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Research profile

Eline Sijbesma is a PhD student in the Chemical Biology research group of professor Luc Brunsveld. Her current research focusses on the exploration of fragment-based drug discovery to identify small molecule stabilizers, that act as 'molecular glues' enhancing interactions between proteins. This approach is inspired by nature - which makes extensive use of the stabilization of protein complexes - and aims to provide new modalities to expand the druggable proteome, address therapeutic resistance and tackle challenging diseases.

Quote

Interactions between proteins are at the core of all biological processes yet inherently challenging drug targets. This inspires us to employ unexplored approaches at the forefronts of drug discovery.

Academic background

Eline Sijbesma first joined the Chemical Biology group as an undergraduate student. During her MSc graduation project she worked on elucidating the binding mode of natural compound Estrogen Receptor modulators. Part of this research was performed in the group of dr. Wilbert Zwart at the Netherlands Cancer Institute (NKI-AVL). She then joined the Small Molecule Discovery Center (SMDC) in the group of prof. Michelle Arkin, PhD at the University of California in San Francisco (UCSF) where she initiated a fragment-based drug discovery project that explores protein-protein interactions as novel drug targets. For this research internship she was awarded a travel grant from the Nora Baart Foundation (NVBMB) and a Scholarship by the Dr Hendrik Muller’s Fund. Eline obtained her Master of Science degree cum laude in 2015 and started her PhD under supervision of prof. dr. ir. Luc Brunsveld and dr. Christian Ottmann.

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Research Output 2016 2019

  • 104 Citations
  • 8 Article
  • 1 Review article

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

Maity, D., Gigante, A., Sánchez-Murcia, P. A., Sijbesma, E., Li, M., Bier, D., Mosel, S., Knauer, S., Ottmann, C. & Schmuck, C., 2 Apr 2019, In : Organic and Biomolecular Chemistry. 17, 17, p. 4359-4363 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
peptides
Arginine
Fluorescence
proteins

Modulating protein–protein interaction networks in protein homeostasis

Zhong, M., Lee, G. M., Sijbesma, E., Ottmann, C. & Arkin, M. R., 1 Jun 2019, In : Current Opinion in Chemical Biology. 50, p. 55-65 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Protein Interaction Maps
Homeostasis
Proteins
Complex networks
Molecules
2 Citations (Scopus)

Site-directed fragment-based screening for the discovery of protein-protein interaction stabilizers

Sijbesma, E., Hallenbeck, K. K., Leysen, S., de Vink, P. J., Skóra, L., Jahnke, W., Brunsveld, L., Arkin, M. R. & Ottmann, C., 27 Feb 2019, In : Journal of the American Chemical Society. 141, 8, p. 3524–3531 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Screening
Proteins
Estrogen Receptor alpha
Stabilization
Phosphorylation
2 Citations (Scopus)

A liquid chromatography/mass spectrometry method for screening disulfide tethering fragments

Hallenbeck, K. K., Davies, J. L., Merron, C., Ogden, P., Sijbesma, E., Ottmann, C., Renslo, A. R., Wilson, C. & Arkin, M. R., 2018, In : SLAS Discovery. 23, 2, p. 183-192 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Liquid chromatography
Disulfides
Mass spectrometry
Screening
Pipelines
28 Citations (Scopus)

Modulators of 14-3-3 protein-protein interactions

Stevers, L. M., Sijbesma, E., Botta, M., Mackintosh, C., Obsil, T., Landrieu, I., Cau, Y., Wilson, A. J., Karawajczyk, A., Eickhoff, J., Davis, J., Hann, M., O'Mahony, G., Doveston, R. G., Brunsveld, L. & Ottmann, C., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 3755-3778 24 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
14-3-3 Proteins
Proteins
Biological Products

Student theses

Discovery of new stabilizers for a unique 14-3-3 protein interaction with ChREBP by molecular docking

Author: Visser, E., 28 Mar 2019

Supervisor: Ottmann, C. (Supervisor 1), Sijbesma, E. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Elucidating the dual mechanism of natural product-based Estrogen Receptor modulation

Author: Sijbesma, E., 31 Oct 2015

Supervisor: Zwart, W. (External person) (Supervisor 1), Leysen, S. (Supervisor 2), Scheepstra, M. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Exploring novel binding modes between 14-3-3 and nuclear receptors

Author: van de Gevel, I., 31 Aug 2017

Supervisor: Sijbesma, E. (Supervisor 1) & Brunsveld, L. (Supervisor 2)

Student thesis: Master