Projects per year
Duc Le joined the group of Prof. Jan C. M. van Hest from June 2018. He is the postdoctoral researcher for the project aiming at developing thermoresponsive nanomaterials for anticancer treatment.
Duc trained at the University of Tokyo, Department of Chemical System Engineering. He obtained his Ph.D. degree with the work on designing and developing double hydrophobic elastin-like block polypeptides. His designed block polymers can assemble into flexible beaded nanofibers applicable for tissue engineering.
He started his journey to Case Western Reserve University School of Medicine to gain further experiences in Drug Delivery and Nanomedicine. His targeting material is potato virus X, a plant virus with a filamentous structure that can be functionalized via chemical reactions or genetic fusion to display various therapeutic drugs, which were laterally tested in vitro and in vivo showing tumor inhibiting at high efficiency.
In the current project, he and the team aim to develop a clinically relevant drug delivery system from diblock elastin-like polypeptides with multifunctional modules that can target and destroy cancer cells in controlled manners, i.e. light or heat, for ovarian cancer treatment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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TKI-LSH EUREKA COVID-19 Network Call application form 2020 Solutions for the next human high-impact pandemic
van Hest, J. C. M., van Hest, J. C. M. & Le, H. T. D.
1/12/20 → 30/11/23
Project: Research direct
- 2 Article
Pathway-dependent co-assembly of elastin-like polypeptidesPille, J., Aloi, A., Le, D. H. T., Vialshin, I., van de Laar, N., Kevenaar, K., Merkx, M., Voets, I. K. & van Hest, J. C. M., 1 Apr 2021, In: Small. 17, 13, 7 p., 2007234.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen Access
Self-assembly or coassembly of multiresponsive histidine-containing elastin-like polypeptide block copolymersAbdelghani, M., Shao, J., Le, D. H. T., Wu, H. & van Hest, J. C. M., Jun 2021, In: Macromolecular Bioscience. 21, 6, 9 p., 2100081.
Research output: Contribution to journal › Article › Academic › peer-reviewOpen AccessFile7 Citations (SciVal)71 Downloads (Pure)