• 15974 Citations
1992 …2020

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2020

Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy

Sun, B., Chang, R., Cao, S., Yuan, C., Zhao, L., Yang, H., Li, J., Yan, X. & van Hest, J. C. M., 20 Jul 2020, In : Angewandte Chemie - International Edition. 59, 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Bone-Targeting Prodrug Mesoporous Silica-Based Nanoreactor with Reactive Oxygen Species Burst for Enhanced Chemotherapy

Tong, F., Ye, Y., Chen, B., Gao, J., Liu, L., Ou, J., van Hest, J. C. M., Liu, S., Peng, F. & Tu, Y., 5 Aug 2020, In : ACS Applied Materials & Interfaces. 12, 31, p. 34630-34642 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice

Zhong, Y., Meng, F., Zhang, W., Li, B., van Hest, J. C. M. & Zhong, Z., 10 Apr 2020, In : Journal of Controlled Release. 320, p. 421-430 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Compartmentalized cross-linked enzymatic nano -aggregates (c -CLE n A) for efficient in-flow biocatalysis

de Martino, M. T., Tonin, F., Yewdall, N. A., Abdelghani, M., Williams, D. S., Hanefeld, U., Rutjes, F. P. J. T., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 14 Mar 2020, In : Chemical Science. 11, 10, p. 2765-2769 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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17 Downloads (Pure)

Degradation and excretion of poly(2-oxazoline) based hemostatic materials

Boerman, M. A., Roozen, E. A., Franssen, G. M., Bender, J. C. M. E., Hoogenboom, R., Leeuwenburgh, S. C. G., Laverman, P., van Hest, J. C. M., van Goor, H. & Félix Lanao, R. P., Aug 2020, In : Materialia. 12, 11 p., 100763.

Research output: Contribution to journalArticleAcademicpeer-review

GE11 Peptide-Installed Chimaeric Polymersomes Tailor-Made for High-Efficiency EGFR-Targeted Protein Therapy of Orthotopic Hepatocellular Carcinoma

Zhou, C., Xia, Y., Wei, Y., Cheng, L., Wei, J., Guo, B., Meng, F., Cao, S., van Hest, J. C. M. & Zhong, Z., 1 Sep 2020, In : Acta Biomaterialia. 113, p. 512-521 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis

Pijpers, I. A. B., Cao, S., Llopis-Lorente, A., Zhu, J., Song, S., Joosten, R. R. M., Meng, F., Friedrich, H., Williams, D. S., Sánchez, S., van Hest, J. C. M. & Abdelmohsen, L. K. E. A., 10 Jun 2020, In : Nano Letters. 20, 6, p. 4472-4480 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Hyperthermia-Triggered On-Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy

Gao, J., Wang, F., Wang, S., Liu, L., Liu, K., Ye, Y., Wang, Z., Wang, H., Chen, B., Jiang, J., Ou, J., van Hest, J. C. M., Peng, F. & Tu, Y., 1 Jun 2020, In : Advanced Science. 7, 11, 9 p., 1903642.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Influence of surface charge on the formulation of elongated PEG-b-PDLLA nanoparticles

Ridolfo, R., Williams, D. S. & van Hest, J. C. M., 28 Apr 2020, In : Polymer Chemistry. 11, 16, p. 2775-2780 6 p.

Research output: Contribution to journalArticleAcademic

Open Access

Intercellular communication between artificial cells by allosteric amplification of a molecular signal

Buddingh', B. C., Elzinga, J. & van Hest, J. C. M., 3 Apr 2020, In : Nature Communications. 11, 1, 10 p., 1652.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
28 Downloads (Pure)

Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

Pijpers, I., Meng, F., van Hest, J. & Abdelmohsen, L., 14 Jan 2020, In : Polymer Chemistry. 11, 2, p. 275-280 6 p., 2.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
25 Downloads (Pure)

Multifunctional PVCL nanogels with redox-responsiveness enable enhanced MR imaging and ultrasound-promoted tumor chemotherapy

Xu, F., Zhu, J., Lin, L., Zhang, C., Sun, W., Fan, Y., Yin, F., van Hest, J. C. M., Wang, H., Du, L. & Shi, X., 1 Jan 2020, In : Theranostics. 10, 10, p. 4349-4358 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications

Georgilis, E., Abdelghani, M., Pille, J., Aydinlioglu, E., van Hest, J. C. M., Lecommandoux, S. & Garanger, E., 30 Aug 2020, In : International Journal of Pharmaceutics. 586, 119537.

