• 1793 Citations
20072019
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Personal profile

Research profile

Holger Grüll

studied chemistry in Cologne, Germany, where he obtained his PhD in 1996 in physical chemistry for research on interfacial phenomena in critical mixtures. After his PhD, Holger Grüll received a Feodor-Lynen Fellowship of the Alexander von Humboldt Society and stayed from 1997 to 1999 at the National Institute of Standards and Technology (NIST, Gaithersburg, USA), where he specialized on surface and interfacial phenomena in polymer thin films and biomimetic membranes. From 1999 to 2000, a post-doctorial stay followed at the Ben-Gurion University of Be’er Sheva, Israel, with research on dewetting phenomena in thin films and Langmuir-Blodgett layers. In 2000, Holger Grüll started at Philips Research in the area of molecular diagnostics. Since 2004, Holger Grüll is scientifically responsible for several research projects on new agents for molecular imaging and therapy.

In 2007, Holger Grüll was appointed part-time professor in the group of  Biomedical NMR at the Faculty of Biomedical Engineering at Eindhoven University of Technology. His chair is focusing on development of new nanoconstructs for molecular imaging and therapy.

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Research Output 2007 2019

Correction to: imaging of tumor spheroids, dual-isotope SPECT, and autoradiographic analysis to assess the tumor uptake and distribution of different nanobodies

Beltrán Hernández, I., Rompen, R., Rossin, R., Xenaki, K. T., Katrukha, E. A., Nicolay, K., Henegouwen, P. V. B. E., Grüll, H. & Oliveira, S., 15 Apr 2019, In : Molecular Imaging and Biology. 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access
Single-Domain Antibodies
Single-Photon Emission-Computed Tomography
Isotopes
Neoplasms
1 Citation (Scopus)

Imaging of tumor spheroids, dual-isotope SPECT, and autoradiographic analysis to assess the tumor uptake and distribution of different nanobodies

Beltrán Hernández, I., Rompen, R., Rossin, R., Xenaki, K. T., Katrukha, E. A., Nicolay, K., van Bergen en Henegouwen, P., Grüll, H. & Oliveira, S., 11 Mar 2019, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Single-Domain Antibodies
Single-Photon Emission-Computed Tomography
Isotopes
Neoplasms
Autoradiography

Offset-free model predictive control for enhancing MR-HIFU hyperthermia in cancer treatment

Deenen, D. A., Maljaars, E., Sebeke, L., de Jager, B., Heijman, E., Grüll, H. & Heemels, W. P. M. H., 22 Nov 2018, In : IFAC-PapersOnLine. 51, 20, p. 191-196 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Oncology
Model predictive control
Tumors
Magnetic resonance
Temperature control
1 Citation (Scopus)

Development of a novel, fibrin-specific PET tracer

van Mourik, T. R., Claesener, M., Nicolay, K. & Grüll, H., 30 May 2017, In : Journal of Labelled Compounds and Radiopharmaceuticals. 60, 6, p. 286-293 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fibrin
Gallium
Peptides
Tumors
Blood
7 Citations (Scopus)

Interleaved mapping of temperature and longitudinal relaxation rate to monitor drug delivery during magnetic resonance-guided high-intensity focused ultrasound-induced hyperthermia

Kneepkens, E. C. M., Heijman, E., Keupp, J., Weiss, S., Nicolay, K. & Grüll, H., 1 Oct 2017, In : Investigative Radiology. 52, 10, p. 620-630 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Induced Hyperthermia
Magnetic Resonance Spectroscopy
Temperature
Pharmaceutical Preparations
Thermometry

Press / Media

Student theses

19F MRI : methods and applications for quantitative molecular imaging

Author: Abdurrachim, D., 31 Oct 2008

Supervisor: Nicolaij, K. (Supervisor 1), Grüll, H. (Supervisor 2), Merkx, M. (Supervisor 2), Strijkers, G. (Supervisor 2), Lamerichs, R. M. (External coach), Yildirim, M. (External person) (External coach) & Kok, M. (Supervisor 2)

Student thesis: Master

Constructing a polyglycerol based dual targeting probe for imaging angiogenesis in tumors

Author: van 't Erve, M., 28 Feb 2013

Supervisor: Brunsveld, L. (Supervisor 1), Grüll, H. (Supervisor 2), Merkx, M. (Supervisor 2), Petkau - Milroy, K. (Supervisor 2) & van Mourik, T. (Supervisor 2)

Student thesis: Master

Dual-isotope SPECT comparison of 111In/177Lu radiolabelled tumor-targeting nanobodies

Author: Rompen, R., 31 Aug 2015

Supervisor: Nicolaij, K. (Supervisor 1), Grüll, H. (Supervisor 2), Rossin, R. (Supervisor 2), Oliveira, S. (External person) (External coach), van Bergen en Henegouwen, P. M. (External person) (External coach) & Ottmann, C. (Supervisor 2)

Student thesis: Master

Dual istotope SPECT imaging using 201Tl, 111In and 177Lu

Author: Hijnen, N., 31 Jan 2009

Supervisor: Grüll, H. (Supervisor 1), Nicolaij, K. (Supervisor 2), Mutsaers, P. (Supervisor 2), Robillard, M. (External coach) & de Vries, A. (Supervisor 2)

Student thesis: Master

Influence of cell-internationalization on relaxometric, optical and structural properties of targeted paramagnetic quantum dot micelles

Author: Starmans, L., 31 Jan 2010

Supervisor: Nicolaij, K. (Supervisor 1), Grüll, H. (Supervisor 2), Strijkers, G. (Supervisor 2), De Mello Donega, C. (External person) (Supervisor 2), Sanders, H. (Supervisor 2) & Kok, M. (Supervisor 2)

Student thesis: Master