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"Molecular biosensors for continuous patient monitoring will help to make healthcare truly personal"

Research profile

With his research group, Menno Prins aims at the development of technologies to detect proteins and study protein function with single-molecule resolution in complex macromolecular environments such as blood plasma. This entails the investigation of biophysical manipulation and detection methods with emphasis on the use of small particles. These particles offer the possibility to actively transport biological materials and to detect the presence and properties of specific targets. 

The capability to probe individual molecules enables the researchers to reveal novel characteristics of the molecules, e.g. distributions of molecular properties (such as affinity or kinetic parameters, variations in space and/or in time). Moreover, it allows the study of properties that are difficult or even impossible to measure on ensembles of molecules, e.g. molecular torsion constants. The research of the MBx group leads to novel biosensing technologies and to a better understanding of molecular functions within complex and crowded environments.

Menno Prins is the founder and organizer of SensUs, the annual international student competition in the field of bioensors for health (www.sensus.org). SensUs serves as a platform to accelerate education and innovation in the field of biosensing, with participation of international academic research groups, companies, and healthcare organizations.

The research activities are part of the Institute for Complex Molecular Systems (ICMS) and the Strategic Area Health (SA Health).

Academic background

Menno Prins studied Applied Physics at Université Paris XI and Delft University of Technology where he obtained his MSc degree cum laude. He received his PhD from Radboud University Nijmegen in 1995. He then moved to Philips Research where he worked on microfluidics and point-of-care biosensing. In 2005, he was appointed as part-time professor at Eindhoven University of Technology in the department of Applied Physics. In 2014, he was appointed full Professor in Molecular Biosensing for Medical Diagnostics in the departments of BioMedical Engineering and Applied Physics. 

Fingerprint Dive into the research topics where Menno W.J. Prins is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Assays Chemical Compounds
Biosensors Engineering & Materials Science
bioinstrumentation Physics & Astronomy
actuation Physics & Astronomy
biomarkers Physics & Astronomy
Fluids Engineering & Materials Science
Nanoparticles Engineering & Materials Science
fluids Physics & Astronomy

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1989 2019

4 Downloads (Pure)

Conformation switching of single native proteins revealed by nanomechanical probing without a pulling force

Gutierrez Mejia, F. A., Moerland, C., van Ijzendoorn, L. & Prins, M., 24 Sep 2019, In : Nanoscale. 11, 42, p. 19933-19942 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Conformations
Proteins
Calcium
Antibodies
Troponin
1 Citation (Scopus)
7 Downloads (Pure)

Rate of dimer formation in stable colloidal solutions quantified using an attractive interparticle force

Scheepers, M. R. W., Romijn, A. R., van Ijzendoorn, L. J. & Prins, M. W. J., 13 Aug 2019, In : Langmuir. 35, 32, p. 10533-10541 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Dimers
dimers
Agglomeration
Chemical reactivity
Particle interactions
2 Citations (Scopus)
25 Downloads (Pure)

Rotating magnetic particles for lab-on-chip applications-a comprehensive review

Moerland, C. P., van IJzendoorn, L. J. & Prins, M. W. J., 1 Jan 2019, In : Lab on a Chip. 19, 6, p. 919-933 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Magnetic Fields
Magnetic fields
Torque
Molecules
Biomolecules
3 Downloads (Pure)

Single-dimer formation rate reveals heterogeneous particle surface reactivity

Scheepers, M. R. W., van IJzendoorn, L. J. & Prins, M. W. J., 13 Oct 2019, In : Langmuir. 35, 44, p. 14272-14281 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Dimers
Agglomeration
reactivity
dimers
Antibodies
6 Citations (Scopus)
65 Downloads (Pure)

Continuous biomarker monitoring by particle mobility sensing with single molecule resolution

Visser, E. W. A., Yan, J., van IJzendoorn, L. J. & Prins, M. W. J., 1 Dec 2018, In : Nature Communications. 9, 1, 10 p., 2541.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
biomarkers
Biomarkers
Technology
Molecules
Monitoring

Activities 2011 2014

  • 5 Contributed talk
  • 3 Invited talk

Lecture during Summer School UAB, Barcelona, Spain

Menno W.J. Prins (Invited speaker)
30 Jun 2014

Activity: Talk or presentation typesInvited talkScientific

Physics@FOM Veldhoven 2013, January 22-23, 2013, Veldhoven, The Netherlands

Menno W.J. Prins (Invited speaker)
22 Jan 2013

Activity: Talk or presentation typesInvited talkScientific

International Symposium Technologies for Diagnostics, 22 October 2012, Uppsala, Sweden

Menno W.J. Prins (Invited speaker)
22 Oct 2012

Activity: Talk or presentation typesInvited talkScientific

Symposium Bossche Chemische Kring, 8 Mei 2012, Den Bosch, Nederland, 's-Hertogenbosch

Menno W.J. Prins (Speaker)
8 May 2012

Activity: Talk or presentation typesContributed talkScientific

Workshop ITN (International Training Network) BioMaX, 13 February 2012, Eindhoven, The Netherlands

Menno W.J. Prins (Speaker)
13 Feb 2012

Activity: Talk or presentation typesContributed talkScientific

Courses

DBL Biosensor for the skin

1/09/14 → …

Course

Electromagnetism and optics

1/09/13 → …

Course

Molecular biosensing

1/09/15 → …

Course

Press / Media

Final programme published for Sensors in Medicine 2016

Menno W.J. Prins

25/10/16

1 item of Media coverage

Press/Media: Expert Comment

Biology becomes digital

Menno W.J. Prins

1/01/14

1 Media contribution

Press/Media: Public Engagement Activities

Student theses

Achromatic beam focusing with magnetic lenses

Author: Reints, H., 31 May 1984

Supervisor: Hagedoorn, H. (Supervisor 1) & Prins, M. (Supervisor 2)

Student thesis: Master

File

Airless two-liquid system for dynamic beam attenuation : orientation dependence and switching lifetime

Author: Damen, D., 28 Feb 2001

Supervisor: Wolter, J. (Supervisor 1) & Prins, M. (External coach)

Student thesis: Master

File

A magnetic bead actuator: design and experimental analysis of a sub-microliter actuation device for superparamagnetic beads applicable on biosensing

Author: Derks, R., 2005

Supervisor: Prins, M. (Supervisor 1) & Wimberger-Friedl, R. (External person) (External coach)

Student thesis: Master

Continuous monitoring of C-reactive protein by particle mobility sensing with single-molecule resolution

Author: Buskermolen, A., 31 Oct 2019

Supervisor: Merkx, M. (Supervisor 1), Prins, M. (Supervisor 2) & Yan, J. (Supervisor 2)

Student thesis: Master

Detection of superparamagnetic nanobeads with GMR technology for biosensor applications

Author: Verheyden, K., 30 Jun 2003

Supervisor: Prins, M. (Supervisor 1) & Coehoorn, R. (Supervisor 2)

Student thesis: Master

File