Research output: Contribution to journalArticleAcademicpeer-review

Pathway dependent shape-transformation of azide-decorated polymersomes

Che, H., de Windt, L. N. J., Zhu, J., Pijpers, I. A. B., Mason, A. F., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 18 Feb 2020, In : Chemical Communications. 56, 14, p. 2127-2130 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
21 Downloads (Pure)

Photoactivated Polymersome Nanomotors: Traversing Biological Barriers

Shao, J., Cao, S., Williams, D. S., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 21 Sep 2020, In : Angewandte Chemie - International Edition. 59, 39, p. 16918-16925 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Photoactivated Polymersome Nanomotors: Traversing Biological Barriers

Shao, J., Cao, S., Williams, D. S., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 21 Sep 2020, In : Angewandte Chemie. 132, 39, p. 17066-17073 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: a combined COSMO-RS and experimental approach

Zhang, C., Song, Z., Jin, C., Nijhuis, J., Zhou, T., Noël, T., Gröger, H., Sundmacher, K., van Hest, J. & Hessel, V., 1 Apr 2020, In : Chemical Engineering Journal. 385, 10 p., 123399.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
59 Downloads (Pure)

Supramolecular nanoscaffolds within cytomimetic protocells as signal localization hubs

Magdalena Estirado, E., Mason, A. F., Garcia, M. A., van Hest, J. C. M. & Brunsveld, L., 20 May 2020, In : Journal of the American Chemical Society. 142, 20, p. 9106-9111 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy

Zhu, J., Xiao, T., Zhang, J., Che, H., Shi, Y., Shi, X. & van Hest, J. C. M., 22 Sep 2020, In : ACS Nano. 14, 9, p. 11225-11237 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Wormlike nanovector with enhanced drug loading using blends of biodegradable block copolymers

Ridolfo, R., Arends, J. J., van Hest, J. C. M. & Williams, D. S., 8 Jun 2020, In : Biomacromolecules. 21, 6, p. 2199-2207 9 p.

Research output: Contribution to journalArticleAcademic

α3β1 Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutic for Nonsmall Cell Lung Cancer Treatment

Zou, Y., Sun, Y., Guo, B., Wei, Y., Xia, Y., Huangfu, Z., Meng, F., van Hest, J. C. M., Yuan, J. & Zhong, Z., 1 Apr 2020, In : ACS Applied Materials and Interfaces. 12, 13, p. 14905-14913 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2019

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
72 Downloads (Pure)

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 12 Aug 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
27 Downloads (Pure)

A revised modular approach to (–)-trans-Δ 8 -THC and derivatives through late-stage Suzuki–Miyaura cross-coupling reactions

Bloemendal, V. R. L. J., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C. M. & Rutjes, F. P. J. T., 31 Mar 2019, In : European Journal of Organic Chemistry. 2019, 12, p. 2289-2296 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
38 Downloads (Pure)

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 6 Mar 2019, In : Advanced Science. 6, 5, 8 p., 1801678.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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10 Citations (Scopus)
44 Downloads (Pure)

Chemoenzymatic synthesis of sialic acid derivatives using immobilized N-acetylneuraminate lyase in a continuous flow reactor

Bloemendal, V. R. L. J., Moons, S. J., Heming, J. J. A., Chayoua, M., Niesink, O., van Hest, J. C. M., Boltje, T. J. & Rutjes, F. P. J. T., 6 Jun 2019, In : Advanced Synthesis & Catalysis. 361, 11, p. 2443-2447 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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14 Downloads (Pure)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 14 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
101 Downloads (Pure)

Dynamic assembly of micellar mesostructures

Altay, Y., Pijpers - Welzen, I., Abdelmohsen, L. & van Hest, J., 28 Oct 2019, In : ChemSystemsChem. 2, 2, 5 p., e1900049.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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9 Downloads (Pure)

Mimicking cellular compartmentalization in a hierarchical protocell through spontaneous spatial organization

