Projects per year
Personal profile
Quote
“One of the most fascinating scientific trends of today is the merging of technology and biology: new technological solutions are inspired by biology, and technology is used to study, understand, and even steer biological processes.”
Research profile
Jaap den Toonder is full professor and Chair of the Microsystems research Section at Eindhoven University of Technology (TU/e). His group focuses its research on the investigation and development of smart materials, innovative technological concepts, and microfabrication methods for microsystems, to enable novel applications often in the health and wellbeing domain. The application focus is on microfluidic chips, organ-on-chip, biomedical microdevices, and soft microrobotics. The group’s research approaches are often biologically inspired, translating principles from nature into technological innovations.
Den Toonder’s main personal research interests are microfluidics, nature-inspired micro-actuators, smart medical microdevices, and organs-on-chips to understand cancer. Den Toonder teaches courses on microfabrication methods, microfluidics, and heat and flow in microsystems, in which hands-on learning is a key element. He received two ERC Advanced Grants, in 2019 and in 2025. Den Toonder was elected Fellow of the Netherlands Academy of Engineering in 2023.
Academic background
Jaap den Toonder studied at Delft University of Technology where he obtained his MSc in Applied Mathematics (cum laude). He received his PhD (cum laude) from the same university on a numerical/theoretical and experimental study of drag reduction in turbulent flows by polymer additives. In 1995, he joined Philips Research Laboratories in Eindhoven, and began working in mechanics of solid materials. He worked on a wide variety of applications, such as ceramic capacitors, optical storage systems, IC low-k materials, RF MEMS, soft electronics, biomedical devices, polymer MEMS, and micro-fluidics. In 2008, he became Chief Technologist, leading the R&D program on (micro-)fluidics, and (starting 2011) materials science and engineering. He was involved in research programs on molecular diagnostics, lab-on-chip, immersion lithography and energy applications.
Next to his main job at Philips, he was a part-time professor of Microfluidics Technology at Eindhoven University of Technology between 2004 and 2013.
Affiliated with
- Member of the Executive Board of the human organ and Disease Model Technologies Institute (hDMT)
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Scientific advisor of AZAR Innovations
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Scientific advisor of ShanX Medtex
- Scientific advisor of InnoFluidics
Main partners in (semi-)industry
- Philips
- ASML
- Micronit
- TNO
- IMEC
- Santen-Innfocus
- DEMCON
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 7 Affordable and Clean Energy
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SDG 14 Life Below Water
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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bOne metaStatis chip with microphysiological Circulation for cAncer pRofiling LSHI22004
den Toonder, J. M. J. (Project Manager)
1/04/23 → 31/12/24
Project: Third tier
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Accelerating Innovation in Microfabricated Medical Devices
den Toonder, J. M. J. (Project Manager), Jouybar, M. (Project member) & Wang, Y. (Project member)
1/06/20 → 30/09/23
Project: Research direct
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Magnetic control of micro-particles and integrated micro-actuators for high precision handheld diagnostics
den Toonder, J. M. J. (Project Manager) & Shanko, E.-S. (Project member)
1/11/16 → 31/10/20
Project: Research direct
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Magnetically actuated glaucoma drainage device for regulating intraocular pressure after implantation
Pereira, I. C. F., van Mechelen, R., Wyss, H. M., Pinchuk, L., Beckers, H. J. M. & den Toonder, J. M. J. (Corresponding author), 20 Jul 2023, In: Microsystems & Nanoengineering. 9, 15 p., 92.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Link opens in a new tab Citations (Scopus)162 Downloads (Pure) -
Highly motile nanoscale magnetic artificial cilia
Ul Islam, T., Bellouard, Y. J. & den Toonder, J. M. J. (Corresponding author), 31 Aug 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 35, 7 p., e2104930118.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile35 Link opens in a new tab Citations (SciVal)142 Downloads (Pure) -
An artificial aquatic polyp that wirelessly attracts, grasps, and releases objects
Pilz da Cunha, M., Kandail, H. S., den Toonder, J. M. J. (Corresponding author) & Schenning, A. P. H. J. (Corresponding author), 28 Jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17571-17577 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access52 Link opens in a new tab Citations (Scopus) -
Removal of microparticles by ciliated surfaces: an experimental study
Zhang, S., Wang, Y., Onck, P. R. & den Toonder, J. M. J. (Corresponding author), 8 Feb 2019, In: Advanced Functional Materials. 29, 6, 11 p., 1806434.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile54 Link opens in a new tab Citations (Scopus)410 Downloads (Pure) -
A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing"
Eslami Amirabadi, H., Sahebali, S., Frimat, J. M. S., Luttge, R. & den Toonder, J. M. J., 17 Oct 2017, In: Biomedical Microdevices. 19, 4, 11 p., 19:92.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Link opens in a new tab Citations (Scopus)295 Downloads (Pure)
Datasets
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Source data for the publication: Curved Surfaces Induce Metachronal Motion of Microscopic Magnetic Cilia
