• 566 Citations

Research output per year

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Personal profile


Relating the Genetic Code, Nature’s amazing invention, with the Gray Code, a pure human artifact, yet again proves Galileo right: The Grand Book is written in the language of mathematics.

Research profile

Dragan Bosnacki is an assistant professor at the TU/e department of Biomedical Engineering. His current main research interests are in (Big) Data and Health, and modelling of High Intensity Focused Ultrasound (HIFU) for cancer therapies. His previous work includes algorithms for reconstruction of biological networks and various applications of formal verification techniques in biology and medicine.   

Dr. Bosnacki has an extensive track record in formal verification of hardware and software, in particular in model checking. He has developed several improvements of state space reduction techniques, like partial-order reduction and symmetry reduction, and contributed several improvements of the probably most prominent model checking tool SPIN. Currently he serves as a steering committee chair of the SPIN symposiums. He has also co-pioneered the areas of multi-core and GPU model checking, which cover parallel model checking techniques on shared memory systems. Recently he has worked in separation logic and its applications in the tool VeriFast. 

Academic background

Dragan Bosnacki obtained both his BSc in Electrical Engineering and his MSc in Computer Science from Sts. Cyril and Methodius University in Skopje (Macedonia). From 1990 to 1997 he was a Teaching and Research Assistant at the Institute of Informatics at the same university. He then moved to Eindhoven University of Technology (TU/e, The Netherlands) for his PhD studies. In 2001 he obtained his PhD at the Department of Mathematics and Computer Science under supervision of Jos Baeten and Dennis Dams. Since 2000 he has been an Assistant Professor at the TU/e departments of Biomedical Engineering and Mathematics and Computer Science.

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Research Output

Deep learning with convolutional neural networks for histopathology image analysis

Bosnacki, D., van Riel, N. A. W. & Veta, M., 2019, Automated reasoning for systems biology and medicine. Lio, P. & Zuliani, P. (eds.). Springer, p. 453-469 (Computational Biology Series; vol. 30).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Dependency safety for Java: implementing and testing failboxes

Zhang, D., Bošnački, D., van den Brand, M., Huizing, C., Jacobs, B., Kuiper, R. & Wijs, A., 1 Oct 2019, In : Science of Computer Programming. 184, 22 p., 102316.

Research output: Contribution to journalArticleAcademicpeer-review

  • Model checking: recent improvements and applications

    Bošnački, D. & Wijs, A., 1 Oct 2018, In : International Journal on Software Tools for Technology Transfer. 20, 5, p. 493–497 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 59 Downloads (Pure)

    Modeling the interference between shear and longitudinal waves under high intensity focused ultrasound propagation in bone

    Modena, D., Baragona, M., Bošnački, D., Breuer, B. J. T., Elevelt, A., Maessen, R. T. H., Hilbers, P. A. J. & ten Eikelder, H. M. M., 4 Dec 2018, In : Physics in Medicine and Biology. 63, 23, 12 p., 235024.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • 1 Citation (Scopus)
    42 Downloads (Pure)

    Modular termination verification of single-threaded and multithreaded programs

    Jacobs, B., Bosnacki, D. & Kuiper, R., 1 Aug 2018, In : ACM Transactions on Programming Languages and Systems. 40, 3, A12.

    Research output: Contribution to journalArticleAcademicpeer-review

  • 2 Citations (Scopus)


    • 1 Workshop, seminar, course or exhibition

    11th Nordic Workshop on Programming Theory (NWPT'99), October 6-8, 1999, Uppsala, Sweden

    Dragan Bosnacki (Organiser)
    6 Oct 1999

    Activity: Participating in or organising an event typesWorkshop, seminar, course or exhibitionScientific

    Student theses

    A computational biology framework: a data analysis tool to support biomedical engineers in their research

    Author: Beishuizen, T., 29 Nov 2018

    Supervisor: Bosnacki, D. (Supervisor 1), Cheplygina, V. (Supervisor 2), Hilbers, P. (Supervisor 2), Fletcher, G. (Supervisor 2) & Vanschoren, J. (Supervisor 2)

    Student thesis: Master

    Algorithms for gene regulatory networks reconstruction

    Author: Maksimov, N., 31 Aug 2015

    Supervisor: Bosnacki, D. (Supervisor 1)

    Student thesis: Master


    A parallel algorithm for comparing metabolic pathways

    Author: Datema, R., 31 Aug 2006

    Supervisor: Hilbers, P. (Supervisor 1), Bosnacki, D. (Supervisor 2), Zwaan, G. (Supervisor 2) & Mak, R. (Supervisor 2)

    Student thesis: Master


    Causal candidate genes identification for familial hypercholesterolemia family based on whole-genome sequencing

    Author: Wang, Q., 31 Aug 2017

    Supervisor: Hilbers, P. (Supervisor 1), van Riel, N. (Supervisor 2), Hovingh, K. (External person) (External coach), Bosnacki, D. (Supervisor 2) & Veta, M. (Supervisor 2)

    Student thesis: Master

    Finding maximal frequent subgraphs

    Author: Wagemans, J., 30 Jun 2008

    Supervisor: Zantema, H. (Supervisor 1) & Bosnacki, D. (Supervisor 2)

    Student thesis: Master