C.C. (René) van Donkelaar

dr.

  • 3349 Citations
19952019

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Personal profile

Research profile

René van Donkelaar is Associate Professor in Cartilage Mechanics at the department of Biomedical Engineering (research group Orthopaedic Biomechanics). In his research he approaches cartilage from a mechanical point of view. Using fundamental insights on the mechanical behavior of cartilage, he established a well-recognized computational model of cartilage mechanics. The main asset of this model is that it directly links biochemical contents (distributions of proteoglycans and collagen) and structural features (collagen fiber orientation), to mechanical properties. Van Donkelaar has now shifted his focus from fundamental to applied cartilage research in two main research areas. First, he aims to develop improved loading protocols for cartilage tissue engineering. Second, he aims to understand how adverse mechanical loading leads to progression of osteoarthritis, ultimately leading to the development of diagnostic tools. All topics are studied by means of experimental work using cell cultures and explant systems, in conjunction with numerical modeling using the aforementioned cartilage mechanics model. The latter is being adapted such that cartilage growth and developmental as well as cartilage degeneration can be computed and predicted.

Academic background

René van Donkelaar studied Human Health Sciences at Radboud University Nijmegen (The Netherlands) where he obtained his MSc in 1994. Subsequently, he was a PhD student at the Department of Movement Sciences of Maastricht University (UM, The Netherlands) under supervision of professors Maarten Drost (UM), Harm Kuipers (UM), and Jan Janssen (Eindhoven Unversity of Technology, TU/e, The Netherlands). He obtained his PhD in 1999 with his thesis 'Skeletal muscle mechanics, a numerical and experimental approach to spatial phenomena'. Since 1998, Van Donkelaar has been appointed at the TU/e Biomedical Engineering Department, where he was one of the first faculty members. He has worked at the groups of professors Frank Baaijens and Rik Huiskes, and since 2010 he is Associate Professor in Cartilage Mechanics at professor Keita Ito's group for Orthopaedic Biomechanics.

Quote

To me, science is chasing the moment you finally understand how many findings fit together. I wish everybody a few of such Eureca-moments in their carreer.

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Research Output

Characterizing the invasion of different breast cancer cell lines with distinct E-cadherin status in 3D using a microfluidic system

Eslami Amirabadi, H., Tuerlings, M., Hollestelle, A., Sahebali, S., Luttge, R., van Donkelaar, C. C. R., Martens, J. W. M. & den Toonder, J. M. J., 1 Dec 2019, In : Biomedical Microdevices. 21, 4, 11 p., 101.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
  • 13 Downloads (Pure)

    The relationship between proteoglycan loss, overloading-induced collagen damage, and cyclic loading in articular cartilage

    Henao Murillo, L., Pastrama, M., Ito, K. & van Donkelaar, R., 15 Nov 2019, In : Cartilage.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Breast cancer cells with distinct E-cadherin status exhibit different 3-D invasion behavior in a novel microfluidic system

    Eslami Amirabadi, H., Tuerlings, M., SahebAli, S., Luttge, R., van Donkelaar, C. C., Martens, J. W. M. & den Toonder, J. M. J., 1 Jan 2018, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. Chemical and Biological Microsystems Society, Vol. 3. p. 1658-1660 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

  • Collagen damage location in articular cartilage differs if damage is caused by excessive loading magnitude or rate

    Henao-Murillo, L., Ito, K. & van Donkelaar, C. C., 1 Apr 2018, In : Annals of Biomedical Engineering. 46, 4, p. 605-615 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 9 Citations (Scopus)
    42 Downloads (Pure)

    Comparison between in vitro and in vivo cartilage overloading studies based on a systematic literature review

    Nickien, M., Heuijerjans, A., Ito, K. & van Donkelaar, C. C., 1 Aug 2018, In : Journal of Orthopaedic Research. 36, 8, p. 2076-2086 11 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
    File
  • 4 Citations (Scopus)
    57 Downloads (Pure)

    Student theses

    A compressible biphasic mixture theory with a fluid content dependent stiffness

    Author: Cornelissen, L., 30 Jun 2004

    Supervisor: Baaijens, F. (Supervisor 1), Oomens, C. (Supervisor 2), Huyghe, J. (Supervisor 2), Bovendeerd, P. (Supervisor 2) & van Donkelaar, C. (Supervisor 2)

    Student thesis: Master

    A computational model of the human growth plate

    Author: Brouwers, J., 30 Sep 2004

    Supervisor: Huiskes, H. (Supervisor 1), van Donkelaar, C. (Supervisor 2) & Sengers, B. (Supervisor 2)

    Student thesis: Master

    A fiber-reinforced hydrogel aortic valve: fabrication and characteristics of pHEMA reinforced with HP-PE fibers

    Author: de Jager, K., 30 Sep 2000

    Supervisor: Baaijens, F. (Supervisor 1), van Donkelaar, C. (Supervisor 2) & Cacciola, G. R. (External person) (Supervisor 2)

    Student thesis: Master

    A new method for analysing FRAP data in inhomogeneous tissues: application in the growth plate

    Author: Sniekers, Y., 29 Feb 2004

    Supervisor: Huiskes, H. (Supervisor 1), van Donkelaar, C. (Supervisor 2), Huyghe, J. (Supervisor 2) & Broers, J. (Supervisor 2)

    Student thesis: Master

    An in vitro culturing system for the study of solute transport and mechanical loading in intact intervertebral discs

    Author: Grünhagen, T., 30 Jun 2004

    Supervisor: Lee, C. (External person) (External coach), van Donkelaar, C. (Supervisor 2), Huyghe, J. (Supervisor 2), Huiskes, H. (Supervisor 2) & Ito, K. (Supervisor 2)

    Student thesis: Master