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2020
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Open Access
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Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

Tanaka, N., Kanatani, S., Kaczynska, D., Fukumoto, K., Louhivuori, L., Mizutani, T., Kopper, O., Kronqvist, P., Robertson, S., Lindh, C., Kis, L., Pronk, R., Niwa, N., Matsumoto, K., Oya, M., Miyakawa, A., Falk, A., Hartman, J., Sahlgren, C., Clevers, H. & 1 others, Uhlén, P., 29 Jun 2020, In : Nature Biomedical Engineering. 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019
Open Access
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20 Downloads (Pure)

Influence of the assembly state on the functionality of a supramolecular jagged1-mimicking peptide additive

Putti, M., Stassen, O. M. J. A., Schotman, M. J. G., Sahlgren, C. M. & Dankers, P. Y. W., 3 May 2019, In : ACS Omega. 4, 5, p. 8178-8187 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
47 Downloads (Pure)

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 27 Aug 2019, In : Scientific Reports. 9, 1, 14 p., 12415.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
21 Downloads (Pure)
2018
Open Access
File
17 Citations (Scopus)
50 Downloads (Pure)

Mapping of the three-dimensional lymphatic microvasculature in bladder tumours using light-sheet microscopy

Tanaka, N., Kaczynska, D., Kanatani, S., Sahlgren, C., Mitura, P., Stepulak, A., Miyakawa, A., Wiklund, P. & Uhlén, P., 1 Apr 2018, In : British Journal of Cancer. 118, 7, p. 995-999 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
63 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
58 Downloads (Pure)

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Loerakker, S., Stassen, O. M. J. A., ter Huurne, F. M., Boareto, M., Bouten, C. V. C. & Sahlgren, C. M., 17 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 115, 16, p. E3682-E3691 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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9 Citations (Scopus)
53 Downloads (Pure)

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 11 p., 13524.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
57 Downloads (Pure)

Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

Driessen, R. C. H., Stassen, O. M. J. A., Sjöqvist, M., Suarez Rodriguez, F., Grolleman, J., Bouten, C. V. C. & Sahlgren, C. M., 1 Nov 2018, In : Integrative Biology. 10, 11, p. 719-726 8 p.

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Open Access
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5 Citations (Scopus)
40 Downloads (Pure)

Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro

Tiemeijer, L. A., Frimat, J. P., Stassen, O. M. J. A., Bouten, C. V. C. & Sahlgren, C. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 10 p., 6392.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
62 Downloads (Pure)

Sumoylation of Notch1 represses its target gene expression during cell stress

Antila, C. J. M., Rraklli, V., Blomster, H. A., Dahlström, K. M., Salminen, T. A., Holmberg, J., Sistonen, L. & Sahlgren, C. M., 1 Mar 2018, In : Cell Death and Differentiation. 25, 3, p. 600-615 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Citations (Scopus)
69 Downloads (Pure)

Targeting somatostatin receptors by functionalized mesoporous silica nanoparticles-are we striking home?

Paramonov, V. M., Desai, D., Kettiger, H., Mamaeva, V., Rosenholm, J. M., Sahlgren, C. & Rivero-Müller, A., Jan 2018, In : Nanotheranostics. 2, 4, p. 320-346 27 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
21 Downloads (Pure)
2017

Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes

Paatero, I., Casals, E., Niemi, R., Özliseli, E., Rosenholm, J. M. & Sahlgren, C., 1 Dec 2017, In : Scientific Reports. 7, 1, 8423.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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15 Citations (Scopus)
62 Downloads (Pure)

Cardiac progenitor cells and the interplay with their microenvironment

Mauretti, A., Spaans, S., Bax, N. A. M., Sahlgren, C. & Bouten, C. V. C., 2017, In : Stem Cells International. 2017, 20 p., 7471582.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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15 Citations (Scopus)
90 Downloads (Pure)

Selective regulation of Notch ligands during angiogenesis is mediated by vimentin

Antfolk, D., Sjoqvist, M., Cheng, F., Isoniemi, K., Duran, C., Rivero-Muller, A., Antila, C., Niemi, R., Landor, S., Bouten, C., Bayless, K. J., Eriksson, J. E. & Sahlgren, C., 6 Jun 2017, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 114, 23, p. E4574–E4581

