Research Output per year
Personal profile
Quote
"Molecular biosensors for continuous patient monitoring will help to make healthcare truly personal"
Research profile
With his research group, Menno Prins aims at the development of technologies to detect proteins and study protein function with single-molecule resolution in complex macromolecular environments such as blood plasma. This entails the investigation of biophysical manipulation and detection methods with emphasis on the use of small particles. These particles offer the possibility to actively transport biological materials and to detect the presence and properties of specific targets.
The capability to probe individual molecules enables the researchers to reveal novel characteristics of the molecules, e.g. distributions of molecular properties (such as affinity or kinetic parameters, variations in space and/or in time). Moreover, it allows the study of properties that are difficult or even impossible to measure on ensembles of molecules, e.g. molecular torsion constants. The research of the MBx group leads to novel biosensing technologies and to a better understanding of molecular functions within complex and crowded environments.
Menno Prins is the founder and organizer of SensUs, the annual international student competition in the field of bioensors for health (www.sensus.org). SensUs serves as a platform to accelerate education and innovation in the field of biosensing, with participation of international academic research groups, companies, and healthcare organizations.
The research activities are part of the Institute for Complex Molecular Systems (ICMS) and the Strategic Area Health (SA Health).
Academic background
Menno Prins studied Applied Physics at Université Paris XI and Delft University of Technology where he obtained his MSc degree cum laude. He received his PhD from Radboud University Nijmegen in 1995. He then moved to Philips Research where he worked on microfluidics and point-of-care biosensing. In 2005, he was appointed as part-time professor at Eindhoven University of Technology in the department of Applied Physics. In 2014, he was appointed full Professor in Molecular Biosensing for Medical Diagnostics in the departments of BioMedical Engineering and Applied Physics.
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Research Output
Multiplexed continuous biosensing by single-molecule encoded nanoswitches
Lubken, R. M., de Jong, A. M. & Prins, M. W. J., 12 Mar 2020, In : Nano Letters.Research output: Contribution to journal › Article › Academic › peer-review
Conformation switching of single native proteins revealed by nanomechanical probing without a pulling force
Gutierrez Mejia, F. A., Moerland, C., van Ijzendoorn, L. & Prins, M., 14 Nov 2019, In : Nanoscale. 11, 42, p. 19933-19942 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Rate of dimer formation in stable colloidal solutions quantified using an attractive interparticle force
Scheepers, M. R. W., Romijn, A. R., van Ijzendoorn, L. J. & Prins, M. W. J., 13 Aug 2019, In : Langmuir. 35, 32, p. 10533-10541 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
1
Citation
(Scopus)
17
Downloads
(Pure)
Rotating magnetic particles for lab-on-chip applications-a comprehensive review
Moerland, C. P., van IJzendoorn, L. J. & Prins, M. W. J., 21 Mar 2019, In : Lab on a Chip. 19, 6, p. 919-933 15 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access
File
6
Citations
(Scopus)
33
Downloads
(Pure)
Single-dimer formation rate reveals heterogeneous particle surface reactivity
Scheepers, M. R. W., van IJzendoorn, L. J. & Prins, M. W. J., 13 Oct 2019, In : Langmuir. 35, 44, p. 14272-14281 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Activities
Lecture during Summer School UAB, Barcelona, Spain
Menno W.J. Prins (Invited speaker)30 Jun 2014
Activity: Talk or presentation types › Invited talk › Scientific
Physics@FOM Veldhoven 2013, January 22-23, 2013, Veldhoven, The Netherlands
Menno W.J. Prins (Invited speaker)22 Jan 2013
Activity: Talk or presentation types › Invited talk › Scientific
International Symposium Technologies for Diagnostics, 22 October 2012, Uppsala, Sweden
Menno W.J. Prins (Invited speaker)22 Oct 2012
Activity: Talk or presentation types › Invited talk › Scientific
Symposium Bossche Chemische Kring, 8 Mei 2012, Den Bosch, Nederland, 's-Hertogenbosch
Menno W.J. Prins (Speaker)8 May 2012
Activity: Talk or presentation types › Contributed talk › Scientific
Workshop ITN (International Training Network) BioMaX, 13 February 2012, Eindhoven, The Netherlands
Menno W.J. Prins (Speaker)13 Feb 2012
Activity: Talk or presentation types › Contributed talk › Scientific
Courses
Press / Media
Eindhoven University of Technology: Wanted - Best Sensor to Measure Medication for Rheumatism
31/08/19
1 item of Media coverage
Press/Media: Expert Comment
-Eindhoven University of Technology; 'Measuring the exact dosage of medicine can save lives'
6/06/19
1 item of Media coverage
Press/Media: Expert Comment
New sensor technology enables super-sensitive live monitoring of human biomolecules
Menno W.J. Prins & Emiel W.A. Visser
29/06/18
4 items of Media coverage
Press/Media: Expert Comment
Final programme published for Sensors in Medicine 2016
25/10/16
1 item of Media coverage
Press/Media: Expert Comment
Student theses
Achromatic beam focusing with magnetic lenses
Author: Reints, H., 31 May 1984Supervisor: Hagedoorn, H. (Supervisor 1) & Prins, M. (Supervisor 2)
Student thesis: Master
File
Airless two-liquid system for dynamic beam attenuation : orientation dependence and switching lifetime
Author: Damen, D., 28 Feb 2001Supervisor: Wolter, J. (Supervisor 1) & Prins, M. (External coach)
Student thesis: Master
File
A magnetic bead actuator: design and experimental analysis of a sub-microliter actuation device for superparamagnetic beads applicable on biosensing
Author: Derks, R., 2005Supervisor: Prins, M. (Supervisor 1) & Wimberger-Friedl, R. (External person) (External coach)
Student thesis: Master
Continuous monitoring of C-reactive protein by particle mobility sensing with single-molecule resolution
Author: Buskermolen, A., 31 Oct 2019Supervisor: Merkx, M. (Supervisor 1), Prins, M. (Supervisor 2) & Yan, J. (Supervisor 2)
Student thesis: Master
Detection of superparamagnetic nanobeads with GMR technology for biosensor applications
Author: Verheyden, K., 30 Jun 2003Supervisor: Prins, M. (Supervisor 1) & Coehoorn, R. (Supervisor 2)
Student thesis: Master
File