhorst, V. & Houthuizen, P., 14 Mar 2022, In: BMC Cardiovascular Disorders. 22, 1, 10 p., 104.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure)
Prizes
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AMC Principal Investigator
van Riel, Natal A.W. (Recipient), 1 May 2016
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
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COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE)
van Riel, Natal A.W. (Recipient), 1 Dec 2014
Prize: Other › Discipline related › Scientific
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Koninklijke Onderscheiding; Lid in de Orde van Oranje-Nassau/ Recipient of Dutch Royal Order of Chivalry, Order of Orange-Nassau
van Riel, Natal A.W. (Recipient), 27 Mar 2014
Prize: Other › Career, activity or publication related prizes (lifetime, best paper, poster etc.) › Scientific
Activities
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Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery
Natal van Riel (Speaker)
6 Jul 2018Activity: Talk or presentation types › Invited talk › Scientific
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A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass
L.C.P. Thijssen (Speaker) & Natal van Riel (Member)
15 May 2018Activity: Talk or presentation types › Contributed talk › Scientific
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4th Dutch Bioinformatics & Systems Biology Conference
Natal van Riel (Organiser)
15 May 2018 → 16 May 2018Activity: Participating in or organising an event types › Conference › Scientific
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Systems Medicine of Metabolic Syndrome; metabolic benefits of bariatric surgery
Natal van Riel (Speaker)
2 Mar 2018Activity: Talk or presentation types › Invited talk › Scientific
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Modeling of postprandial metabolic dynamics in human individuals
Natal van Riel (Organiser)
22 Jan 2018Activity: Participating in or organising an event types › Workshop, seminar, course or exhibition › Scientific
Courses
Press / Media
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Digital copy of your body could determine success of bariatric surgery
23/06/20
1 item of Media coverage
Press/Media: Expert Comment
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-Eindhoven University of Technology: Digital copy of your body allows treatments to be tried out; Natal van Riel builds simplified digital twin of your metabolic system
18/06/20
1 item of Media coverage
Press/Media: Expert Comment
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Eindhoven University of Technology: Digital Copy of Your Body Allows Treatments to Be Tried Out
18/06/20
2 items of Media coverage
Press/Media: Expert Comment
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Virtual Patients Help Improve Blue Light Treatment for Psoriasis
Natal A.W. van Riel & Peter A.J. Hilbers
13/08/19
1 item of Media coverage
Press/Media: Expert Comment
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Mary Ann Liebert Inc.: Virtual Patients and in Silico Clinical Studies Can Improve Blue Light Treatment for Psoriasis
Natal A.W. van Riel & Peter A.J. Hilbers
8/08/19
1 item of Media coverage
Press/Media: Expert Comment
Thesis
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Algorithms for estimation of model errors and uncertainties arising in black box system identification
Author: van Riel, N. A. W., 31 Oct 1995Supervisor: van den Bosch, P. P. J. (Supervisor 1)
Student thesis: Master
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