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
22 Citations (Scopus)
2 Downloads (Pure)

Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells

Mauretti, A., Rossi, F., Bax, N. A. M., Miano, C., Miraldi, F., Goumans, M. J., Messina, E., Giacomello, A., Bouten, C. V. C. & Sahlgren, C., 1 Sep 2017, In : MRS Communications. 7, 3, p. 496-501 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Downloads (Pure)

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity

Tanaka, N., Kanatani, S., Tomer, R., Sahlgren, C., Kronqvist, P., Kaczynska, D., Louhivuori, L., Kis, L., Lindh, C., Mitura, P., Stepulak, A., Corvigno, S., Hartman, J., Micke, P., Mezheyeuski, A., Strell, C., Carlson, J. W., Fernández Moro, C., Dahlstrand, H., Östman, A. & 6 others, Matsumoto, K., Wiklund, P., Oya, M., Miyakawa, A., Deisseroth, K. & Uhlén, P., 1 Oct 2017, In : Nature Biomedical Engineering. 1, 10, p. 796-806 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)
2016

Cardiomyocyte progenitor cell mechanoresponse unrevealed: strain avoidance and mechanosome development.

Mauretti, A., Bax, N. A. M., van Marion, M. H., Goumans, M. J. T. H., Sahlgren, C. M. & Bouten, C. V. C., 12 Sep 2016, In : Integrative Biology. 8, 9, p. 991-1001 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
17 Downloads (Pure)

Inhibiting notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying γ-secretase inhibitors

Mamaeva, V., Niemi, R., Beck, M., Özliseli, E., Desai, D., Landor, S., Gronroos, T., Kronqvist, P., Pettersen, I. K. N., McCormack, E., Rosenholm, J. M., Linden, M. & Sahlgren, C. M., 1 May 2016, In : Molecular Therapy. 24, 5, p. 926-936 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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48 Citations (Scopus)
97 Downloads (Pure)

Loss of CSL unlocks a hypoxic response and enhanced tumor growth potential in breast cancer cells

Braune, E-B., Tsoi, Y. L., Phoon, Y. P., Landor, S., Silva Cascales, H., Ramsköld, D., Deng, Q., Lindqvist, A., Lian, X., Sahlgren, C. M., Jin, S-B. & Lendahl, U., 10 May 2016, In : Stem cell reports. 6, 5, p. 643-51 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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16 Citations (Scopus)
72 Downloads (Pure)

Mesoporous silica nanoparticles in tissue engineering : a perspective

Rosenholm, J. M., Zhang, J., Linden, M. & Sahlgren, C. M., 1 Feb 2016, In : Nanomedicine. 11, 4, p. 391-402 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Santio, N. M., Landor, SK-J., Vahtera, L., Ylä-Pelto, J., Paloniemi, E., Imanishi, S. Y., Corthals, G., Varjosalo, M., Manoharan, G. B., Uri, A., Lendahl, U., Sahlgren, C. M. & Koskinen, P. J., 12 Jul 2016, In : Oncotarget. 7, 28, p. 43220-43238 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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23 Citations (Scopus)
136 Downloads (Pure)

Prolonged dye release from mesoporous silica-based imaging probes facilitates long-term optical tracking of cell populations in vivo

Rosenholm, J. M., Gulin-Sarfraz, T., Mamaeva, V., Niemi, R., Özliseli, E., Desai, D., Antfolk, D., von Haartman, E., Lindberg, D., Prabhakar, N., Näreoja, T. & Sahlgren, C. M., 23 Mar 2016, In : Small. 12, 12, p. 1578-1592

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles

Desai, D., Prabhakar, N., Mamaeva, V., Karaman, D. Ş., Lähdeniemi, I. A. K., Sahlgren, C., Rosenholm, J. M. & Toivola, D. M., 18 Jan 2016, In : International Journal of Nanomedicine. 11, p. 299-313 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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22 Citations (Scopus)
251 Downloads (Pure)
2015

Decoding breast cancer tissue-stroma interactions using species-specific sequencing

