• 10714 Citations

Research output per year

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Personal profile


"Addressing biomedical challenges via bottom-up chemical approaches provides a unique training ground and offers fantastic opportunities for interdisciplinary science."

Research profile

Luc Brunsveld is professor of Chemical Biology at the department of Biomedical Engineering. His research interests are focused on chemical biology approaches studying protein-protein interactions, particularly drug discovery and supramolecular signalling systems. Combining synthetic and supramolecular chemistry with chemical biology allows exact molecular modulation of biological systems. Since 2011 the Chemical Biology group has been embedded in the interdepartmental Institute of Complex Molecular Systems (ICMS) and the NWO Gravity Research Center for Functional Molecular Systems. The group has developed a strong expertise in organic synthesis, peptide and protein chemistry, chemical biology, and supramolecular chemistry, enabling the development of new molecules and materials to study, engineer, and modulate protein-protein interactions. The realization of a synthetic cell and novel drugs via the modulation of protein-protein interactions are high on the group's wish list.

Academic background

Luc Brunsveld studied Chemistry and Chemical Engineering at the Technische Universiteit Eindhoven (TU/e, The Netherlands) and Osaka University (Japan). After obtaining his Master's degree in 1997 he performed his PhD research at TU/e and the University of Illinois at Urbana-Champaign (USA) in the field of supramolecular chemistry, under supervision of Prof. E.W. (Bert) Meijer. In 2001, he obtained his doctorate cum laude. From 2001-2003, he was a postdoctoral fellow with Prof. Herbert Waldmann at the Max-Planck Institute of Molecular Physiology (MPI, Dortmund, Germany) working on protein semi-synthesis. From 2003-2004, he was group leader in medicinal chemistry at Organon (Oss, the Netherlands, now Merck). In 2005, he started a research group at MPI in Dortmund working on supramolecular chemical biology, and subsequently also became group leader at the Chemical Genomics Centre of the Max Planck Society, working on Nuclear Receptor protein interactions. In 2008, he moved to TU/e where he was appointed Full Professor of Chemical Biology in the Department of Biomedical Engineering. Brunsveld has received numerous appealing grants, among which ERC Starting and Proof of Concept grants (2008 and 2010, respectively) and the NWO Vici grant (2015). He was awarded the NVBMB Award of the Dutch Society for Biochemistry and Molecular Biology in 2010 and the Gold Medal of the Royal Netherlands Chemical Society KNCV in 2013.

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Research Output

Conjugated protein domains as engineered scaffold proteins

Lemmens, L., Ottmann, C. & Brunsveld, L., 17 Jun 2020, In : Bioconjugate Chemistry. 31, 6, p. 1596-1603 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt

    Leijten-van de Gevel, I. A. & Brunsveld, L., 3 Jul 2020, In : Journal of Biological Chemistry. 295, 27, p. 9183-9191 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Designed asymmetric protein assembly on a symmetric scaffold

    Lemmens, L. J. M., Roodhuizen, J. A. L., de Greef, T. F. A., Markvoort, A. J. & Brunsveld, L., 18 May 2020, In : Angewandte Chemie - International Edition. 59, 29, p. 12113-12121 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

    Magdalena Estirado, E., Rosier, B. J. H. M., de Greef, T. F. A. & Brunsveld, L., 28 May 2020, In : Chemical Communications. 56, 43, p. 5747-5750 4 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Elucidation of an allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

    de Vries, R. M. J. M., Doveston, R. G., Meijer, F. A. & Brunsveld, L., 3 Apr 2020, In : ChemMedChem : chemistry enabling drug discovery. 15, 7, p. 561-565 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 9 Downloads (Pure)


    Golden Medal Royal Dutch Chemical Society 2012

    Luc Brunsveld (Recipient), 2012

    Prize: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

    NWO Vici Award : Synthetic Supramolecular Signalling Systems

    L. Brunsveld (Recipient), 2014

    Prize: NWOViciScientific

  • Research Center for Functional Molecular Systems

    E.W. Meijer (Recipient), J.C.M. van Hest (Recipient), L. Brunsveld (Recipient), R.A.J. Janssen (Recipient) & R.P. Sijbesma (Recipient), 2013

    Prize: NWOGravitationScientific

  • Courses

    Biological physics

    1/09/12 → …


    Chemical biology



    Clinical Chemistry

    1/09/15 → …


    DBL Entering the lab

    1/09/13 → …


    Student theses

    ABCB1 variants in association with clopidogrel response

    Author: de Kock, R., 29 Sep 2016

    Supervisor: Brunsveld, L. (Supervisor 1), Hilbers, P. (Supervisor 2), Scharnhorst, V. (Supervisor 2) & Deiman, B. (External person) (External coach)

    Student thesis: Master

    Alternative modulation of nuclear receptor function

    Author: Hoek, N., 31 Mar 2014

    Supervisor: Milroy, L. (Supervisor 1), Scheepstra, M. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

    Student thesis: Master

    Characterization of the interaction between 14-3-3 and the R-domain of CFTR

    Author: van de Sande, M., 29 Mar 2018

    Supervisor: Stevers, L. (Supervisor 1) & Brunsveld, L. (Supervisor 2)

    Student thesis: Master

    Characterization of the interaction of 14-3-3 proteins and estrogen receptor alpha as a potential drug target

    Author: den Hamer, A., 30 Nov 2013

    Supervisor: de Vries - van Leeuwen, I. (External coach), Tharun, I. (Supervisor 1), Ottmann, C. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

    Student thesis: Master

    Chemical biological evaluation of the estrogen receptor F domain on folding and activity

    Author: Kurdi, M., 31 Jan 2009

    Supervisor: Phan, T. (External person) (Supervisor 1) & Brunsveld, L. (Supervisor 2)

    Student thesis: Master