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Personal profile

Quote

I use big microscopes to look at small objects.

Research profile

Lorenzo Albertazzi is an associate professor at the TU/e department of Biomedical Engineering (research group Molecular Biosensing for Medical Diagnostics). He is also junior group leader at the Institute of Bioengineering of Catalonia (IBEC) in Barcelona, where he leads the 'Nanoscopy for Nanomedicine' group. For most of his career he has been jumping between Chemistry and Biophysics; in his research he now aims to combine both to achieve a molecular understanding of synthetic materials in the biological environment, using optical microscopy and nanoscopy.

With his 2017 ERC Starting Grant, Lorenzo aims at the 'Design of Nanomaterials for Targeted Therapies Guided by Super Resolution Imaging'. In the NANOSTORM project he plans to use super resolution microscopy to examine nanomaterials that have potential as cancer therapies, and understand their interactions with their target: the diseased cells. Doing so will help identify the key principles that are needed to rationally design the next generation of targeted, super-efficient cancer treatments

Academic background

Lorenzo Albertazzi obtained a MSc in Chemistry (2007) and a PhD in Biophysics (2011) from Scuola Normale Superiore (Pisa, Italy). He then joined Eindhoven University of Technology (TU/e, The Netherlands) as postdoctoral researcher. In 2013, he was awarded a fellowship of the Institute for Complex Molecular Systems (ICMS) at TU/e, and in 2014 he became a NWO/VENI fellow (2014). In 2015, he moved to Barcelona (Spain) to the Institute of Bioengineering of Catalonia (IBEC) to start the 'Nanoscopy for Nanomedicine' group that he currently leads. In 2017, he received an ERC starting grant and in 2018 he was appointed Associate Professor at the TU/e department of Biomedical Engineering, with the research group Molecular Biosensing.

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Research Output 2009 2019

  • 2292 Citations
  • 61 Article
  • 3 Review article
  • 1 Poster
3 Citations (Scopus)

A stochastic view on surface inhomogeneity of nanoparticles

Post, R. A. J., van der Zwaag, D., Bet, G., Wijnands, S. P. W., Albertazzi, L., Meijer, E. W. & van der Hofstad, R. W., 10 Apr 2019, In : Nature Communications. 10, 1, 11 p., 1663

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoparticles
inhomogeneity
nanoparticles
Microscopy
Microscopic examination

Efficient small-scale conjugation of DNA to primary antibodies for multiplexed cellular targeting

Cremers, G., Rosier, B., Riera Brillas, R., Albertazzi, L. & de Greef, T., 22 Aug 2019, In : Bioconjugate Chemistry. 30, 9, p. 2384-2392

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Antibodies
DNA
Labeling
Fluorescence
Affinity Labels
1 Citation (Scopus)

Quantifying guest–host dynamics in supramolecular assemblies to analyze their robustness

Bastings, M. M. C., Hermans, T. M., Spiering, A. J. H., Kemps, E. W. L., Albertazzi, L., Kurisinkal, E. E. & Dankers, P. Y. W., 1 Jan 2019, In : Macromolecular Bioscience. 19, 1, 11 p., 1800296

Research output: Contribution to journalArticleAcademicpeer-review

Pyrimidinones
Fluorescence Recovery After Photobleaching
Photobleaching
Fluorescence Resonance Energy Transfer
Microfluidics
2 Citations (Scopus)

Super-resolution imaging of structure, molecular composition, and stability of single oligonucleotide polyplexes

Feiner-Gracia, N., Olea, R. A., Fitzner, R., El Boujnouni, N., van Asbeck, A. H., Brock, R. & Albertazzi, L., 8 May 2019, In : Nano Letters. 19, 5, p. 2784-2792 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
oligonucleotides
Oligonucleotides
Cell-Penetrating Peptides
Molecular structure
Peptides
7 Citations (Scopus)

Super-resolution microscopy as a powerful tool to study complex synthetic materials

Pujals, S., Feiner-Gracia, N., Delcanale, P., Voets, I. & Albertazzi, L., 1 Feb 2019, In : Nature Reviews Chemistry. 3, 2, p. 68-84 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Microscopic examination
Nanotechnology
Biocompatible Materials
Materials science
Biomaterials

Prizes

Nanostructured materials
Imaging techniques
Microscopic examination
Drug delivery
Nanostructures
Nanorobots
Intelligent materials
Viruses
Robots

Personalized attack on cancer cells

Lorenzo Albertazzi (Recipient), 2019

Recognition: NWOVidiScientific

Neoplasms
Nanoparticles
Microscopy
Biomedical Engineering
Pharmaceutical Preparations

Courses

Student theses

Binding a BTA fiber to dsDNA via intercalation

Author: Visser, P., 31 Aug 2015

Supervisor: Baker, M. (Supervisor 1), Albertazzi, L. (Supervisor 2) & Meijer, E. (Supervisor 2)

Student thesis: Master

File

Crosslinking supramolecular polymers : gaining control over dynamics

Author: Hoogland, D., 31 Aug 2014

Supervisor: Albertazzi, L. (Supervisor 1) & Meijer, E. (Supervisor 2)

Student thesis: Master

Enzyme-responsive supramolecular polymers

Author: van der Veeken, N., 31 Jan 2015

Supervisor: Albertazzi, L. (Supervisor 1), Meijer, E. (Supervisor 2), de Greef, T. (Supervisor 2) & Merkx, M. (Supervisor 2)

Student thesis: Master

Exploring multistep non-covalent synthesis: investigating supramolecular host-guest assemblies

Author: Goor, O., 31 May 2013

Supervisor: Bastings, M. (Supervisor 1), Albertazzi, L. (Supervisor 2) & Dankers, P. (Supervisor 2)

Student thesis: Master