• 7822 Citations
1991 …2020

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Article
2020

Accuracy of beam theory for estimating bone tissue modulus and yield stress from 3-point bending tests on rat femora

Arias-Moreno, A. J., Ito, K. & van Rietbergen, B., 5 Mar 2020, In : Journal of Biomechanics. 101, 8 p., 109654.

Research output: Contribution to journalArticleAcademicpeer-review

Orbital seeding of mesenchymal stromal cells increases osteogenic differentiation and bone-like tissue formation

Melke, J., Zhao, F., Ito, K. & Hofmann, S., 10 Jan 2020, In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019
Open Access
File
1 Citation (Scopus)
14 Downloads (Pure)

Bi-layered micro-fibre reinforced hydrogels for articular cartilage regeneration

Castilho, M., Mouser, V., Chen, M., Malda, J. & Ito, K., 1 Sep 2019, In : Acta Biomaterialia. 95, Sept 2019, p. 297-306 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Development of a novel murine delayed secondary fracture healing in vivo model using periosteal cauterization

Gröngröft, I., Wissing, S., Meesters, D. M., Poeze, M., Matthys‑Mark, R., Ito, K. & Zeiter, S., 1 Dec 2019, In : Archives of Orthopaedic and Trauma Surgery. 12, p. 1743-1753 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
15 Downloads (Pure)

From bone regeneration to three-dimensional in vitro models: tissue engineering of organized bone extracellular matrix

de Wildt, B., Ansari, S., Sommerdijk, N., Ito, K., Akiva, A. & Hofmann, S., 12 Jun 2019, In : Current Opinion in Biomedical Engineering. 10, p. 107-115 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
20 Downloads (Pure)

Hypotonicity differentially affects inflammatory marker production by nucleus pulposus tissue in simulated disc degeneration versus herniation

Mouser, V. H. M., Arkesteijn, I. T. M., van Dijk, B. G. M., Wuertz-Kozak, K. & Ito, K., 1 May 2019, In : Journal of Orthopaedic Research. 37, 5, p. 1110-1116 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
36 Downloads (Pure)

Notochordal cell matrix as a therapeutic agent for intervertebral disc regeneration

de Vries, S., van Doeselaar, M., Meij, B., Tryfonidou, M. & Ito, K., 1 Jun 2019, In : Tissue engineering. Part A. 25, 11-12, p. 830-841 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2 Downloads (Pure)

Resorption of the calcium phosphate layer on S53P4 bioactive glass by osteoclasts

van Gestel, N., Schuiringa, R., Hennissen, J. H. P. H., Delsing, A., Ito, K., van Rietbergen, B., Hofmann, S. & Arts, C., 1 Aug 2019, In : Journal of Materials Science: Materials in Medicine. 30, 8, 13 p., 94.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
19 Downloads (Pure)

The implantation of bioactive glass granules can contribute the load-bearing capacity of bones weakened by large cortical defects

van Gestel, N., Gabriels, F., Geurts, J., Hulsen, D., Wyers, C. E., van den Bergh, J. P., Ito, K., Hofmann, S., Arts, C. & van Rietbergen, B., 1 Nov 2019, In : Materials. 12, 21, 13 p., 3481.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
13 Downloads (Pure)

The relationship between proteoglycan loss, overloading-induced collagen damage, and cyclic loading in articular cartilage

Henao Murillo, L., Pastrama, M., Ito, K. & van Donkelaar, R., 15 Nov 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Validation of distal radius failure load predictions by homogenized- and micro-finite element analyses based on second-generation high-resolution peripheral quantitative CT images

Arias Moreno, A. J., Hosseini, H., Bevers, M. S. A. M., Ito, K., Zysset, P. K. & van Rietbergen, B., 1 Jul 2019, In : Osteoporosis International. 30, 7, p. 1433-1443 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
15 Downloads (Pure)
2018

Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside

Bach, F. C., Tellegen, A. R., Beukers, M., Miranda-Bedate, A., Teunissen, M., de Jong, W. A. M., de Vries, S. A. H., Creemers, L. B., Benz, K., Meij, B. P., Ito, K. & Tryfonidou, M. A., 29 May 2018, In : Oncotarget. 9, 41, p. 26507-26526 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
4 Citations (Scopus)
51 Downloads (Pure)

Collagen damage location in articular cartilage differs if damage is caused by excessive loading magnitude or rate

