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Research Output

2014

Active targeting of mesoporous silica drug carriers enhances γ-secretase inhibitor efficacy in an in vivo model for breast cancer

Wittig, R., Rosenholm, J. M., Haartman, Von, E., Hemming, J., Genze, F., Bergman, L., Simmet, T., Lindén, M. & Sahlgren, C., 2014, In : Nanomedicine. 9, 7, p. 971-987

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Cell-matrix interactions in cardiac progenitor cell niche

Mauretti, A., Sahlgren, C. M., Baaijens, F. P. T. & Bouten, C. V. C., 2014.

Research output: Contribution to conferencePosterAcademic

11 Downloads (Pure)

Combination of magnetic field and surface functionalization for reaching synergistic effects in cellular labeling by magnetic core-shell nanospheres

Gulin-Sarfraz, T., Zhang, J., Desai, D., Teuho, J., Sarfraz, J., Jiang, H., Zhang, C., Sahlgren, C., Lindén, M., Gu, H. & Rosenholm, J. M., 1 Dec 2014, In : Biomaterials Science. 2, 12, p. 1750-1760 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Mesoporous silica nanoparticle-based substrates for cell directed delivery of Notch signalling modulators to control myoblast differentiation

Böcking, D., Wiltschka, O., Niinimäki, J., Shokry, H., Brenner, R., Lindén, M. & Sahlgren, C., 2014, In : Nanoscale. 6, 3, p. 1490-1498 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)
2 Downloads (Pure)

Modular scaffold fabrication platform to produce biohybrid scaffolds

Thakkar, S. H., Dankers, P. Y. W., Sahlgren, C. M., Baaijens, F. P. T. & Bouten, C. V. C., 2014.

Research output: Contribution to conferencePosterAcademic

11 Downloads (Pure)

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

Sjöqvist, M., Antfolk, D., Ferraris, S., Rraklli, V., Haga, C., Antila, C., Mutvei, A., Imanishi, S. Y., Holmberg, J., Jin, S., Eriksson, J. E., Lendahl, U. & Sahlgren, C. M., Apr 2014, In : Cell. 24, 4, p. 433-50 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)
2 Downloads (Pure)
2013

Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery, II : Application

Prabhakar, N., Näreoja, T., Haartman, Von, E., Karaman, D. S., Jiang, H., Koho, S., Dolenko, T. A., Hänninen, P. E., Vlasov, D. I., Ralchenko, V. G., Hosomi, S., Vlasov, I. I., Sahlgren, C. M. & Rosenholm, J. M., 2013, In : Special Publication - Royal Society of Chemistry. 5, 9, p. 3713-3722

Research output: Contribution to journalArticleAcademicpeer-review

74 Citations (Scopus)
1 Downloads (Pure)

Mesoporous silica nanoparticles in medicine : recent advances

Mamaeva, V., Sahlgren, C. & Lindén, M., May 2013, In : Advanced Drug Delivery Reviews. 65, 5, p. 689-702 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

419 Citations (Scopus)
1 Downloads (Pure)

Non-canonical notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ

Jin, S., Mutvei, A. P., Chivukula, I. V., Andersson, E. R. E., Ramsköld, D., Sandberg, R., Lee, K. L., Kronqvist, P., Mamaeva, V., Östling, P., Mpindi, J-P., Kallioniemi, O., Screpanti, I., Poellinger, L., Sahlgren, C. & Lendahl, U., 2013, In : Oncogene. 32, 41, p. 4892-4902 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

74 Citations (Scopus)
2012

Astrocytes negatively regulate neurogenesis through the Jagged1-mediated notch pathway

Wilhelmsson, U., Faiz, M., Pablo, De, Y., Sjöqvist, M., Andersson, D., Widestrand, Å., Potokar, M., Stenovec, M., Smith, P. L. P., Shinjyo, N., Pekny, T., Zorec, R., Ståhlberg, A., Pekna, M., Sahlgren, C. & Pekny, M., 2012, In : Stem Cells. 30, 10, p. 2320-2329

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)
1 Downloads (Pure)

Nanoparticles in targeted cancer therapy : mesoporous silica nanoparticles entering preclinical development stage

Rosenholm, J. M., Mamaeva, V., Sahlgren, C. & Lindén, M., 2012, In : Nanomedicine. 7, 1, p. 111-120

