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20202020

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Research profile

As part of the BioMonitor project funded by NWO-TTW, Laura van Smeden aims to develop a new technology for continuous biochemical monitoring that is suitable for a wide range of biomarkers. Her first focus lies on the development of a sandwich immunoassay for cytokines using Biosensing by Particle Mobility. The method is based on the tracking of the motion of particles that are molecularly tethered to a substrate, where the Brownian motion of the particles indicates the (un)binding of single biomarker molecules. Her research is part of the research group of Menno Prins, being Molecular Biosensing for Medical Diagnostics (MBx), under the departments of BioMedical Engineering and Applied Physics. The research activities at the TU/e are part of the Institute for Complex Molecular Systems (ICMS) and the Strategic Area Health (SA Health).

Academic background

Laura van Smeden studied BioMedical Engineering at Eindhoven University of Technology (TU/e) where she obtained her MSc degree. During her education at the TU/e, she participated in two iGEM teams, one in 2015 and one in 2017. The first project was about Clickable Outer Membrane Biosensors and the second project about Gelation Using Protein Protein Interactions. As graduation project, she combined Protein Engineering with Biosensing by Particle Mobility. The goal of her project was to development of a system for continuously monitoring creatinine concentrations via a competition immunoassay. For her internship, she worked on thiol-ene click chemistry for hydrogel formation at FUJIFILM Tilburg. Since 2019, she started working as PhD student under full Professor Menno Prins in the group Molecular Biosensing for Medical Diagnostics (MBx) of the departments of BioMedical Engineering and Applied Physics.

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Research Output

Continuous small-molecule monitoring with a digital single particle switch

Yan, J., van Smeden, L., Merkx, M., Zijlstra, P. & Prins, M. W. J., 24 Apr 2020, In : ACS Sensors. 5, 4, p. 1168-1176 9 p.

Research output: Contribution to journalArticleAcademicpeer-review