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Personal profile


"Organs-on-a-chip, born from the marriage between microsystems and biology, can help us understand the mechanisms underlying health and disease"

Academic background

Jelle Sleeboom, born in Utrecht in 1989, obtained his BSc in Mechanical Engineering at Eindhoven University of Technology in 2012. During his final bachelor project, under supervision of dr. Hans Wyss, he contributed to microfluidic single particle trapping and squeezing technology. His sparked interest in microfluidic technology drove him to join prof.dr.ir. Jaap den Toonder's Microsystems group as an MSc student in 2013. During his time in the group, he spent several months abroad at Harvard's Wyss Institute in Boston, USA, where he worked on a microfluidic model of the Blood Brain Barrier. After graduating (with honors) in the brain-on-a-chip project of dr. Regina Luttge, he started his joint PhD in the Soft Tissue Engineering & Mechanobiology (STEM) and Microsystems groups in 2016.

Research profile

Jelle Sleeboom is a PhD candidate in two different research groups: prof.dr. Carlijn Bouten's Soft Tissue Engineering & Mechanobiology (STEM) group, and prof.dr.ir. Jaap den Toonder's Microsystems group. His current research focuses on developing "breast-cancer-on-a-chip" technology to study the mechanisms that underlie cancer metastasis, in close collaboration with dr.Cecilia Sahlgren. His personal research interests are in developing and understanding microfabrication methods, microfluidics, organ-on-chip technology, mechanobiology, the Notch pathway, and cancer-on-chip technology.

Fingerprint Dive into the research topics where Jelle Sleeboom is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

shock Physics & Astronomy
gels Physics & Astronomy
Pericytes Medicine & Life Sciences
blood-brain barrier Agriculture & Biology
osmosis Physics & Astronomy
microfluidic devices Physics & Astronomy
astrocytes Agriculture & Biology
chromatography Physics & Astronomy

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Research Output 2012 2018

  • 115 Citations
  • 4 Article
  • 3 Poster
  • 1 Review article
2 Citations (Scopus)
Open Access
Lab-On-A-Chip Devices
multiple docking adapters
Neoplastic Stem Cells
stem cells
Stem cells
12 Citations (Scopus)

Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

Sleeboom, J. J. F., Amirabadi, H. E., Nair, P., Sahlgren, C. M. & Den Toonder, J. M. J., 1 Mar 2018, In : Disease Models & Mechanisms. 11, 3, 033100

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Tumor Microenvironment
Neoplasm Metastasis

A novel breast-cancer model of early stage invasion

Sleeboom, J. J. F., Sahlgren, C. M. & den Toonder, J. M. J., 2 May 2017

Research output: Contribution to conferencePosterAcademic

Breast Neoplasms
Neoplasm Metastasis
Extracellular Matrix
9 Citations (Scopus)

Compression and reswelling of microgel particles after an osmotic shock

Sleeboom, J. J. F., Voudouris, P., Punter, M. T. J. J. M., Aangenendt, F. J., Florea, D., van der Schoot, P. P. A. M. & Wyss, H. M., 31 Aug 2017, In : Physical Review Letters. 119, 9, 5 p., 098001

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
microfluidic devices