Chivukula, I. V., Ramsköld, D., Storvall, H., Anderberg, C., Jin, S., Mamaeva, V., Sahlgren, C. M., Pietras, K., Sandberg, R. & Lendahl, U., 2015, In : Breast cancer research : BCR. 17, p. 1-14 109.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
96 Downloads (Pure)

Genetically-encoded tools for cAMP probing and modulation in living systems

Paramonov, V. M., Mamaeva, V., Sahlgren, C. M. & Rivero-Müller, A., 2015, In : Frontiers in Pharmacology. 6, p. 1-21 196.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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17 Citations (Scopus)
75 Downloads (Pure)

Mesoporous silica particle-PLA-PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization

Shokry, H., Vanamo, U., Wiltschka, O., Niinimäki, J., Lerche, M., Levon, K., Linden, M. & Sahlgren, C. M., 14 Sep 2015, In : Nanoscale. 7, 34, p. 14434-43 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)
2014

Active targeting of mesoporous silica drug carriers enhances γ-secretase inhibitor efficacy in an in vivo model for breast cancer

Wittig, R., Rosenholm, J. M., Haartman, Von, E., Hemming, J., Genze, F., Bergman, L., Simmet, T., Lindén, M. & Sahlgren, C., 2014, In : Nanomedicine. 9, 7, p. 971-987

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Combination of magnetic field and surface functionalization for reaching synergistic effects in cellular labeling by magnetic core-shell nanospheres

Gulin-Sarfraz, T., Zhang, J., Desai, D., Teuho, J., Sarfraz, J., Jiang, H., Zhang, C., Sahlgren, C., Lindén, M., Gu, H. & Rosenholm, J. M., 1 Dec 2014, In : Biomaterials Science. 2, 12, p. 1750-1760 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Mesoporous silica nanoparticle-based substrates for cell directed delivery of Notch signalling modulators to control myoblast differentiation

Böcking, D., Wiltschka, O., Niinimäki, J., Shokry, H., Brenner, R., Lindén, M. & Sahlgren, C., 2014, In : Nanoscale. 6, 3, p. 1490-1498 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)
2 Downloads (Pure)

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

Sjöqvist, M., Antfolk, D., Ferraris, S., Rraklli, V., Haga, C., Antila, C., Mutvei, A., Imanishi, S. Y., Holmberg, J., Jin, S., Eriksson, J. E., Lendahl, U. & Sahlgren, C. M., Apr 2014, In : Cell. 24, 4, p. 433-50 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)
2 Downloads (Pure)
2013

Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery, II : Application

Prabhakar, N., Näreoja, T., Haartman, Von, E., Karaman, D. S., Jiang, H., Koho, S., Dolenko, T. A., Hänninen, P. E., Vlasov, D. I., Ralchenko, V. G., Hosomi, S., Vlasov, I. I., Sahlgren, C. M. & Rosenholm, J. M., 2013, In : Special Publication - Royal Society of Chemistry. 5, 9, p. 3713-3722

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)
1 Downloads (Pure)

Mesoporous silica nanoparticles in medicine : recent advances

Mamaeva, V., Sahlgren, C. & Lindén, M., May 2013, In : Advanced Drug Delivery Reviews. 65, 5, p. 689-702 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

409 Citations (Scopus)
1 Downloads (Pure)

Non-canonical notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ

Jin, S., Mutvei, A. P., Chivukula, I. V., Andersson, E. R. E., Ramsköld, D., Sandberg, R., Lee, K. L., Kronqvist, P., Mamaeva, V., Östling, P., Mpindi, J-P., Kallioniemi, O., Screpanti, I., Poellinger, L., Sahlgren, C. & Lendahl, U., 2013, In : Oncogene. 32, 41, p. 4892-4902 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)
2012

Astrocytes negatively regulate neurogenesis through the Jagged1-mediated notch pathway

Wilhelmsson, U., Faiz, M., Pablo, De, Y., Sjöqvist, M., Andersson, D., Widestrand, Å., Potokar, M., Stenovec, M., Smith, P. L. P., Shinjyo, N., Pekny, T., Zorec, R., Ståhlberg, A., Pekna, M., Sahlgren, C. & Pekny, M., 2012, In : Stem Cells. 30, 10, p. 2320-2329

