• 162 Citations
20142018

Research output per year

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Personal profile

Research profile

Loes Stevers (1989) received her Bachelor degree in Biomedical Engineering at Eindhoven University of Technology (TU/e) and started her master in Biomedical Engineering in the Chemical Biology group of Professor Luc Brunsveld in 2010. Here she worked on supramolecular membrane protein dimerization in living cells. Additionally, she did an internship in the development of a bioactive membrane for a bioartificial renal mimic (at the Organic Chemistry group of Professor Bert Meijer under supervision of Dr Patricia Dankers at TU/e) and an internship in in vitro mapping of interactions between human SNX-BAR proteins (in the group of Kirill Alexandrov at IMB, University of Queensland, Brisbane, Australia). After receiving her master degree in 2013, Loes stayed in the group of Luc Brunsveld to obtain her PhD degree. During her research she is investigating a new therapeutic approach related to 14-3-3 to find a cure for Cystic Fibrosis.

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Research Output

  • 162 Citations
  • 4 Article
  • 1 Review article
  • 1 Phd Thesis 1 (Research TU/e / Graduation TU/e)

A thermodynamic model for multivalency in 14-3-3 protein-protein interactions

Stevers, L. M., de Vink, P. J., Ottmann, C., Huskens, J. & Brunsveld, L., Oct 2018, In : Journal of the American Chemical Society. 140, 43, p. 14498–14510 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
  • 16 Citations (Scopus)
    57 Downloads (Pure)

    Modulators of 14-3-3 protein-protein interactions

    Stevers, L. M., Sijbesma, E., Botta, M., Mackintosh, C., Obsil, T., Landrieu, I., Cau, Y., Wilson, A. J., Karawajczyk, A., Eickhoff, J., Davis, J., Hann, M., O'Mahony, G., Doveston, R. G., Brunsveld, L. & Ottmann, C., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 3755-3778 24 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 63 Citations (Scopus)
    100 Downloads (Pure)

    Stabilization of multivalent 14-3-3 protein-protein interactions

    Stevers, L. M., 10 Oct 2017, Eindhoven: Technische Universiteit Eindhoven. 160 p.

    Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

    Open Access
    File
    646 Downloads (Pure)

    Structural interface between LRRK2 and 14-3-3 protein

    Stevers, L. M., de Vries, R. M. J. M., Doveston, R. G., Milroy, L. G., Brunsveld, L. & Ottmann, C., 1 Apr 2017, In : Biochemical Journal. 474, 7, p. 1273-1287 15 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 18 Citations (Scopus)
    290 Downloads (Pure)

    Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR

    Stevers, L. M., Lam, C. V., Leysen, S. F. R., Meijer, F. A., van Scheppingen, D. S., de Vries, R. M. J. M., Carlile, G. W., Milroy, L. G., Thomas, D. Y., Brunsveld, L. & Ottmann, C., 1 Mar 2016, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 113, 9, p. E1152-E1161 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 52 Citations (Scopus)
    13 Downloads (Pure)

    Student theses

    Cucurbit[8]uril-induced membrane protein dimerization in living cells

    Author: Stevers, L., 31 May 2013

    Supervisor: Brunsveld, L. (Supervisor 1) & Dang, T. (Supervisor 2)

    Student thesis: Master