• 4232 Citations

Research output per year

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Personal profile


“One of the most fascinating scientific trends of today is the merging of technology and biology: new technological solutions are inspired by biology, and technology is used to study, understand, and even steer biological processes.”

Research profile

Jaap den Toonder is full professor and Chair of the Microsystems research Section at Eindhoven University of Technology (TU/e). His group focuses its research on the investigation and development of innovative technological concepts and fabrication methods for microsystems for a wide range of applications. The application focus is on microfluidic chips, biomedical microdevices, and soft microrobotics. The group’s research approaches are often biologically inspired, translating principles from nature into technological innovations.

Den Toonder’s main personal research interests are microfluidics, mechanical properties of biological cells and tissues, nature-inspired micro-actuators and organs-on-chips to understand cancer. Den Toonder teaches courses on microfabrication methods, microfluidics, and heat and flow in microsystems, in which hands-on learning is a key element.


Academic background

Jaap den Toonder studied at Delft University of Technology where he obtained his MSc in Applied Mathematics (with honors). He received his PhD  (with honors) from the same university on a numerical/theoretical and experimental study of drag reduction in turbulent flows by polymer additives. In 1995, he joined Philips Research Laboratories in Eindhoven, and began working in mechanics of solid materials. He worked on a wide variety of applications, such as ceramic capacitors, optical storage systems, IC low-k materials, RF MEMS, soft electronics, biomedical devices, polymer MEMS, and micro-fluidics. In 2008, he became Chief Technologist, leading the R&D program on (micro-)fluidics, and (starting  2011) materials science and engineering. He was involved in research programs on molecular diagnostics, lab-on-chip, immersion lithography and energy applications.  

In addition to his job at Philips, Jaap den Toonder was a part-time professor at the TU/e  Materials Technology group between 2004 and 2013.  He has (co-)authored over 100 scientific papers, as well as over 40 patent applications. He is a member of the Editorial Board of Lab on a Chip, Micro-and Nanoelectromechanical Systems, Micromachines, and Biomimetics.

Den Toonder is recipient of an ERC Advancd Grant in 2019.

Affiliated with

  • Chairman of the Consortium Assembly of the human organ and Disease Model Technologies Institute (hDMT)
  • Chairman of the Board of Examiners, Department of Mechanical Engineering, TU/e
  • Scientific Advisor to Philips Research

Partners in (semi-)industry

  • Philips
  • ASML
  • Micronit
  • TNO

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Research Output

Climbing droplets driven by mechanowetting on transverse waves

De Jong, E., Wang, Y., den Toonder, J. & Onck, P. R., 14 Jun 2019, In : Science Advances. 5, 6, 8 p., eaaw0914.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • 5 Citations (Scopus)
    59 Downloads (Pure)

    Removal of microparticles by ciliated surfaces: an experimental study

    Zhang, S., Wang, Y., Onck, P. R. & den Toonder, J. M. J., 8 Feb 2019, In : Advanced Functional Materials. 29, 6, 11 p., 1806434.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 6 Citations (Scopus)
    86 Downloads (Pure)

    A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing"

    Eslami Amirabadi, H., Sahebali, S., Frimat, J. M. S., Luttge, R. & den Toonder, J. M. J., 17 Oct 2017, In : Biomedical Microdevices. 19, 4, 11 p., 19:92.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    13 Citations (Scopus)
    127 Downloads (Pure)

    Microfluidic magnetic bead conveyor belt

    van Pelt, S., Frijns, A. J. H. & den Toonder, J. M. J., 21 Nov 2017, In : Lab on a Chip. 17, 22, p. 3826-3840 15 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 7 Citations (Scopus)
    91 Downloads (Pure)

    An integrated flex-microfluidic-Si chip device towards sweat sensing applications

    Nie, C., Frijns, A. J. H., Zevenbergen, M. A. G. & den Toonder, J. M. J., 1 Jan 2016, In : Sensors and Actuators, B: Chemical. 227, p. 427-437

    Research output: Contribution to journalArticleAcademicpeer-review

    20 Citations (Scopus)
    12 Downloads (Pure)


    Unraveling forces on cells with artificial microscopic hairs

    Jaap den Toonder (Recipient), 29 Mar 2019

    Prize: ERCAdvancedScientific

  • Courses

    Heat and flow in microsystems

    1/09/15 → …


    Microfabrication methods

    1/09/15 → …


    Microfluidics put-to-work

    1/09/15 → …


    Student theses

    3D printing of microfluidic chips with different modules for point-of-care testing applications

    Author: Ojha, A., 30 Aug 2019

    Supervisor: den Toonder, J. M. (Supervisor 1), Bernards, J. (External person) (External coach) & Planken, K. L. (External coach)

    Student thesis: Master


    Active microfluidic mixing using integrated actuators

    Author: Bos, F., 31 May 2007

    Supervisor: den Toonder, J. (Supervisor 1), Anderson, P. (Supervisor 2) & van de Vosse, F. (Supervisor 2)

    Student thesis: Master

    Biomechanical regulation of endothelial phenotypic heterogeneity: arterial versus venous

    Author: Norouzi, Y., 30 Sep 2013

    Supervisor: Bouten, C. (Supervisor 1), van de Stolpe, A. (External person) (Supervisor 2) & den Toonder, J. (Supervisor 2)

    Student thesis: Master

    Characterisation of interfacial strength of low-k dielectric materials used in ICs

    Author: Kouters, M., 31 Aug 2006

    Supervisor: Geers, M. (Supervisor 1), den Toonder, J. (Supervisor 2), Peerlings, R. (Supervisor 2), van Hal, B. (Supervisor 2) & van Silfhout, R. (Supervisor 2)

    Student thesis: Master

    Characterization of freestanding thin film properties for RF-MEMS

    Author: Burg, V., 30 Jun 2006

    Supervisor: den Toonder, J. (Supervisor 1), van Dijken, A. R. (External person) (External coach), Hoefnagels, J. (Supervisor 2) & Geers, M. (Supervisor 2)

    Student thesis: Master