Cui, Z. (Creator), Ul Islam, T. (Creator), Wang, Y. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7, https://data.4tu.nl/datasets/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7 and one more link, https://data.4tu.nl/datasets/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7/1 (show fewer)
Dataset
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Source data for the publication: Enhancement of microalgae growth using magnetic artificial cilia
Verburg, T. H. C. M. (Creator), Schaap, A. (Creator), Zhang, S. (Creator), den Toonder, J. (Creator) & Wang, Y. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc, https://data.4tu.nl/datasets/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc and one more link, https://data.4tu.nl/datasets/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc/1 (show fewer)
Dataset
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Source data for the publication: A Cell Pre-Wrapping Seeding Technique for Hydrogel-Based Tubular Organ-On-A-Chip
Nie, J. (Creator), Lou, S. (Creator), Pollet, A. (Creator), van Vegchel, M. (Creator), Bouten, C. V. C. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/6b6afa04-cf9c-4273-8150-8eb34c22b138, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138 and one more link, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138/1 (show fewer)
Dataset
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Source data for the publication: Highly motile nanoscale magnetic artificial cilia
den Toonder, J. M. J. (Contributor), Ul Islam, T. (Contributor) & Bellouard, Y. (Contributor), 4TU.Centre for Research Data, 30 May 2022
DOI: 10.4121/19915318, https://data.4tu.nl/articles/_/19915318
Dataset
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Source data for the publication: Nanomagnetic Elastomers for Realizing Highly Responsive Micro- and Nanosystems
den Toonder, J. M. J. (Creator), Venkataramanachar, B. (Creator), Li, J. (Creator), Islam, T. U. (Contributor) & Wang, Y. (Creator), 4TU.Centre for Research Data, 27 May 2024
DOI: 10.4121/ab5e2e3c-0a22-4fdf-936c-b8f7c2952391, https://data.4tu.nl/datasets/ab5e2e3c-0a22-4fdf-936c-b8f7c2952391 and one more link, https://data.4tu.nl/datasets/ab5e2e3c-0a22-4fdf-936c-b8f7c2952391/1 (show fewer)
Dataset
Prizes
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Netherlands Academy of Engineering Fellow
den Toonder, J. M. J. (Recipient), 2023
Prize: Other › Fellowships & memberships › Scientific
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Unraveling forces on cells with artificial microscopic hairs
den Toonder, J. (Recipient), 29 Mar 2019
Prize: ERC › Advanced › Scientific
Activities
- 6 Editorial activity
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Bio-Design and Manufacturing (Journal)
den Toonder, J. M. J. (Editorial board member)
2024 → …Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
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Micromachines (Journal)
den Toonder, J. M. J. (Editorial board member)
2018 → …Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
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Biomicrofluidics (Journal)
den Toonder, J. M. J. (Editorial board member)
2018 → …Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
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Biomimetics (Journal)
den Toonder, J. M. J. (Editorial board member)
2017 → …Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
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Frontiers in Mechanical Engineering (Journal)
den Toonder, J. M. J. (Editorial board member)
2014 → …Activity: Publication peer-review and editorial work types › Editorial activity › Scientific
Courses
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Advanced Micromanufacturing
Pollet, A., Lüttge, R., den Toonder, J. M. J., Pereira, I. C. F. & van de Burgt, Y. B. 1/09/15 → 31/08/27
Course
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Device Integrated Responsive Materials
Liu, D., Overvelde, J. T. B., den Toonder, J. M. J. & Bruns, M. 1/09/18 → 31/08/27
Course
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Heat and flow in microsystems
Frijns, A. J. H., den Toonder, J. M. J. & Luna-Triguero, A. 1/09/15 → 31/08/27
Course
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Microfluidics put to work
den Toonder, J. M. J., Wyss, H. M., Spanjaards, M., Pelssers, E., Pollet, A. & Saade, Y. 1/09/15 → 31/08/27
Course
Press/Media
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GLOBAL ROUND UP SECTOR WEEKLY: UNIVERSITY NEWSLETTER OF WEEK-ENDED NOV 05, 2023
Baaijens, F. P. T., Steinbuch, M., Mulder, W. J. M., den Toonder, J. M. J. & Lüttge, R.
6/11/23
1 item of Media coverage
Press/Media: Expert Comment
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Six TU/e researchers appointed fellows of the new Netherlands Academy of Engineering
Baaijens, F. P. T., Steinbuch, M., Mulder, W. J. M., den Toonder, J. M. J., Lüttge, R. & Fitzgerald, B.
2/11/23 → 3/11/23
2 items of Media coverage
Press/Media: Expert Comment
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Eindhoven University of Technology: Glow-In-the-Dark at the General Practitioner
Merkx, M., den Toonder, J. M. J. & van Aalen, E. A.
15/09/23
1 item of Media coverage
Press/Media: Expert Comment
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New Findings from Eindhoven University of Technology in the Area of Science Published (Miniaturized metachronal magnetic artificial cilia)
Wang, T., Cui, Z., den Toonder, J. M. J. & Wang, Y.
7/09/23
1 item of Media coverage
Press/Media: Expert Comment
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Reports from Eindhoven University of Technology Describe Recent Advances in Nanomagnetic (Nanomagnetic Elastomers for Realizing Highly Responsive Micro- and Nanosystems)
den Toonder, J. M. J., Wang, Y., Ul Islam, T. & Li, J.
24/08/23
1 item of Media coverage
Press/Media: Expert Comment