Iris A. Leijten-van de Gevel

ir.

  • 2 Citations
20192019
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Personal profile

Research profile

Iris van de Gevel is a PhD candidate under the supervision of prof. dr. ir. Luc Brunsveld. In this group, she investigates allosteric mechanisms in which Nuclear Receptors can be targeted. This could yield new possibilities for selective modulation of these receptors. In her research, she combines computational biology, protein engineering and biochemical assays.

Academic background

Iris van de Gevel (1994) received her Bachelor and Master degree in Biomedical Engineering at Eindhoven University of Technology (TU/e) in 2015 and 2017 respectively, both with great appreciation. In her Master she joined the Chemical Biology group of prof. dr. ir. Luc Brunsveld. For her Master’s graduation project, she investigated the interactions between 14-3-3 proteins and different regions of Nuclear Receptors to screen for drug interference possibilities. She completed her degree with a 3 month internship at AstraZeneca Mölndal. Here, she worked on the development of high throughput cellular thermal shift assays for use in several phases of drug discovery.

Fingerprint Dive into the research topics where Iris A. Leijten-van de Gevel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Biomedical Engineering Medicine & Life Sciences
14-3-3 Proteins Medicine & Life Sciences
Protein Engineering Medicine & Life Sciences
Iris Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences
Internship and Residency Medicine & Life Sciences
Computational Biology Medicine & Life Sciences

Research Output 2019 2019

  • 2 Citations
  • 1 Article
2 Citations (Scopus)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 1 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology

Student theses

Exploring novel binding modes between 14-3-3 and nuclear receptors

Author: van de Gevel, I., 31 Aug 2017

Supervisor: Sijbesma, E. (Supervisor 1) & Brunsveld, L. (Supervisor 2)

Student thesis: Master