Henao-Murillo, L., Ito, K. & van Donkelaar, C. C., 1 Apr 2018, In : Annals of Biomedical Engineering. 46, 4, p. 605-615 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
9 Citations (Scopus)
44 Downloads (Pure)

Comparison of patient-specific computational models vs. clinical follow-up, for adjacent segment disc degeneration and bone remodelling after spinal fusion

Rijsbergen, M. V., van Rietbergen, B., Barthelemy, V., Eltes, P., Lazáry, Á., Lacroix, D., Noailly, J., Ho Ba Tho, M-C., Wilson, W. & Ito, K., Aug 2018, In : PLoS ONE. 13, 8, 24 p., e0200899.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)
56 Downloads (Pure)

Flow rates in perfusion bioreactors to maximise mineralisation in bone tissue engineering in vitro

Zhao, F., van Rietbergen, B., Ito, K. & Hofmann, S., 5 Oct 2018, In : Journal of Biomechanics. 79, p. 232-237 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
11 Citations (Scopus)
48 Downloads (Pure)

Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical

Thorpe, A. A., Bach, F. C., Tryfonidou, M. A., Le Maitre, C. L., Mwale, F., Diwan, A. D. & Ito, K., 4 Jul 2018, In : Journal of Orthopaedic Research. 1, 3, 18 p., e1027.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
32 Downloads (Pure)

Localisation of mineralised tissue in a complex spinner flask environment correlates with predicted wall shear stress level localisation

Melke, J., Zhao, F., van Rietbergen, B., Ito, K. & Hofmann, S., 1 Jul 2018, In : European Cells and Materials. 36, p. 57-68 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
4 Citations (Scopus)
160 Downloads (Pure)

Mechanical behavior of a soft hydrogel reinforced with three-dimensional printed microfibre scaffolds

Castilho, M., Hochleitner, G., Wilson, W. E., van Rietbergen, B., Dalton, P. D., Groll, J., Malda, J. & Ito, K., 1 Dec 2018, In : Scientific Reports. 8, 1, 10 p., 1245.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
23 Citations (Scopus)
82 Downloads (Pure)

Melt electrowriting allows tailored microstructural and mechanical design of scaffolds to advance functional human myocardial tissue formation

Castilho, M., van Mil, A., Maher, M., Metz, C. H. G., Hochleitner, G., Groll, J., Doevendans, P. A., Ito, K., Sluijter, J. P. G. & Malda, J., 4 Oct 2018, In : Advanced Functional Materials. 28, 40, 10 p., 1803151.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
2 Downloads (Pure)

Notochordal cell matrix: An inhibitor of neurite and blood vessel growth?

de Vries, S. A. H., van Doeselaar, M., Meij, B. P., Tryfonidou, M. A. & Ito, K., 1 Dec 2018, In : Journal of Orthopaedic Research. 36, 12, p. 3188-3195 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
49 Downloads (Pure)

Notochordal cell matrix as a bioactive lubricant for the osteoarthritic joint

De Vries, S. A. H., Van Doeselaar, M., Kaper, H. J., Sharma, P. K. & Ito, K., 1 Dec 2018, In : Scientific Reports. 8, 1, 11 p., 8875.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
30 Downloads (Pure)

Osteochondral resurfacing implantation angle is more important than implant material stiffness

Heuijerjans, A., Wilson, W., Ito, K. & van Donkelaar, C. C., 1 Nov 2018, In : Journal of Orthopaedic Research. 36, 11, p. 2911-2922 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
48 Downloads (Pure)

Quantifying joint stiffness in clubfoot patients

van der Steen, M. C., Andrei, P. A., van Rietbergen, B., Ito, K. & Besselaar, A. T., 1 Dec 2018, In : Clinical Biomechanics. 60, p. 185-190 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
1 Downloads (Pure)
2017

Bone morphogenetic protein-2, but not mesenchymal stromal cells, exert regenerative effects on Canine and human nucleus pulposus cells

Bach, F. C., Miranda-Bedate, A., van Heel, F. W. M., Riemers, F. M., Müller, M. C. M. E., Creemers, L. B., Ito, K., Benz, K., Meij, B. P. & Tryfonidou, M. A., 1 Mar 2017, In : Tissue engineering. Part A. 23, 5-6, p. 233-242 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
9 Citations (Scopus)
94 Downloads (Pure)

