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Personal profile


"As a scientist I feel that I have to give something back to society. I am doing that by helping to solve hard-to-crack biomedical problems such as drugging protein-protein interactions."

Research profile

Christian Ottmann is Associate Professor of Molecular Cell and Structural Biology at the department of Biomedical Engineering (research group Chemical Biology). He works on small-molecule modulation of Protein-Protein Interactions (PPIs) with a special focus on stabilization of 14-3-3 adapter protein PPIs. He is involved in several early drug discovery projects with the pharmaceutical industry, targeting disease as diverse as cancer, Alzheimer’s disease, inflammation and cystic fibrosis. In this context he also is coordinator of the FP7 Industry-Academia Partnership and Pathways (IAPP) 14-3-3STABS and the Horizon2020 European Training Network (ETN) TASPPI. 

Academic background

Christian Ottmann studied Biology (Dipl.) at the Ruhr-University in Bochum (Germany). From 1999-2003, he did his PhD research at the Eberhard-Karls-University of Tübingen under supervision of Prof. Claudia Oecking and graduated summa cum laude. From 2003-2004, he was a Postdoctoral Research Assistant with Prof. Oecking. Beginning of 2005, he founded the biotech company AmbAgon Technology in Dortmund, Germany. In 2006, he became a group leader at the Chemical Genomics Centre (CGC) of the Max Planck Society (Dortmund, Germany). In 2012, Christian Ottmann was appointed Associate Professor of Molecular and Structural Cell Biology at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e). In that same year he was recipient of the Innovation Award in Medicinal/Pharmaceutical Chemistry of the Gesellschaft Deutscher Chemiker and the Deutsche Pharmazeutische Gesellschaft. In 2013, Christian Ottmann received the Young Chemical Biologist Award of the International Chemical Biology Society (ICBS). In 2014 he was appointed professor at the Institute for Organic Chemistry of the University of Duisburg-Essen (Germany).

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  • 11 Similar Profiles
14-3-3 Proteins Medicine & Life Sciences
Proteins Chemical Compounds
Molecules Chemical Compounds
Stabilization Chemical Compounds
Drug Discovery Medicine & Life Sciences
Ligands Medicine & Life Sciences
Screening Chemical Compounds
Biological Products Chemical Compounds

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Research Output 2007 2020

3 Downloads (Pure)

Adoption of a turn conformation drives the binding affinity of p53 C-terminal domain peptides to 14-3-3σ

Kuusk, A., Neves, J. F., Bravo-Rodriguez, K., Gunnarsson, A., Ruiz-Blanco, Y. B., Ehrmann, M., Chen, H., Landrieu, I., Sanchez-Garcia, E., Boyd, H., Ottmann, C. & Doveston, R. G., 17 Jan 2020, In : ACS Chemical Biology. 15, 1, p. 262-271 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14-3-3 Proteins
Protein Binding
13 Downloads (Pure)

Ligand-based design of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists

Meijer, F. A., Doveston, R. G., de Vries, R. M. J. M., Vos, G. M., Vos, A. A. A., Leysen, S., Scheepstra, M., Ottmann, C., Milroy, L-G. & Brunsveld, L., 9 Jan 2020, In : Journal of Medicinal Chemistry. 63, 1, p. 241-259 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Retinoic Acid Receptors
Cytoplasmic and Nuclear Receptors
1 Citation (Scopus)

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Saline, M., Badertscher, L., Wolter, M., Lau, R., Gunnarsson, A., Jacso, T., Norris, T., Ottmann, C. & Snijder, A., 30 Aug 2019, In : Journal of Biological Chemistry. 294, 35, p. 13106-13116 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins
AMP-Activated Protein Kinases
Protein Kinases
Transcription Factors
2 Citations (Scopus)

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Gigante, A., Grad, J. N., Briels, J., Bartel, M., Hoffmann, D., Ottmann, C. & Schmuck, C., 4 Jan 2019, In : Chemical Communications. 55, 1, p. 111-114 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Neurodegenerative diseases
14-3-3 Proteins
Signal transduction
1 Citation (Scopus)
2 Downloads (Pure)

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

Maity, D., Gigante, A., Sánchez-Murcia, P. A., Sijbesma, E., Li, M., Bier, D., Mosel, S., Knauer, S., Ottmann, C. & Schmuck, C., 2 Apr 2019, In : Organic & Biomolecular Chemistry. 17, 17, p. 4359-4363 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

14-3-3 Proteins


Chemical biology




1/09/13 → …


Project Molecular biology

1/09/15 → …


Student theses

Cell directed nanoparticle drug delivery for tissue engineering

Author: Vogel, M., 30 Sep 2015

Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Ottmann, C. (Supervisor 2) & Kurniawan, N. (External coach)

Student thesis: Master

Characterization of the interaction of 14-3-3 proteins and estrogen receptor alpha as a potential drug target

Author: den Hamer, A., 30 Nov 2013

Supervisor: de Vries - van Leeuwen, I. (External coach), Tharun, I. (Supervisor 1), Ottmann, C. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Creating a non-linear response in dCas9-based gene repression: tuning the sgRNA concentration with the use of enzymatic coupled degradation

Author: Uittenbogaard, P., 20 May 2019

Supervisor: Hilbers, P. (Supervisor 1), de Greef, T. (Supervisor 2), Ottmann, C. (Supervisor 2) & Dubuc, E. (Supervisor 2)

Student thesis: Master

Discovery of new stabilizers for a unique 14-3-3 protein interaction with ChREBP by molecular docking

Author: Visser, E., 28 Mar 2019

Supervisor: Ottmann, C. (Supervisor 1), Sijbesma, E. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

Student thesis: Master

Dual-isotope SPECT comparison of 111In/177Lu radiolabelled tumor-targeting nanobodies

Author: Rompen, R., 31 Aug 2015

Supervisor: Nicolaij, K. (Supervisor 1), Grüll, H. (Supervisor 2), Rossin, R. (Supervisor 2), Oliveira, S. (External person) (External coach), van Bergen en Henegouwen, P. M. (External person) (External coach) & Ottmann, C. (Supervisor 2)

Student thesis: Master