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Personal profile


"Addressing biomedical challenges via bottom-up chemical approaches provides a unique training ground and offers fantastic opportunities for interdisciplinary science."

Research profile

Luc Brunsveld is professor of Chemical Biology at the department of Biomedical Engineering. His research interests are focused on chemical biology approaches studying protein-protein interactions, particularly drug discovery and supramolecular signalling systems. Combining synthetic and supramolecular chemistry with chemical biology allows exact molecular modulation of biological systems. Since 2011 the Chemical Biology group has been embedded in the interdepartmental Institute of Complex Molecular Systems (ICMS) and the NWO Gravity Research Center for Functional Molecular Systems. The group has developed a strong expertise in organic synthesis, peptide and protein chemistry, chemical biology, and supramolecular chemistry, enabling the development of new molecules and materials to study, engineer, and modulate protein-protein interactions. The realization of a synthetic cell and novel drugs via the modulation of protein-protein interactions are high on the group's wish list.

Academic background

Luc Brunsveld studied Chemistry and Chemical Engineering at the Technische Universiteit Eindhoven (TU/e, The Netherlands) and Osaka University (Japan). After obtaining his Master's degree in 1997 he performed his PhD research at TU/e and the University of Illinois at Urbana-Champaign (USA) in the field of supramolecular chemistry, under supervision of Prof. E.W. (Bert) Meijer. In 2001, he obtained his doctorate cum laude. From 2001-2003, he was a postdoctoral fellow with Prof. Herbert Waldmann at the Max-Planck Institute of Molecular Physiology (MPI, Dortmund, Germany) working on protein semi-synthesis. From 2003-2004, he was group leader in medicinal chemistry at Organon (Oss, the Netherlands, now Merck). In 2005, he started a research group at MPI in Dortmund working on supramolecular chemical biology, and subsequently also became group leader at the Chemical Genomics Centre of the Max Planck Society, working on Nuclear Receptor protein interactions. In 2008, he moved to TU/e where he was appointed Full Professor of Chemical Biology in the Department of Biomedical Engineering. Brunsveld has received numerous appealing grants, among which ERC Starting and Proof of Concept grants (2008 and 2010, respectively) and the NWO Vici grant (2015). He was awarded the NVBMB Award of the Dutch Society for Biochemistry and Molecular Biology in 2010 and the Gold Medal of the Royal Netherlands Chemical Society KNCV in 2013.

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  • 15 Similar Profiles
Proteins Chemical Compounds
14-3-3 Proteins Medicine & Life Sciences
Molecules Chemical Compounds
Peptides Chemical Compounds
Ligands Chemical Compounds
Scaffolds Chemical Compounds
Estrogen Receptors Medicine & Life Sciences
Polymers Chemical Compounds

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Research Output 1997 2020

6 Downloads (Pure)

Ligand-based design of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists

Meijer, F. A., Doveston, R. G., de Vries, R. M. J. M., Vos, G. M., Vos, A. A. A., Leysen, S., Scheepstra, M., Ottmann, C., Milroy, L-G. & Brunsveld, L., 9 Jan 2020, In : Journal of Medicinal Chemistry. 63, 1, p. 241-259 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Retinoic Acid Receptors
Cytoplasmic and Nuclear Receptors
4 Downloads (Pure)

Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome

Rosier, B., Markvoort, B., Gumi Audenis, B., Roodhuizen, J., den Hamer, A., Brunsveld, L. & de Greef, T. F. A., 6 Jan 2020, In : Nature Catalysis. 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Caspase 9
Protein Engineering
Multiprotein Complexes
5 Citations (Scopus)
109 Downloads (Pure)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 5 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Cytoplasmic and Nuclear Receptors
Allosteric Site
Drug Discovery
3 Downloads (Pure)

A study on the effect of synthetic α-to-β3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins

Andrei, S. A., Thijssen, V., Brunsveld, L., Ottmann, C. & Milroy, L-G., 5 Dec 2019, In : Chemical Communications. 55, 98, p. 14809-14812 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14-3-3 Proteins
Amino acids
Substitution reactions
1 Citation (Scopus)
45 Downloads (Pure)

Cooperativity basis for small-molecule stabilization of protein-protein interactions

de Vink, P. J., Andrei, S. A., Higuchi, Y., Ottmann, C., Milroy, L-G. & Brunsveld, L., 14 Mar 2019, In : Chemical Science. 10, 10, p. 2869-2874 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14-3-3 Proteins


Golden Medal Royal Dutch Chemical Society 2012

Luc Brunsveld (Recipient), 2012

Prize: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

NWO Vici Award : Synthetic Supramolecular Signalling Systems

L. Brunsveld (Recipient), 2014

Prize: NWOViciScientific


Research Center for Functional Molecular Systems

E.W. Meijer (Recipient), J.C.M. van Hest (Recipient), L. Brunsveld (Recipient), R.A.J. Janssen (Recipient) & R.P. Sijbesma (Recipient), 2013

Prize: NWOGravitationScientific

selection procedure
Ministry of Education
Supramolecular chemistry
Imaging techniques
Molecular imaging
Acoustic waves


Biological physics

1/09/12 → …


Chemical biology



Clinical Chemistry

1/09/15 → …


DBL Entering the lab

1/09/13 → …


Student theses

ABCB1 variants in association with clopidogrel response

Author: de Kock, R., 29 Sep 2016

Supervisor: Brunsveld, L. (Supervisor 1), Hilbers, P. (Supervisor 2), Scharnhorst, V. (Supervisor 2) & Deiman, B. (External person) (External coach)

Student thesis: Master

Alternative modulation of nuclear receptor function

Author: Hoek, N., 31 Mar 2014

Supervisor: Milroy, L. (Supervisor 1), Scheepstra, M. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Characterization of the interaction between 14-3-3 and the R-domain of CFTR

Author: van de Sande, M., 29 Mar 2018

Supervisor: Stevers, L. (Supervisor 1) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Characterization of the interaction of 14-3-3 proteins and estrogen receptor alpha as a potential drug target

Author: den Hamer, A., 30 Nov 2013

Supervisor: de Vries - van Leeuwen, I. (External coach), Tharun, I. (Supervisor 1), Ottmann, C. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Chemical biological evaluation of the estrogen receptor F domain on folding and activity

Author: Kurdi, M., 31 Jan 2009

Supervisor: Phan, T. (External person) (Supervisor 1) & Brunsveld, L. (Supervisor 2)

Student thesis: Master