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Personal profile

Quote

"Creating molecular assemblies with life-like properties is not only of crucial importance to better understand the living cell, but also leads to the design of the next generation adaptive materials."

Research profile

Jan van Hest works at the cutting edge of (polymer) chemistry and biomedicine. He focuses on the design and synthesis of bio-inspired peptide-based materials and the development of conjugation methods for the preparation of biohybrid systems. The objective of his research is to construct smart compartments with life-like features, which develops along two main lines of research: nanomedicine and artificial cells and organelles.

The nanomedicine research line in particular concerns medicine transport systems and synthetic vaccines. Using a combination of techniques from polymer science to protein engineering, well-defined carriers and scaffolds are developed for application in e.g. cancer treatment, immunology and ophthalmology.

Van Hest is also active in the field of artificial and hybrid cells where he designs and constructs adaptive nano- and microcompartments that simulate living cells. His artificial nanoreactors can be incorporated as artificial organelles in living cells to complement or affect cellular processes.

Academic background

Jan van Hest obtained his PhD in macro-organic chemistry with professor Bert Meijer from Eindhoven University of Technology (TU/e) in 1996. He then worked as a postdoc researcher on protein engineering with professor David A. Tirrell at the University of Massachusetts. In 1997 van Hest started working at DSM (Geleen), first as a researcher and later as group head in the development of new material concepts. In 2000 Van Hest was appointed as full professor at Radboud University Nijmegen. As of September 2016 he holds the chair of Bio-organic Chemistry at TU/e. Over 30 PhD candidates have gained their doctorates under his supervision. He has published over 300 scientific articles (H-index 57) and is (co-)inventor of 17 patents and patent applications. Jan van Hest is also the joint founder of the start-ups Encapson, FutureChemistry, Noviosense and Noviotech.

Affiliated with

  • Gravitation program Functional Molecular Systems
  • ICMS
  • PTN (postgraduate education polymer technology the Netherlands)

Partners in (semi-)industry

  • GATT BV
  • Zoetis
  • GSK

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1992 2019

95 Citations (Scopus)

A virus-based biocatalyst

Carette, N., Engelkamp, H., Akpa, E., Pierre, S. J., Cameron, N. R., Christianen, P. C. M., Maan, J. C., Thies, J. C., Weberskirch, R., Rowan, A. E., Nolte, R. J. M., Michon, T. & van Hest, J. C. M., Apr 2007, In : Nature Nanotechnology. 2, 4, p. 226-229 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biocatalysts
viruses
Viruses
Lipases
Enzymes
284 Citations (Scopus)

Autonomous movement of platinum-loaded stomatocytes

Wilson, D. A., Nolte, R. J. M. & van Hest, J. C. M., Apr 2012, In : Nature Chemistry. 4, 4, p. 268-274 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Platinum
Polymers
Nanoparticles
Monopropellants
Nanoreactors
220 Citations (Scopus)

Cascade reactions in multicompartmentalized polymersomes

Peters, R. J. R. W., Marguet, M., Marais, S., Fraaije, M. W., van Hest, J. C. M. & Lecommandoux, S., 3 Jan 2014, In : Angewandte Chemie - International Edition. 53, 1, p. 146-150 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Enzymes
Nanoreactors
Thiophenes
Polystyrenes
Thiophene

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Medical nanotechnology
Adaptive systems

Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations

Sánchez-Fernández, M. J., Immers, M. R., Félix Lanao, R. P., Yang, F., Bender, J. C. M. E., Mecinović, J., Leeuwenburgh, S. C. G. & van Hest, J. C. M., 1 Jan 2019, In : Biomacromolecules. 20, 8, p. 2913-2921 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alendronate
Cations
Calcium
Polymers
Positive ions

Prizes

Artificial endosymbiosis

Jan van Hest (Recipient), 2015

Recognition: ERCAdvancedScientific

symbiosis
organelles
cells
synthetic biology
uptake mechanisms

Research Center for Functional Molecular Systems

Bert Meijer (Recipient), Jan van Hest (Recipient), Luc Brunsveld (Recipient), Rene Janssen (Recipient) & Rint Sijbesma (Recipient), 2013

Recognition: NWOGravitationScientific

Netherlands
selection procedure
Ministry of Education
funding
organization

Press / Media

Jan van Hest named the new scientific director of ICMS

Jan van Hest

6/02/18

1 item of media coverage

Press/Media: Expert Comment

Artificial life and nanomedicine

Jan van Hest

20/06/16

1 item of media coverage

Press/Media: Expert Comment

Van Hest appointed as head of new group Bio-organic Chemistry

Jan van Hest

28/04/16

1 item of media coverage

Press/Media: Expert Comment

TU/e appoints Jan van Hest as head of new research group

Jan van Hest

25/04/16

1 item of media coverage

Press/Media: Expert Comment

World-first working eukaryotic cell made from plastic

Jan van Hest

16/01/14

1 item of media coverage

Press/Media: Expert Comment

Student theses

Development of reduction responsive polymersomes for controlled drug delivery

Author: Stam, R., 13 Nov 2018

Supervisor: Pijpers, I. (Supervisor 1), van Hest, J. (Supervisor 2), Brunsveld, L. (Supervisor 2) & Abdelmohsen, L. (Supervisor 2)

Student thesis: Master