• 88 Citations
20162020

Research output per year

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Personal profile

Research profile

Polymeric nanoparticles composed out of biodegradable polymers have promising properties as a (drug delivery) platform in nanomedicine. My research involves the chemical engineering of these polymer particles, or polymersomes, and control their morphology for optimal biological behaviour. Our particles are specifically developed to encapsulate certain drugs or functional motifs and can for example be deployed as mini-reactors for in situ generation of molecules. Some of the key points in these studies involve the use of morphologically distinct particles in vitro and in vivo, studying their drug encapsulation and retention and determining how their structure is influenced by ex- and internal parameters. With this information at hand, we hope we become one small step further towards the development of a new generation of drug delivery carriers.

Quote

Utilizing morphology of polymeric nanoparticles towards a better implementation in biomedical applications

Academic background

Imke Pijpers received her M.Sc. degree in molecular materials from Radboud University in 2016. During her master internship, she worked on the development and physically and chemically crosslinked hydrogels for applications in tissue engineering in the group of Professor Jan van Hest and Dr. Dennis Löwik. She did additional internships at TNO (silica nanoparticles), Nano4Imaging (coatings) and TU Eindhoven (supramolecular chemistry). She is currently working as a PhD candidate in the Bio-Organic Chemistry group under supervision of Dr. Loai Abdelmohsen and Professor Jan van Hest.

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Research Output

  • 88 Citations
  • 10 Article
  • 1 Review article

Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis

Pijpers, I. A. B., Cao, S., Llopis-Lorente, A., Zhu, J., Song, S., Joosten, R. R. M., Meng, F., Friedrich, H., Williams, D. S., Sánchez, S., van Hest, J. C. M. & Abdelmohsen, L. K. E. A., 10 Jun 2020, In : Nano Letters. 20, 6, p. 4472-4480 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
  • Open Access
    File
  • 2 Citations (Scopus)
    17 Downloads (Pure)

    Pathway dependent shape-transformation of azide-decorated polymersomes

    Che, H., de Windt, L. N. J., Zhu, J., Pijpers, I. A. B., Mason, A. F., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 18 Feb 2020, In : Chemical Communications. 56, 14, p. 2127-2130 4 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 10 Downloads (Pure)

    ATP-mediated transient behavior of stomatocyte nanosystems

    Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 9 Sep 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118 6 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
    File
  • 5 Citations (Scopus)
    3 Downloads (Pure)

    Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

    Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 6 Mar 2019, In : Advanced Science. 6, 5, 8 p., 1801678.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 6 Citations (Scopus)
    36 Downloads (Pure)

    Student theses

    Development of reduction responsive polymersomes for controlled drug delivery

    Author: Stam, R., 13 Nov 2018

    Supervisor: Pijpers, I. (Supervisor 1), van Hest, J. (Supervisor 2), Brunsveld, L. (Supervisor 2) & Abdelmohsen, L. (Supervisor 2)

    Student thesis: Master