If you made any changes in Pure these will be visible here soon.

Personal profile

Quote

“The intriguing capacity of living cells to shape and adapt their own environment teaches us how to engineer new tissues for the heart.”

Research profile

Carlijn Bouten is professor of Cell-Matrix Interactions in Cardiovascular Regeneration at the department of Biomedical Engineering (research group Soft Tissue Engineering & Mechanobiology). Her research group investigates the interplay between living cells and the mechanobiological cues originating from the extracellular matrix under conditions of tissue growth, adaptation, and regeneration and degeneration. The group uses ‘living’ model systems at different length scales (cell, cell-matrix, engineered tissue, native tissue) to quantify these aspects, preferably in real-time.

The obtained knowledge is applied in engineering approaches to regenerate living tissues, in particular for the human heart. A prominent example is the development of a synthetic, biodegradable heart valve prosthesis that seduces the body to create a new, living heart valve at the site of implantation. Bouten performs her multidisciplinary research in close collaboration with material scientists, life scientists, clinicians, and medtech spin-offs. She leads several national and international public-private-patient research consortia in the field of Regenerative Medicine and Tissue Engineering.

Academic background

Carlijn Bouten was trained in functional anatomy and biomechanics as well as muscle physiology at the department of Human Movement Sciences of Vrije Universiteit Amsterdam, where she received her MSc degree in 1991. In 1995, she obtained her PhD degree from Eindhoven University of Technology (TU/e, the Netherlands). She performed postdoctoral research at the Université Laval (Quebec), University of London, and at TU/e. In 1998, she was appointed assistant professor in Cellular Biomechanics in the department of Mechanical Engineering at TU/e, and in 2002 she became associate professor of Tissue Engineering in the department of Biomedical Engineering at the same university. In 2010, Carlijn Bouten was appointed full professor of Cell-Matrix Interaction in Cardiovascular Regeneration at TU/e. She is a recipient of the Aspasia Career Development award of the Dutch Science Foundation NWO (2002), which awarded her a VICI grant for her research on heart valve tissue engineering in 2003. From 2005-2010 Bouten was member of The Young Academy of the Royal Netherlands Academy of Arts and Sciences (KNAW).Since 2017, she leads the national gravitation program Materials-Driven Regeneration. In that same year she was elected member of the KNAW.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1991 2018

3 Citations
Open Access
File
Biomimetics
Microfluidics
Endothelial cells
Hemodynamics
Vascular Smooth Muscle

An automated quantitative analysis of cell, nucleus and focal adhesion morphology

Buskermolen, A. B. C., Kurniawan, N. A. & Bouten, C. V. C., 1 Mar 2018, In : PLoS ONE. 13, 3, 16 p., e0195201

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Focal Adhesions
cell nucleus
Cell Nucleus
Cell Adhesion
adhesion

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., van der Meer, A. D., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 24 Apr 2018, 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Piscataway: Institute of Electrical and Electronics Engineers (IEEE), p. 318-321 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Polydimethylsiloxane
organs
assembly
chips
Throughput

Anti-fibrotic effects of cardiac progenitor cells in a 3D-model of human cardiac fibrosis

Gartner, T. B., Deddens, J. C., Mol, E. A., Ferrer, M. M., van Laake, L. W., Bouten, C. V. C., Khademhosseini, A., Suyker, W. J. L., Sluijter, J. P. G. & Hjortnaes, J., Apr 2018, In : Cardiovascular Research. 114, p. S37-S37

Research output: Contribution to journalMeeting AbstractAcademic

Bio-inspired design strategies for semi-flexible polymer networks

Vrusch, C. H. M. P., 7 May 2018, Eindhoven: Technische Universiteit Eindhoven. 126 p.

Research output: ThesisPhd Thesis 1 (Research TU/e / Graduation TU/e)Academic

Open Access
File

Prizes

Materials-driven regeneration

Carlijn Bouten (Recipient), 2016

Recognition: NWOGravitationScientific

Netherlands
selection procedure
Ministry of Education
funding
organization

Activities 1993 1993

  • 4 Contributed talk

16th Annual Int. Conf. IEEE Eng. in Medicine and Biology, San Diego, USA

Bouten, C. (Speaker)
29 Oct 1993

Activity: Talk or presentationContributed talkScientific

RL Maastricht

Bouten, C. (Speaker)
24 Sep 1993

Activity: Talk or presentationContributed talkScientific

UT, BMTI

Bouten, C. (Speaker)
5 Oct 1993

Activity: Talk or presentationContributed talkScientific

2e Plenaire wetenschappelijke dag RL/TUE, Eindhoven

Bouten, C. (Speaker)
17 Sep 1993

Activity: Talk or presentationContributed talkScientific

Courses

BMT Science class: Prof. Bouten

1/09/13 → …

Course

Graduation project RMT

1/09/13 → …

Course

Heart and blood

1/09/15 → …

Course

Literature report RMT

1/09/13 → …

Course

Press / Media

Rebuilding tissues inside the human body

Carlijn Bouten

11/09/18

1 item of media coverage

Press/Media: Expert Comment

Prof. Van Marken Lichtenbelt nominated for Huibregtsen Prize

Carlijn Bouten

15/06/17

1 item of media coverage

Press/Media: Expert Comment

Kick-off for collaboration on regenerative medicine, RegMed XB

Carlijn Bouten

29/03/17

1 item of media coverage

Press/Media: Expert Comment

Impacts

Soft tissue biomechanics

Carlijn V.C. Bouten (Content manager)

Impact: Research Topic/Theme (at group level)

Tissue engineering

Carlijn V.C. Bouten (Content manager)

Impact: Research Topic/Theme (at group level)

Student theses

A 2-D finite element model of a muscle cell in agarose gel-matrix

Author: Tran, N. H., 29 Feb 2000

Supervisor: Baaijens, F. (Supervisor 1), Oomens, C. (Supervisor 2), Bouten, C. (Supervisor 2) & Breuls, R. (Supervisor 2)

Student thesis: Master

A 3-D finite element model of the tibialis anterior muscle of a rat: a contribution to pressure sores research

Author: Breuls, R., 31 Mar 1998

Supervisor: Janssen, J. (Supervisor 1), Oomens, C. (Supervisor 2), Bosboom, E. (Supervisor 2) & Bouten, C. (Supervisor 2)

Student thesis: Master

A finite element model to study the viability of muscle cells under compression

Author: Hendriks, F., 30 Jun 1999

Supervisor: Baaijens, F. (Supervisor 1), Oomens, C. (Supervisor 2), Bouten, C. (Supervisor 2) & Breuls, R. (Supervisor 2)

Student thesis: Master

A multilevel finite element method for studying muscle cell damage

Author: Sengers, B., 30 Nov 2000

Supervisor: Oomens, C. (Supervisor 1), Baaijens, F. (Supervisor 2), Bouten, C. (Supervisor 2) & Breuls, R. (Supervisor 2)

Student thesis: Master

Anisotropic changes in material behavior of murine dilated myocardium

Author: Schmidt, J., 31 Mar 2013

Supervisor: Bax, N. (Supervisor 1) & Bouten, C. (Supervisor 2)

Student thesis: Master