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Personal profile

Quote

"Addressing biomedical challenges via bottom-up chemical approaches provides a unique training ground and offers fantastic opportunities for interdisciplinary science."

Research profile

Luc Brunsveld is professor of Chemical Biology at the department of Biomedical Engineering. His research interests are focused on chemical biology approaches studying protein-protein interactions, particularly drug discovery and supramolecular signalling systems. Combining synthetic and supramolecular chemistry with chemical biology allows exact molecular modulation of biological systems. Since 2011 the Chemical Biology group has been embedded in the interdepartmental Institute of Complex Molecular Systems (ICMS) and the NWO Gravity Research Center for Functional Molecular Systems. The group has developed a strong expertise in organic synthesis, peptide and protein chemistry, chemical biology, and supramolecular chemistry, enabling the development of new molecules and materials to study, engineer, and modulate protein-protein interactions. The realization of a synthetic cell and novel drugs via the modulation of protein-protein interactions are high on the group's wish list.

Academic background

Luc Brunsveld studied Chemistry and Chemical Engineering at the Technische Universiteit Eindhoven (TU/e, The Netherlands) and Osaka University (Japan). After obtaining his Master's degree in 1997 he performed his PhD research at TU/e and the University of Illinois at Urbana-Champaign (USA) in the field of supramolecular chemistry, under supervision of Prof. E.W. (Bert) Meijer. In 2001, he obtained his doctorate cum laude. From 2001-2003, he was a postdoctoral fellow with Prof. Herbert Waldmann at the Max-Planck Institute of Molecular Physiology (MPI, Dortmund, Germany) working on protein semi-synthesis. From 2003-2004, he was group leader in medicinal chemistry at Organon (Oss, the Netherlands, now Merck). In 2005, he started a research group at MPI in Dortmund working on supramolecular chemical biology, and subsequently also became group leader at the Chemical Genomics Centre of the Max Planck Society, working on Nuclear Receptor protein interactions. In 2008, he moved to TU/e where he was appointed Full Professor of Chemical Biology in the Department of Biomedical Engineering. Brunsveld has received numerous appealing grants, among which ERC Starting and Proof of Concept grants (2008 and 2010, respectively) and the NWO Vici grant (2015). He was awarded the NVBMB Award of the Dutch Society for Biochemistry and Molecular Biology in 2010 and the Gold Medal of the Royal Netherlands Chemical Society KNCV in 2013.

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Research Output 1997 2019

3 Citations (Scopus)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 1 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
1 Citation (Scopus)

Cooperativity basis for small-molecule stabilization of protein-protein interactions

de Vink, P. J., Andrei, S. A., Higuchi, Y., Ottmann, C., Milroy, L-G. & Brunsveld, L., 2019, In : Chemical Science. 10, 10, p. 2869-2874 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Stabilization
Molecules
Proteins
14-3-3 Proteins
Fluorescence

Engineering stabilizers of 14-3-3 protein-protein interactions

Andrei, S., 9 May 2019, Eindhoven: Technische Universiteit Eindhoven. 192 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

3 Citations (Scopus)

Site-directed fragment-based screening for the discovery of protein-protein interaction stabilizers

Sijbesma, E., Hallenbeck, K. K., Leysen, S., de Vink, P. J., Skóra, L., Jahnke, W., Brunsveld, L., Arkin, M. R. & Ottmann, C., 27 Feb 2019, In : Journal of the American Chemical Society. 141, 8, p. 3524–3531 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Screening
Proteins
Estrogen Receptor alpha
Stabilization
Phosphorylation
1 Citation (Scopus)

Tetrazine - trans-cyclooctene chemistry applied to fabricate self-assembled fluorescent and radioactive nanoparticles for in vivo dual mode imaging

van Onzen, A. H. A. M., Rossin, R., Schenning, A. P. H. J., Nicolay, K., Milroy, L. G., Robillard, M. S. & Brunsveld, L., 1 Jan 2019, In : Bioconjugate Chemistry. 30, 3, p. 547–551 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
Imaging techniques
Molecules
Multimodal Imaging
Radioactivity

Prizes

Golden Medal Royal Dutch Chemical Society 2012

Luc Brunsveld (Recipient), 2012

Recognition: OtherCareer, activity or publication related prizes (lifetime, best paper, poster etc.)Scientific

NWO Vici Award : Synthetic Supramolecular Signalling Systems

Luc Brunsveld (Recipient), 2014

Recognition: NWOViciScientific

Biomolecules

Research Center for Functional Molecular Systems

Bert Meijer (Recipient), Jan van Hest (Recipient), Luc Brunsveld (Recipient), Rene Janssen (Recipient) & Rint Sijbesma (Recipient), 2013

Recognition: NWOGravitationScientific

Netherlands
selection procedure
Ministry of Education
funding
organization

Supramolecular Chemical Biology Modulation of Protein-Protein Interactions

Luc Brunsveld (Recipient), 2007

Recognition: ERCStartingScientific

Modulation
Proteins
Supramolecular chemistry
Scaffolds
Dimerization

Targeting the biological imaging market with multifunctional fluorescent nanoparticles

Luc Brunsveld (Recipient), 2011

Recognition: ERCProof of conceptScientific

Nanoparticles
Imaging techniques
Molecular imaging
Industry
Acoustic waves

Courses

Biological physics

1/09/12 → …

Course

Chemical biology

1/09/1331/08/20

Course

Clinical Chemistry

1/09/15 → …

Course

DBL Entering the lab

1/09/13 → …

Course

Press / Media

Gold medal for TU/e iGEM team

Tom de Greef & Luc Brunsveld

20/10/15

1 item of media coverage

Press/Media: Expert Comment

Student theses

ABCB1 variants in association with clopidogrel response

Author: de Kock, R., 29 Sep 2016

Supervisor: Brunsveld, L. (Supervisor 1), Hilbers, P. (Supervisor 2), Scharnhorst, V. (Supervisor 2) & Deiman, B. (External person) (External coach)

Student thesis: Master

Alternative modulation of nuclear receptor function

Author: Hoek, N., 31 Mar 2014

Supervisor: Milroy, L. (Supervisor 1), Scheepstra, M. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Characterization of the interaction between 14-3-3 and the R-domain of CFTR

Author: van de Sande, M., 29 Mar 2018

Supervisor: Stevers, L. (Supervisor 1) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Characterization of the interaction of 14-3-3 proteins and estrogen receptor alpha as a potential drug target

Author: den Hamer, A., 30 Nov 2013

Supervisor: de Vries - van Leeuwen, I. (External coach), Tharun, I. (Supervisor 1), Ottmann, C. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Chemical biological evaluation of the estrogen receptor F domain on folding and activity

Author: Kurdi, M., 31 Jan 2009

Supervisor: Phan, T. (External person) (Supervisor 1) & Brunsveld, L. (Supervisor 2)

Student thesis: Master