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Personal profile

Quote

"As a scientist I feel that I have to give something back to society. I am doing that by helping to solve hard-to-crack biomedical problems such as drugging protein-protein interactions."

Research profile

Christian Ottmann is Associate Professor of Molecular Cell and Structural Biology at the department of Biomedical Engineering (research group Chemical Biology). He works on small-molecule modulation of Protein-Protein Interactions (PPIs) with a special focus on stabilization of 14-3-3 adapter protein PPIs. He is involved in several early drug discovery projects with the pharmaceutical industry, targeting disease as diverse as cancer, Alzheimer’s disease, inflammation and cystic fibrosis. In this context he also is coordinator of the FP7 Industry-Academia Partnership and Pathways (IAPP) 14-3-3STABS and the Horizon2020 European Training Network (ETN) TASPPI. 

Academic background

Christian Ottmann studied Biology (Dipl.) at the Ruhr-University in Bochum (Germany). From 1999-2003, he did his PhD research at the Eberhard-Karls-University of Tübingen under supervision of Prof. Claudia Oecking and graduated summa cum laude. From 2003-2004, he was a Postdoctoral Research Assistant with Prof. Oecking. Beginning of 2005, he founded the biotech company AmbAgon Technology in Dortmund, Germany. In 2006, he became a group leader at the Chemical Genomics Centre (CGC) of the Max Planck Society (Dortmund, Germany). In 2012, Christian Ottmann was appointed Associate Professor of Molecular and Structural Cell Biology at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e). In that same year he was recipient of the Innovation Award in Medicinal/Pharmaceutical Chemistry of the Gesellschaft Deutscher Chemiker and the Deutsche Pharmazeutische Gesellschaft. In 2013, Christian Ottmann received the Young Chemical Biologist Award of the International Chemical Biology Society (ICBS). In 2014 he was appointed professor at the Institute for Organic Chemistry of the University of Duisburg-Essen (Germany).

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Research Output 2007 2019

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Gigante, A., Grad, J. N., Briels, J., Bartel, M., Hoffmann, D., Ottmann, C. & Schmuck, C., 1 Jan 2019, In : Chemical Communications. 55, 1, p. 111-114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
Ligands
Proteins

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

Maity, D., Gigante, A., Sánchez-Murcia, P. A., Sijbesma, E., Li, M., Bier, D., Mosel, S., Knauer, S., Ottmann, C. & Schmuck, C., 2 Apr 2019, In : Organic and Biomolecular Chemistry. 17, 17, p. 4359-4363 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
peptides
Arginine
Fluorescence
proteins
1 Citation (Scopus)

Clinical candidates modulating protein-protein interactions: the fragment-based experience

Valenti, D., Hristeva, S., Tzalis, D. & Ottmann, C., 1 Apr 2019, In : European Journal of Medicinal Chemistry. 167, p. 76-95 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Proteins
Modulators
Lead compounds
Drug Discovery
Chemical properties
1 Citation (Scopus)

Cooperativity basis for small-molecule stabilization of protein-protein interactions

de Vink, P. J., Andrei, S. A., Higuchi, Y., Ottmann, C., Milroy, L-G. & Brunsveld, L., 2019, In : Chemical Science. 10, 10, p. 2869-2874 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Stabilization
Molecules
Proteins
14-3-3 Proteins
Fluorescence

Engineering stabilizers of 14-3-3 protein-protein interactions

Andrei, S., 9 May 2019, Eindhoven: Technische Universiteit Eindhoven. 192 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Courses

Chemical biology

1/09/1331/08/19

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DBL Entering the lab

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DBL Entering the lab

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Pharmacology

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Project Instrumental analysis

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Press / Media

Science fights back: Tackling disease to recover homeostasis

Christian Ottmann

20/05/15

1 item of media coverage

Press/Media: Expert Comment

Student theses

Cell directed nanoparticle drug delivery for tissue engineering

Author: Vogel, M., 30 Sep 2015

Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Ottmann, C. (Supervisor 2) & Kurniawan, N. (External coach)

Student thesis: Master

Characterization of the interaction of 14-3-3 proteins and estrogen receptor alpha as a potential drug target

Author: den Hamer, A., 30 Nov 2013

Supervisor: de Vries - van Leeuwen, I. (External coach), Tharun, I. (Supervisor 1), Ottmann, C. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Creating a non-linear response in dCas9-based gene repression: tuning the sgRNA concentration with the use of enzymatic coupled degradation

Author: Uittenbogaard, P., 20 May 2019

Supervisor: Hilbers, P. (Supervisor 1), de Greef, T. (Supervisor 2), Ottmann, C. (Supervisor 2) & Dubuc, E. (Supervisor 2)

Student thesis: Master

Discovery of new stabilizers for a unique 14-3-3 protein interaction with ChREBP by molecular docking

Author: Visser, E., 28 Mar 2019

Supervisor: Ottmann, C. (Supervisor 1), Sijbesma, E. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Dual-isotope SPECT comparison of 111In/177Lu radiolabelled tumor-targeting nanobodies

Author: Rompen, R., 31 Aug 2015

Supervisor: Nicolaij, K. (Supervisor 1), Grüll, H. (Supervisor 2), Rossin, R. (Supervisor 2), Oliveira, S. (External person) (External coach), van Bergen en Henegouwen, P. M. (External person) (External coach) & Ottmann, C. (Supervisor 2)

Student thesis: Master