• 380 Citations
20052019
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Personal profile

Quote

“The relation between structure, function and pain in tendon & ligament is complex to the level that one may wonder whether we are missing a variable in the equation” 

Research profile

Jasper Foolen is Assistant Professor at the Orthopaedic Biomechanics group of the department of Biomedical Engineering. His main research interest is mechanobiology and regenerative strategies of tendons and ligaments. Tendon and ligament injuries are involved in over 30% of all musculoskeletal consultations. Over the past decades there has been limited progress in the treatment of tendinopathy and connective tissue fibrosis (scarring). It suffers from poor innate regenerative capacity, the clinical outcome of surgical interventions has remained rather poor and there is controversy concerning adequate treatment.

In his research, Jasper Foolen explores the mechanobiological processes that initiate degeneration and promote healing of tendons and ligaments. Experimental platforms (e.g. biomimetic tendons and ligaments) are exploited in combination with numerical models, to develop strategies to improve the structure and functionality of affected tendons and ligaments.

Current projects are concerned with the role of cellular junctions in tendon tissue organization, and the impact of cellular organization in 3D tissue on the healing capacity of tendon-derived cells. 

Academic background

Jasper Foolen studied Mechanical Engineering at Fontys University for Higher Education (Eindhoven, The Netherlands) and obtained his BSc in 2000. He then started his study in Biomedical Engineering at Eindhoven University of Technology (TU/e) where he obtained his BSc in 2003 and his MSc in 2005. From 2005 – 2009, he was a PhD student at the TU/e research group Orthopedic Biomechanics. In 2009 Foolen obtained his PhD with his thesis 'How periosteum is involved in long bone growth' under supervision of professors Keita Ito, Rik Huiskes and René van Donkelaar. From 2009 – 2013, he was a Postdoctoral Fellow at the TU/e research group for Soft Tissue Biomechanics and Engineering. In 2013 Foolen moved to Switzerland to become a Marie Curie Fellow at the Lab of Applied Mechanobiology at ETH Zurich. From 2015 – 2016, he was Group Leader at the Lab for Orthopaedic Biomechanics of University Hospital Balgrist / ETH Zurich. In 2016 Jasper Foolen was appointed Assistant Professor in Tendon and Ligament Mechanobiology at the TU/e research group Orthopedic Biomechanics. 

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  • 18 Similar Profiles
Periosteum Medicine & Life Sciences
Collagen Medicine & Life Sciences
Tissue Engineering & Materials Science
Stress Fibers Medicine & Life Sciences
Bone Development Medicine & Life Sciences
Tendons Medicine & Life Sciences
Fibers Engineering & Materials Science
Fibroblasts Medicine & Life Sciences

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Research Output 2005 2019

21 Citations (Scopus)

European Society of Biomechanics SM Perren Award 2010 : an adaptation mechanism for fibrous tissue to sustained shortening

Foolen, J., Donkelaar, van, C. C., Soekhradj - Soechit, R. S. & Ito, K., 2010, In : Journal of Biomechanics. 43, 16, p. 3168-3176

Research output: Contribution to journalArticleAcademicpeer-review

Biomechanics
Biomechanical Phenomena
Periosteum
Tissue
Fibers
40 Citations (Scopus)
307 Downloads (Pure)

Tendon injury and repair - A perspective on the basic mechanisms of tendon disease and future clinical therapy

Snedeker, J. G. & Foolen, J., 1 Nov 2017, In : Acta Biomaterialia. 63, p. 18-36

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tendon Injuries
Tendons
Repair
Physiology
Therapeutics
49 Citations (Scopus)
4 Downloads (Pure)

The influence of matrix integrity on stress-fiber remodeling in 3D

Foolen, J., Deshpande, V. S., Kanters, F. M. W. & Baaijens, F. P. T., Oct 2012, In : Biomaterials. 33, 30, p. 7508-7518 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stress Fibers
Collagen
Actins
Fibers
Tissue
12 Citations (Scopus)
71 Downloads (Pure)

Tissue alignment enhances remodeling potential of tendon-derived cells - lessons from a novel microtissue model of tendon scarring

Foolen, J., Wunderli, S. L., Loerakker, S. & Snedeker, J. G., Jan 2018, In : Matrix Biology. 65, p. 14-29 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tendons
Cicatrix
Tendinopathy
Extracellular Matrix
Matrix Metalloproteinases
7 Citations (Scopus)
64 Downloads (Pure)

Full-length fibronectin drives fibroblast accumulation at the surface of collagen microtissues during cell-induced tissue morphogenesis

Foolen, J., Shiu, J-Y., Mitsi, M., Zhang, Y., Chen, C. & Vogel, V., 2016, In : PLoS ONE. 11, 8, p. 1-24 e0160369.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
fibronectins
Fibroblasts
Morphogenesis
Fibronectins
morphogenesis

Student theses

Mechanical behaviour of porcine knee perichondrium during embryonic development

Author: Boumans, J., 28 Feb 2007

Supervisor: Huiskes, H. (Supervisor 1), van Donkelaar, C. (Supervisor 2), Oomens, C. (Supervisor 2) & Foolen, J. (Supervisor 2)

Student thesis: Master

Taking the orientation score framework one step further: from theory to applications in biomedical engineering

Author: Levink, J., 31 Aug 2009

Supervisor: ter Haar Romenij, B. (Supervisor 1), Kanters, F. (Supervisor 2), Duits, R. (Supervisor 2), van Donkelaar, C. (Supervisor 2) & Foolen, J. (Supervisor 2)

Student thesis: Master

The feasibility of inducing endochondral ossification by mechanical loading in osteochondral explants

Author: Foolen, J., 31 Aug 2005

Supervisor: Huiskes, H. (Supervisor 1), van Donkelaar, C. (Supervisor 2), Wilson, W. (Supervisor 2) & Buma, P. (External person) (Supervisor 2)

Student thesis: Master