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Research Output

2020
Open Access
Open Access
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17 Downloads (Pure)

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

Tanaka, N., Kanatani, S., Kaczynska, D., Fukumoto, K., Louhivuori, L., Mizutani, T., Kopper, O., Kronqvist, P., Robertson, S., Lindh, C., Kis, L., Pronk, R., Niwa, N., Matsumoto, K., Oya, M., Miyakawa, A., Falk, A., Hartman, J., Sahlgren, C., Clevers, H. & 1 others, Uhlén, P., 1 Sep 2020, In : Nature Biomedical Engineering. 4, 9, p. 875-888 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

A microfluidic oxygen gradient device to assess EMT state and migrational responses of cancer cells

Sleeboom, J., van der Doelen, K., Kruyt, F., Sahlgren, C. M. & den Toonder, J. M. J., Jun 2019.

Research output: Contribution to conferencePoster

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13 Downloads (Pure)

A microfluidic oxygen gradient device to assess EMT state and migrational responses of cancer cells

Sleeboom, J., van der Doelen, K., Kruyt, F., Sahlgren, C. M. & den Toonder, J. M. J., Jul 2019.

Research output: Contribution to conferencePoster

Open Access
File
27 Downloads (Pure)

Decoding the PTM-switchboard of Notch

Antfolk, D., Antila, C., Kemppainen, K., Landor, S. K. J. & Sahlgren, C., 1 Dec 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 21 p., 118507.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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43 Downloads (Pure)
Open Access
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47 Downloads (Pure)

Influence of the assembly state on the functionality of a supramolecular jagged1-mimicking peptide additive

Putti, M., Stassen, O. M. J. A., Schotman, M. J. G., Sahlgren, C. M. & Dankers, P. Y. W., 3 May 2019, In : ACS Omega. 4, 5, p. 8178-8187 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
53 Downloads (Pure)

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 27 Aug 2019, In : Scientific Reports. 9, 1, 14 p., 12415.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
31 Downloads (Pure)
2018
Open Access
File
17 Citations (Scopus)
63 Downloads (Pure)

Cancer stem cell migration in an oxygen gradient characterized using a microfluidic device

Sleeboom, J. J. F., Sahlgren, C. M. & Den Toonder, J. M. J., 2018, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. Chemical and Biological Microsystems Society, Vol. 3. p. 1517-1520 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Mapping of the three-dimensional lymphatic microvasculature in bladder tumours using light-sheet microscopy

Tanaka, N., Kaczynska, D., Kanatani, S., Sahlgren, C., Mitura, P., Stepulak, A., Miyakawa, A., Wiklund, P. & Uhlén, P., 1 Apr 2018, In : British Journal of Cancer. 118, 7, p. 995-999 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
67 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
66 Downloads (Pure)

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Loerakker, S., Stassen, O. M. J. A., ter Huurne, F. M., Boareto, M., Bouten, C. V. C. & Sahlgren, C. M., 17 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 115, 16, p. E3682-E3691 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
11 Citations (Scopus)
63 Downloads (Pure)

Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

Sleeboom, J. J. F., Amirabadi, H. E., Nair, P., Sahlgren, C. M. & Den Toonder, J. M. J., 1 Mar 2018, In : Disease Models & Mechanisms. 11, 3, 17 p., 033100.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
31 Citations (Scopus)
209 Downloads (Pure)

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 11 p., 13524.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
62 Downloads (Pure)

Publisher correction: Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity

Tanaka, N., Kanatani, S., Tomer, R., Sahlgren, C., Kronqvist, P., Kaczynska, D., Louhivuori, L., Kis, L., Lindh, C., Mitura, P., Stepulak, A., Corvigno, S., Hartman, J., Micke, P., Mezheyeuski, A., Strell, C., Carlson, J. W., Fernández Moro, C., Dahlstrand, H., Östman, A. & 6 others, Matsumoto, K., Wiklund, P., Oya, M., Miyakawa, A., Deisseroth, K. & Uhlén, P., 2 Jan 2018, In : Nature Biomedical Engineering. 2, 1, p. 48 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access
1 Citation (Scopus)

Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

Driessen, R. C. H., Stassen, O. M. J. A., Sjöqvist, M., Suarez Rodriguez, F., Grolleman, J., Bouten, C. V. C. & Sahlgren, C. M., 1 Nov 2018, In : Integrative Biology. 10, 11, p. 719-726 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
46 Downloads (Pure)

Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro

Tiemeijer, L. A., Frimat, J. P., Stassen, O. M. J. A., Bouten, C. V. C. & Sahlgren, C. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 10 p., 6392.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)
72 Downloads (Pure)

Sumoylation of Notch1 represses its target gene expression during cell stress

Antila, C. J. M., Rraklli, V., Blomster, H. A., Dahlström, K. M., Salminen, T. A., Holmberg, J., Sistonen, L. & Sahlgren, C. M., 1 Mar 2018, In : Cell Death and Differentiation. 25, 3, p. 600-615 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
79 Downloads (Pure)

Targeting somatostatin receptors by functionalized mesoporous silica nanoparticles-are we striking home?

