Projects per year
Personal profile
Quote
“One of the most fascinating scientific trends of today is the merging of technology and biology: new technological solutions are inspired by biology, and technology is used to study, understand, and even steer biological processes.”
Research profile
Jaap den Toonder is full professor and Chair of the Microsystems research Section at Eindhoven University of Technology (TU/e). His group focuses its research on the investigation and development of innovative technological concepts, fabrication methods, and interactive polymer materials for microsystems for a wide range of applications. The application focus is on microfluidic chips, biomedical microdevices, and soft microrobotics. The group’s research approaches are often biologically inspired, translating principles from nature into technological innovations.
Den Toonder’s main personal research interests are microfluidics, nature-inspired micro-actuators, smart medical microdevices, and organs-on-chips to understand cancer. Den Toonder teaches courses on microfabrication methods, microfluidics, and heat and flow in microsystems, in which hands-on learning is a key element. He received an ERC Advanced Grant in 2019. Den Toonder was elected Fellow of the Netherlands Academy of Engineering in 2023.
Academic background
Jaap den Toonder studied at Delft University of Technology where he obtained his MSc in Applied Mathematics (cum laude). He received his PhD (cum laude) from the same university on a numerical/theoretical and experimental study of drag reduction in turbulent flows by polymer additives. In 1995, he joined Philips Research Laboratories in Eindhoven, and began working in mechanics of solid materials. He worked on a wide variety of applications, such as ceramic capacitors, optical storage systems, IC low-k materials, RF MEMS, soft electronics, biomedical devices, polymer MEMS, and micro-fluidics. In 2008, he became Chief Technologist, leading the R&D program on (micro-)fluidics, and (starting 2011) materials science and engineering. He was involved in research programs on molecular diagnostics, lab-on-chip, immersion lithography and energy applications.
Next to his main job at Philips, he was a part-time professor of Microfluidics Technology at Eindhoven University of Technology between 2004 and 2013.
Affiliated with
- Member of the Executive Board of the human organ and Disease Model Technologies Institute (hDMT)
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Scientific advisor of AZAR Innovations
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Scientific advisor of ShanX Medtex
- Scientific advisor of InnoFluidics
Main partners in (semi-)industry
- Philips
- ASML
- Micronit
- TNO
- IMEC
- Santen-Innfocus
- DEMCON
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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bOne metaStatis chip with microphysiological Circulation for cAncer pRofiling LSHI22004
den Toonder, J. M. J. (Project Manager)
1/04/23 → 31/12/24
Project: Third tier
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Accelerating Innovation in Microfabricated Medical Devices
den Toonder, J. M. J. (Project Manager), Jouybar, M. (Project member) & Wang, Y. (Project member)
1/06/20 → 30/09/23
Project: Research direct
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Magnetic control of micro-particles and integrated micro-actuators for high precision handheld diagnostics
den Toonder, J. M. J. (Project Manager) & Shanko, E. (Project member)
1/11/16 → 31/10/20
Project: Research direct
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Magnetically actuated glaucoma drainage device for regulating intraocular pressure after implantation
Pereira, I. C. F., van Mechelen, R., Wyss, H. M., Pinchuk, L., Beckers, H. J. M. & den Toonder, J. M. J. (Corresponding author), 20 Jul 2023, In: Microsystems & Nanoengineering. 9, 15 p., 92.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)86 Downloads (Pure) -
Highly motile nanoscale magnetic artificial cilia
Ul Islam, T., Bellouard, Y. J. & den Toonder, J. M. J. (Corresponding author), 31 Aug 2021, In: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 118, 35, 7 p., e2104930118.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Citations (Scopus)91 Downloads (Pure) -
An artificial aquatic polyp that wirelessly attracts, grasps, and releases objects
Pilz da Cunha, M., Kandail, H. S., den Toonder, J. M. J. (Corresponding author) & Schenning, A. P. H. J. (Corresponding author), 28 Jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 117, 30, p. 17571-17577 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access40 Citations (Scopus) -