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)
1 Downloads (Pure)

Nanoparticles in targeted cancer therapy : mesoporous silica nanoparticles entering preclinical development stage

Rosenholm, J. M., Mamaeva, V., Sahlgren, C. & Lindén, M., 2012, In : Nanomedicine. 7, 1, p. 111-120

Research output: Contribution to journalArticleAcademicpeer-review

173 Citations (Scopus)

Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization

Karaman, D. S., Desai, D., Senthilkumar, R., Johansson, E. M., Råtts, N., Odén, M., Eriksson, J. E., Sahlgren, C., Toivola, D. M. & Rosenholm, J. M., 2012, In : Nanoscale Research Letters. 7, 1, p. 2-32

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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36 Citations (Scopus)
39 Downloads (Pure)
2011

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms

Landor, S., Mutvei, A. P., Mamaeva, V., Jin, S., Busk, M., Borra, R., Grönroos, T. J., Kronqvist, P., Lendahl, U. & Sahlgren, C. M., 2011, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 108, 46, p. 18814-18819

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Scopus)

Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of notch signaling in cancer

Mamaeva, V., Rosenholm, J. M., Bate-Eya, L. T., Bergman, L., Peuhu, E., Duchanoy, A., Fortelius, L. E., Landor, S., Lindén, M. & Sahlgren, C., 31 May 2011, In : Molecular Therapy. 19, 8, p. 1538-1546

Research output: Contribution to journalArticleAcademicpeer-review

149 Citations (Scopus)
1 Downloads (Pure)

Multifunctional mesoporous silica nanoparticles for combined therapeutic, diagnostic and targeted action in cancer treatment

Rosenholm, J. M., Sahlgren, C. & Lindén, M., 2011, In : Current Drug Targets. 12, 8, p. 1166-1186

Research output: Contribution to journalArticleAcademicpeer-review

102 Citations (Scopus)

Nestin as a regulator of Cdk5 in differentiating myoblasts

Pallari, H-M., Lindqvist, J., Torvaldson, E., Ferraris, S. E., He, T., Sahlgren, C. & Eriksson, J. E., 23 Feb 2011, In : Molecular Biology of the Cell. 22, 9, p. 1539-1549

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
1 Downloads (Pure)
2010

Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors

Rosenholm, J. M., Peuhu, E., Bate-Eya, L. T., Eriksson, J. E., Sahlgren, C. & Lindén, M., 2010, In : Small. 6, 11, p. 1234-1241

Research output: Contribution to journalArticleAcademicpeer-review

135 Citations (Scopus)

Cancer-cell targeting and cell-specific delivery by mesoporous silica nanoparticles

Rosenholm, J. M., Sahlgren, C. & Lindén, M., 2010, In : Journal of Materials Chemistry. 20, 14, p. 2707-2713

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)
1 Downloads (Pure)

Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells

Main, H., Lee, K. L., Yang, H., Haapa-Paananen, S., Edgren, H., Jin, S., Sahlgren, C., Kallioniemi, O., Poellinger, L., Lim, B. & Lendahl, U., 2010, In : Experimental Cell Research. 316, 9, p. 1610-1624

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells

Das, D., Lanner, F., Main, H., Andersson, E. R. E., Bergmann, O., Sahlgren, C., Heldring, N., Hermanson, O., Hansson, E. M. & Lendahl, U., 2010, In : Developmental Biology. 348, 2, p. 153-166 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Protein kinase Cζ regulates Cdk5/p25 signaling during myogenesis

Thonel, De, A., Ferraris, S. E., Pallari, H-M., Imanishi, S. Y., Kochin, V., Hosokawa, T., Hisanaga, S-I., Sahlgren, C. & Eriksson, J. E., 3 Mar 2010, In : Molecular Biology of the Cell. 21, 8, p. 1423-1434

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles : opportunities & challenges

Rosenholm, J. M., Sahlgren, C. & Lindén, M., 2010, In : Special Publication - Royal Society of Chemistry. 2, 10, p. 1870-1883

Research output: Contribution to journalArticleAcademicpeer-review

404 Citations (Scopus)