Projects per year
Personal profile
Quote
"Creating molecular assemblies with life-like properties is not only of crucial importance to better understand the living cell, but also leads to the design of the next generation adaptive materials."
Research profile
Jan van Hest works at the cutting edge of (polymer) chemistry and biomedicine. He focuses on the design and synthesis of bio-inspired peptide-based materials and the development of conjugation methods for the preparation of biohybrid systems. The objective of his research is to construct smart compartments with life-like features, which develops along two main lines of research: nanomedicine and artificial cells and organelles.
The nanomedicine research line in particular concerns medicine transport systems and synthetic vaccines. Using a combination of techniques from polymer science to protein engineering, well-defined carriers and scaffolds are developed for application in e.g. cancer treatment, immunology and ophthalmology.
Van Hest is also active in the field of artificial and hybrid cells where he designs and constructs adaptive nano- and microcompartments that simulate living cells. His artificial nanoreactors can be incorporated as artificial organelles in living cells to complement or affect cellular processes.
Academic background
Jan van Hest obtained his PhD in macro-organic chemistry with professor Bert Meijer from Eindhoven University of Technology (TU/e) in 1996. He then worked as a postdoc researcher on protein engineering with professor David A. Tirrell at the University of Massachusetts. In 1997 van Hest started working at DSM (Geleen), first as a researcher and later as group head in the development of new material concepts. In 2000 Van Hest was appointed as full professor at Radboud University Nijmegen. As of September 2016 he holds the chair of Bio-organic Chemistry at TU/e. Over 30 PhD candidates have gained their doctorates under his supervision. He has published over 300 scientific articles (H-index 57) and is (co-)inventor of 17 patents and patent applications. Jan van Hest is also the joint founder of the start-ups Encapson, FutureChemistry, Noviosense and Noviotech.
Affiliated with
- Gravitation program Functional Molecular Systems
- ICMS
- PTN (postgraduate education polymer technology the Netherlands)
Partners in (semi-)industry
- GATT BV
- Zoetis
- GSK
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
Projects
- 1 Active
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TKI-LSH EUREKA COVID-19 Network Call application form 2020 Solutions for the next human high-impact pandemic
van Hest, J. C. M., van Hest, J. C. M. & Le, H. T. D.
1/12/20 → 30/11/23
Project: Research direct
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A virus-based biocatalyst
Carette, N., Engelkamp, H., Akpa, E., Pierre, S. J., Cameron, N. R., Christianen, P. C. M., Maan, J. C., Thies, J. C., Weberskirch, R., Rowan, A. E., Nolte, R. J. M., Michon, T. & van Hest, J. C. M., Apr 2007, In: Nature Nanotechnology. 2, 4, p. 226-229 4 p.Research output: Contribution to journal › Article › Academic › peer-review
108 Citations (Scopus)2 Downloads (Pure) -
Autonomous movement of platinum-loaded stomatocytes
Wilson, D. A., Nolte, R. J. M. & van Hest, J. C. M., Apr 2012, In: Nature Chemistry. 4, 4, p. 268-274 7 p.Research output: Contribution to journal › Article › Academic › peer-review
432 Citations (Scopus)6 Downloads (Pure) -
Cascade reactions in multicompartmentalized polymersomes
Peters, R. J. R. W., Marguet, M., Marais, S., Fraaije, M. W., van Hest, J. C. M. & Lecommandoux, S., 3 Jan 2014, In: Angewandte Chemie - International Edition. 53, 1, p. 146-150 5 p.Research output: Contribution to journal › Article › Academic › peer-review
379 Citations (Scopus)3 Downloads (Pure) -
Achieving Control in Micro-/Nanomotor Mobility
Fusi, A. D., Li, Y., Llopis-Lorente, A., Patiño, T., van Hest, J. C. M. & Abdelmohsen, L., 26 Jan 2023, In: Angewandte Chemie - International Edition. 62, 5, 16 p., e202214754.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
Chemical Cascading Between Polymersomal Nanoreactor Populations
Altay, Y., Llopis-Lorente, A., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., Jan 2023, In: Macromolecular Chemistry and Physics. 224, 1, 5 p., 2200269.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure)
Prizes
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Research Center for Functional Molecular Systems
Meijer, E.W. (Recipient), van Hest, J.C.M. (Recipient), Brunsveld, L. (Recipient), Janssen, R.A.J. (Recipient) & Sijbesma, R.P. (Recipient), 2013
Prize: NWO › Gravitation › Scientific
Courses
Press / Media
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Technische Universiteit Eindhoven Reports Findings in Nanomotors (Achieving Control in Micro-/Nanomotor Mobility)
Jan C.M. van Hest & Loai K.E.A. Abdelmohsen
22/12/22
1 item of Media coverage
Press/Media: Expert Comment
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Radboud University Reports Findings in Nanoparticles (Cargo-loading of hybrid cowpea chlorotic mottle virus capsids via a co-expression approach)
18/11/22
1 item of Media coverage
Press/Media: Expert Comment
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-Eindhoven University of Technology : Synthetic cells communicate with organic cells
12/10/22
2 items of Media coverage
Press/Media: Expert Comment
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Synthetic cells communicate with organic cells
11/10/22 → 12/10/22
2 items of Media coverage
Press/Media: Expert Comment
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-Eindhoven University of Technology : 'Women are often too modest. You do have a dream, don't you? Let's hear about it!'
Jan C.M. van Hest & Niels G. Deen
5/10/22
2 items of Media coverage
Press/Media: Expert Comment
Thesis
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De synthese van amfifiele polystyreen-ionene blockcopolymeren en de toepassing als polymere cokatalysator voor de katalytische oxidatie van 1-dodecaanthiol
Author: van Hest, J. C. M., 31 Dec 1991Supervisor: German, A. L. (Supervisor 1) & Schipper, F. (Coach)
Student thesis: Master