Composition dependent mechanical behaviour of S53P4 bioactive glass putty for bone defect grafting

van Gestel, N. A. P., Hulsen, D. J. W., Geurts, J. A. P., Hofmann, S., Ito, K., Arts, J. J. C. & van Rietbergen, B., 1 May 2017, In : Journal of the Mechanical Behavior of Biomedical Materials. 69, p. 301–306 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
63 Downloads (Pure)

Link-N: the missing link towards intervertebral disc repair is species-specific

Bach, F. C., Laagland, L. T., Grant, M. P., Creemers, L. B., Ito, K., Meij, B. P., Mwale, F. & Tryfonidou, M. A., 1 Nov 2017, In : PLoS ONE. 12, 11, p. 1-21 e0187831.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
45 Downloads (Pure)

Melt electrospinning writing of poly-Hydroxymethylglycolide-co-ε-Caprolactone-based scaffolds for cardiac tissue engineering

Castilho, M., Feyen, D., Flandes-Iparraguirre, M., Hochleitner, G., Groll, J., Doevendans, P. A. F., Vermonden, T., Ito, K., Sluijter, J. P. G. & Malda, J., 20 Sep 2017, In : Advanced Healthcare Materials. 6, 18, 9 p., 1700311.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
34 Citations (Scopus)
106 Downloads (Pure)

Moderately degenerated lumbar motion segments: are they truly unstable?

van Rijsbergen, M. M., Barthelemy, V. M. P., Vrancken, A. C. T., Crijns, S. P. M., Wilke, H. J., Wilson, W., van Rietbergen, B. & Ito, K., 1 Apr 2017, In : Biomechanics and Modeling in Mechanobiology. 16, 2, p. 537–547 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
68 Downloads (Pure)

Notochordal-cell derived extracellular vesicles exert regenerative effects on canine and human nucleus pulposus cells

Bach, F. C., Libregts, S., Creemers, L. B., Meij, B., Ito, K., Wauben, M. & Tryfonidou, M. A., 24 Oct 2017, In : Oncotarget. 8, 51, p. 88845-88856

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)
53 Downloads (Pure)

Osteogenic protein 1 does not stimulate a regenerative effect in cultured human degenerated nucleus pulposus tissue

van Dijk, B. G. M., Potier, E., van Dijk, M., Creemers, L. B. & Ito, K., 1 Jul 2017, In : Journal of Tissue Engineering and Regenerative Medicine. 11, 7, p. 2127-2135 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
119 Downloads (Pure)

Relative contribution of articular cartilage's constitutive components to load support depending on strain rate

Párraga Quiroga, J. M., Wilson, W., Ito, K. & van Donkelaar, C. C., 2017, In : Biomechanics and Modeling in Mechanobiology. 16, 1, p. 151-158 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
16 Citations (Scopus)
77 Downloads (Pure)

The critical size of focal articular cartilage defects is associated with strains in the collagen fibers

Heuijerjans, A., Wilson, W., Ito, K. & van Donkelaar, C. C., 1 Dec 2017, In : Clinical Biomechanics. 50, 12, p. 40-46 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
5 Downloads (Pure)

The effect of loading rate on the development of early damage in articular cartilage

Parraga, J. M., Wilson, W., Ito, K. & van Donkelaar, C. C., Feb 2017, In : Biomechanics and Modeling in Mechanobiology. 16, 1, p. 263–273 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
13 Citations (Scopus)
83 Downloads (Pure)

The initial repair response of articular cartilage after mechanically induced damage

van Haaften, E. E., Ito, K. & van Donkelaar, C. C., 1 Jun 2017, In : Journal of Orthopaedic Research. 35, 6, p. 1265-1273 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
6 Citations (Scopus)
87 Downloads (Pure)

The regenerative potential of notochordal cells in a nucleus pulposus explant

Arkesteijn, I. T. M., Potier, E. & Ito, K., 1 Feb 2017, In : Global Spine Journal. 7, 1, p. 14-20 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)
62 Downloads (Pure)
2016

A computational spinal motion segment model incorporating a matrix composition-based model of the intervertebral disc

Barthelemy, V. M. P., Rijsbergen, van, M. M., Wilson, W., Huyghe, J. M. R. J., Rietbergen, van, B. & Ito, K., 2016, In : Journal of the Mechanical Behavior of Biomedical Materials. 54, p. 194-204

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
15 Downloads (Pure)

An inflammatory nucleus pulposus tissue culture model to test molecular regenerative therapies: validation with Epigallocatechin 3-Gallate

