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Personal profile

Research profile

Cecilia Sahlgren is a part-time Associate Professor at the TU/e department of Biomechanical Engineering (research group Soft Tissue Engineering & Mechanobiology) and Professor of Cell Biology at Åbo Akademi University in Turku, Finland. Her research aims at understanding the basic molecular principles of signaling mechanisms regulating cell fate choices of stem cells in cardiovascular tissue engineering. Another important goal is to develop technology to specifically monitor and tune these signals at will in specific cell populations, in order to steer stem cell fate and curtail disease activities. The specific focus of her research is on the role and regulation of the evolutionary conserved Notch signaling pathway, a key regulator of stem cell function. 

The main objectives are: 1) to understand how the cellular microenvironment influences Notch signaling activities and how this impinges on cell identity and function 2) to understand how Notch activity in stem cells influence remodelling of the environment  and 2) to develop technology platforms to regulate Notch signaling in engineered tissues and probes for cellular and molecular imaging.

Increased knowledge of these processes can provide insights into regenerative processes and has the potential to find applications in material based stem cell therapy. Specific projects are focusing on Notch signaling in cardiovascular tissue and on directing engineered tissue fate by modulating Notch signaling.

Academic background

Cecilia Sahlgren obtained her PhD at Åbo Akademi University (Turku, Finland) focusing on the role of intermediate filaments as signaling orchestrators in cell fate decisions. From 2005-2008, she was a postdoc researcher at the Department of Cell and Molecular Biology of the Karolinska Institutet (Stockholm, Sweden). She then returned to Finland to establish the Cell Fate Lab at the Turku Centre for Biotechnology, a joint department of the University of Turku and Åbo Akademi University. In 2013, she moved to the Department of Biomedical Engineering of Eindhoven University of Technology (TU/e, The Netherlands), first as assistant professor and subsequently as associate professor. In 2016, she again returned to Finland to become Professor of Cell Biology at Åbo Akademi University but kept her affiliation to TU/e, now as a part-time professor. In 2017, she was awarded an ERC Consolidator Grant to investigate the interplay between blood flow and cell signaling, and to clarify their effects on the architecture of blood vessels in the ForceMorph project.

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Research Output

Open Access
  • A microfluidic oxygen gradient device to assess EMT state and migrational responses of cancer cells

    Sleeboom, J., van der Doelen, K., Kruyt, F., Sahlgren, C. M. & den Toonder, J. M. J., Jun 2019.

    Research output: Contribution to conferencePoster

    File

    A microfluidic oxygen gradient device to assess EMT state and migrational responses of cancer cells

    Sleeboom, J., van der Doelen, K., Kruyt, F., Sahlgren, C. M. & den Toonder, J. M. J., Jul 2019.

    Research output: Contribution to conferencePoster

    Open Access
    File
  • 14 Downloads (Pure)

    Decoding the PTM-switchboard of Notch

    Antfolk, D., Antila, C., Kemppainen, K., Landor, S. K. J. & Sahlgren, C., 1 Dec 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 21 p., 118507.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
    File
  • 10 Downloads (Pure)

    Courses

    Regeneration

    1/09/13 → …

    Course

    Press / Media

    Cells Protect Themselves Against Stress by Keeping Together

    Cecilia M. Sahlgren

    20/01/20

    1 item of Media coverage

    Press/Media: Expert Comment

    Cell adhesion essential for cells to survive stress

    Cecilia M. Sahlgren

    16/01/20

    1 item of Media coverage

    Press/Media: Expert Comment

    Cells protect themselves against stress by keeping together

    Cecilia M. Sahlgren

    16/01/20

    2 items of Media coverage

    Press/Media: Expert Comment

    Two Million Euros for Blood Vessel Research

    Cecilia M. Sahlgren

    3/12/17

    1 item of Media coverage

    Press/Media: Expert Comment

    3D microscopy gives more accurate cancer diagnosis

    C.M. Sahlgren

    3/10/17

    1 item of Media coverage

    Press/Media: Expert Comment

    Student theses

    Cell directed nanoparticle drug delivery for tissue engineering

    Author: Vogel, M., 30 Sep 2015

    Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Ottmann, C. (Supervisor 2) & Kurniawan, N. (External coach)

    Student thesis: Master

    Gas plasma modification for in situ tissue engineering

    Author: Driessen, R., 31 Mar 2015

    Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Hofmann Boss, S. (Supervisor 2), Smits, P. (Supervisor 2) & Stevens, A. (External person) (External coach)

    Student thesis: Master

    Optogenetics: a tool to induce actin formation

    Author: Quiñonez Uribe, R., 31 Jan 2016

    Supervisor: Merkx, M. (Supervisor 1), Bax, N. (Supervisor 2), Sahlgren, C. (Supervisor 2) & Bouten, C. (Supervisor 2)

    Student thesis: Master

    The influence of fluid shear stress on the spatial organization of Notch/Jagged signalling in vascular cells

    Author: Lancee, G., 30 Jun 2014

    Supervisor: Sahlgren, C. (Supervisor 1) & Bouten, C. (Supervisor 2)

    Student thesis: Master

    The mechanoresponse of Jagged1 to shear stress in endothelial cells

    Author: Grolleman, J., 29 Mar 2018

    Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Stassen, O. (Supervisor 2) & Driessen, R. (Supervisor 2)

    Student thesis: Master