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Personal profile

Research profile

Cecilia Sahlgren is a part-time Associate Professor at the TU/e department of Biomechanical Engineering (research group Soft Tissue Engineering & Mechanobiology) and Professor of Cell Biology at Åbo Akademi University in Turku, Finland. Her research aims at understanding the basic molecular principles of signaling mechanisms regulating cell fate choices of stem cells in cardiovascular tissue engineering. Another important goal is to develop technology to specifically monitor and tune these signals at will in specific cell populations, in order to steer stem cell fate and curtail disease activities. The specific focus of her research is on the role and regulation of the evolutionary conserved Notch signaling pathway, a key regulator of stem cell function. 

The main objectives are: 1) to understand how the cellular microenvironment influences Notch signaling activities and how this impinges on cell identity and function 2) to understand how Notch activity in stem cells influence remodelling of the environment  and 2) to develop technology platforms to regulate Notch signaling in engineered tissues and probes for cellular and molecular imaging.

Increased knowledge of these processes can provide insights into regenerative processes and has the potential to find applications in material based stem cell therapy. Specific projects are focusing on Notch signaling in cardiovascular tissue and on directing engineered tissue fate by modulating Notch signaling.

Academic background

Cecilia Sahlgren obtained her PhD at Åbo Akademi University (Turku, Finland) focusing on the role of intermediate filaments as signaling orchestrators in cell fate decisions. From 2005-2008, she was a postdoc researcher at the Department of Cell and Molecular Biology of the Karolinska Institutet (Stockholm, Sweden). She then returned to Finland to establish the Cell Fate Lab at the Turku Centre for Biotechnology, a joint department of the University of Turku and Åbo Akademi University. In 2013, she moved to the Department of Biomedical Engineering of Eindhoven University of Technology (TU/e, The Netherlands), first as assistant professor and subsequently as associate professor. In 2016, she again returned to Finland to become Professor of Cell Biology at Åbo Akademi University but kept her affiliation to TU/e, now as a part-time professor. In 2017, she was awarded an ERC Consolidator Grant to investigate the interplay between blood flow and cell signaling, and to clarify their effects on the architecture of blood vessels in the ForceMorph project.

Fingerprint Dive into the research topics where Cecilia M. Sahlgren is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Silicon Dioxide Chemical Compounds
Nanoparticles Medicine & Life Sciences
Silica Engineering & Materials Science
Stem Cells Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Drug delivery Chemical Compounds
Neoplasms Medicine & Life Sciences
Cells Chemical Compounds

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Research Output 1995 2019

Influence of the assembly state on the functionality of a supramolecular jagged1-mimicking peptide additive

Putti, M., Stassen, O. M. J. A., Schotman, M. J. G., Sahlgren, C. M. & Dankers, P. Y. W., 3 May 2019, In : ACS Omega. 4, 5, p. 8178-8187 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pyrimidinones
DSL
Peptides
Polycaprolactone
Self assembly
9 Citations (Scopus)
Open Access
File
Biomimetics
Microfluidics
Endothelial cells
Hemodynamics
Vascular Smooth Muscle
2 Citations (Scopus)

Mapping of the three-dimensional lymphatic microvasculature in bladder tumours using light-sheet microscopy

Tanaka, N., Kaczynska, D., Kanatani, S., Sahlgren, C., Mitura, P., Stepulak, A., Miyakawa, A., Wiklund, P. & Uhlén, P., 8 Mar 2018, In : British Journal of Cancer. 118, p. 995-999 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microvessels
Urinary Bladder Neoplasms
Microscopy
Light
Paraffin
1 Citation (Scopus)
Open Access
File
Lab-On-A-Chip Devices
multiple docking adapters
Neoplastic Stem Cells
stem cells
Stem cells
3 Citations (Scopus)

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Loerakker, S., Stassen, O. M. J. A., ter Huurne, F. M., Boareto, M., Bouten, C. V. C. & Sahlgren, C. M., 17 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. E3682-E3691 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Blood Vessels
Homeostasis
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hemodynamics

Courses

Regeneration

1/09/13 → …

Course

Student theses

Cell directed nanoparticle drug delivery for tissue engineering

Author: Vogel, M., 30 Sep 2015

Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Ottmann, C. (Supervisor 2) & Kurniawan, N. (External coach)

Student thesis: Master

Gas plasma modification for in situ tissue engineering

Author: Driessen, R., 31 Mar 2015

Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Hofmann Boss, S. (Supervisor 2), Smits, P. (Supervisor 2) & Stevens, A. (External person) (External coach)

Student thesis: Master

Optogenetics: a tool to induce actin formation

Author: Quiñonez Uribe, R., 31 Jan 2016

Supervisor: Merkx, M. (Supervisor 1), Bax, N. (Supervisor 2), Sahlgren, C. (Supervisor 2) & Bouten, C. (Supervisor 2)

Student thesis: Master

The influence of fluid shear stress on the spatial organization of Notch/Jagged signalling in vascular cells

Author: Lancee, G., 30 Jun 2014

Supervisor: Sahlgren, C. (Supervisor 1) & Bouten, C. (Supervisor 2)

Student thesis: Master

The mechanoresponse of Jagged1 to shear stress in endothelial cells

Author: Grolleman, J., 29 Mar 2018

Supervisor: Bouten, C. (Supervisor 1), Sahlgren, C. (Supervisor 2), Stassen, O. (Supervisor 2) & Driessen, R. (Supervisor 2)

Student thesis: Master