Removal of microparticles by ciliated surfaces: an experimental study
Zhang, S., Wang, Y., Onck, P. R. & den Toonder, J. M. J. (Corresponding author), 8 Feb 2019, In: Advanced Functional Materials. 29, 6, 11 p., 1806434.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile49 Citations (Scopus)308 Downloads (Pure) -
A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing"
Eslami Amirabadi, H., Sahebali, S., Frimat, J. M. S., Luttge, R. & den Toonder, J. M. J., 17 Oct 2017, In: Biomedical Microdevices. 19, 4, 11 p., 19:92.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Citations (Scopus)234 Downloads (Pure)
Datasets
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Source data for the publication: Curved Surfaces Induce Metachronal Motion of Microscopic Magnetic Cilia
Cui, Z. (Creator), Ul Islam, T. (Creator), Wang, Y. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7, https://data.4tu.nl/datasets/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7 and one more link, https://data.4tu.nl/datasets/49513019-dc6d-4f6e-9bc5-36bc4d8db1a7/1 (show fewer)
Dataset
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Source data for the publication: Enhancement of microalgae growth using magnetic artificial cilia
Verburg, T. H. C. M. (Creator), Schaap, A. (Creator), Zhang, S. (Creator), den Toonder, J. (Creator) & Wang, Y. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc, https://data.4tu.nl/datasets/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc and one more link, https://data.4tu.nl/datasets/90b75bcc-fe98-4c92-bfd1-97d1801d2cdc/1 (show fewer)
Dataset
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Source data for the publication: A Cell Pre-Wrapping Seeding Technique for Hydrogel-Based Tubular Organ-On-A-Chip
Nie, J. (Creator), Lou, S. (Creator), Pollet, A. (Creator), van Vegchel, M. (Creator), Bouten, C. V. C. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 15 Nov 2024
DOI: 10.4121/6b6afa04-cf9c-4273-8150-8eb34c22b138, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138 and one more link, https://data.4tu.nl/datasets/6b6afa04-cf9c-4273-8150-8eb34c22b138/1 (show fewer)
Dataset
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Microfluidic Models of Metastasis: In vitro approaches to study the tumor microenvironment - supplementary design and video files
Sleeboom, J. (Creator), Sahlgren, C. M. (Creator) & den Toonder, J. M. J. (Creator), 4TU.Centre for Research Data, 21 Aug 2020
DOI: 10.4121/uuid:08ac69b6-6430-4ffa-a33e-40da88821dc6
Dataset
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Source data for the publication: Controlled multidirectional particle transportation by magnetic artificial cilia
Zhang, S. (Contributor), Zhang, R. (Contributor), Wang, Y. (Contributor), Onck, P. R. (Contributor) & den Toonder, J. M. J. (Contributor), 4TU.Centre for Research Data, 30 May 2022
DOI: 10.4121/19915390
Dataset
Prizes
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Unraveling forces on cells with artificial microscopic hairs
den Toonder, J. (Recipient), 29 Mar 2019
Prize: ERC › Advanced › Scientific
Courses
Press/Media
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New Findings from Eindhoven University of Technology in the Area of Science Published (Miniaturized metachronal magnetic artificial cilia)
Wang, T., Cui, Z., den Toonder, J. M. J. & Wang, Y.
7/09/23
1 item of Media coverage
Press/Media: Expert Comment
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-Eindhoven University of Technology: Major EU grants for groundbreaking research into scoliosis and transplant organ rejection
Ito, K., Mulder, W. J. M., den Toonder, J. M. J. & Bakkers, E. P. A. M.
23/04/21
1 item of Media coverage
Press/Media: Expert Comment
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Major EU grants for groundbreaking research into scoliosis and transplant organ rejection
Ito, K., Mulder, W. J. M., den Toonder, J. M. J. & Bakkers, E. P. A. M.
22/04/21
1 item of Media coverage
Press/Media: Expert Comment
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-TU/e involved in all six Perspectief programs
Govaert, L. E., Voeten, J. P. M., den Toonder, J. M. J., Nijmeijer, K. & Kok, J. K.
11/03/21
1 item of Media coverage
Press/Media: Expert Comment
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-TU Delft and partners to create superhighway for digital data:
den Toonder, J. M. J. & Kok, J. K.
11/03/21
1 item of Media coverage
Press/Media: Expert Comment