Krupkova, O., Hlavna, M., Amir Tahmasseb, J., Zvick, J., Kunz, D., Ito, K., Ferguson, S. J. & Wuertz-Kozak, K., 27 Sep 2016, In : International Journal of Molecular Sciences. 17, 10, p. 1-18 18 p., 1640.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
7 Citations (Scopus)
56 Downloads (Pure)

A well-controlled nucleus pulposus tissue culture system with injection port for evaluating regenerative therapies

Arkesteijn, I. T. M., Mouser, W. H. M., Mwale, F., Dijk, van, B. G. M. & Ito, K., May 2016, In : Annals of Biomedical Engineering. 44, 5, p. 1798-1807

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
107 Downloads (Pure)

Deficiency of inducible and endothelial nitric oxide synthase results in diminished bone formation and delayed union and nonunion development

Meesters, D. M., Neubert, S., Wijnands, K. A. P., Heyer, F., Zeiter, S., Ito, K., Brink, P. R. G. & Poeze, M., 2016, In : Bone. 83, p. 111-118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
10 Citations (Scopus)
67 Downloads (Pure)

Increased caveolin-1 in intervertebral disc degeneration facilitates repair

Bach, F. C., Zhang, Y., Miranda-Bedate, A., Verdonschot, L. C., Ito, K., Sakai, D., Meij, B. P. & Tryfonidou, M. A., 2016, In : Arthritis Research & Therapy. 18, p. 1-15 59.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
5 Citations (Scopus)
57 Downloads (Pure)

Micro-aggregates do not influence bone marrow stromal cell chondrogenesis

Potier, E., Rivron, N. C., Blitterswijk, C. A. & Ito, K., Dec 2016, In : Journal of Tissue Engineering and Regenerative Medicine. 10, 12, p. 1021–1032 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Micro-Finite Element analysis will overestimate the compressive stiffness of fractured cancellous bone

Arias Moreno, A. J., Ito, K. & van Rietbergen, B., 6 Sep 2016, In : Journal of Biomechanics. 49, 13, p. 2613–2618

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
4 Downloads (Pure)

Moderately degenerated human intervertebral discs exhibit a less geometrically specific collagen fiber orientation distribution

Dittmar, R., Van Rijsbergen, M. M. & Ito, K., 1 Aug 2016, In : Global Spine Journal. 6, 5, p. 439-446 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
4 Citations (Scopus)
118 Downloads (Pure)

Simulating the sensitivity of cell nutritive environment to composition changes within the intervertebral disc

Ruiz Wills, C. E., Malandrino, A., van Rijsbergen, M. M., Lacroix, D., Ito, K. & Noailly, J., 2016, In : Journal of the Mechanics and Physics of Solids. 90, p. 108-123

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
3 Downloads (Pure)

Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration

Bach, F. C., de Vries, S. A. H., Riemers, F. M., Boere, J., van Heel, F. W. M., van Doeselaar, M., Goerdayal, S. S., Nikkels, P. G. J., Benz, K., Creemers, L. B., Altelaar, A. F. M., Meij, B. P., Ito, K. & Tryfonidou, M. A., 2016, In : European Cells and Materials. 32, p. 163-180

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
10 Citations (Scopus)
98 Downloads (Pure)

The stimulatory effect of notochordal cell-conditioned medium in a nucleus pulposus explant culture

De Vries, S. A. H., van Doeselaar, M., Meij, B. P., Tryfonidou, M. A. & Ito, K., 1 Jan 2016, In : Tissue engineering. Part A. 22, 1-2, p. 103-110 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
3 Downloads (Pure)
2015

A novel approach to estimate trabecular bone anisotropy from stress tensors

Hazrati Marangalou, J., Ito, K. & Rietbergen, van, B., 2015, In : Biomechanics and Modeling in Mechanobiology. 14, 1, p. 39-48 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
21 Citations (Scopus)
181 Downloads (Pure)

A potential mechanism for allometric trabecular bone scaling in terrestrial mammals

Christen, P., Ito, K. & Rietbergen, van, B., Mar 2015, In : Journal of Anatomy. 226, 3, p. 236-243

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
7 Downloads (Pure)

A survey of micro-finite element analysis for clinical assessment of bone strength : the first decade

Rietbergen, van, B. & Ito, K., 2015, In : Journal of Biomechanics. 48, 5, p. 832-841

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)
4 Downloads (Pure)