• 4 Citations
20192019

Research output per year

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Personal profile

Academic background

Bregje de Wildt studied Physiotherapy at Fontys University of Applied Sciences where she received her BSc degree in 2015. She received her MSc degree in 2018 in Human Movement Sciences at the VU University of Amsterdam. In November 2018 she joined the Orthopedic Biomechanics group at the Biomedical Engineering department of Eindhoven University of Technology (TU/e) as a Doctoral Candidate. In her research, she works under supervision of Associate Professor Sandra Hofmann on the development of a three-dimensional in vitro model for bone remodeling.

Research profile

Bregje de Wildt is a Doctoral Candidate (PhD) in Bioengineering Bone at the Orthopaedic Biomechanics research group. Her research focuses on the development of the three-dimensional in vitro model for human bone remodeling. Bone is a highly dynamic tissue with multiple mechanical and metabolic functions that are maintained by the process of bone remodeling. In this process, osteoblasts, osteoclasts, and osteocytes work together to maintain bone strength and mineral homeostasis. In skeletal diseases like osteoporosis, this bone remodeling is affected resulting in a net bone loss. To develop and test drugs for these bone diseases, an in vitro model for human bone remodeling might be used, addressing the principle reduction, refinement, and replacement of animal experiments. In this model, osteoblasts, osteocytes, and osteoclasts will be cultured within one construct under physiological biochemical and biomechanical conditions. To develop of this model covers the following techniques: cell (co-)culture, bioreactor culture, biomaterials, micro-computed tomography, (confocal) light microscopy, scanning electron microscopy, and biochemical analyses.  

Education/Academic qualification

Kinesiology, Master, Vrije Universiteit Amsterdam

1 Sep 201631 Aug 2018

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Research Output

  • 4 Citations
  • 1 Article

From bone regeneration to three-dimensional in vitro models: tissue engineering of organized bone extracellular matrix

de Wildt, B., Ansari, S., Sommerdijk, N., Ito, K., Akiva, A. & Hofmann, S., 12 Jun 2019, In : Current Opinion in Biomedical Engineering. 10, p. 107-115 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

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  • 4 Citations (Scopus)
    30 Downloads (Pure)

    Prizes

    MDR Young Talent Incentives Program 2020

    Bregje W.M. de Wildt (Recipient), 29 May 2020

    Prize: OtherScholarshipsScientific

    Student theses

    Predicting wall-shear-stress-dependent in vitro tissue growth using multiscale in silico models

    Author: Lauwers, I., 26 Mar 2020

    Supervisor: Hofmann, S. (Supervisor 1), Zhao, F. (Supervisor 2), de Wildt, B. W. (Supervisor 2) & Ito, K. (Supervisor 2)

    Student thesis: Master

    Towards intervertebral disc regeneration using notochordal cell matrix hydrogel

    Author: de Wildt, B., 2018

    Supervisor: Ito, K. (Supervisor 2), Helder, M. (External person) (Supervisor 1), van Hooijdonk - Mouser, V. (Coach) & Rustenburg, C. (External person) (Coach)

    Student thesis: Master