• 13 Citations
20182020

Research output per year

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Personal profile

Research profile

Madita Wolter (1991) received her bachelor’s degree in Biology from the University of Bayreuth (Germany) in 2013. During her graduate studies she focused on molecular biology and biochemistry and graduated in 2015. As part of her master’s program she spent three months at the department of biology at the University of York (United Kingdom) in the group led by Dr. Sangeeta Chawla where she worked on gene expression patterns in mouse and rat brains. Madita submitted her master thesis at the institute of cell biology at the University of Bayreuth. The main part of her thesis was a screen on genetic interaction partners in baker’s yeast extending our knowledge of the inheritance of mitochondria. After her graduation she worked as a scientific assistant at the Heinrich-Heine-University Düsseldorf, Germany for eight months.

In September 2016 she started working as a PhD candidate in the group of dr. Christian Ottmann and prof. dr. ir. Luc Brunsveld as part of the TASPPI (Targeted Stabilization of Protein-Protein Interactions) project.  The project’s aim is to discover new drugs through the stabilization of specific protein-protein interactions. Since the 14-3-3 proteins are involved in a huge variety of diseases from small infections to severe metabolic diseases and are highly abundant in human cells, she will concentrate on this protein family. Therefore she will explore the interface of 14-3-3 proteins and their interaction partners and identify small molecules which stabilize this interface. Additionally to the biophysical and structural analysis, these compounds will be tested in cell culture to explore their potential as drugs.

 

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Research Output

  • 13 Citations
  • 5 Article

Interaction of an IκBα Peptide with 14-3-3

Wolter, M., Santo, D. L., Herman, P., Ballone, A., Centorrino, F., Obsil, T. & Ottmann, C., 6 Mar 2020, In : ACS Omega. 5, 10, p. 5380-5388 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
  • AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

    Saline, M., Badertscher, L., Wolter, M., Lau, R., Gunnarsson, A., Jacso, T., Norris, T., Ottmann, C. & Snijder, A., 30 Aug 2019, In : Journal of Biological Chemistry. 294, 35, p. 13106-13116 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • 3 Citations (Scopus)

    Biophysical and structural insight into the USP8/14-3-3 interaction

    Centorrino, F., Ballone, A., Wolter, M. & Ottmann, C., Apr 2018, In : FEBS Letters. 592, 7, p. 1211-1220 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 4 Citations (Scopus)
    50 Downloads (Pure)

    Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex

    Ballone, A., Centorrino, F., Wolter, M. & Ottmann, C., 1 Aug 2018, In : Data in Brief. 19, p. 1683-1687 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 1 Citation (Scopus)
    41 Downloads (Pure)

    Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1)

    Ballone, A., Centorrino, F., Wolter, M. & Ottmann, C., 1 Jun 2018, In : Journal of Structural Biology. 202, 3, p. 210-215 6 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 5 Citations (Scopus)
    32 Downloads (Pure)

    Student theses

    Stabilization of the 14-3-3 YAP/TAZ interaction by small-molecules

    Author: Genet, S., 30 Aug 2018

    Supervisor: Brunsveld, L. (Supervisor 1), Wolter, M. (Supervisor 2), Guillory, X. (Supervisor 2) & Ottmann, C. (Supervisor 2)

    Student thesis: Master