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Research profile

Hailong Che currently pursues a PhD at Eindhoven University of Technology, The Netherlands, on the topic of out-of-equilibrium polymeric systems. Inspired by biology, chemists have created a plethora of synthetic adaptive or life-like materials with temporal control over structure and function by employing chemical and enzymatic reaction networks. These materials are endowed with unique features because of their out-of-equilibrium state, compared to conventional equilibrium systems that demonstrate thermodynamic stability. In this regard, fuel-driven functional operations under temporal control are thought to play a key role in bridging man-made materials and biology in terms of natural organization and function.Therefore, this project focus on out-of-equilibrium polymer assemblies with adaptive or self-adaptive structure and function.

Academic background

In 2012, Hailong Che started his Master study on the topic of “CO2-responsive polymeric nanomaterials” at Tsinghua University (THU) under the supervision of Prof. Jinying Yuan. In 2015, he received his MSc and graduated as Outstanding Graduates and Outstanding Master's Thesis of THU. From 2015 September, he started his PhD research under the supervision of Prof. Jan van Hest in the Bio-organic Chemistry group. In 2019, He obtained Chinese Government Award for Outstanding Students Abroad.

Education/Academic qualification

Macromolecular chemistry, polymer chemistry, Master, Tsinghua University

1 Sep 20121 Jul 2015

Macromolecular chemistry, polymer chemistry, Doctor, Eindhoven University of Technology

1 Sep 201531 Aug 2019

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Polymers Chemical Compounds
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Biocatalysis Medicine & Life Sciences

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Research Output 2016 2019

  • 107 Citations
  • 6 Article
  • 1 Phd Thesis 1 (Research TU/e / Graduation TU/e)

Adaptive polymersome nanoreactors

Che, H. & van Hest, J. C. M., 1 Sep 2019, In : ChemNanoMat. 5, 9, p. 1092-1109

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Medical nanotechnology
Adaptive systems

ATP-mediated transient behavior of stomatocyte nanosystems

Che, H., Zhu, J., Song, S., Mason, A. F., Cao, S., Pijpers, I. A. B., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 2 Jul 2019, In : Angewandte Chemie - International Edition. 58, 37, p. 13113-13118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanosystems
Adenosine Triphosphate
Polylysine
Nanoreactors
Molecular interactions

Molecular programming of biodegradable nanoworms via ionically induced morphology switch toward asymmetric therapeutic carriers

Cao, S., Shao, J., Xia, Y., Che, H., Zhong, Z., Meng, F., van Hest, J. C. M., Abdelmohsen, L. K. E. A. & Williams, D. S., 5 Aug 2019, In : Small. 1901849

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nanostructures
Micelles
Block copolymers
Switches
Nanomedicine

Self-regulated out-of-equilibrium polymer assemblies

Che, H., 20 Sep 2019, Eindhoven: Technische Universiteit Eindhoven. 148 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File
26 Citations (Scopus)

Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors

Che, H., Cao, S. & van Hest, J. C. M., 4 Apr 2018, In : Journal of the American Chemical Society. 140, 16, p. 5356–5359 16

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanoreactors
Horseradish Peroxidase
Respiration
Biocatalysis
Artificial Cells