• 54 Citations
20162019
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Personal profile

Research profile

Femke Meijer is a PhD candidate in the Chemical Biology group under supervision of prof. Luc Brunsveld. Her project focusses on the identification of novel small molecule ligands for the selective modulation of nuclear receptors, especially for RORγt which plays an important role in several autoimmune diseases. The main interest is to target the recently discovered allosteric binding site of RORγt, which has many advantages in comparison to the common orthosteric site, in terms of selectivity and preventing competition issues. Femke uses a combination of medicinal chemistry, organic synthesis, computational biology and biochemical assays to gain insight into this topic.

Academic background

Femke Meijer (1993) has studied Biomedical Engineering at the Eindhoven University of Technology (TU/e). After receiving her Bachelor degree in 2014, she continued with her Master in the Chemical Biology group of prof. Luc Brunsveld. During her Master’s graduation project, she worked on the design and synthesis of peptide-small molecule hybrids for the modulation of certain protein-protein interactions (PPIs) that are involved in Alzheimer’s disease. Additionally, she performed an internship at Imperial College London (in the research group of prof. Ed Tate), on the organic synthesis of photo-crosslinkable α-helix mimetics and testing their selectivity for inhibiting the p53/hDM2 interaction, which is an important target in cancer therapy. Femke received her Master degree cum laude in 2017.

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  • 3 Similar Profiles
Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Retinoid X Receptors Medicine & Life Sciences
Cystic Fibrosis Transmembrane Conductance Regulator Medicine & Life Sciences
Proteins Medicine & Life Sciences
Ligands Medicine & Life Sciences
Alleles Medicine & Life Sciences
Switches Chemical Compounds
Molecules Chemical Compounds

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Research Output 2016 2019

  • 54 Citations
  • 5 Article
3 Citations (Scopus)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 1 Apr 2019, In : Molecular and Cellular Endocrinology. 485, p. 20-34 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
4 Citations (Scopus)

Characterization of coding/noncoding variants for SHROOM3 in patients with CKD

Prokop, J. W., Ottmann, C., Chhetri, S. B., Florus, K. L., Ross, E. J., Sosonkina, N., Link, B. A., Freedman, B. I., Coppola, C. J., McDermott-Roe, C., Leysen, S. F. R., Milroy, L. G., Meijer, F. A., Geurts, A. M., Rauscher III, F. J., Ramaker, R., Flister, M. J., Jacob, H. J., Mendenhall, E. M., Lazar, J. & 1 othersYeo, N. C., 23 Feb 2018, In : Journal of the American Society of Nephrology. 29, May 2018, p. 1525-1535

Research output: Contribution to journalArticleAcademicpeer-review

Alleles
Gene Frequency
Molecular Biology
Transcription Factor 7-Like 2 Protein
Clustered Regularly Interspaced Short Palindromic Repeats
6 Citations (Scopus)

Inhibition of 14-3-3/Tau by hybrid small-molecule peptides operating via two different binding modes

Andrei, S. A., Meijer, F., Neves, J., Brunsveld, L., Landrieu, I., Ottmann, C. & Milroy, L. G., 1 Nov 2018, In : ACS Chemical Neuroscience. 9, 11, p. 2639–2654

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Peptides
Molecules
Alzheimer Disease
Proteins
Drug Interactions
5 Citations (Scopus)

Ligand dependent switch from RXR homo- to RXR-NURR1 heterodimerization

Scheepstra, M., Andrei, S. A., de Vries, R. M. J. M., Meijer, F. A., Ma, J-N., Burstein, E. S., Olsson, R., Ottmann, C., Milroy, L-G. & Brunsveld, L., 1 Sep 2017, In : ACS Chemical Neuroscience. 8, 9, p. 2065-2077 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Switches
Ligands
Proteins
36 Citations (Scopus)

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR

Stevers, L. M., Lam, C. V., Leysen, S. F. R., Meijer, F. A., van Scheppingen, D. S., de Vries, R. M. J. M., Carlile, G. W., Milroy, L. G., Thomas, D. Y., Brunsveld, L. & Ottmann, C., 1 Mar 2016, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 113, 9, p. E1152-E1161 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cystic Fibrosis Transmembrane Conductance Regulator
14-3-3 Proteins
Binding Sites
Cystic Fibrosis
Cell Membrane