Mason, A. F., Yewdall, A., Welzen, P. L. W., Shao, J., van Stevendaal, M., van Hest, J. C. M., Williams, D. S. & Abdelmohsen, L. K. E. A., 28 Aug 2019, In : ACS Central Science. 5, 8, p. 1360-1365 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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17 Citations (Scopus)
48 Downloads (Pure)

Molecular programming of biodegradable nanoworms via ionically induced morphology switch toward asymmetric therapeutic carriers

Cao, S., Shao, J., Xia, Y., Che, H., Zhong, Z., Meng, F., van Hest, J. C. M., Abdelmohsen, L. K. E. A. & Williams, D. S., 1 Sep 2019, In : Small. 15, 38, 8 p., 1901849.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Citations (Scopus)
44 Downloads (Pure)

Multifaceted cell mimicry in coacervate-based synthetic cells

Mason, A. & Hest, van, J. C. M., Nov 2019, In : Emerging Topics in Life Sciences. 3, 5, p. 567-571 5.

Research output: Contribution to journalArticleAcademicpeer-review

Myosin II isoforms play distinct roles in adherens junction biogenesis

Heuzé, M. L., Sankara Narayana, G. H. N., D'Alessandro, J., Cellerin, V., Dang, T., Williams, D. S., van Hest, J. C. M., Marcq, P., Mège, R. M. & Ladoux, B., 5 Sep 2019, In : eLife. 8, 30 p., e46599.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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10 Citations (Scopus)
166 Downloads (Pure)

Octa-arginine boosts the penetration of elastin-like polypeptide nanoparticles in 3D cancer models

van Oppen, L. M. P. E., Pille, J., Stuut, C., van Stevendaal, M., van der Vorm, L. N., Smeitink, J. A. M., Koopman, W. J. H., Willems, P. H. G. M., van Hest, J. C. M. & Brock, R., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 175-184 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
1 Downloads (Pure)

Physicochemical characterization of polymer-stabilized coacervate protocells

Yewdall, N. A., Buddingh, B. C., Altenburg, W. J., Timmermans, S. B. P. E., Vervoort, D. F. M., Abdelmohsen, L. K. E. A., Mason, A. F. & van Hest, J., 15 Oct 2019, In : ChemBioChem. 20, 20, p. 2643-2652 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
37 Downloads (Pure)

Scale-up of the manufacturing process to produce docetaxel-loaded mPEG- b-p(HPMA-Bz) block copolymer micelles for pharmaceutical applications

Bresseleers, J., Bagheri, M., Storm, G., Metselaar, J. M., Hennink, W. E., Meeuwissen, S. A. & van Hest, J. C. M., 20 Dec 2019, In : Organic Process Research and Development. 23, 12, p. 2707-2715 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
27 Downloads (Pure)

Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy

Zhu, J., Li, Z., Zhang, C., Lin, L., Cao, S., Che, H., Shi, X., Wang, H. & van Hest, J. C. M., 1 Jan 2019, In : Theranostics. 9, 26, p. 8048-8060 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
26 Downloads (Pure)

Versatile reversible cross-linking strategy to stabilize CCMV virus like particles for efficient siRNA delivery

Pretto, C. & van Hest, J. C. M., 18 Dec 2019, In : Bioconjugate Chemistry. 30, 12, p. 3069-3077 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
37 Downloads (Pure)
2018

Adaptive polymersome and micelle morphologies in anticancer nanomedicine: from design rationale to fabrication and proof-of-concept studies

Pijpers, I. A. B., Abdelmohsen, L. K. E. A., Xia, Y., Cao, S., Williams, D. S., Meng, F., van Hest, J. C. M. & Zhong, Z., 1 Dec 2018, In : Advanced Therapeutics. 1, 8, 14 p., 1800068.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Downloads (Pure)

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy

De Jong, E., Williams, D. S., Abdelmohsen, L. K. E. A., van Hest, J. C. M. & Zuhorn, I. S., 10 Nov 2018, In : Journal of Controlled Release. 289, p. 14-22 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
50 Downloads (Pure)

Biodegradable, drug-loaded nanovectors via direct hydration as a new platform for cancer therapeutics

