• 2237 Citations
19952020

Research output per year

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Personal profile

Quote

"Non-invasive imaging of metabolic processes inside the human body will be key to understanding the mechanism of metabolic diseases"

Research profile

Jeanine Prompers is associate professor of Biomedical Magnetic Resonance Spectroscopy (MRS) in the TU/e department of Biomedical Engineering. Her research interest is to characterize metabolic disturbances underlying the etiology of metabolic diseases, in particular the metabolic syndrome and its complications, including type 2 diabetes, fatty liver disease and cardiovascular disease. To this end, she develops in vivo MRS methods to study metabolic processes in skeletal muscle, heart and liver, such as mitochondrial bioenergetics and carbohydrate and lipid metabolism. She combines pre-clinical studies with translational research in patients. For the latter, she is involved in the development of world’s first dedicated whole-body 7 tesla (7T) MR scanner for metabolic imaging (META-scan) in humans. In addition, she applies ultra-high field MRI (22.3 T, uNMR-NL facility) to study very small model systems, such as organoids and zebrafish. 

Currently, Jeanine Prompers is also setting up a research line in the field of Image Based Regenerative Medicine. The goal is to develop innovative MRI methods to non-invasively monitor the success of regenerative therapies, for example in the heart after a myocardial infarction.

Academic background

Jeanine Prompersstudied Chemistry at Radboud University Nijmegen (the Netherlands), where she graduated cum laude in 1994. The following years she performed PhD research in the field of high-resolution protein Magnetic Resonance Spectroscopy in the group of Prof. Cees Hilbers at the same university. In 1999, she obtained her PhD degree with her dissertation "NMR studies of Fusarium solanipisicutinase - Structure-mobility-function relationships". After her PhD, she was awarded a long-term postdoctoral fellowship of the Human Frontier of Science Program,to perform two years of research with Prof. RafaëlBrüschweilerat Clark University (USA). In 2002, she joined the Biomedical NMR group of Prof. KlaasNicolay at Eindhoven University of Technology as an assistant professor. In 2008, she was awarded a NWO VIDI grant entitled ‘’In vivo magnetic resonance spectroscopy of lipid dynamics in insulin-resistant muscle’’. In 2012, she was promoted to associate professor.In 2016, she took on a position in the High Field MRI Group at the University Medical Center Utrecht (UMCU).

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Research Output

31P magnetic resonance spectroscopy in skeletal muscle: experts' consensus recommendations

Experts' Working Group on 31P MR Spectroscopy of Skeletal Muscle, Meyerspeer, M., Jeneson, J. A. L. & Prompers, J. J., 1 Jan 2020, (Accepted/In press) In : NMR in Biomedicine. e4246.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 2 Citations (Scopus)

    Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

    de Bruijn, H. S., Mashayekhi, V., Schreurs, T. J. L., van Driel, P. B. A. A., Strijkers, G. J., van Diest, P. J., Lowik, C. W. G. M., Seynhaeve, A. L. B., Hagen, T. L. M. T., Prompers, J. J., van Bergen en Henegouwen, P. M. P., Robinson, D. J. & Oliveira, S., 1 Jan 2020, In : Theranostics. 10, 5, p. 2436-2452 17 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 2 Citations (Scopus)

    On the magnetic field dependence of deuterium metabolic imaging

    de Graaf, R. A., Hendriks, A. D., Klomp, D. W. J., Kumaragamage, C., Welting, D., Arteaga de Castro, C. S., Brown, P. B., McIntyre, S., Nixon, T. W., Prompers, J. J. & De Feyter, H. M., 1 Mar 2020, In : NMR in Biomedicine. 33, 3, 9 p., e4235.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH

    Khlebnikov, V., van der Kemp, W. J. M., Hoogduin, H., Klomp, D. W. J. & Prompers, J. J., 31 Jan 2019, In : Scientific Reports. 9, 1, 11 p., 1089.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
    5 Citations (Scopus)
    16 Downloads (Pure)

    Dynamics in human muscle bioenergetics: in silico and in vivo studies of metabolism during exercise

    Hendriks, A., Nabben, M. W., Schmitz, J. P. J., Hilbers, P. A. J., Prompers, J. J. & van Riel, N. A. W., 2019, (In preparation) Eindhoven: Technische Universiteit Eindhoven.

    Research output: Working paperAcademic

    Student theses

    31P NMR measurement of ATP synthesis flux in skeletal muscle for assessment of mitochondrial function

    Author: Wong, C., 30 Sep 2011

    Supervisor: Prompers, J. (Supervisor 1)

    Student thesis: Master

    A quantitative description of the ex- and in-vivo whole heart myocardial fiber architecture using DWI

    Author: Vergoossen, L., 23 Jun 2016

    Supervisor: Froeling, M. (Supervisor 1), Nicolaij, K. (Supervisor 2), Bovendeerd, P. (Supervisor 2), Prompers, J. (Supervisor 2) & Leiner, T. (External person) (Supervisor 2)

    Student thesis: Master

    Assessing the effects of training in patients with type 2 diabetes Mellitus and co-morbidity using 31P-MRS and NIRS

    Author: Kramer, A., 30 Nov 2005

    Supervisor: van Pul, C. (Supervisor 1), Prompers, J. (Supervisor 2), Wijn, P. (Supervisor 2) & Nicolaij, K. (Supervisor 2)

    Student thesis: Master

    A versatile MATLAB toolbox for the quantification of MRS data

    Author: Vanlier, J., 30 Apr 2009

    Supervisor: Jeneson, J. (Supervisor 1), van Riel, N. (Supervisor 2), Prompers, J. (Supervisor 2), Hilbers, P. (Supervisor 2) & Nicolaij, K. (Supervisor 2)

    Student thesis: Master

    Behind the murine lipoprotein in profile: a computational model of heterogeneous lipoprotein metabolism

    Author: Sips, F., 31 Aug 2012

    Supervisor: Hilbers, P. (Supervisor 1), van Riel, N. (Supervisor 2), Prompers, J. (Supervisor 2), Bakker, B. (External person) (Supervisor 2) & Tiemann, C. (Supervisor 2)

    Student thesis: Master