Paramonov, V. M., Desai, D., Kettiger, H., Mamaeva, V., Rosenholm, J. M., Sahlgren, C. & Rivero-Müller, A., Jan 2018, In : Nanotheranostics. 2, 4, p. 320-346 27 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
24 Downloads (Pure)
2017

Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes

Paatero, I., Casals, E., Niemi, R., Özliseli, E., Rosenholm, J. M. & Sahlgren, C., 1 Dec 2017, In : Scientific Reports. 7, 1, 8423.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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16 Citations (Scopus)
72 Downloads (Pure)

A novel breast-cancer model of early stage invasion

Sleeboom, J. J. F., Sahlgren, C. M. & den Toonder, J. M. J., 2 May 2017.

Research output: Contribution to conferencePosterAcademic

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68 Downloads (Pure)

Cardiac progenitor cells and the interplay with their microenvironment

Mauretti, A., Spaans, S., Bax, N. A. M., Sahlgren, C. & Bouten, C. V. C., 2017, In : Stem Cells International. 2017, 20 p., 7471582.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
16 Citations (Scopus)
96 Downloads (Pure)

Modeling the pre-invasive breast cancer microenvironment using high-throughput microfluidic cell encapsulation

Sleeboom, J. J. F., Sahlgren, C. M. & den Toonder, J. M. J., 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, p. 798-799 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Selective regulation of Notch ligands during angiogenesis is mediated by vimentin

Antfolk, D., Sjoqvist, M., Cheng, F., Isoniemi, K., Duran, C., Rivero-Muller, A., Antila, C., Niemi, R., Landor, S., Bouten, C., Bayless, K. J., Eriksson, J. E. & Sahlgren, C., 6 Jun 2017, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 114, 23, p. E4574–E4581

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
22 Citations (Scopus)
2 Downloads (Pure)

Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells

Mauretti, A., Rossi, F., Bax, N. A. M., Miano, C., Miraldi, F., Goumans, M. J., Messina, E., Giacomello, A., Bouten, C. V. C. & Sahlgren, C., 1 Sep 2017, In : MRS Communications. 7, 3, p. 496-501 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Downloads (Pure)

Tailored approaches in drug development and diagnostics: from molecular design to biological model systems

Sahlgren, C. M., Meinander, A., Zhang, H., Cheng, F., Preis, M., Xu, C., Salminen, T. A., Toivola, D. M., Abankwa, D., Rosling, A., Karaman, D. Ş., Salo-Ahen, O. M. H., Österbacka, R., Eriksson, J. E., Willför, S., Petre, I., Peltonen, J., Leino, R., Johnson, M., Rosenholm, J. & 1 others, Sandler, N., 8 Nov 2017, In : Advanced Healthcare Materials. 6, 21, p. 1-34 1700258.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
17 Citations (Scopus)

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity

Tanaka, N., Kanatani, S., Tomer, R., Sahlgren, C., Kronqvist, P., Kaczynska, D., Louhivuori, L., Kis, L., Lindh, C., Mitura, P., Stepulak, A., Corvigno, S., Hartman, J., Micke, P., Mezheyeuski, A., Strell, C., Carlson, J. W., Fernández Moro, C., Dahlstrand, H., Östman, A. & 6 others, Matsumoto, K., Wiklund, P., Oya, M., Miyakawa, A., Deisseroth, K. & Uhlén, P., 1 Oct 2017, In : Nature Biomedical Engineering. 1, 10, p. 796-806 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)
2016
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55 Downloads (Pure)

Cardiac stem cell mechanosome and mechanosensitivity develop with differentiation

Mauretti, A., Bax, N. A. M., Goumans, M. J. T. H., Sahlgren, C. M. & Bouten, C. V. C., 22 Mar 2016.

Research output: Contribution to conferencePosterAcademic

Open Access
File
89 Downloads (Pure)

Cardiac stem cell mechanosome and mechanosensitivity develop with differentiation

Mauretti, A., Bax, N. A. M., van Marion, M. H., Goumans, M. J. T. H., Sahlgren, C. M. & Bouten, C. V. C., 28 Jun 2016.

Research output: Contribution to conferencePosterAcademic

Open Access
File
30 Downloads (Pure)

Cardiomyocyte progenitor cell mechanoresponse unrevealed: strain avoidance and mechanosome development.

Mauretti, A., Bax, N. A. M., van Marion, M. H., Goumans, M. J. T. H., Sahlgren, C. M. & Bouten, C. V. C., 12 Sep 2016, In : Integrative Biology. 8, 9, p. 991-1001 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
17 Downloads (Pure)

Fluid shear stress induces jagged1 Ligand clustering in endothelial cells.