Ridolfo, R., Ede, B. C., Diamanti, P., White, P. B., Perriman, A. W., van Hest, J. C. M., Blair, A. & Williams, D. S., 9 Aug 2018, In : Small. 14, 32, 10 p., 1703774.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
66 Downloads (Pure)

Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts

van Oppen, L. M. P. E., Abdelmohsen, L. K. E. A., van Emst-de Vries, S. E., Welzen, P. L. W., Wilson, D. A., Smeitink, J. A. M., Koopman, W. J. H., Brock, R., Willems, P. H. G. M., Williams, D. S. & van Hest, J. C. M., 25 Jul 2018, In : ACS Central Science. 4, 7, p. 917-928 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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17 Citations (Scopus)
101 Downloads (Pure)

Effect of formulation and processing parameters on the size of mPEG-b-p(HPMA-Bz) polymeric micelles

Bagheri, M., Bresseleers, J., Varela-Moreira, A., Sandre, O., Meeuwissen, S. A., Schiffelers, R. M., Metselaar, J. M., Van Nostrum, C. F., van Hest, J. C. M. & Hennink, W. E., 18 Dec 2018, In : Langmuir. 34, 50, p. 15495-15506 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
1 Downloads (Pure)

Erythrocyte membrane modified janus polymeric motors for thrombus therapy

Shao, J., Abdelghani, M., Shen, G., Cao, S., Williams, D. S. & van Hest, J. C. M., 22 May 2018, In : ACS Nano. 12, 5, p. 4877-4885 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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38 Citations (Scopus)
84 Downloads (Pure)

Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors

Che, H., Cao, S. & van Hest, J. C. M., 25 Apr 2018, In : Journal of the American Chemical Society. 140, 16, p. 5356–5359 4 p., 16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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58 Citations (Scopus)
135 Downloads (Pure)

Modular, bioorthogonal strategy for the controlled loading of cargo into a protein nanocage

Schoonen, L., Eising, S., van Eldijk, M. B., Bresseleers, J., Van Der Pijl, M., Nolte, R. J. M., Bonger, K. M. & van Hest, J. C. M., 18 Apr 2018, In : Bioconjugate Chemistry. 29, 4, p. 1186-1193 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
88 Downloads (Pure)

Nanoreactors for green catalysis

De Martino, M. T., Abdelmohsen, L. K. E. A., Rutjes, F. P. J. T., van Hest, J. C. M. & Hessel, V. (Guest ed.), 29 Mar 2018, In : Beilstein Journal of Organic Chemistry. 14, p. 716–733 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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23 Citations (Scopus)
121 Downloads (Pure)

PH-induced transformation of biodegradable multilamellar nanovectors for enhanced tumor penetration

Cao, S., Abdelmohsen, L. K. E. A., Shao, J., van den Dikkenberg, J., Mastrobattista, E., Williams, D. S. & van Hest, J. C. M., 20 Nov 2018, In : ACS Macro Letters. 7, 11, p. 1394-1399 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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12 Citations (Scopus)
59 Downloads (Pure)

Self-assembly and stabilization of hybrid cowpea chlorotic mottle virus particles under nearly physiological conditions

Timmermans, S. B. P. E., Vervoort, D. F. M., Schoonen, L., Nolte, R. J. M. & van Hest, J. C. M., 16 Nov 2018, In : Chemistry - An Asian Journal. 13, 22, p. 3518-3525 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
32 Downloads (Pure)

Temperature-induced collapse of elastin-like peptides studied by 2DIR spectroscopy

Selig, O., da Cunha, A. M. D. C. V., van Eldijk, M. B., van Hest, J. C. M., Jansen, T. L. C., Bakker, H. J. & Rezus, Y. L. A., 30 Aug 2018, In : Journal of Physical Chemistry B. 122, 34, p. 8243-8254 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
52 Downloads (Pure)

Virus-like particles as crosslinkers in fibrous biomimetic hydrogels: Approaches towards capsid rupture and gel repair

Schoenmakers, D. C., Schoonen, L., Rutten, M. G. T. A., Nolte, R. J. M., Rowan, A. E., van Hest, J. C. M. & Kouwer, P. H. J., 28 Feb 2018, In : Soft Matter. 14, 8, p. 1442-1448 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
128 Downloads (Pure)