• 3309 Citations
19952019
If you made any changes in Pure these will be visible here soon.

Personal profile

Research profile

René van Donkelaar is Associate Professor in Cartilage Mechanics at the department of Biomedical Engineering (research group Orthopaedic Biomechanics). In his research he approaches cartilage from a mechanical point of view. Using fundamental insights on the mechanical behavior of cartilage, he established a well-recognized computational model of cartilage mechanics. The main asset of this model is that it directly links biochemical contents (distributions of proteoglycans and collagen) and structural features (collagen fiber orientation), to mechanical properties. Van Donkelaar has now shifted his focus from fundamental to applied cartilage research in two main research areas. First, he aims to develop improved loading protocols for cartilage tissue engineering. Second, he aims to understand how adverse mechanical loading leads to progression of osteoarthritis, ultimately leading to the development of diagnostic tools. All topics are studied by means of experimental work using cell cultures and explant systems, in conjunction with numerical modeling using the aforementioned cartilage mechanics model. The latter is being adapted such that cartilage growth and developmental as well as cartilage degeneration can be computed and predicted.

Academic background

René van Donkelaar studied Human Health Sciences at Radboud University Nijmegen (The Netherlands) where he obtained his MSc in 1994. Subsequently, he was a PhD student at the Department of Movement Sciences of Maastricht University (UM, The Netherlands) under supervision of professors Maarten Drost (UM), Harm Kuipers (UM), and Jan Janssen (Eindhoven Unversity of Technology, TU/e, The Netherlands). He obtained his PhD in 1999 with his thesis 'Skeletal muscle mechanics, a numerical and experimental approach to spatial phenomena'. Since 1998, Van Donkelaar has been appointed at the TU/e Biomedical Engineering Department, where he was one of the first faculty members. He has worked at the groups of professors Frank Baaijens and Rik Huiskes, and since 2010 he is Associate Professor in Cartilage Mechanics at professor Keita Ito's group for Orthopaedic Biomechanics.

Quote

To me, science is chasing the moment you finally understand how many findings fit together. I wish everybody a few of such Eureca-moments in their carreer.

Fingerprint Dive into the research topics where C.C. (René) van Donkelaar is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Cartilage Engineering & Materials Science
Collagen Engineering & Materials Science
Tissue Engineering & Materials Science
Articular Cartilage Medicine & Life Sciences
Periosteum Medicine & Life Sciences
Chondrocytes Medicine & Life Sciences
Proteoglycans Medicine & Life Sciences
Bone Development Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1995 2019

10 Downloads (Pure)

Characterizing the invasion of different breast cancer cell lines with distinct E-cadherin status in 3D using a microfluidic system

Eslami Amirabadi, H., Tuerlings, M., Hollestelle, A., Sahebali, S., Luttge, R., van Donkelaar, C. C. R., Martens, J. W. M. & den Toonder, J. M. J., 1 Dec 2019, In : Biomedical Microdevices. 21, 4, 11 p., 101.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Cadherins
Cells
Breast Neoplasms
Cell Line

The relationship between proteoglycan loss, overloading-induced collagen damage, and cyclic loading in articular cartilage

Henao Murillo, L., Pastrama, M., Ito, K. & van Donkelaar, R., 15 Nov 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cartilage
Articular Cartilage
Proteoglycans
Collagen
Phosphates
9 Citations (Scopus)
40 Downloads (Pure)

Collagen damage location in articular cartilage differs if damage is caused by excessive loading magnitude or rate

Henao-Murillo, L., Ito, K. & van Donkelaar, C. C., 8 Feb 2018, In : Annals of Biomedical Engineering. 46, 4, p. 605-615 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cartilage
Collagen
Histology
Flow of fluids
Tissue
2 Citations (Scopus)
54 Downloads (Pure)

Comparison between in vitro and in vivo cartilage overloading studies based on a systematic literature review

Nickien, M., Heuijerjans, A., Ito, K. & van Donkelaar, C. C., 1 Aug 2018, In : Journal of Orthopaedic Research. 36, 8, p. 2076-2086 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Cartilage
Articular Cartilage
In Vitro Techniques
Osteoarthritis
Cell Survival
1 Citation (Scopus)
44 Downloads (Pure)

Osteochondral resurfacing implantation angle is more important than implant material stiffness

Heuijerjans, A., Wilson, W., Ito, K. & van Donkelaar, C. C., 1 Nov 2018, In : Journal of Orthopaedic Research. 36, 11, p. 2911-2922 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cartilage
Hydrostatic Pressure
Collagen

Student theses

A compressible biphasic mixture theory with a fluid content dependent stiffness

Author: Cornelissen, L., 30 Jun 2004

Supervisor: Baaijens, F. (Supervisor 1), Oomens, C. (Supervisor 2), Huyghe, J. (Supervisor 2), Bovendeerd, P. (Supervisor 2) & van Donkelaar, C. (Supervisor 2)

Student thesis: Master

A computational model of the human growth plate

Author: Brouwers, J., 30 Sep 2004

Supervisor: Huiskes, H. (Supervisor 1), van Donkelaar, C. (Supervisor 2) & Sengers, B. (Supervisor 2)

Student thesis: Master

A fiber-reinforced hydrogel aortic valve: fabrication and characteristics of pHEMA reinforced with HP-PE fibers

Author: de Jager, K., 30 Sep 2000

Supervisor: Baaijens, F. (Supervisor 1), van Donkelaar, C. (Supervisor 2) & Cacciola, G. R. (External person) (Supervisor 2)

Student thesis: Master

A new method for analysing FRAP data in inhomogeneous tissues: application in the growth plate

Author: Sniekers, Y., 29 Feb 2004

Supervisor: Huiskes, H. (Supervisor 1), van Donkelaar, C. (Supervisor 2), Huyghe, J. (Supervisor 2) & Broers, J. (Supervisor 2)

Student thesis: Master

An in vitro culturing system for the study of solute transport and mechanical loading in intact intervertebral discs

Author: Grünhagen, T., 30 Jun 2004

Supervisor: Lee, C. (External person) (External coach), van Donkelaar, C. (Supervisor 2), Huyghe, J. (Supervisor 2), Huiskes, H. (Supervisor 2) & Ito, K. (Supervisor 2)

Student thesis: Master