• 3111 Citations
1986 …2019
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Personal profile

Quote

I am fascinated by how the use of particles can provide an observation window to the biomolecular world.

Research profile

Leo van IJzendoorn is an Associated Professor in Particle Based Biosensing and Biophysics in the research group Molecular Biosensing for Medical Diagnostics, a joint group of the TU/e departments of Applied Physics and Biomedical Engineering. His research focus is on the detection of biomolecules in complex environments and on the discovery of biomolecule properties. He investigates methods for point-of-care detection and for continuous monitoring of biomarkers, using magnetic as well as non-magnetic particles. Van IJzendoorn uses thermal particle motion and magnetic actuation combined with light scattering and optical microscopy for biomarker detection. His use of magnetic tweezers provides unique insights in the nanomechanical properties of individual biomolecules, in the interactions between biomolecules, and in the interactions between biofunctionalized particles and surfaces.

Academic background

Leo van IJzendoorn studied at Leiden University, The Netherlands, where he obtained a combined Bachelor's degree in chemistry and physics in 1979. He obtained both his Master's degree in physics (1981) and his PhD degree (1985) at the same university in the group Laboratory Astrophysics; in this interdisciplinary research group of Prof. Mayo Greenberg he worked under the guidance of Dr. Louis Allamandola and used laser induced fluorescence and molecular spectroscopy to study interstellar ices. After his PhD, he moved to Eindhoven and joined Philips Research to use ion beams for materials research. In 1991, Leo van IJzendoorn moved to Eindhoven University of Technology as an Assistant Professor in the group of Prof. Martien de Voigt. He focused on materials analysis with ion beams as well as positron emission profiling on catalysts using the cyclotron at TU/e, and became Associate Professor in 1997. After a short sabbatical at Philips Research in 2004, he founded (together with Prof. Menno Prins) the research group Molecular Biosensing for Medical Diagnostics. Leo van IJzendoorn is a core member of the Institute for Complex Molecular Systems at TU/e, where groups from different disciplines (chemistry, physics, biomedical engineering and mathematics) collaborate on multidisciplinary research topics.

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  • 6 Similar Profiles
biomarkers Physics & Astronomy
bioinstrumentation Physics & Astronomy
Biosensors Engineering & Materials Science
Proteins Chemical Compounds
Assays Chemical Compounds
Polystyrenes Chemical Compounds
nanoparticles Physics & Astronomy
Nanoparticles Engineering & Materials Science

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1986 2019

10 Downloads (Pure)

Conformation switching of single native proteins revealed by nanomechanical probing without a pulling force

Gutierrez Mejia, F. A., Moerland, C., van Ijzendoorn, L. & Prins, M., 14 Nov 2019, In : Nanoscale. 11, 42, p. 19933-19942 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Conformations
Proteins
Calcium
Antibodies
Troponin
1 Citation (Scopus)
11 Downloads (Pure)

Rate of dimer formation in stable colloidal solutions quantified using an attractive interparticle force

Scheepers, M. R. W., Romijn, A. R., van Ijzendoorn, L. J. & Prins, M. W. J., 13 Aug 2019, In : Langmuir. 35, 32, p. 10533-10541 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Dimers
dimers
Agglomeration
Chemical reactivity
Particle interactions
6 Citations (Scopus)
26 Downloads (Pure)

Rotating magnetic particles for lab-on-chip applications-a comprehensive review

Moerland, C. P., van IJzendoorn, L. J. & Prins, M. W. J., 21 Mar 2019, In : Lab on a Chip. 19, 6, p. 919-933 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Magnetic Fields
Magnetic fields
Torque
Molecules
Biomolecules
7 Downloads (Pure)

Single-dimer formation rate reveals heterogeneous particle surface reactivity

Scheepers, M. R. W., van IJzendoorn, L. J. & Prins, M. W. J., 13 Oct 2019, In : Langmuir. 35, 44, p. 14272-14281 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Dimers
Agglomeration
reactivity
dimers
Antibodies
7 Citations (Scopus)
71 Downloads (Pure)

Continuous biomarker monitoring by particle mobility sensing with single molecule resolution

Visser, E. W. A., Yan, J., van IJzendoorn, L. J. & Prins, M. W. J., 1 Dec 2018, In : Nature Communications. 9, 1, 10 p., 2541.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
biomarkers
Biomarkers
Technology
Molecules
Monitoring

Activities 1997 2012

  • 3 Contributed talk

Erasmus Mundus Lectures on Nanoscience and Nanotechnology, 20 March 2012, Leuven, Belgium, K.U.Leuven

Leo van Ijzendoorn (Speaker)
20 Mar 2012

Activity: Talk or presentation typesContributed talkScientific

Biosensors 2010, Glasgow, UK

Leo van Ijzendoorn (Speaker)
26 May 2010

Activity: Talk or presentation typesContributed talkScientific

Courses

Biological physics

1/09/12 → …

Course

Molecular biosensing

1/09/15 → …

Course

Molecular biosensing

1/09/15 → …

Course

Subatomic physics

1/09/13 → …

Course

Student theses

A feasibility study on the use of ion beam analysis for poly-phenylene-Vinylene

Author: van Lisdonk, S., 30 Jun 1996

Supervisor: de Voigt, M. (Supervisor 1), van Ijzendoorn, L. (Supervisor 2) & De Coster, W. (External person) (External coach)

Student thesis: Master

File

Analysis of light elements in thin films using high energy ion scattering techniques

Author: van Dijk, P., 29 Feb 1992

Supervisor: de Voigt, M. (Supervisor 1), Brongersma, H. (Supervisor 2), van Ijzendoorn, L. (Supervisor 2), Klein, S. (External person) (Supervisor 2) & Rijken, H. (External person) (Supervisor 2)

Student thesis: Master

File

Artificial cilia for microfluidics: exploring the use of a horizontally micro-structured ferromagnetic PDMS composite

Author: van Engen, W., 31 Aug 2008

Supervisor: Fahrni, F. (Supervisor 1) & van Ijzendoorn, L. (Supervisor 2)

Student thesis: Master

Assay optimization for single DNA tethered particle motion

Author: Hoeven, F., 2014

Supervisor: Visser, E. (Supervisor 1) & van Ijzendoorn, L. (Supervisor 2)

Student thesis: Bachelor

File

A study on the isomerisation of hexane in a packed zeolite bed

Author: Verbeek, N., 31 Dec 1996

Supervisor: van Ijzendoorn, L. (Supervisor 1) & de Voigt, M. (Supervisor 2)

Student thesis: Master

File