Research output: Contribution to journalArticleAcademicpeer-review

177 Citations (Scopus)

Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization

Karaman, D. S., Desai, D., Senthilkumar, R., Johansson, E. M., Råtts, N., Odén, M., Eriksson, J. E., Sahlgren, C., Toivola, D. M. & Rosenholm, J. M., 2012, In : Nanoscale Research Letters. 7, 1, p. 2-32

Research output: Contribution to journalArticleAcademicpeer-review

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36 Citations (Scopus)
40 Downloads (Pure)
2011

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms

Landor, S., Mutvei, A. P., Mamaeva, V., Jin, S., Busk, M., Borra, R., Grönroos, T. J., Kronqvist, P., Lendahl, U. & Sahlgren, C. M., 2011, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 108, 46, p. 18814-18819

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Scopus)

Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of notch signaling in cancer

Mamaeva, V., Rosenholm, J. M., Bate-Eya, L. T., Bergman, L., Peuhu, E., Duchanoy, A., Fortelius, L. E., Landor, S., Lindén, M. & Sahlgren, C., 31 May 2011, In : Molecular Therapy. 19, 8, p. 1538-1546

Research output: Contribution to journalArticleAcademicpeer-review

150 Citations (Scopus)
1 Downloads (Pure)

Multifunctional mesoporous silica nanoparticles for combined therapeutic, diagnostic and targeted action in cancer treatment

Rosenholm, J. M., Sahlgren, C. & Lindén, M., 2011, In : Current Drug Targets. 12, 8, p. 1166-1186

Research output: Contribution to journalArticleAcademicpeer-review

103 Citations (Scopus)

Nestin as a regulator of Cdk5 in differentiating myoblasts

Pallari, H-M., Lindqvist, J., Torvaldson, E., Ferraris, S. E., He, T., Sahlgren, C. & Eriksson, J. E., 23 Feb 2011, In : Molecular Biology of the Cell. 22, 9, p. 1539-1549

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
1 Downloads (Pure)
2010

Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors

Rosenholm, J. M., Peuhu, E., Bate-Eya, L. T., Eriksson, J. E., Sahlgren, C. & Lindén, M., 2010, In : Small. 6, 11, p. 1234-1241

Research output: Contribution to journalArticleAcademicpeer-review

135 Citations (Scopus)

Cancer-cell targeting and cell-specific delivery by mesoporous silica nanoparticles

Rosenholm, J. M., Sahlgren, C. & Lindén, M., 2010, In : Journal of Materials Chemistry. 20, 14, p. 2707-2713

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)
1 Downloads (Pure)

Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells

Main, H., Lee, K. L., Yang, H., Haapa-Paananen, S., Edgren, H., Jin, S., Sahlgren, C., Kallioniemi, O., Poellinger, L., Lim, B. & Lendahl, U., 2010, In : Experimental Cell Research. 316, 9, p. 1610-1624

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells

Das, D., Lanner, F., Main, H., Andersson, E. R. E., Bergmann, O., Sahlgren, C., Heldring, N., Hermanson, O., Hansson, E. M. & Lendahl, U., 2010, In : Developmental Biology. 348, 2, p. 153-166 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Protein kinase Cζ regulates Cdk5/p25 signaling during myogenesis

Thonel, De, A., Ferraris, S. E., Pallari, H-M., Imanishi, S. Y., Kochin, V., Hosokawa, T., Hisanaga, S-I., Sahlgren, C. & Eriksson, J. E., 3 Mar 2010, In : Molecular Biology of the Cell. 21, 8, p. 1423-1434

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles : opportunities & challenges

Rosenholm, J. M., Sahlgren, C. & Lindén, M., 2010, In : Special Publication - Royal Society of Chemistry. 2, 10, p. 1870-1883

Research output: Contribution to journalArticleAcademicpeer-review

406 Citations (Scopus)
2009

Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems

Rosenholm, J. M., Eriksson, J. E., Peuhu, E., Sahlgren, C. & Lindén, M., 2009, In : Nano Letters. 9, 9, p. 3308-3311

Research output: Contribution to journalArticleAcademicpeer-review

187 Citations (Scopus)
1 Downloads (Pure)

Targeting of porous hybrid silica nanoparticles to cancer cells

Rosenholm, J. M., Meinander, A., Peuhu, E., Niemi, R., Eriksson, J. E., Sahlgren, C. & Lindén, M., 2009, In : ACS Nano. 3, 1, p. 197-206

