• 2092 Citations
19952019
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Personal profile

Quote

"Non-invasive imaging of metabolic processes inside the human body will be key to understanding the mechanism of metabolic diseases"

Research profile

Jeanine Prompers is associate professor of Biomedical Magnetic Resonance Spectroscopy (MRS) in the TU/e department of Biomedical Engineering. Her research interest is to characterize metabolic disturbances underlying the etiology of metabolic diseases, in particular the metabolic syndrome and its complications, including type 2 diabetes, fatty liver disease and cardiovascular disease. To this end, she develops in vivo MRS methods to study metabolic processes in skeletal muscle, heart and liver, such as mitochondrial bioenergetics and carbohydrate and lipid metabolism. She combines pre-clinical studies with translational research in patients. For the latter, she is involved in the development of world’s first dedicated whole-body 7 tesla (7T) MR scanner for metabolic imaging (META-scan) in humans. In addition, she applies ultra-high field MRI (22.3 T, uNMR-NL facility) to study very small model systems, such as organoids and zebrafish. 

Currently, Jeanine Prompers is also setting up a research line in the field of Image Based Regenerative Medicine. The goal is to develop innovative MRI methods to non-invasively monitor the success of regenerative therapies, for example in the heart after a myocardial infarction.

Academic background

Jeanine Prompersstudied Chemistry at Radboud University Nijmegen (the Netherlands), where she graduated cum laude in 1994. The following years she performed PhD research in the field of high-resolution protein Magnetic Resonance Spectroscopy in the group of Prof. Cees Hilbers at the same university. In 1999, she obtained her PhD degree with her dissertation "NMR studies of Fusarium solanipisicutinase - Structure-mobility-function relationships". After her PhD, she was awarded a long-term postdoctoral fellowship of the Human Frontier of Science Program,to perform two years of research with Prof. RafaëlBrüschweilerat Clark University (USA). In 2002, she joined the Biomedical NMR group of Prof. KlaasNicolay at Eindhoven University of Technology as an assistant professor. In 2008, she was awarded a NWO VIDI grant entitled ‘’In vivo magnetic resonance spectroscopy of lipid dynamics in insulin-resistant muscle’’. In 2012, she was promoted to associate professor.In 2016, she took on a position in the High Field MRI Group at the University Medical Center Utrecht (UMCU).

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  • 2 Similar Profiles
Magnetic Resonance Spectroscopy Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Muscles Medicine & Life Sciences
Lipids Medicine & Life Sciences
Muscle Chemical Compounds
Long-Chain Acyl-CoA Dehydrogenase Medicine & Life Sciences
Liver Medicine & Life Sciences
Magnetic resonance spectroscopy Chemical Compounds

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Research Output 1995 2019

2 Citations (Scopus)

Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH

Khlebnikov, V., van der Kemp, W. J. M., Hoogduin, H., Klomp, D. W. J. & Prompers, J. J., 31 Jan 2019, In : Scientific Reports. 9, 11 p., 1089

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Dynamics in human muscle bioenergetics: in silico and in vivo studies of metabolism during exercise

Hendriks, A., Nabben, M. W., Schmitz, J. P. J., Hilbers, P. A. J., Prompers, J. J. & van Riel, N. A. W., 2019, (In preparation) Eindhoven: Technische Universiteit Eindhoven

Research output: Working paperAcademic

7 Citations (Scopus)

Detection of early cartilage damage: feasibility and potential of gagCEST imaging at 7T

Brinkhof, S., Nizak, R., Khlebnikov, V., Prompers, J. J., Klomp, D. W. J. & Saris, D. B. F., Jul 2018, In : European Radiology. 28, 7, p. 2874-2881 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)

Evaluation of cardiac energetics by non-invasive 31P magnetic resonance spectroscopy

Abdurrachim, D. & Prompers, J. J., Jan 2018, In : Biochimica et Biophysica Acta, Molecular Basis of Disease. 1864, 5, Part B, p. 1939-1948

Research output: Contribution to journalArticleAcademicpeer-review

Magnetic Resonance Spectroscopy
Energy Metabolism
Heart Failure
Diabetic Cardiomyopathies
Phosphorus
3 Citations (Scopus)

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes

NIGRAM consortium, 1 Apr 2018, In : Physiological Reports. 6, 7, 13 p., e13591

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cardiac Myocytes
Renal Insufficiency
Chronic Renal Insufficiency
Calcium
Systole

Student theses

31P NMR measurement of ATP synthesis flux in skeletal muscle for assessment of mitochondrial function

Author: Wong, C., 30 Sep 2011

Supervisor: Prompers, J. (Supervisor 1)

Student thesis: Master

A quantitative description of the ex- and in-vivo whole heart myocardial fiber architecture using DWI

Author: Vergoossen, L., 23 Jun 2016

Supervisor: Froeling, M. (Supervisor 1), Nicolaij, K. (Supervisor 2), Bovendeerd, P. (Supervisor 2), Prompers, J. (Supervisor 2) & Leiner, T. (External person) (Supervisor 2)

Student thesis: Master

Assessing the effects of training in patients with type 2 diabetes Mellitus and co-morbidity using 31P-MRS and NIRS

Author: Kramer, A., 30 Nov 2005

Supervisor: van Pul, C. (Supervisor 1), Prompers, J. (Supervisor 2), Wijn, P. (Supervisor 2) & Nicolaij, K. (Supervisor 2)

Student thesis: Master

A versatile MATLAB toolbox for the quantification of MRS data

Author: Vanlier, J., 30 Apr 2009

Supervisor: Jeneson, J. (Supervisor 1), van Riel, N. (Supervisor 2), Prompers, J. (Supervisor 2), Hilbers, P. (Supervisor 2) & Nicolaij, K. (Supervisor 2)

Student thesis: Master

Behind the murine lipoprotein in profile: a computational model of heterogeneous lipoprotein metabolism

Author: Sips, F., 31 Aug 2012

Supervisor: Hilbers, P. (Supervisor 1), van Riel, N. (Supervisor 2), Prompers, J. (Supervisor 2), Bakker, B. (External person) (Supervisor 2) & Tiemann, C. (Supervisor 2)

Student thesis: Master