• 10 Citations
20182019
If you made any changes in Pure these will be visible here soon.

Personal profile

Research profile

Madita Wolter (1991) received her bachelor’s degree in Biology from the University of Bayreuth (Germany) in 2013. During her graduate studies she focused on molecular biology and biochemistry and graduated in 2015. As part of her master’s program she spent three months at the department of biology at the University of York (United Kingdom) in the group led by Dr. Sangeeta Chawla where she worked on gene expression patterns in mouse and rat brains. Madita submitted her master thesis at the institute of cell biology at the University of Bayreuth. The main part of her thesis was a screen on genetic interaction partners in baker’s yeast extending our knowledge of the inheritance of mitochondria. After her graduation she worked as a scientific assistant at the Heinrich-Heine-University Düsseldorf, Germany for eight months.

In September 2016 she started working as a PhD candidate in the group of dr. Christian Ottmann and prof. dr. ir. Luc Brunsveld as part of the TASPPI (Targeted Stabilization of Protein-Protein Interactions) project.  The project’s aim is to discover new drugs through the stabilization of specific protein-protein interactions. Since the 14-3-3 proteins are involved in a huge variety of diseases from small infections to severe metabolic diseases and are highly abundant in human cells, she will concentrate on this protein family. Therefore she will explore the interface of 14-3-3 proteins and their interaction partners and identify small molecules which stabilize this interface. Additionally to the biophysical and structural analysis, these compounds will be tested in cell culture to explore their potential as drugs.

 

Fingerprint Dive into the research topics where Madita Wolter is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
SOS1 Protein Medicine & Life Sciences
14-3-3 Proteins Medicine & Life Sciences
Ubiquitin-Specific Proteases Medicine & Life Sciences
Phosphorylation Chemical Compounds
AMP-Activated Protein Kinases Medicine & Life Sciences
X Ray Crystallography Medicine & Life Sciences
Protein Kinases Medicine & Life Sciences
Proteins Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2018 2019

  • 10 Citations
  • 4 Article
1 Citation (Scopus)

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Saline, M., Badertscher, L., Wolter, M., Lau, R., Gunnarsson, A., Jacso, T., Norris, T., Ottmann, C. & Snijder, A., 30 Aug 2019, In : Journal of Biological Chemistry. 294, 35, p. 13106-13116 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
Phosphorylation
AMP-Activated Protein Kinases
Protein Kinases
Transcription Factors
3 Citations (Scopus)
48 Downloads (Pure)

Biophysical and structural insight into the USP8/14-3-3 interaction

Centorrino, F., Ballone, A., Wolter, M. & Ottmann, C., 2 Mar 2018, In : FEBS Letters. 592, 7, p. 1211-1220 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ubiquitin-Specific Proteases
Epidermal Growth Factor Receptor
Pituitary ACTH Hypersecretion
14-3-3 Proteins
Calorimetry
1 Citation (Scopus)
38 Downloads (Pure)

Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex

Ballone, A., Centorrino, F., Wolter, M. & Ottmann, C., 1 Aug 2018, In : Data in Brief. 19, p. 1683-1687 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
SOS1 Protein
X Ray Crystallography
14-3-3 Proteins
Crystallization
Pancreatic Neoplasms
5 Citations (Scopus)
25 Downloads (Pure)

Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1)

Ballone, A., Centorrino, F., Wolter, M. & Ottmann, C., 1 Jun 2018, In : Journal of Structural Biology. 202, 3, p. 210-215

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
SOS1 Protein
Proteins
14-3-3 Proteins
Cell Differentiation
Cell Proliferation

Student theses

Stabilization of the 14-3-3 YAP/TAZ interaction by small-molecules

Author: Genet, S., 30 Aug 2018

Supervisor: Brunsveld, L. (Supervisor 1), Wolter, M. (Supervisor 2), Guillory, X. (Supervisor 2) & Ottmann, C. (Supervisor 2)

Student thesis: Master