Research output: Contribution to journalArticleAcademicpeer-review

425 Citations (Scopus)
2 Downloads (Pure)
2008

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Sahlgren, C., Gustafsson, M. V., Jin, S., Poellinger, L. & Lendahl, U., 2008, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 105, 17, p. 6392-6397

Research output: Contribution to journalArticleAcademicpeer-review

556 Citations (Scopus)
1 Downloads (Pure)

Notch signaling regulates platelet-derived growth factor receptor-β expression in vascular smooth muscle cells

Jin, S., Hansson, E. M., Tikka, S., Lanner, F., Sahlgren, C., Farnebo, F., Baumann, M., Kalimo, H. & Lendahl, U., 2008, In : Circulation Research. 102, 12, p. 1483-1491

Research output: Contribution to journalArticleAcademicpeer-review

119 Citations (Scopus)
1 Downloads (Pure)
2006

A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death

Sahlgren, C. M., Pallari, H-M., He, T., Chou, Y-H., Goldman, R. D. & Eriksson, J. E., 2006, In : EMBO Journal. 25, 20, p. 4808-4819

Research output: Contribution to journalArticleAcademicpeer-review

119 Citations (Scopus)

High levels of Notch signaling down-regulate Numb and Numblike

Chapman, G., Liu, L., Sahlgren, C., Dahlqvist, C. & Lendahl, U., 2006, In : Journal of Cell Biology. 175, 4, p. 535-540 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Scopus)

Notch signaling and its integration with other signaling mechanisms

Sahlgren, C. & Lendahl, U., 2006, In : Regenerative Medicine. 1, 2, p. 195-205

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
2003

Cdk5 regulates the organization of nestin and its association with p35

Sahlgren, C. M., Mikhailov, A., Vaittinen, S., Kalimo, H., Pant, H. C. & Eriksson, J. E., 2003, In : Molecular and cellular biology. 23, 14, p. 5090-5106

Research output: Contribution to journalArticleAcademicpeer-review

113 Citations (Scopus)
2001

Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase

Sahlgren, C. M., Mikhailov, A., Hellman, J., Chou, Y-H., Lendahl, U., Goldman, R. D. & Eriksson, J. E., 2001, In : Journal of Biological Chemistry. 276, 19, p. 16456-16463

Research output: Contribution to journalArticleAcademicpeer-review

99 Citations (Scopus)

The expression of intermediate filament protein nestin as related to vimentin and desmin in regenerating skeletal muscle

Vaittinen, S., Lukka, R., Sahlgren, C., Hurme, T., Rantanen, J., Lendahl, U., Eriksson, J. E. & Kalimo, H., 2001, In : Journal of Neuropathology and Experimental Neurology. 60, 6, p. 588-597

Research output: Contribution to journalArticleAcademicpeer-review

127 Citations (Scopus)
1999

Intermediate filament protein partnership in astrocytes

Eliasson, C., Sahlgren, C., Berthold, C-H., Stakeberg, J., Celis, J. E., Betsholtz, C. & Pekny, M., 1999, In : Journal of Biological Chemistry. 274, 34, p. 23996-24006 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

281 Citations (Scopus)

Specific and innervation-regulated expression of the intermediate filament protein nestin at neuromuscular and myotendinous junctions in skeletal muscle

Vaittinen, S., Lukka, R., Sahlgren, C., Rantanen, J., Hurme, T., Lendahl, U., Eriksson, J. E. & Kalimo, H., 1999, In : American Journal of Pathology. 154, 2, p. 591-600

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)
1 Downloads (Pure)
1998

[42] Strategies to assess phosphoprotein phosphatase and protein kinase- mediated regulation of the cytoskeleton

Eriksson, J. E., Toivola, D. M., Sahlgren, C., Mikhailov, A. & Härmälä-Braskén, A-S., 1998, Molecular Motors and the Cytoskeleton Part B. Vallee, R. B. (ed.). San Diego, Calif: Academic Press Inc., p. 542-569 (Methods in Enzymology; vol. 298).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

16 Citations (Scopus)
1995

The nervous system of Tricladida. I. Neuroanatomy of Procerodes littoralis (Maricola, Procerodidae) : an immunocytochemical study

Reuter, M., Gustafsson, M. K. S., Sahlgren, C., Halton, D. W., Maule, A. G. & Shaw, C., 1995, In : Invertebrate Neuroscience. 1, 2, p. 113-122

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)
4 Downloads (Pure)