• 7 Citations
20182019

Research output per year

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Personal profile

Academic background

Jaleesa Bresseleers received her M.Sc. in Molecular Life Sciences from Radboud University in 2013. During her master’s she worked on both capsid protein nanoparticles for the creation of nanoreactors in the Bio-Organic Chemistry group of Prof. Jan van Hest at Radboud University, and protein hydrogels for the development of a stress sensor in the group of Prof. David Tirrell at California Institute of Technology. Currently she is a Ph.D. candidate working on GMP production of nanomedicines in a company: ChemConnection under the supervision of Prof. Jan van Hest.

Research profile

The aim of Jaleesa's PhD project is to prepare robust and scalable manufacturing processes for the production of biodegradable nanomedicines and their building blocks. To achieve this, both batch and continuous flow processes will be developed and evaluated for the manufacture of highly potent materials. The development of these nanomedicines not only entails their preparation but also includes purification, reduction of production costs and the implementation of analytical methods to characterize the products. The main idea is to develop scalable routes towards a final nanomedicine product which is then tested for appropriate drug release, biodegradation and toxicology. Also investigation regarding shelf life, regulatory issues and safety issues will eventually readily translate into the GMP manufacturing of a clinical product.

Quote

Development of scalable processes for the manufacture of nanocarriers

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Research Output

  • 7 Citations
  • 3 Article

Scale-up of the manufacturing process to produce docetaxel-loaded mPEG- b-p(HPMA-Bz) block copolymer micelles for pharmaceutical applications

Bresseleers, J., Bagheri, M., Storm, G., Metselaar, J. M., Hennink, W. E., Meeuwissen, S. A. & van Hest, J. C. M., 20 Dec 2019, In : Organic Process Research and Development. 23, 12, p. 2707-2715 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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  • 5 Downloads (Pure)

    Effect of formulation and processing parameters on the size of mPEG-b-p(HPMA-Bz) polymeric micelles

    Bagheri, M., Bresseleers, J., Varela-Moreira, A., Sandre, O., Meeuwissen, S. A., Schiffelers, R. M., Metselaar, J. M., Van Nostrum, C. F., van Hest, J. C. M. & Hennink, W. E., 18 Dec 2018, In : Langmuir. 34, 50, p. 15495-15506 12 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • 3 Citations (Scopus)
    1 Downloads (Pure)

    Modular, bioorthogonal strategy for the controlled loading of cargo into a protein nanocage

    Schoonen, L., Eising, S., van Eldijk, M. B., Bresseleers, J., Van Der Pijl, M., Nolte, R. J. M., Bonger, K. M. & van Hest, J. C. M., 18 Apr 2018, In : Bioconjugate Chemistry. 29, 4, p. 1186-1193 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 4 Citations (Scopus)
    71 Downloads (Pure)