• 2913 Citations
20072020

Research output per year

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Personal profile

Quote

"As a scientist I feel that I have to give something back to society. I am doing that by helping to solve hard-to-crack biomedical problems such as drugging protein-protein interactions."

Research profile

Christian Ottmann is Associate Professor of Molecular Cell and Structural Biology at the department of Biomedical Engineering (research group Chemical Biology). He works on small-molecule modulation of Protein-Protein Interactions (PPIs) with a special focus on stabilization of 14-3-3 adapter protein PPIs. He is involved in several early drug discovery projects with the pharmaceutical industry, targeting disease as diverse as cancer, Alzheimer’s disease, inflammation and cystic fibrosis. In this context he also is coordinator of the FP7 Industry-Academia Partnership and Pathways (IAPP) 14-3-3STABS and the Horizon2020 European Training Network (ETN) TASPPI. 

Academic background

Christian Ottmann studied Biology (Dipl.) at the Ruhr-University in Bochum (Germany). From 1999-2003, he did his PhD research at the Eberhard-Karls-University of Tübingen under supervision of Prof. Claudia Oecking and graduated summa cum laude. From 2003-2004, he was a Postdoctoral Research Assistant with Prof. Oecking. Beginning of 2005, he founded the biotech company AmbAgon Technology in Dortmund, Germany. In 2006, he became a group leader at the Chemical Genomics Centre (CGC) of the Max Planck Society (Dortmund, Germany). In 2012, Christian Ottmann was appointed Associate Professor of Molecular and Structural Cell Biology at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e). In that same year he was recipient of the Innovation Award in Medicinal/Pharmaceutical Chemistry of the Gesellschaft Deutscher Chemiker and the Deutsche Pharmazeutische Gesellschaft. In 2013, Christian Ottmann received the Young Chemical Biologist Award of the International Chemical Biology Society (ICBS). In 2014 he was appointed professor at the Institute for Organic Chemistry of the University of Duisburg-Essen (Germany).

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Research Output

Adoption of a turn conformation drives the binding affinity of p53 C-terminal domain peptides to 14-3-3σ

Kuusk, A., Neves, J. F., Bravo-Rodriguez, K., Gunnarsson, A., Ruiz-Blanco, Y. B., Ehrmann, M., Chen, H., Landrieu, I., Sanchez-Garcia, E., Boyd, H., Ottmann, C. & Doveston, R. G., 17 Jan 2020, In : ACS Chemical Biology. 15, 1, p. 262-271 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

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    A supramolecular stabilizer of the 14-3-3ζ/ERα protein-protein interaction with a synergistic mode of action

    Gigante, A., Sijbesma, E., Sánchez-Murcia, P. A., Hu, X., Bier, D., Bäcker, S., Knauer, S., Gago, F., Ottmann, C. & Schmuck, C., 11 Feb 2020, In : Angewandte Chemie - International Edition. 59, 13, p. 5284-5287 4 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 1 Citation (Scopus)
    14 Downloads (Pure)

    Conjugated protein domains as engineered scaffold proteins

    Lemmens, L., Ottmann, C. & Brunsveld, L., 6 May 2020, In : Bioconjugate Chemistry.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Design of Drug-Like Protein–Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization

    Bosica, F., Andrei, S. A., Neves, J. F., Brandt, P., Gunnarsson, A., Landrieu, I., Ottmann, C. & O'Mahony, G., 2 Jun 2020, In : Chemistry - A European Journal. p. 7131-7139 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Discovery of small-molecule stabilizers of 14-3-3 protein-protein interactions via dynamic combinatorial chemistry

    Hartman, A. M., Elgaher, W. A. M., Hertrich, N., Andrei, S. A., Ottmann, C. & Hirsch, A. K. H., 14 May 2020, In : ACS Medicinal Chemistry Letters. 11, 5, p. 1041-1046 6 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Courses

    Chemical biology

    1/09/1331/08/20

    Course

    Pharmacology

    1/09/13 → …

    Course

    Project Molecular biology

    1/09/15 → …

    Course

    Student theses

    Cell directed nanoparticle drug delivery for tissue engineering

    Author: Vogel, M., 30 Sep 2015

    Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Ottmann, C. (Supervisor 2) & Kurniawan, N. (External coach)

    Student thesis: Master

    Characterization of the interaction of 14-3-3 proteins and estrogen receptor alpha as a potential drug target

    Author: den Hamer, A., 30 Nov 2013

    Supervisor: de Vries - van Leeuwen, I. (External coach), Tharun, I. (Supervisor 1), Ottmann, C. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

    Student thesis: Master

    Creating a non-linear response in dCas9-based gene repression: tuning the sgRNA concentration with the use of enzymatic coupled degradation

    Author: Uittenbogaard, P., 20 May 2019

    Supervisor: Hilbers, P. (Supervisor 1), de Greef, T. (Supervisor 2), Ottmann, C. (Supervisor 2) & Dubuc, E. (Supervisor 2)

    Student thesis: Master

    Discovery of new stabilizers for a unique 14-3-3 protein interaction with ChREBP by molecular docking

    Author: Visser, E., 28 Mar 2019

    Supervisor: Ottmann, C. (Supervisor 1), Sijbesma, E. (Supervisor 2) & Brunsveld, L. (Supervisor 2)

    Student thesis: Master

    Dual-isotope SPECT comparison of 111In/177Lu radiolabelled tumor-targeting nanobodies

    Author: Rompen, R., 31 Aug 2015

    Supervisor: Nicolaij, K. (Supervisor 1), Grüll, H. (Supervisor 2), Rossin, R. (Supervisor 2), Oliveira, S. (External person) (External coach), van Bergen en Henegouwen, P. M. (External person) (External coach) & Ottmann, C. (Supervisor 2)

    Student thesis: Master