• 19 Citations
20172020

Research output per year

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Personal profile

Research profile

Lenne Lemmens (1992) received her Bachelor degree and subsequent Master degree in Biomedical Engineering at the Eindhoven University of Technology in 2013 and 2016, respectively. For her master thesis in the group of prof. L. Brunsveld, she worked on synthetic signaling networks, investigating combinatorial inhibition of scaffold proteins and extension of the existing network by incorporating phosphorylation. During an internship at the Centralised and Point-of-Care Solutions division of Roche Diagnostics GmbH Mannheim, she developed an assay to quantify an enzyme of interest in complex matrix.

Currently, Lenne is a PhD candidate in the Chemical Biology group of prof. L. Brunsveld. Her research focuses on heterodimerization of the scaffold protein 14-3-3, following two directions: orthogonal and human heterodimerization. In the orthogonal dimerization project, orthogonal 14-3-3 heterodimerization modules will be created, which form the basis for synthetic signaling networks. The human heterodimerization project aims to create a better understanding of human 14-3-3 isoform heterodimerization by making use of 14-3-3 fusion scaffolds.

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Research Output

  • 19 Citations
  • 5 Article
  • 1 Phd Thesis 1 (Research TU/e / Graduation TU/e)

Conjugated protein domains as engineered scaffold proteins

Lemmens, L., Ottmann, C. & Brunsveld, L., 17 Jun 2020, In : Bioconjugate Chemistry. 31, 6, p. 1596-1603 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Designed asymmetric protein assembly on a symmetric scaffold

    Lemmens, L. J. M., Roodhuizen, J. A. L., de Greef, T. F. A., Markvoort, A. J. & Brunsveld, L., 13 Jul 2020, In : Angewandte Chemie - International Edition. 59, 29, p. 12113-12121 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Modular bioengineered kinase sensorsviascaffold protein-mediated split-luciferase complementation

    Xu, X., Lemmens, L. J. M., den Hamer, A., Merkx, M., Ottmann, C. & Brunsveld, L., 7 Jun 2020, In : Chemical Science. 11, 21, p. 5532-5536 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 1 Citation (Scopus)

    Scaffold-mediated assembly of engineered protein complexes

    Lemmens, L. J. M., 9 Sep 2020, (Accepted/In press) Eindhoven: Technische Universiteit Eindhoven. 141 p.

    Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)

    Open Access
    File
    25 Downloads (Pure)

    Protease-activatable scaffold proteins as versatile molecular hubs in synthetic signaling networks

    Aper, S. J. A., den Hamer, A., Wouters, S., Lemmens, L., Ottmann, C., Brunsveld, L. & Merkx, M., 21 Sep 2018, In : ACS Synthetic Biology. 7, 9, p. 2216-2225 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 7 Citations (Scopus)
    64 Downloads (Pure)

    Student theses

    Synthetic signaling networks by 14-3-3 induced dimerization of caspase 9

    Author: Lemmens, L., 31 May 2016

    Supervisor: den Hamer, A. (Supervisor 1)

    Student thesis: Master