• 75 Citations
20162020
If you made any changes in Pure these will be visible here soon.

Personal profile

Research profile

Polymeric nanoparticles composed out of biodegradable polymers have promising properties as a (drug delivery) platform in nanomedicine. My research involves the chemical engineering of these polymer particles, or polymersomes, and control their morphology for optimal biological behaviour. Our particles are specifically developed to encapsulate certain drugs or functional motifs and can for example be deployed as mini-reactors for in situ generation of molecules. Some of the key points in these studies involve the use of morphologically distinct particles in vitro and in vivo, studying their drug encapsulation and retention and determining how their structure is influenced by ex- and internal parameters. With this information at hand, we hope we become one small step further towards the development of a new generation of drug delivery carriers.

Quote

Utilizing morphology of polymeric nanoparticles towards a better implementation in biomedical applications

Academic background

Imke Pijpers received her M.Sc. degree in molecular materials from Radboud University in 2016. During her master internship, she worked on the development and physically and chemically crosslinked hydrogels for applications in tissue engineering in the group of Professor Jan van Hest and Dr. Dennis Löwik. She did additional internships at TNO (silica nanoparticles), Nano4Imaging (coatings) and TU Eindhoven (supramolecular chemistry). She is currently working as a PhD candidate in the Bio-Organic Chemistry group under supervision of Dr. Loai Abdelmohsen and Professor Jan van Hest.

Fingerprint Dive into the research topics where Imke A.B. Pijpers is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Polyethylene glycols Chemical Compounds
Medical nanotechnology Chemical Compounds
Nanosystems Chemical Compounds
Self assembly Chemical Compounds
Polymers Chemical Compounds
Micelles Chemical Compounds
Nanoparticles Chemical Compounds
erythrocytes Physics & Astronomy

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2016 2020

  • 75 Citations
  • 8 Article
  • 1 Review article
6 Downloads (Pure)
Open Access
File
Ethylene Glycol
Self assembly
Polyethylene glycols
Polymers
Organic solvents
3 Citations (Scopus)
2 Downloads (Pure)

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 9 Sep 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions
5 Citations (Scopus)
22 Downloads (Pure)

Biomorphic engineering of multifunctional polylactide stomatocytes toward therapeutic nano-red blood cells

Shao, J., Pijpers, I. A. B., Cao, S., Williams, D. S., Yan, X., Li, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 6 Mar 2019, In : Advanced Science. 6, 5, 8 p., 1801678.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
erythrocytes
Blood
Erythrocytes
Cells
engineering
5 Citations (Scopus)
58 Downloads (Pure)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 14 Jan 2019, In : Biomacromolecules. 20, 1, p. 177-183 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures

Dynamic assembly of micellar mesostructures

Altay, Y., Pijpers - Welzen, I., Abdelmohsen, L. & van Hest, J., 28 Oct 2019, In : ChemSystemsChem. 5 p., e1900049.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Biological systems
Nanosystems
Micelles
Disulfides
Association reactions

Student theses

Development of reduction responsive polymersomes for controlled drug delivery

Author: Stam, R., 13 Nov 2018

Supervisor: Pijpers, I. (Supervisor 1), van Hest, J. (Supervisor 2), Brunsveld, L. (Supervisor 2) & Abdelmohsen, L. (Supervisor 2)

Student thesis: Master