Driessen, R. C. H., Bouten, C. V. C. & Sahlgren, C. M., 23 Jul 2016.

Research output: Contribution to conferenceAbstractAcademic

Inhibiting notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying γ-secretase inhibitors

Mamaeva, V., Niemi, R., Beck, M., Özliseli, E., Desai, D., Landor, S., Gronroos, T., Kronqvist, P., Pettersen, I. K. N., McCormack, E., Rosenholm, J. M., Linden, M. & Sahlgren, C. M., 1 May 2016, In : Molecular Therapy. 24, 5, p. 926-936 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
53 Citations (Scopus)
104 Downloads (Pure)

Loss of CSL unlocks a hypoxic response and enhanced tumor growth potential in breast cancer cells

Braune, E-B., Tsoi, Y. L., Phoon, Y. P., Landor, S., Silva Cascales, H., Ramsköld, D., Deng, Q., Lindqvist, A., Lian, X., Sahlgren, C. M., Jin, S-B. & Lendahl, U., 10 May 2016, In : Stem cell reports. 6, 5, p. 643-51 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
17 Citations (Scopus)
78 Downloads (Pure)

Mechanosensitivity of cardiomyocyte progenitor cells: the strain response in 2D and 3D environments

Bax, N. A. M., Mauretti, A., Van Marion, M. H., Van Turnhout, M. C., Van der Schaft, D. W. J., Sahlgren, C. M., Goumans, M. J. T. H. & Bouten, C. V. C., 1 Jul 2016, In : Cardiovascular Research. 111, suppl 1, p. S94-S94 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

Open Access
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47 Downloads (Pure)

Mechanosensitivity of CMPCs :strain response in 2D and 3D environments

Bax, N. A. M., Mauretti, A., van Marion, M. H., van Turnhout, M. C., van der Schaft, D. W. J., Goumans, M. J. T. H., Sahlgren, C. M. & Bouten, C. V. C., Sep 2016, International Society for Applied Cardiovascular Biology : ISACB, 7-10 September, Banff, Canada.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

8 Downloads (Pure)

Mesoporous silica nanoparticles in tissue engineering : a perspective

Rosenholm, J. M., Zhang, J., Linden, M. & Sahlgren, C. M., 1 Feb 2016, In : Nanomedicine. 11, 4, p. 391-402 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Santio, N. M., Landor, SK-J., Vahtera, L., Ylä-Pelto, J., Paloniemi, E., Imanishi, S. Y., Corthals, G., Varjosalo, M., Manoharan, G. B., Uri, A., Lendahl, U., Sahlgren, C. M. & Koskinen, P. J., 12 Jul 2016, In : Oncotarget. 7, 28, p. 43220-43238 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
25 Citations (Scopus)
156 Downloads (Pure)

Prolonged dye release from mesoporous silica-based imaging probes facilitates long-term optical tracking of cell populations in vivo

Rosenholm, J. M., Gulin-Sarfraz, T., Mamaeva, V., Niemi, R., Özliseli, E., Desai, D., Antfolk, D., von Haartman, E., Lindberg, D., Prabhakar, N., Näreoja, T. & Sahlgren, C. M., 23 Mar 2016, In : Small. 12, 12, p. 1578-1592

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles

Desai, D., Prabhakar, N., Mamaeva, V., Karaman, D. Ş., Lähdeniemi, I. A. K., Sahlgren, C., Rosenholm, J. M. & Toivola, D. M., 18 Jan 2016, In : International Journal of Nanomedicine. 11, p. 299-313 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
25 Citations (Scopus)
270 Downloads (Pure)
2015

Cell-matrix interactions in cardiomyocyte progenitor cells upon cyclic strain

Mauretti, A., Sahlgren, C. M., Baaijens, F. P. T. & Bouten, C. V. C., May 2015.

Research output: Contribution to conferencePosterAcademic

Open Access
File
59 Downloads (Pure)

Decoding breast cancer tissue-stroma interactions using species-specific sequencing

Chivukula, I. V., Ramsköld, D., Storvall, H., Anderberg, C., Jin, S., Mamaeva, V., Sahlgren, C. M., Pietras, K., Sandberg, R. & Lendahl, U., 2015, In : Breast cancer research : BCR. 17, p. 1-14 109.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
6 Citations (Scopus)
100 Downloads (Pure)

Genetically-encoded tools for cAMP probing and modulation in living systems

Paramonov, V. M., Mamaeva, V., Sahlgren, C. M. & Rivero-Müller, A., 2015, In : Frontiers in Pharmacology. 6, p. 1-21 196.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
17 Citations (Scopus)
84 Downloads (Pure)

Mesoporous silica particle-PLA-PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization

Shokry, H., Vanamo, U., Wiltschka, O., Niinimäki, J., Lerche, M., Levon, K., Linden, M. & Sahlgren, C. M., 14 Sep 2015, In : Nanoscale. 7, 34, p. 14434-43 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)