• 3704 Citations
1989 …2020

Research output per year

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Personal profile

Quote

"Molecular biosensors for continuous patient monitoring will help to make healthcare truly personal"

Research profile

With his research group, Menno Prins aims at the development of technologies to detect proteins and study protein function with single-molecule resolution in complex macromolecular environments such as blood plasma. This entails the investigation of biophysical manipulation and detection methods with emphasis on the use of small particles. These particles offer the possibility to actively transport biological materials and to detect the presence and properties of specific targets. 

The capability to probe individual molecules enables the researchers to reveal novel characteristics of the molecules, e.g. distributions of molecular properties (such as affinity or kinetic parameters, variations in space and/or in time). Moreover, it allows the study of properties that are difficult or even impossible to measure on ensembles of molecules, e.g. molecular torsion constants. The research of the MBx group leads to novel biosensing technologies and to a better understanding of molecular functions within complex and crowded environments.

Menno Prins is the founder and organizer of SensUs, the annual international student competition in the field of bioensors for health (www.sensus.org). SensUs serves as a platform to accelerate education and innovation in the field of biosensing, with participation of international academic research groups, companies, and healthcare organizations.

The research activities are part of the Institute for Complex Molecular Systems (ICMS) and the Strategic Area Health (SA Health).

Academic background

Menno Prins studied Applied Physics at Université Paris XI and Delft University of Technology where he obtained his MSc degree cum laude. He received his PhD from Radboud University Nijmegen in 1995. He then moved to Philips Research where he worked on microfluidics and point-of-care biosensing. In 2005, he was appointed as part-time professor at Eindhoven University of Technology in the department of Applied Physics. In 2014, he was appointed full Professor in Molecular Biosensing for Medical Diagnostics in the departments of BioMedical Engineering and Applied Physics. 

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Research Output

Multiplexed continuous biosensing by single-molecule encoded nanoswitches

Lubken, R. M., de Jong, A. M. & Prins, M. W. J., 12 Mar 2020, In : Nano Letters.

Research output: Contribution to journalArticleAcademicpeer-review

  • 36 Downloads (Pure)

    Conformation switching of single native proteins revealed by nanomechanical probing without a pulling force

    Gutierrez Mejia, F. A., Moerland, C., van Ijzendoorn, L. & Prins, M., 14 Nov 2019, In : Nanoscale. 11, 42, p. 19933-19942 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 14 Downloads (Pure)

    Rate of dimer formation in stable colloidal solutions quantified using an attractive interparticle force

    Scheepers, M. R. W., Romijn, A. R., van Ijzendoorn, L. J. & Prins, M. W. J., 13 Aug 2019, In : Langmuir. 35, 32, p. 10533-10541 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 1 Citation (Scopus)
    17 Downloads (Pure)

    Rotating magnetic particles for lab-on-chip applications-a comprehensive review

    Moerland, C. P., van IJzendoorn, L. J. & Prins, M. W. J., 21 Mar 2019, In : Lab on a Chip. 19, 6, p. 919-933 15 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
    File
  • 6 Citations (Scopus)
    33 Downloads (Pure)

    Single-dimer formation rate reveals heterogeneous particle surface reactivity

    Scheepers, M. R. W., van IJzendoorn, L. J. & Prins, M. W. J., 13 Oct 2019, In : Langmuir. 35, 44, p. 14272-14281 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 11 Downloads (Pure)

    Activities

    • 5 Contributed talk
    • 3 Invited talk

    Lecture during Summer School UAB, Barcelona, Spain

    Menno W.J. Prins (Invited speaker)
    30 Jun 2014

    Activity: Talk or presentation typesInvited talkScientific

    Physics@FOM Veldhoven 2013, January 22-23, 2013, Veldhoven, The Netherlands

    Menno W.J. Prins (Invited speaker)
    22 Jan 2013

    Activity: Talk or presentation typesInvited talkScientific

    International Symposium Technologies for Diagnostics, 22 October 2012, Uppsala, Sweden

    Menno W.J. Prins (Invited speaker)
    22 Oct 2012

    Activity: Talk or presentation typesInvited talkScientific

    Symposium Bossche Chemische Kring, 8 Mei 2012, Den Bosch, Nederland, 's-Hertogenbosch

    Menno W.J. Prins (Speaker)
    8 May 2012

    Activity: Talk or presentation typesContributed talkScientific

    Workshop ITN (International Training Network) BioMaX, 13 February 2012, Eindhoven, The Netherlands

    Menno W.J. Prins (Speaker)
    13 Feb 2012

    Activity: Talk or presentation typesContributed talkScientific

    Courses

    DBL Biosensor for the skin

    1/09/14 → …

    Course

    Electromagnetism and optics

    1/09/13 → …

    Course

    Molecular biosensing

    1/09/15 → …

    Course

    Press / Media

    Final programme published for Sensors in Medicine 2016

    Menno W.J. Prins

    25/10/16

    1 item of Media coverage

    Press/Media: Expert Comment

    Biology becomes digital

    Menno W.J. Prins

    1/01/14

    1 Media contribution

    Press/Media: Public Engagement Activities

    Student theses

    Achromatic beam focusing with magnetic lenses

    Author: Reints, H., 31 May 1984

    Supervisor: Hagedoorn, H. (Supervisor 1) & Prins, M. (Supervisor 2)

    Student thesis: Master

    File

    Airless two-liquid system for dynamic beam attenuation : orientation dependence and switching lifetime

    Author: Damen, D., 28 Feb 2001

    Supervisor: Wolter, J. (Supervisor 1) & Prins, M. (External coach)

    Student thesis: Master

    File

    A magnetic bead actuator: design and experimental analysis of a sub-microliter actuation device for superparamagnetic beads applicable on biosensing

    Author: Derks, R., 2005

    Supervisor: Prins, M. (Supervisor 1) & Wimberger-Friedl, R. (External person) (External coach)

    Student thesis: Master

    Continuous monitoring of C-reactive protein by particle mobility sensing with single-molecule resolution

    Author: Buskermolen, A., 31 Oct 2019

    Supervisor: Merkx, M. (Supervisor 1), Prins, M. (Supervisor 2) & Yan, J. (Supervisor 2)

    Student thesis: Master

    Detection of superparamagnetic nanobeads with GMR technology for biosensor applications

    Author: Verheyden, K., 30 Jun 2003

    Supervisor: Prins, M. (Supervisor 1) & Coehoorn, R. (Supervisor 2)

    Student thesis: Master

    File