Research Output per year
Personal profile
Research profile
Cecilia Sahlgren is a part-time Associate Professor at the TU/e department of Biomechanical Engineering (research group Soft Tissue Engineering & Mechanobiology) and Professor of Cell Biology at Åbo Akademi University in Turku, Finland. Her research aims at understanding the basic molecular principles of signaling mechanisms regulating cell fate choices of stem cells in cardiovascular tissue engineering. Another important goal is to develop technology to specifically monitor and tune these signals at will in specific cell populations, in order to steer stem cell fate and curtail disease activities. The specific focus of her research is on the role and regulation of the evolutionary conserved Notch signaling pathway, a key regulator of stem cell function.
The main objectives are: 1) to understand how the cellular microenvironment influences Notch signaling activities and how this impinges on cell identity and function 2) to understand how Notch activity in stem cells influence remodelling of the environment and 2) to develop technology platforms to regulate Notch signaling in engineered tissues and probes for cellular and molecular imaging.
Increased knowledge of these processes can provide insights into regenerative processes and has the potential to find applications in material based stem cell therapy. Specific projects are focusing on Notch signaling in cardiovascular tissue and on directing engineered tissue fate by modulating Notch signaling.
Academic background
Cecilia Sahlgren obtained her PhD at Åbo Akademi University (Turku, Finland) focusing on the role of intermediate filaments as signaling orchestrators in cell fate decisions. From 2005-2008, she was a postdoc researcher at the Department of Cell and Molecular Biology of the Karolinska Institutet (Stockholm, Sweden). She then returned to Finland to establish the Cell Fate Lab at the Turku Centre for Biotechnology, a joint department of the University of Turku and Åbo Akademi University. In 2013, she moved to the Department of Biomedical Engineering of Eindhoven University of Technology (TU/e, The Netherlands), first as assistant professor and subsequently as associate professor. In 2016, she again returned to Finland to become Professor of Cell Biology at Åbo Akademi University but kept her affiliation to TU/e, now as a part-time professor. In 2017, she was awarded an ERC Consolidator Grant to investigate the interplay between blood flow and cell signaling, and to clarify their effects on the architecture of blood vessels in the ForceMorph project.
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Research Output
Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls
Ristori, T., Stassen, O. M. J. A., Sahlgren, C. M. & Loerakker, S., 14 Feb 2020, In : International Journal for Numerical Methods in Biomedical Engineering. p. e3323Research output: Contribution to journal › Article › Academic › peer-review
Open Access
A microfluidic oxygen gradient device to assess EMT state and migrational responses of cancer cells
Sleeboom, J., van der Doelen, K., Kruyt, F., Sahlgren, C. M. & den Toonder, J. M. J., Jun 2019.Research output: Contribution to conference › Poster
File
A microfluidic oxygen gradient device to assess EMT state and migrational responses of cancer cells
Sleeboom, J., van der Doelen, K., Kruyt, F., Sahlgren, C. M. & den Toonder, J. M. J., Jul 2019.Research output: Contribution to conference › Poster
A supramolecular platform for the introduction of Fc-fusion bioactive proteins on biomaterial surfaces
Sahlgren, C. M., de Jong, S. M. J., Stassen, O. M. J. A., Sahlgren, C. M. & Dankers, P. Y. W., 9 Aug 2019, In : ACS Applied Polymer Materials. 1, 8, p. 2044-2054 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Decoding the PTM-switchboard of Notch
Antfolk, D., Antila, C., Kemppainen, K., Landor, S. K. J. & Sahlgren, C., 1 Dec 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 21 p., 118507.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access
File
Courses
Press / Media
Cells Protect Themselves Against Stress by Keeping Together
20/01/20
1 item of Media coverage
Press/Media: Expert Comment
Cell adhesion essential for cells to survive stress
16/01/20
1 item of Media coverage
Press/Media: Expert Comment
Cells protect themselves against stress by keeping together
16/01/20
2 items of Media coverage
Press/Media: Expert Comment
Two Million Euros for Blood Vessel Research
3/12/17
1 item of Media coverage
Press/Media: Expert Comment
3D microscopy gives more accurate cancer diagnosis
3/10/17
1 item of Media coverage
Press/Media: Expert Comment
Student theses
Cell directed nanoparticle drug delivery for tissue engineering
Author: Vogel, M., 30 Sep 2015Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Ottmann, C. (Supervisor 2) & Kurniawan, N. (External coach)
Student thesis: Master
Gas plasma modification for in situ tissue engineering
Author: Driessen, R., 31 Mar 2015Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Hofmann Boss, S. (Supervisor 2), Smits, P. (Supervisor 2) & Stevens, A. (External person) (External coach)
Student thesis: Master
Optogenetics: a tool to induce actin formation
Author: Quiñonez Uribe, R., 31 Jan 2016Supervisor: Merkx, M. (Supervisor 1), Bax, N. (Supervisor 2), Sahlgren, C. (Supervisor 2) & Bouten, C. (Supervisor 2)
Student thesis: Master
The influence of fluid shear stress on the spatial organization of Notch/Jagged signalling in vascular cells
Author: Lancee, G., 30 Jun 2014Supervisor: Sahlgren, C. (Supervisor 1) & Bouten, C. (Supervisor 2)
Student thesis: Master
The mechanoresponse of Jagged1 to shear stress in endothelial cells
Author: Grolleman, J., 29 Mar 2018Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Stassen, O. (Supervisor 2) & Driessen, R. (Supervisor 2)
Student thesis: Master